SidaGhanaV1, PascalFrancis, Corpus, bibRecord, 000009

High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians

Identifieur interne : 000009 ( PascalFrancis/Corpus ); précédent : 000008; suivant : 000010

High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians

Auteurs : Fred S. Sarfo ; Rosie Keegan ; Lambert Appiah ; Shaid Shakoor ; Richard Phillips ; Betty Norman ; Yasmin Hardy ; George Bedu-Addo ; Lydia Longstaff ; David R. Chadwick

Source :

The Journal of infection [ 0163-4453 ] ; 2013.

RBID : Pascal:13-0221562

Descripteurs français

Pascal (Inist)
- SIDA, Prévalence, Rein, Trouble fonctionnel, Facteur risque, Mortalité, Pronostic.

English descriptors

KwdEn :
- AIDS, Dysfunction, Kidney, Mortality, Prevalence, Prognosis, Risk factor.

Abstract

Objectives: To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana. Methods: Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) was calculated in patients attending an HIV clinic between 2004 and 2011 using Cockcroft-Gault, MDRD and CKD-EPI formulae. Logistic regression analysis was used to identify risk factors associated with RD and Kaplan-Meier/Cox proportional regression analyses to explore associations between baseline CrCl/eGFR and subsequent mortality. Results: In 3137 patients starting antiretroviral therapy (ART) the frequency (95%-CI) of RD, defined by CrCl <60 ml/min/1.73 m² using Cockroft-Gault formula was 38.8% (37.1-40.5%). RD prevalence in a sub-population of 238 patients, including proteinuria in the definition, was 15.3% (10.3-22.1%) in ART-treated and 43.6% (34.0-53.7%) in ART-naïve patients. RD at baseline was associated with increasing age, low CD4 counts, advanced WHO stage and female gender. Cox proportional hazard analysis identified an increased hazard of death with decreasing CrCl, HR 1.46 (1.31-1.63) for each tertile lower than CrCl of 90 ml/min/1.73 m². Conclusions: RD is very common in HIV-infected ART-naïve Ghanaians, and associated with increased risk of mortality. Screening and monitoring of RD is important in this setting, particularly as tenofovir use increases.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0163-4453`
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A03		`1`		`@0 J. infect.`
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A08	`01`	`1`	`ENG`	`@1 High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians`
A11	`01`	`1`		`@1 SARFO (Fred S.)`
A11	`02`	`1`		`@1 KEEGAN (Rosie)`
A11	`03`	`1`		`@1 APPIAH (Lambert)`
A11	`04`	`1`		`@1 SHAKOOR (Shaid)`
A11	`05`	`1`		`@1 PHILLIPS (Richard)`
A11	`06`	`1`		`@1 NORMAN (Betty)`
A11	`07`	`1`		`@1 HARDY (Yasmin)`
A11	`08`	`1`		`@1 BEDU-ADDO (George)`
A11	`09`	`1`		`@1 LONGSTAFF (Lydia)`
A11	`10`	`1`		`@1 CHADWICK (David R.)`
A14	`01`			`@1 Komfo Anokye Teaching Hospital @2 Kumasi @3 GHA @Z 1 aut. @Z 3 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.`
A14	`02`			`@1 James Cook University Hospital @2 Middlesbrough @3 GBR @Z 2 aut. @Z 4 aut. @Z 9 aut. @Z 10 aut.`
A20				`@1 43-50`
A21				`@1 2013`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18250 @5 354000503053180060`
A44				`@0 0000 @1 © 2013 INIST-CNRS. All rights reserved.`
A45				`@0 27 ref.`
A47	`01`	`1`		`@0 13-0221562`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 The Journal of infection`
A66	`01`			`@0 NLD`
C01	`01`		`ENG`	@0 Objectives: To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana. Methods: Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) was calculated in patients attending an HIV clinic between 2004 and 2011 using Cockcroft-Gault, MDRD and CKD-EPI formulae. Logistic regression analysis was used to identify risk factors associated with RD and Kaplan-Meier/Cox proportional regression analyses to explore associations between baseline CrCl/eGFR and subsequent mortality. Results: In 3137 patients starting antiretroviral therapy (ART) the frequency (95%-CI) of RD, defined by CrCl <60 ml/min/1.73 m² using Cockroft-Gault formula was 38.8% (37.1-40.5%). RD prevalence in a sub-population of 238 patients, including proteinuria in the definition, was 15.3% (10.3-22.1%) in ART-treated and 43.6% (34.0-53.7%) in ART-naïve patients. RD at baseline was associated with increasing age, low CD4 counts, advanced WHO stage and female gender. Cox proportional hazard analysis identified an increased hazard of death with decreasing CrCl, HR 1.46 (1.31-1.63) for each tertile lower than CrCl of 90 ml/min/1.73 m². Conclusions: RD is very common in HIV-infected ART-naïve Ghanaians, and associated with increased risk of mortality. Screening and monitoring of RD is important in this setting, particularly as tenofovir use increases.
C02	`01`	`X`		`@0 002B01`
C02	`02`	`X`		`@0 002B05C02D`
C02	`03`	`X`		`@0 002B06D01`
C03	`01`	`X`	`FRE`	`@0 SIDA @5 01`
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C03	`01`	`X`	`SPA`	`@0 SIDA @5 01`
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C03	`02`	`X`	`ENG`	`@0 Prevalence @5 07`
C03	`02`	`X`	`SPA`	`@0 Prevalencia @5 07`
C03	`03`	`X`	`FRE`	`@0 Rein @5 08`
C03	`03`	`X`	`ENG`	`@0 Kidney @5 08`
C03	`03`	`X`	`SPA`	`@0 Riñón @5 08`
C03	`04`	`X`	`FRE`	`@0 Trouble fonctionnel @5 09`
C03	`04`	`X`	`ENG`	`@0 Dysfunction @5 09`
C03	`04`	`X`	`SPA`	`@0 Trastorno funcional @5 09`
C03	`05`	`X`	`FRE`	`@0 Facteur risque @5 13`
C03	`05`	`X`	`ENG`	`@0 Risk factor @5 13`
C03	`05`	`X`	`SPA`	`@0 Factor riesgo @5 13`
C03	`06`	`X`	`FRE`	`@0 Mortalité @5 14`
C03	`06`	`X`	`ENG`	`@0 Mortality @5 14`
C03	`06`	`X`	`SPA`	`@0 Mortalidad @5 14`
C03	`07`	`X`	`FRE`	`@0 Pronostic @5 30`
C03	`07`	`X`	`ENG`	`@0 Prognosis @5 30`
C03	`07`	`X`	`SPA`	`@0 Pronóstico @5 30`
C07	`01`	`X`	`FRE`	`@0 Virose`
C07	`01`	`X`	`ENG`	`@0 Viral disease`
C07	`01`	`X`	`SPA`	`@0 Virosis`
C07	`02`	`X`	`FRE`	`@0 Infection`
C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
C07	`03`	`X`	`FRE`	`@0 Epidémiologie @5 37`
C07	`03`	`X`	`ENG`	`@0 Epidemiology @5 37`
C07	`03`	`X`	`SPA`	`@0 Epidemiología @5 37`
C07	`04`	`X`	`FRE`	`@0 Immunodéficit @5 38`
C07	`04`	`X`	`ENG`	`@0 Immune deficiency @5 38`
C07	`04`	`X`	`SPA`	`@0 Inmunodeficiencia @5 38`
C07	`05`	`X`	`FRE`	`@0 Immunopathologie @5 40`
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C07	`05`	`X`	`SPA`	`@0 Inmunopatología @5 40`
N21				`@1 203`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 13-0221562 INIST
ET :	High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians
AU :	SARFO (Fred S.); KEEGAN (Rosie); APPIAH (Lambert); SHAKOOR (Shaid); PHILLIPS (Richard); NORMAN (Betty); HARDY (Yasmin); BEDU-ADDO (George); LONGSTAFF (Lydia); CHADWICK (David R.)
AF :	Komfo Anokye Teaching Hospital/Kumasi/Ghana (1 aut., 3 aut., 5 aut., 6 aut., 7 aut., 8 aut.); James Cook University Hospital/Middlesbrough/Royaume-Uni (2 aut., 4 aut., 9 aut., 10 aut.)
DT :	Publication en série; Niveau analytique
SO :	The Journal of infection; ISSN 0163-4453; Coden JINFD2; Pays-Bas; Da. 2013; Vol. 67; No. 1; Pp. 43-50; Bibl. 27 ref.
LA :	Anglais
EA :	Objectives: To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana. Methods: Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) was calculated in patients attending an HIV clinic between 2004 and 2011 using Cockcroft-Gault, MDRD and CKD-EPI formulae. Logistic regression analysis was used to identify risk factors associated with RD and Kaplan-Meier/Cox proportional regression analyses to explore associations between baseline CrCl/eGFR and subsequent mortality. Results: In 3137 patients starting antiretroviral therapy (ART) the frequency (95%-CI) of RD, defined by CrCl <60 ml/min/1.73 m² using Cockroft-Gault formula was 38.8% (37.1-40.5%). RD prevalence in a sub-population of 238 patients, including proteinuria in the definition, was 15.3% (10.3-22.1%) in ART-treated and 43.6% (34.0-53.7%) in ART-naïve patients. RD at baseline was associated with increasing age, low CD4 counts, advanced WHO stage and female gender. Cox proportional hazard analysis identified an increased hazard of death with decreasing CrCl, HR 1.46 (1.31-1.63) for each tertile lower than CrCl of 90 ml/min/1.73 m². Conclusions: RD is very common in HIV-infected ART-naïve Ghanaians, and associated with increased risk of mortality. Screening and monitoring of RD is important in this setting, particularly as tenofovir use increases.
CC :	002B01; 002B05C02D; 002B06D01
FD :	SIDA; Prévalence; Rein; Trouble fonctionnel; Facteur risque; Mortalité; Pronostic
FG :	Virose; Infection; Epidémiologie; Immunodéficit; Immunopathologie
ED :	AIDS; Prevalence; Kidney; Dysfunction; Risk factor; Mortality; Prognosis
EG :	Viral disease; Infection; Epidemiology; Immune deficiency; Immunopathology
SD :	SIDA; Prevalencia; Riñón; Trastorno funcional; Factor riesgo; Mortalidad; Pronóstico
LO :	INIST-18250.354000503053180060
ID :	13-0221562

Links to Exploration step

Pascal:13-0221562

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians</title>
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<author><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name>
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<front><div type="abstract" xml:lang="en">Objectives: To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana. Methods: Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) was calculated in patients attending an HIV clinic between 2004 and 2011 using Cockcroft-Gault, MDRD and CKD-EPI formulae. Logistic regression analysis was used to identify risk factors associated with RD and Kaplan-Meier/Cox proportional regression analyses to explore associations between baseline CrCl/eGFR and subsequent mortality. Results: In 3137 patients starting antiretroviral therapy (ART) the frequency (95%-CI) of RD, defined by CrCl <60 ml/min/1.73 m<sup>2</sup>
 using Cockroft-Gault formula was 38.8% (37.1-40.5%). RD prevalence in a sub-population of 238 patients, including proteinuria in the definition, was 15.3% (10.3-22.1%) in ART-treated and 43.6% (34.0-53.7%) in ART-naïve patients. RD at baseline was associated with increasing age, low CD4 counts, advanced WHO stage and female gender. Cox proportional hazard analysis identified an increased hazard of death with decreasing CrCl, HR 1.46 (1.31-1.63) for each tertile lower than CrCl of 90 ml/min/1.73 m<sup>2</sup>
. Conclusions: RD is very common in HIV-infected ART-naïve Ghanaians, and associated with increased risk of mortality. Screening and monitoring of RD is important in this setting, particularly as tenofovir use increases.</div>
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<fA03 i2="1"><s0>J. infect.</s0>
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<fA08 i1="01" i2="1" l="ENG"><s1>High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians</s1>
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<fA11 i1="02" i2="1"><s1>KEEGAN (Rosie)</s1>
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<fA11 i1="03" i2="1"><s1>APPIAH (Lambert)</s1>
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<fA11 i1="04" i2="1"><s1>SHAKOOR (Shaid)</s1>
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<fA11 i1="05" i2="1"><s1>PHILLIPS (Richard)</s1>
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<fA11 i1="06" i2="1"><s1>NORMAN (Betty)</s1>
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<fA11 i1="07" i2="1"><s1>HARDY (Yasmin)</s1>
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<fA11 i1="08" i2="1"><s1>BEDU-ADDO (George)</s1>
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<fA11 i1="09" i2="1"><s1>LONGSTAFF (Lydia)</s1>
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<fA11 i1="10" i2="1"><s1>CHADWICK (David R.)</s1>
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<sZ>3 aut.</sZ>
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<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<s2>Middlesbrough</s2>
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<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA20><s1>43-50</s1>
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<fA64 i1="01" i2="1"><s0>The Journal of infection</s0>
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<fA66 i1="01"><s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Objectives: To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana. Methods: Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) was calculated in patients attending an HIV clinic between 2004 and 2011 using Cockcroft-Gault, MDRD and CKD-EPI formulae. Logistic regression analysis was used to identify risk factors associated with RD and Kaplan-Meier/Cox proportional regression analyses to explore associations between baseline CrCl/eGFR and subsequent mortality. Results: In 3137 patients starting antiretroviral therapy (ART) the frequency (95%-CI) of RD, defined by CrCl <60 ml/min/1.73 m<sup>2</sup>
 using Cockroft-Gault formula was 38.8% (37.1-40.5%). RD prevalence in a sub-population of 238 patients, including proteinuria in the definition, was 15.3% (10.3-22.1%) in ART-treated and 43.6% (34.0-53.7%) in ART-naïve patients. RD at baseline was associated with increasing age, low CD4 counts, advanced WHO stage and female gender. Cox proportional hazard analysis identified an increased hazard of death with decreasing CrCl, HR 1.46 (1.31-1.63) for each tertile lower than CrCl of 90 ml/min/1.73 m<sup>2</sup>
. Conclusions: RD is very common in HIV-infected ART-naïve Ghanaians, and associated with increased risk of mortality. Screening and monitoring of RD is important in this setting, particularly as tenofovir use increases.</s0>
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<server><NO>PASCAL 13-0221562 INIST</NO>
<ET>High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians</ET>
<AU>SARFO (Fred S.); KEEGAN (Rosie); APPIAH (Lambert); SHAKOOR (Shaid); PHILLIPS (Richard); NORMAN (Betty); HARDY (Yasmin); BEDU-ADDO (George); LONGSTAFF (Lydia); CHADWICK (David R.)</AU>
<AF>Komfo Anokye Teaching Hospital/Kumasi/Ghana (1 aut., 3 aut., 5 aut., 6 aut., 7 aut., 8 aut.); James Cook University Hospital/Middlesbrough/Royaume-Uni (2 aut., 4 aut., 9 aut., 10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The Journal of infection; ISSN 0163-4453; Coden JINFD2; Pays-Bas; Da. 2013; Vol. 67; No. 1; Pp. 43-50; Bibl. 27 ref.</SO>
<LA>Anglais</LA>
<EA>Objectives: To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana. Methods: Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) was calculated in patients attending an HIV clinic between 2004 and 2011 using Cockcroft-Gault, MDRD and CKD-EPI formulae. Logistic regression analysis was used to identify risk factors associated with RD and Kaplan-Meier/Cox proportional regression analyses to explore associations between baseline CrCl/eGFR and subsequent mortality. Results: In 3137 patients starting antiretroviral therapy (ART) the frequency (95%-CI) of RD, defined by CrCl <60 ml/min/1.73 m<sup>2</sup>
 using Cockroft-Gault formula was 38.8% (37.1-40.5%). RD prevalence in a sub-population of 238 patients, including proteinuria in the definition, was 15.3% (10.3-22.1%) in ART-treated and 43.6% (34.0-53.7%) in ART-naïve patients. RD at baseline was associated with increasing age, low CD4 counts, advanced WHO stage and female gender. Cox proportional hazard analysis identified an increased hazard of death with decreasing CrCl, HR 1.46 (1.31-1.63) for each tertile lower than CrCl of 90 ml/min/1.73 m<sup>2</sup>
. Conclusions: RD is very common in HIV-infected ART-naïve Ghanaians, and associated with increased risk of mortality. Screening and monitoring of RD is important in this setting, particularly as tenofovir use increases.</EA>
<CC>002B01; 002B05C02D; 002B06D01</CC>
<FD>SIDA; Prévalence; Rein; Trouble fonctionnel; Facteur risque; Mortalité; Pronostic</FD>
<FG>Virose; Infection; Epidémiologie; Immunodéficit; Immunopathologie</FG>
<ED>AIDS; Prevalence; Kidney; Dysfunction; Risk factor; Mortality; Prognosis</ED>
<EG>Viral disease; Infection; Epidemiology; Immune deficiency; Immunopathology</EG>
<SD>SIDA; Prevalencia; Riñón; Trastorno funcional; Factor riesgo; Mortalidad; Pronóstico</SD>
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High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians

High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians

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