SidaGhanaV1, PascalFrancis, Checkpoint, bibRecord, 000043

Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial

Identifieur interne : 000043 ( PascalFrancis/Checkpoint ); précédent : 000042; suivant : 000044

Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial

Auteurs : Philippe Mayaud [Royaume-Uni] ; Jérôme Legoff [France] ; Helen A. Weiss [Royaume-Uni] ; Gérard Gresenguet [France] ; Khonde Nzambi [Ghana] ; Hicham Bouhlal [France] ; Eric Frost [Canada] ; Jacques Pepin [Canada] ; Jean-Elie Malkin [France] ; Richard J. Hayes [Royaume-Uni] ; David C. W. Mabey [Royaume-Uni] ; Laurent Belec [France]

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2009.

RBID : Pascal:09-0339639

Descripteurs français

Pascal (Inist)
- Virus HIV1, Herpesvirus hominis 2, Homme, Herpès génital, Ulcère, SIDA, Femelle, Microbiologie, Aciclovir, Antiviral.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- AIDS, Aciclovir, Antiviral, Female, Genital herpes, HIV-1 virus, Human, Human herpesvirus 2, Microbiology, Ulcer.

Abstract

Background. Little is known about the impact of episodic treatment of herpes on human immunodeficiency virus type 1 (HIV-1). Methods. Women from Ghana and the Central African Republic who had genital ulcers were enrolled in a randomized, double-blind, placebo-controlled trial of acyclovir plus antibacterials and were monitored for 28 days. Ulcer etiologies and detection of lesional HIV-1 RNA were determined by polymerase chain reaction (PCR). Cervicovaginal HIV-1 RNA and herpes simplex virus type 2 (HSV-2) DNA and plasma HIV-1 RNA were quantitated by real-time PCR. Primary analyses included 118 HIV-1-infected women with HSV-2 ulcers (54 of whom were given acyclovir and 64 of whom were given placebo). Results. Acyclovir had little impact on (1) detection of cervicovaginal HIV-1 RNA (risk ratio [RR], 0.96; 95% confidence interval [CI], 0.8-1.2) at day 7 of treatment, (2) the mean cervicovaginal HIV-1 RNA load (-0.06 log₁₀ copies/mL; 95% CI, -0.4 to 0.3 log₁₀ copies/mL) at day 7 of treatment, or (3) the plasma HIV-1 RNA load (+0.09 log₁₀ copies/mL; 95% CI, -0.1 to 0.3 log₁₀ copies/mL) at day 14 of treatment. At day 7, women receiving acyclovir were less likely to have detectable lesional HIV-1 RNA (RR, 0.70; 95% CI, 0.4-1.2) or cervicovaginal HSV-2 DNA (RR, 0.69; 95% CI, 0.4-1.3), had a lower quantity of HSV-2 DNA (-0.99 log₁₀ copies/mL; 95% CI, - 1.8 to -0.2 log₁₀ copies/mL), and were more likely to have a healed ulcer (RR, 1.26; 95% CI, 0.9-1.9). Conclusion. Episodic therapy for herpes reduced the quantity of cervicovaginal HSV-2 DNA and slightly improved ulcer healing, but it did not decrease genital and plasma HIV-1 RNA loads.

Affiliations:

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial</title>
<author><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
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</placeName>
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<author><name sortKey="Legoff, Jerome" sort="Legoff, Jerome" uniqKey="Legoff J" first="Jérôme" last="Legoff">Jérôme Legoff</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université Paris Descartes, Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 (Immunologie Humaine), Centre de Recherches Biomédicales des Cordeliers and Laboratoire de Virologie, Hôpital Européen Georges Pompidou</s1>
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<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Université Paris Diderot, Laboratoire de Microbiologie, Hôpital Saint-Louis</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital Saint-Louis</wicri:noRegion>
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<author><name sortKey="Weiss, Helen A" sort="Weiss, Helen A" uniqKey="Weiss H" first="Helen A." last="Weiss">Helen A. Weiss</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Infectious Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine</s1>
<s2>London</s2>
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<author><name sortKey="Gresenguet, Gerard" sort="Gresenguet, Gerard" uniqKey="Gresenguet G" first="Gérard" last="Gresenguet">Gérard Gresenguet</name>
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<author><name sortKey="Nzambi, Khonde" sort="Nzambi, Khonde" uniqKey="Nzambi K" first="Khonde" last="Nzambi">Khonde Nzambi</name>
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<author><name sortKey="Bouhlal, Hicham" sort="Bouhlal, Hicham" uniqKey="Bouhlal H" first="Hicham" last="Bouhlal">Hicham Bouhlal</name>
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<author><name sortKey="Frost, Eric" sort="Frost, Eric" uniqKey="Frost E" first="Eric" last="Frost">Eric Frost</name>
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<s3>CAN</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Pepin, Jacques" sort="Pepin, Jacques" uniqKey="Pepin J" first="Jacques" last="Pepin">Jacques Pepin</name>
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<s2>Sherbrooke</s2>
<s3>CAN</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<author><name sortKey="Malkin, Jean Elie" sort="Malkin, Jean Elie" uniqKey="Malkin J" first="Jean-Elie" last="Malkin">Jean-Elie Malkin</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Centre Médical, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hayes, Richard J" sort="Hayes, Richard J" uniqKey="Hayes R" first="Richard J." last="Hayes">Richard J. Hayes</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Infectious Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mabey, David C W" sort="Mabey, David C W" uniqKey="Mabey D" first="David C. W." last="Mabey">David C. W. Mabey</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belec, Laurent" sort="Belec, Laurent" uniqKey="Belec L" first="Laurent" last="Belec">Laurent Belec</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université Paris Descartes, Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 (Immunologie Humaine), Centre de Recherches Biomédicales des Cordeliers and Laboratoire de Virologie, Hôpital Européen Georges Pompidou</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital Européen Georges Pompidou</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes, Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 (Immunologie Humaine), Centre de Recherches Biomédicales des Cordeliers and Laboratoire de Virologie, Hôpital Européen Georges Pompidou</wicri:noRegion>
<orgName type="university">Université Paris-Descartes</orgName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Aciclovir</term>
<term>Antiviral</term>
<term>Female</term>
<term>Genital herpes</term>
<term>HIV-1 virus</term>
<term>Human</term>
<term>Human herpesvirus 2</term>
<term>Microbiology</term>
<term>Ulcer</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus HIV1</term>
<term>Herpesvirus hominis 2</term>
<term>Homme</term>
<term>Herpès génital</term>
<term>Ulcère</term>
<term>SIDA</term>
<term>Femelle</term>
<term>Microbiologie</term>
<term>Aciclovir</term>
<term>Antiviral</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Background. Little is known about the impact of episodic treatment of herpes on human immunodeficiency virus type 1 (HIV-1). Methods. Women from Ghana and the Central African Republic who had genital ulcers were enrolled in a randomized, double-blind, placebo-controlled trial of acyclovir plus antibacterials and were monitored for 28 days. Ulcer etiologies and detection of lesional HIV-1 RNA were determined by polymerase chain reaction (PCR). Cervicovaginal HIV-1 RNA and herpes simplex virus type 2 (HSV-2) DNA and plasma HIV-1 RNA were quantitated by real-time PCR. Primary analyses included 118 HIV-1-infected women with HSV-2 ulcers (54 of whom were given acyclovir and 64 of whom were given placebo). Results. Acyclovir had little impact on (1) detection of cervicovaginal HIV-1 RNA (risk ratio [RR], 0.96; 95% confidence interval [CI], 0.8-1.2) at day 7 of treatment, (2) the mean cervicovaginal HIV-1 RNA load (-0.06 log<sub>10</sub>
 copies/mL; 95% CI, -0.4 to 0.3 log<sub>10</sub>
 copies/mL) at day 7 of treatment, or (3) the plasma HIV-1 RNA load (+0.09 log<sub>10</sub>
 copies/mL; 95% CI, -0.1 to 0.3 log<sub>10</sub>
 copies/mL) at day 14 of treatment. At day 7, women receiving acyclovir were less likely to have detectable lesional HIV-1 RNA (RR, 0.70; 95% CI, 0.4-1.2) or cervicovaginal HSV-2 DNA (RR, 0.69; 95% CI, 0.4-1.3), had a lower quantity of HSV-2 DNA (-0.99 log<sub>10</sub>
 copies/mL; 95% CI, - 1.8 to -0.2 log<sub>10</sub>
 copies/mL), and were more likely to have a healed ulcer (RR, 1.26; 95% CI, 0.9-1.9). Conclusion. Episodic therapy for herpes reduced the quantity of cervicovaginal HSV-2 DNA and slightly improved ulcer healing, but it did not decrease genital and plasma HIV-1 RNA loads.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1899</s0>
</fA01>
<fA02 i1="01"><s0>JIDIAQ</s0>
</fA02>
<fA03 i2="1"><s0>J. infect. dis.</s0>
</fA03>
<fA05><s2>200</s2>
</fA05>
<fA06><s2>2</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>MAYAUD (Philippe)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>LEGOFF (Jérôme)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>WEISS (Helen A.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>GRESENGUET (Gérard)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>NZAMBI (Khonde)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>BOUHLAL (Hicham)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>FROST (Eric)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>PEPIN (Jacques)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>MALKIN (Jean-Elie)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>HAYES (Richard J.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>MABEY (David C. W.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>BELEC (Laurent)</s1>
</fA11>
<fA14 i1="01"><s1>Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Infectious Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Université Paris Descartes, Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 (Immunologie Humaine), Centre de Recherches Biomédicales des Cordeliers and Laboratoire de Virologie, Hôpital Européen Georges Pompidou</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Université Paris Diderot, Laboratoire de Microbiologie, Hôpital Saint-Louis</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Centre Médical, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Centre National de Référence des Maladies Sexuellement Transmissibles et du SIDA de Bangui and Unité de Recherches et d'Intervention sur les Maladies Sexuellement Transmissibles et du SIDA, Faculté des Sciences de la Santé</s1>
<s2>Bangui</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Central African Republic; 'West African Project To Combat AIDS and STIs</s1>
<s2>Accra</s2>
<s3>GHA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Centre for International Health, University of Sherbrooke</s1>
<s2>Sherbrooke</s2>
<s3>CAN</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>ANRS 1212 Study Group</s1>
<s3>INC</s3>
</fA17>
<fA20><s1>216-226</s1>
</fA20>
<fA21><s1>2009</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>2052</s2>
<s5>354000187517850090</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>47 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>09-0339639</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The Journal of infectious diseases</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background. Little is known about the impact of episodic treatment of herpes on human immunodeficiency virus type 1 (HIV-1). Methods. Women from Ghana and the Central African Republic who had genital ulcers were enrolled in a randomized, double-blind, placebo-controlled trial of acyclovir plus antibacterials and were monitored for 28 days. Ulcer etiologies and detection of lesional HIV-1 RNA were determined by polymerase chain reaction (PCR). Cervicovaginal HIV-1 RNA and herpes simplex virus type 2 (HSV-2) DNA and plasma HIV-1 RNA were quantitated by real-time PCR. Primary analyses included 118 HIV-1-infected women with HSV-2 ulcers (54 of whom were given acyclovir and 64 of whom were given placebo). Results. Acyclovir had little impact on (1) detection of cervicovaginal HIV-1 RNA (risk ratio [RR], 0.96; 95% confidence interval [CI], 0.8-1.2) at day 7 of treatment, (2) the mean cervicovaginal HIV-1 RNA load (-0.06 log<sub>10</sub>
 copies/mL; 95% CI, -0.4 to 0.3 log<sub>10</sub>
 copies/mL) at day 7 of treatment, or (3) the plasma HIV-1 RNA load (+0.09 log<sub>10</sub>
 copies/mL; 95% CI, -0.1 to 0.3 log<sub>10</sub>
 copies/mL) at day 14 of treatment. At day 7, women receiving acyclovir were less likely to have detectable lesional HIV-1 RNA (RR, 0.70; 95% CI, 0.4-1.2) or cervicovaginal HSV-2 DNA (RR, 0.69; 95% CI, 0.4-1.3), had a lower quantity of HSV-2 DNA (-0.99 log<sub>10</sub>
 copies/mL; 95% CI, - 1.8 to -0.2 log<sub>10</sub>
 copies/mL), and were more likely to have a healed ulcer (RR, 1.26; 95% CI, 0.9-1.9). Conclusion. Episodic therapy for herpes reduced the quantity of cervicovaginal HSV-2 DNA and slightly improved ulcer healing, but it did not decrease genital and plasma HIV-1 RNA loads.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05C10</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02D</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Virus HIV1</s0>
<s2>NW</s2>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>HIV-1 virus</s0>
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<s5>01</s5>
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<s2>NW</s2>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Human herpesvirus 2</s0>
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<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Herpesvirus hominis 2</s0>
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<s5>02</s5>
</fC03>
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<s5>05</s5>
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<s5>05</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Herpes genital</s0>
<s5>05</s5>
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<s5>06</s5>
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<s5>06</s5>
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<s5>07</s5>
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<s5>08</s5>
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<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Aciclovir</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Aciclovir</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Aciclovir</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>15</s5>
</fC03>
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<s5>15</s5>
</fC03>
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<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
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<fC07 i1="06" i2="X" l="SPA"><s0>Herpesviridae</s0>
<s2>NW</s2>
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<fC07 i1="07" i2="X" l="FRE"><s0>Virose</s0>
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<fC07 i1="07" i2="X" l="SPA"><s0>Virosis</s0>
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<fC07 i1="08" i2="X" l="FRE"><s0>Infection</s0>
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<fC07 i1="08" i2="X" l="SPA"><s0>Infección</s0>
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<fC07 i1="09" i2="X" l="FRE"><s0>Nucléoside acyclique</s0>
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<s5>16</s5>
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<s5>21</s5>
</fC07>
<fC07 i1="15" i2="X" l="ENG"><s0>Immune deficiency</s0>
<s5>21</s5>
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<fC07 i1="15" i2="X" l="SPA"><s0>Inmunodeficiencia</s0>
<s5>21</s5>
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<fC07 i1="16" i2="X" l="FRE"><s0>Immunopathologie</s0>
<s5>23</s5>
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<fC07 i1="16" i2="X" l="ENG"><s0>Immunopathology</s0>
<s5>23</s5>
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<fC07 i1="16" i2="X" l="SPA"><s0>Inmunopatología</s0>
<s5>23</s5>
</fC07>
<fN21><s1>243</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Canada</li>
<li>France</li>
<li>Ghana</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Région du Grand Accra</li>
<li>Île-de-France</li>
</region>
<settlement><li>Accra</li>
<li>Londres</li>
<li>Paris</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name>
</region>
<name sortKey="Hayes, Richard J" sort="Hayes, Richard J" uniqKey="Hayes R" first="Richard J." last="Hayes">Richard J. Hayes</name>
<name sortKey="Mabey, David C W" sort="Mabey, David C W" uniqKey="Mabey D" first="David C. W." last="Mabey">David C. W. Mabey</name>
<name sortKey="Weiss, Helen A" sort="Weiss, Helen A" uniqKey="Weiss H" first="Helen A." last="Weiss">Helen A. Weiss</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Legoff, Jerome" sort="Legoff, Jerome" uniqKey="Legoff J" first="Jérôme" last="Legoff">Jérôme Legoff</name>
</region>
<name sortKey="Belec, Laurent" sort="Belec, Laurent" uniqKey="Belec L" first="Laurent" last="Belec">Laurent Belec</name>
<name sortKey="Bouhlal, Hicham" sort="Bouhlal, Hicham" uniqKey="Bouhlal H" first="Hicham" last="Bouhlal">Hicham Bouhlal</name>
<name sortKey="Gresenguet, Gerard" sort="Gresenguet, Gerard" uniqKey="Gresenguet G" first="Gérard" last="Gresenguet">Gérard Gresenguet</name>
<name sortKey="Legoff, Jerome" sort="Legoff, Jerome" uniqKey="Legoff J" first="Jérôme" last="Legoff">Jérôme Legoff</name>
<name sortKey="Malkin, Jean Elie" sort="Malkin, Jean Elie" uniqKey="Malkin J" first="Jean-Elie" last="Malkin">Jean-Elie Malkin</name>
</country>
<country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Nzambi, Khonde" sort="Nzambi, Khonde" uniqKey="Nzambi K" first="Khonde" last="Nzambi">Khonde Nzambi</name>
</region>
</country>
<country name="Canada"><noRegion><name sortKey="Frost, Eric" sort="Frost, Eric" uniqKey="Frost E" first="Eric" last="Frost">Eric Frost</name>
</noRegion>
<name sortKey="Pepin, Jacques" sort="Pepin, Jacques" uniqKey="Pepin J" first="Jacques" last="Pepin">Jacques Pepin</name>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaGhanaV1
   |flux=    PascalFrancis
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Pascal:09-0339639
   |texte=   Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial
}}

This area was generated with Dilib version V0.6.31.
Data generation: Tue Nov 7 18:07:38 2017. Site generation: Tue Mar 5 15:01:57 2024

	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA au Ghana (serveur d'exploration)

Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial

Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial

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