SidaGhanaV1, PascalFrancis, Checkpoint, bibRecord, 000004

Long-term responses to first-line antiretroviral therapy in HIV and hepatitis B co-infection in Ghana

Identifieur interne : 000004 ( PascalFrancis/Checkpoint ); précédent : 000003; suivant : 000005

Long-term responses to first-line antiretroviral therapy in HIV and hepatitis B co-infection in Ghana

Auteurs : Fred Stephen Sarfo [Ghana] ; Adetayo Kasim [Royaume-Uni] ; Richard Phillips [Ghana] ; Anna Maria Geretti [Royaume-Uni] ; David R. Chadwick [Royaume-Uni]

Source :

The Journal of infection [ 0163-4453 ] ; 2014.

RBID : Pascal:14-0264029

Descripteurs français

Pascal (Inist)
- SIDA, Hépatite virale B, Antiviral, Chimiothérapie, Long terme, Antirétroviral, Virus immunodéficience humaine, Ghana.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- AIDS, Antiretroviral agent, Antiviral, Chemotherapy, Ghana, Human immunodeficiency virus, Long term, Viral hepatitis B.

Abstract

Objectives: To observe the long term response to first-line antiretroviral therapy (ART) in HIV and hepatitis B virus (HBV) co-infected patients in Ghana and explore predictors of poor clinical outcomes. Methods: Retrospective cohort study of hepatitis B surface antigen (HBsAg) positive and negative patients receiving predominantly NNRTI-based ART with lamivudine plus either zidovudine or stavudine for up to seven years. Cox proportional hazards and Kaplan Meier survival analyses compared clinical outcomes and identified baseline characteristics predictive of poor outcomes. A mixed effects model compared changes in CD4 counts. Results: A total of 299 HBsAg-positive and 1869 HBsAg-negative patients started ART between 2004 and 2008. Over a median 35 months of follow-up, HBsAg-positive patients were more likely to die or default care than HBsAg-negative patients, aHR 1.36 (95% CI, 1.03-1.80). HBsAg-positive patients were also more likely to develop Grade 3/4 hepatotoxicity than HBsAg-negative patients, HR 1.99 (1.16-3.40) on survival analysis. There was no significant difference in CD4 responses between HBsAg-positive and HBsAg-negative patients. Conclusions: HBsAg-positive patients are at significantly increased risk of adverse clinical outcomes after starting ART. Further studies are warranted to evaluate whether these risks remain now that tenofovir is becoming routinely available in Ghana.

Affiliations:

Ghana, Royaume-Uni

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Le document en format XML

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<term>Antiviral</term>
<term>Chemotherapy</term>
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<term>Human immunodeficiency virus</term>
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<term>Viral hepatitis B</term>
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<front><div type="abstract" xml:lang="en">Objectives: To observe the long term response to first-line antiretroviral therapy (ART) in HIV and hepatitis B virus (HBV) co-infected patients in Ghana and explore predictors of poor clinical outcomes. Methods: Retrospective cohort study of hepatitis B surface antigen (HBsAg) positive and negative patients receiving predominantly NNRTI-based ART with lamivudine plus either zidovudine or stavudine for up to seven years. Cox proportional hazards and Kaplan Meier survival analyses compared clinical outcomes and identified baseline characteristics predictive of poor outcomes. A mixed effects model compared changes in CD4 counts. Results: A total of 299 HBsAg-positive and 1869 HBsAg-negative patients started ART between 2004 and 2008. Over a median 35 months of follow-up, HBsAg-positive patients were more likely to die or default care than HBsAg-negative patients, aHR 1.36 (95% CI, 1.03-1.80). HBsAg-positive patients were also more likely to develop Grade 3/4 hepatotoxicity than HBsAg-negative patients, HR 1.99 (1.16-3.40) on survival analysis. There was no significant difference in CD4 responses between HBsAg-positive and HBsAg-negative patients. Conclusions: HBsAg-positive patients are at significantly increased risk of adverse clinical outcomes after starting ART. Further studies are warranted to evaluate whether these risks remain now that tenofovir is becoming routinely available in Ghana.</div>
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<fC07 i1="08" i2="X" l="SPA"><s0>Inmunodeficiencia</s0>
<s5>37</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Immunopathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Immunopathology</s0>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Inmunopatología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Pathologie de l'appareil digestif</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Digestive diseases</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Aparato digestivo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Pathologie du foie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Hepatic disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Hígado patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>328</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Ghana</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Ghana"><noRegion><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name>
</noRegion>
<name sortKey="Phillips, Richard" sort="Phillips, Richard" uniqKey="Phillips R" first="Richard" last="Phillips">Richard Phillips</name>
<name sortKey="Phillips, Richard" sort="Phillips, Richard" uniqKey="Phillips R" first="Richard" last="Phillips">Richard Phillips</name>
<name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Kasim, Adetayo" sort="Kasim, Adetayo" uniqKey="Kasim A" first="Adetayo" last="Kasim">Adetayo Kasim</name>
</noRegion>
<name sortKey="Chadwick, David R" sort="Chadwick, David R" uniqKey="Chadwick D" first="David R." last="Chadwick">David R. Chadwick</name>
<name sortKey="Geretti, Anna Maria" sort="Geretti, Anna Maria" uniqKey="Geretti A" first="Anna Maria" last="Geretti">Anna Maria Geretti</name>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Wicri/Sante
   |area=    SidaGhanaV1
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   |clé=     Pascal:14-0264029
   |texte=   Long-term responses to first-line antiretroviral therapy in HIV and hepatitis B co-infection in Ghana
}}

This area was generated with Dilib version V0.6.31.
Data generation: Tue Nov 7 18:07:38 2017. Site generation: Tue Mar 5 15:01:57 2024

	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA au Ghana (serveur d'exploration)

Long-term responses to first-line antiretroviral therapy in HIV and hepatitis B co-infection in Ghana

Long-term responses to first-line antiretroviral therapy in HIV and hepatitis B co-infection in Ghana

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