Evaluation of the Adequacy of the 2010 Revised World Health Organization Recommended Dosages of the First-line Antituberculosis Drugs for Children.
Identifieur interne : 000B68 ( Ncbi/Merge ); précédent : 000B67; suivant : 000B69Evaluation of the Adequacy of the 2010 Revised World Health Organization Recommended Dosages of the First-line Antituberculosis Drugs for Children.
Auteurs : Hongmei Yang [États-Unis] ; Anthony Enimil ; Fizza S. Gillani ; Sampson Antwi ; Albert Dompreh ; Antoinette Ortsin ; Eugene Adu Awhireng ; Maxwell Owusu ; Lubbe Wiesner ; Charles A. Peloquin ; Awewura KwaraSource :
- The Pediatric infectious disease journal [ 1532-0987 ] ; 2017.
Abstract
The World Health Organization recommended increased dosages of the first-line antituberculosis (anti-TB) drugs for children in 2010. We examined the frequency of and factors associated with low plasma maximum concentration (Cmax) of each drug in children treated with the revised dosages.
DOI: 10.1097/INF.0000000000001687
PubMed: 28719501
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Gillani</name></author><author><name sortKey="Antwi, Sampson" sort="Antwi, Sampson" uniqKey="Antwi S" first="Sampson" last="Antwi">Sampson Antwi</name></author><author><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name></author><author><name sortKey="Ortsin, Antoinette" sort="Ortsin, Antoinette" uniqKey="Ortsin A" first="Antoinette" last="Ortsin">Antoinette Ortsin</name></author><author><name sortKey="Awhireng, Eugene Adu" sort="Awhireng, Eugene Adu" uniqKey="Awhireng E" first="Eugene Adu" last="Awhireng">Eugene Adu Awhireng</name></author><author><name sortKey="Owusu, Maxwell" sort="Owusu, Maxwell" uniqKey="Owusu M" first="Maxwell" last="Owusu">Maxwell Owusu</name></author><author><name sortKey="Wiesner, Lubbe" sort="Wiesner, Lubbe" uniqKey="Wiesner L" first="Lubbe" last="Wiesner">Lubbe Wiesner</name></author><author><name sortKey="Peloquin, Charles A" sort="Peloquin, Charles A" uniqKey="Peloquin C" first="Charles A" last="Peloquin">Charles A. Peloquin</name></author><author><name sortKey="Kwara, Awewura" sort="Kwara, Awewura" uniqKey="Kwara A" first="Awewura" last="Kwara">Awewura Kwara</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28719501</idno><idno type="pmid">28719501</idno><idno type="doi">10.1097/INF.0000000000001687</idno><idno type="wicri:Area/PubMed/Corpus">000888</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000888</idno><idno type="wicri:Area/PubMed/Curation">000887</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000887</idno><idno type="wicri:Area/PubMed/Checkpoint">000887</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000887</idno><idno type="wicri:Area/Ncbi/Merge">000B68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of the Adequacy of the 2010 Revised World Health Organization Recommended Dosages of the First-line Antituberculosis Drugs for Children.</title><author><name sortKey="Yang, Hongmei" sort="Yang, Hongmei" uniqKey="Yang H" first="Hongmei" last="Yang">Hongmei Yang</name><affiliation wicri:level="2"><nlm:affiliation>*Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, United States; ¥Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana; ¶Department of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Medicine, ‖Warren Alpert Medical School of Brown University, Providence, United States, ≠Department of Medicine, The Miriam Hospital, Providence, United States; ♯Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; £College of Pharmacy and Emerging Pathogens Institute, University of Florida, Gainesville, United States; §College of Medicine and Emerging Pathogens Institute, University of Florida, Gainesville, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>*Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, United States; ¥Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana; ¶Department of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Medicine, ‖Warren Alpert Medical School of Brown University, Providence, United States, ≠Department of Medicine, The Miriam Hospital, Providence, United States; ♯Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; £College of Pharmacy and Emerging Pathogens Institute, University of Florida, Gainesville, United States; §College of Medicine and Emerging Pathogens Institute, University of Florida, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Enimil, Anthony" sort="Enimil, Anthony" uniqKey="Enimil A" first="Anthony" last="Enimil">Anthony Enimil</name></author><author><name sortKey="Gillani, Fizza S" sort="Gillani, Fizza S" uniqKey="Gillani F" first="Fizza S" last="Gillani">Fizza S. Gillani</name></author><author><name sortKey="Antwi, Sampson" sort="Antwi, Sampson" uniqKey="Antwi S" first="Sampson" last="Antwi">Sampson Antwi</name></author><author><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name></author><author><name sortKey="Ortsin, Antoinette" sort="Ortsin, Antoinette" uniqKey="Ortsin A" first="Antoinette" last="Ortsin">Antoinette Ortsin</name></author><author><name sortKey="Awhireng, Eugene Adu" sort="Awhireng, Eugene Adu" uniqKey="Awhireng E" first="Eugene Adu" last="Awhireng">Eugene Adu Awhireng</name></author><author><name sortKey="Owusu, Maxwell" sort="Owusu, Maxwell" uniqKey="Owusu M" first="Maxwell" last="Owusu">Maxwell Owusu</name></author><author><name sortKey="Wiesner, Lubbe" sort="Wiesner, Lubbe" uniqKey="Wiesner L" first="Lubbe" last="Wiesner">Lubbe Wiesner</name></author><author><name sortKey="Peloquin, Charles A" sort="Peloquin, Charles A" uniqKey="Peloquin C" first="Charles A" last="Peloquin">Charles A. Peloquin</name></author><author><name sortKey="Kwara, Awewura" sort="Kwara, Awewura" uniqKey="Kwara A" first="Awewura" last="Kwara">Awewura Kwara</name></author></analytic><series><title level="j">The Pediatric infectious disease journal</title><idno type="eISSN">1532-0987</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The World Health Organization recommended increased dosages of the first-line antituberculosis (anti-TB) drugs for children in 2010. We examined the frequency of and factors associated with low plasma maximum concentration (Cmax) of each drug in children treated with the revised dosages.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28719501</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>18</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-0987</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Jul</Month><Day>14</Day></PubDate></JournalIssue><Title>The Pediatric infectious disease journal</Title><ISOAbbreviation>Pediatr. Infect. Dis. J.</ISOAbbreviation></Journal><ArticleTitle>Evaluation of the Adequacy of the 2010 Revised World Health Organization Recommended Dosages of the First-line Antituberculosis Drugs for Children.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1097/INF.0000000000001687</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The World Health Organization recommended increased dosages of the first-line antituberculosis (anti-TB) drugs for children in 2010. We examined the frequency of and factors associated with low plasma maximum concentration (Cmax) of each drug in children treated with the revised dosages.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Children on anti-TB therapy for at least 4 weeks underwent pharmacokinetic testing. Plasma Cmax below the lower limit of proposed reference range was considered low. Bivariate and multivariate analyses were used to examine the factors associated with low Cmax of each drug.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 100 children, 58% were male, 50% HIV-infected and 49% younger than 5 years old. The median (IQR) Cmax was 5.9 (4.5 - 7.7) µg/mL for isoniazid, 6.5 (4.9 - 8.8) µg/mL for rifampin, 26.0 (21.2 - 33.4) µg/mL for pyrazinamide and 1.7 (0.9 - 2.7) µg/mL for ethambutol. There was a strong correlation between Cmax and AUC0-8h for all drugs. Low Cmax occurred in 9/100 (9.0%), 61/100 (61.0%), 17/97 (17.5%), and 60/97 (61.9%) for isoniazid, rifampin, pyrazinamide, and ethambutol, respectively. In addition, 75/97 (77.3%) children had pyrazinamide Cmax < 35 µg/mL. Factors associated with low Cmax were NAT2 metabolizer phenotype status for isoniazid; height, dosage, and HIV coinfection status for rifampin; height for pyrazinamide; and age, dosage and HIV coinfection status for ethambutol.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The high frequency of low rifampin and ethambutol Cmax in our study is consistent with emerging pharmacokinetic data in children treated according to the new WHO recommendations. Higher dosages than currently recommended especially for rifampin may be necessary in children.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Hongmei</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>*Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, United States; ¥Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana; ¶Department of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Medicine, ‖Warren Alpert Medical School of Brown University, Providence, United States, ≠Department of Medicine, The Miriam Hospital, Providence, United States; ♯Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; £College of Pharmacy and Emerging Pathogens Institute, University of Florida, Gainesville, United States; §College of Medicine and Emerging Pathogens Institute, University of Florida, Gainesville, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enimil</LastName><ForeName>Anthony</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gillani</LastName><ForeName>Fizza S</ForeName><Initials>FS</Initials></Author><Author ValidYN="Y"><LastName>Antwi</LastName><ForeName>Sampson</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Dompreh</LastName><ForeName>Albert</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ortsin</LastName><ForeName>Antoinette</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Awhireng</LastName><ForeName>Eugene Adu</ForeName><Initials>EA</Initials></Author><Author ValidYN="Y"><LastName>Owusu</LastName><ForeName>Maxwell</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Wiesner</LastName><ForeName>Lubbe</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Peloquin</LastName><ForeName>Charles A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Kwara</LastName><ForeName>Awewura</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>07</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Infect Dis J</MedlineTA><NlmUniqueID>8701858</NlmUniqueID><ISSNLinking>0891-3668</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28719501</ArticleId><ArticleId IdType="doi">10.1097/INF.0000000000001687</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><noCountry><name sortKey="Antwi, Sampson" sort="Antwi, Sampson" uniqKey="Antwi S" first="Sampson" last="Antwi">Sampson Antwi</name><name sortKey="Awhireng, Eugene Adu" sort="Awhireng, Eugene Adu" uniqKey="Awhireng E" first="Eugene Adu" last="Awhireng">Eugene Adu Awhireng</name><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name><name sortKey="Enimil, Anthony" sort="Enimil, Anthony" uniqKey="Enimil A" first="Anthony" last="Enimil">Anthony Enimil</name><name sortKey="Gillani, Fizza S" sort="Gillani, Fizza S" uniqKey="Gillani F" first="Fizza S" last="Gillani">Fizza S. Gillani</name><name sortKey="Kwara, Awewura" sort="Kwara, Awewura" uniqKey="Kwara A" first="Awewura" last="Kwara">Awewura Kwara</name><name sortKey="Ortsin, Antoinette" sort="Ortsin, Antoinette" uniqKey="Ortsin A" first="Antoinette" last="Ortsin">Antoinette Ortsin</name><name sortKey="Owusu, Maxwell" sort="Owusu, Maxwell" uniqKey="Owusu M" first="Maxwell" last="Owusu">Maxwell Owusu</name><name sortKey="Peloquin, Charles A" sort="Peloquin, Charles A" uniqKey="Peloquin C" first="Charles A" last="Peloquin">Charles A. Peloquin</name><name sortKey="Wiesner, Lubbe" sort="Wiesner, Lubbe" uniqKey="Wiesner L" first="Lubbe" last="Wiesner">Lubbe Wiesner</name></noCountry><country name="États-Unis"><region name="Floride"><name sortKey="Yang, Hongmei" sort="Yang, Hongmei" uniqKey="Yang H" first="Hongmei" last="Yang">Hongmei Yang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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