Incidence, Remission and Mortality of Convulsive Epilepsy in Rural Northeast South Africa.
Identifieur interne : 000836 ( Ncbi/Merge ); précédent : 000835; suivant : 000837Incidence, Remission and Mortality of Convulsive Epilepsy in Rural Northeast South Africa.
Auteurs : Ryan G. Wagner [Suède] ; Christian Bottomley [Royaume-Uni] ; Anthony K. Ngugi [Kenya] ; Fredrick Ibinda [Kenya] ; F Xavier G Mez-Olivé [Ghana] ; Kathleen Kahn [Ghana] ; Stephen Tollman [Ghana] ; Charles R. Newton [Royaume-Uni] ; Ryan Wagner ; Rhian Twine ; Myles Connor ; Mark Collinson ; Honratio Masanja ; Alexander Mathew ; Angelina Kakooza ; George Pariyo ; Stefan Peterson ; Donald Ndyo-Mughenyi ; Rachael Odhiambo ; Eddie Chengo ; Martin Chabi ; Evasius Bauni ; Gathoni Kamuyu ; Victor Mung'Ala Odera ; James O. Mageto ; Ken Ae-Ngibise ; Bright Akpalu ; Albert Akpalu ; Francis Agbokey ; Patrick Adjei ; Seth Owusu-Agyei ; Immo Kleinschmidt ; Victor C K. Doku ; Peter Odermatt ; Brian Neville ; Josemir W. Sander ; Steve White ; Thomas Nutman ; Patricia Wilkins ; John NohSource :
- PloS one [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- mortalité : Épilepsie.
- épidémiologie : République d'Afrique du Sud, Épilepsie.
- Adolescent, Adulte, Cause de décès, Enfant, Facteurs de risque, Femelle, Humains, Incidence, Jeune adulte, Mortalité, Mâle, Population rurale, Surveillance de la population, Études transversales.
- Wicri :
- geographic : Afrique du Sud.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : South Africa.
- epidemiology : Epilepsy.
- mortality : Epilepsy.
- Adolescent, Adult, Cause of Death, Child, Cross-Sectional Studies, Female, Humans, Incidence, Male, Mortality, Population Surveillance, Risk Factors, Rural Population, Young Adult.
Abstract
Epilepsy is one of the most common neurological conditions globally, estimated to constitute 0.75% of the global burden of disease, with the majority of this burden found in low- and middle- income countries (LMICs). Few studies from LMICs, including much of sub-Saharan Africa, have described the incidence, remission or mortality rates due to epilepsy, which are needed to quantify the burden and inform policy. This study investigates the epidemiological parameters of convulsive epilepsy within a context of high HIV prevalence and an emerging burden of cardiovascular disease.
DOI: 10.1371/journal.pone.0129097
PubMed: 26053071
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pubmed:26053071Le document en format XML
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Mageto</name></author><author><name sortKey="Ae Ngibise, Ken" sort="Ae Ngibise, Ken" uniqKey="Ae Ngibise K" first="Ken" last="Ae-Ngibise">Ken Ae-Ngibise</name></author><author><name sortKey="Akpalu, Bright" sort="Akpalu, Bright" uniqKey="Akpalu B" first="Bright" last="Akpalu">Bright Akpalu</name></author><author><name sortKey="Akpalu, Albert" sort="Akpalu, Albert" uniqKey="Akpalu A" first="Albert" last="Akpalu">Albert Akpalu</name></author><author><name sortKey="Agbokey, Francis" sort="Agbokey, Francis" uniqKey="Agbokey F" first="Francis" last="Agbokey">Francis Agbokey</name></author><author><name sortKey="Adjei, Patrick" sort="Adjei, Patrick" uniqKey="Adjei P" first="Patrick" last="Adjei">Patrick Adjei</name></author><author><name sortKey="Owusu Agyei, Seth" sort="Owusu Agyei, Seth" uniqKey="Owusu Agyei S" first="Seth" last="Owusu-Agyei">Seth Owusu-Agyei</name></author><author><name sortKey="Kleinschmidt, Immo" sort="Kleinschmidt, Immo" uniqKey="Kleinschmidt I" first="Immo" last="Kleinschmidt">Immo Kleinschmidt</name></author><author><name sortKey="Doku, Victor C K" sort="Doku, Victor C K" uniqKey="Doku V" first="Victor C K" last="Doku">Victor C K. 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Wagner</name><affiliation wicri:level="4"><nlm:affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Bottomley, Christian" sort="Bottomley, Christian" uniqKey="Bottomley C" first="Christian" last="Bottomley">Christian Bottomley</name><affiliation wicri:level="3"><nlm:affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; MRC Tropical Epidemiology Group, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; MRC Tropical Epidemiology Group, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ngugi, Anthony K" sort="Ngugi, Anthony K" uniqKey="Ngugi A" first="Anthony K" last="Ngugi">Anthony K. Ngugi</name><affiliation wicri:level="1"><nlm:affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; Research Support Unit, Faculty of Health Sciences, Aga Khan University-East Africa, Nairobi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; Research Support Unit, Faculty of Health Sciences, Aga Khan University-East Africa, Nairobi</wicri:regionArea><wicri:noRegion>Nairobi</wicri:noRegion></affiliation></author><author><name sortKey="Ibinda, Fredrick" sort="Ibinda, Fredrick" uniqKey="Ibinda F" first="Fredrick" last="Ibinda">Fredrick Ibinda</name><affiliation wicri:level="1"><nlm:affiliation>KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi</wicri:regionArea><wicri:noRegion>Kilifi</wicri:noRegion></affiliation></author><author><name sortKey="G Mez Olive, F Xavier" sort="G Mez Olive, F Xavier" uniqKey="G Mez Olive F" first="F Xavier" last="G Mez-Olivé">F Xavier G Mez-Olivé</name><affiliation wicri:level="4"><nlm:affiliation>MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network, Accra, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name><affiliation wicri:level="4"><nlm:affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; INDEPTH Network, Accra, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; INDEPTH Network, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Tollman, Stephen" sort="Tollman, Stephen" uniqKey="Tollman S" first="Stephen" last="Tollman">Stephen Tollman</name><affiliation wicri:level="4"><nlm:affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; INDEPTH Network, Accra, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; INDEPTH Network, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Newton, Charles R" sort="Newton, Charles R" uniqKey="Newton C" first="Charles R" last="Newton">Charles R. Newton</name><affiliation wicri:level="4"><nlm:affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya; Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom; Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya; Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom; Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom; Department of Psychiatry, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Wagner, Ryan" sort="Wagner, Ryan" uniqKey="Wagner R" first="Ryan" last="Wagner">Ryan Wagner</name></author><author><name sortKey="Twine, Rhian" sort="Twine, Rhian" uniqKey="Twine R" first="Rhian" last="Twine">Rhian Twine</name></author><author><name sortKey="Connor, Myles" sort="Connor, Myles" uniqKey="Connor M" first="Myles" last="Connor">Myles Connor</name></author><author><name sortKey="Collinson, Mark" sort="Collinson, Mark" uniqKey="Collinson M" first="Mark" last="Collinson">Mark Collinson</name></author><author><name sortKey="Masanja, Honratio" sort="Masanja, Honratio" uniqKey="Masanja H" first="Honratio" last="Masanja">Honratio Masanja</name></author><author><name sortKey="Mathew, Alexander" sort="Mathew, Alexander" uniqKey="Mathew A" first="Alexander" last="Mathew">Alexander Mathew</name></author><author><name sortKey="Kakooza, Angelina" sort="Kakooza, Angelina" uniqKey="Kakooza A" first="Angelina" last="Kakooza">Angelina Kakooza</name></author><author><name sortKey="Pariyo, George" sort="Pariyo, George" uniqKey="Pariyo G" first="George" last="Pariyo">George Pariyo</name></author><author><name sortKey="Peterson, Stefan" sort="Peterson, Stefan" uniqKey="Peterson S" first="Stefan" last="Peterson">Stefan Peterson</name></author><author><name sortKey="Ndyo Mughenyi, Donald" sort="Ndyo Mughenyi, Donald" uniqKey="Ndyo Mughenyi D" first="Donald" last="Ndyo-Mughenyi">Donald Ndyo-Mughenyi</name></author><author><name sortKey="Odhiambo, Rachael" sort="Odhiambo, Rachael" uniqKey="Odhiambo R" first="Rachael" last="Odhiambo">Rachael Odhiambo</name></author><author><name sortKey="Chengo, Eddie" sort="Chengo, Eddie" uniqKey="Chengo E" first="Eddie" last="Chengo">Eddie Chengo</name></author><author><name sortKey="Chabi, Martin" sort="Chabi, Martin" uniqKey="Chabi M" first="Martin" last="Chabi">Martin Chabi</name></author><author><name sortKey="Bauni, Evasius" sort="Bauni, Evasius" uniqKey="Bauni E" first="Evasius" last="Bauni">Evasius Bauni</name></author><author><name sortKey="Kamuyu, Gathoni" sort="Kamuyu, Gathoni" uniqKey="Kamuyu G" first="Gathoni" last="Kamuyu">Gathoni Kamuyu</name></author><author><name sortKey="Odera, Victor Mung Ala" sort="Odera, Victor Mung Ala" uniqKey="Odera V" first="Victor Mung'Ala" last="Odera">Victor Mung'Ala Odera</name></author><author><name sortKey="Mageto, James O" sort="Mageto, James O" uniqKey="Mageto J" first="James O" last="Mageto">James O. Mageto</name></author><author><name sortKey="Ae Ngibise, Ken" sort="Ae Ngibise, Ken" uniqKey="Ae Ngibise K" first="Ken" last="Ae-Ngibise">Ken Ae-Ngibise</name></author><author><name sortKey="Akpalu, Bright" sort="Akpalu, Bright" uniqKey="Akpalu B" first="Bright" last="Akpalu">Bright Akpalu</name></author><author><name sortKey="Akpalu, Albert" sort="Akpalu, Albert" uniqKey="Akpalu A" first="Albert" last="Akpalu">Albert Akpalu</name></author><author><name sortKey="Agbokey, Francis" sort="Agbokey, Francis" uniqKey="Agbokey F" first="Francis" last="Agbokey">Francis Agbokey</name></author><author><name sortKey="Adjei, Patrick" sort="Adjei, Patrick" uniqKey="Adjei P" first="Patrick" last="Adjei">Patrick Adjei</name></author><author><name sortKey="Owusu Agyei, Seth" sort="Owusu Agyei, Seth" uniqKey="Owusu Agyei S" first="Seth" last="Owusu-Agyei">Seth Owusu-Agyei</name></author><author><name sortKey="Kleinschmidt, Immo" sort="Kleinschmidt, Immo" uniqKey="Kleinschmidt I" first="Immo" last="Kleinschmidt">Immo Kleinschmidt</name></author><author><name sortKey="Doku, Victor C K" sort="Doku, Victor C K" uniqKey="Doku V" first="Victor C K" last="Doku">Victor C K. Doku</name></author><author><name sortKey="Odermatt, Peter" sort="Odermatt, Peter" uniqKey="Odermatt P" first="Peter" last="Odermatt">Peter Odermatt</name></author><author><name sortKey="Neville, Brian" sort="Neville, Brian" uniqKey="Neville B" first="Brian" last="Neville">Brian Neville</name></author><author><name sortKey="Sander, Josemir W" sort="Sander, Josemir W" uniqKey="Sander J" first="Josemir W" last="Sander">Josemir W. Sander</name></author><author><name sortKey="White, Steve" sort="White, Steve" uniqKey="White S" first="Steve" last="White">Steve White</name></author><author><name sortKey="Nutman, Thomas" sort="Nutman, Thomas" uniqKey="Nutman T" first="Thomas" last="Nutman">Thomas Nutman</name></author><author><name sortKey="Wilkins, Patricia" sort="Wilkins, Patricia" uniqKey="Wilkins P" first="Patricia" last="Wilkins">Patricia Wilkins</name></author><author><name sortKey="Noh, John" sort="Noh, John" uniqKey="Noh J" first="John" last="Noh">John Noh</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Cause of Death</term><term>Child</term><term>Cross-Sectional Studies</term><term>Epilepsy (epidemiology)</term><term>Epilepsy (mortality)</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Mortality</term><term>Population Surveillance</term><term>Risk Factors</term><term>Rural Population</term><term>South Africa (epidemiology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Cause de décès</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Mortalité</term><term>Mâle</term><term>Population rurale</term><term>République d'Afrique du Sud (épidémiologie)</term><term>Surveillance de la population</term><term>Épilepsie (mortalité)</term><term>Épilepsie (épidémiologie)</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>South Africa</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Epilepsy</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Epilepsy</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Épilepsie</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>République d'Afrique du Sud</term><term>Épilepsie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Cause of Death</term><term>Child</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Mortality</term><term>Population Surveillance</term><term>Risk Factors</term><term>Rural Population</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Cause de décès</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Mortalité</term><term>Mâle</term><term>Population rurale</term><term>Surveillance de la population</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Afrique du Sud</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epilepsy is one of the most common neurological conditions globally, estimated to constitute 0.75% of the global burden of disease, with the majority of this burden found in low- and middle- income countries (LMICs). Few studies from LMICs, including much of sub-Saharan Africa, have described the incidence, remission or mortality rates due to epilepsy, which are needed to quantify the burden and inform policy. This study investigates the epidemiological parameters of convulsive epilepsy within a context of high HIV prevalence and an emerging burden of cardiovascular disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26053071</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>09</Day></DateCreated><DateCompleted><Year>2016</Year><Month>03</Month><Day>04</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>02</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>6</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Incidence, Remission and Mortality of Convulsive Epilepsy in Rural Northeast South Africa.</ArticleTitle><Pagination><MedlinePgn>e0129097</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0129097</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Epilepsy is one of the most common neurological conditions globally, estimated to constitute 0.75% of the global burden of disease, with the majority of this burden found in low- and middle- income countries (LMICs). Few studies from LMICs, including much of sub-Saharan Africa, have described the incidence, remission or mortality rates due to epilepsy, which are needed to quantify the burden and inform policy. This study investigates the epidemiological parameters of convulsive epilepsy within a context of high HIV prevalence and an emerging burden of cardiovascular disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A cross-sectional population survey of 82,818 individuals, in the Agincourt Health and Socio-demographic Surveillance Site (HDSS) in rural northeast South Africa was conducted in 2008, from which 296 people were identified with active convulsive epilepsy. A follow-up survey was conducted in 2012. Incidence and mortality rates were estimated, with duration and remission rates calculated using the DISMOD II software package.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The crude incidence for convulsive epilepsy was 17.4/100,000 per year (95%CI: 13.1-23.0). Remission was 4.6% and 3.9% per year for males and females, respectively. The standardized mortality ratio was 2.6 (95%CI: 1.7-3.5), with 33.3% of deaths directly related to epilepsy. Mortality was higher in men than women (adjusted rate ratio (aRR) 2.6 (95%CI: 1.2-5.4)), and was significantly associated with older ages (50+ years versus those 0-5 years old (RR 4.8 (95%CI: 0.6-36.4)).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The crude incidence was lower whilst mortality rates were similar to other African studies; however, this study found higher mortality amongst older males. Efforts aimed at further understanding what causes epilepsy in older people and developing interventions to reduce prolonged seizures are likely to reduce the overall burden of ACE in rural South Africa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>Ryan G</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bottomley</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; MRC Tropical Epidemiology Group, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ngugi</LastName><ForeName>Anthony K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; Research Support Unit, Faculty of Health Sciences, Aga Khan University-East Africa, Nairobi, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ibinda</LastName><ForeName>Fredrick</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Olivé</LastName><ForeName>F Xavier</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kahn</LastName><ForeName>Kathleen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tollman</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newton</LastName><ForeName>Charles R</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>Studies of Epidemiology of Epilepsy in Demographic Surveillance Systems (SEEDS)-INDEPTH Network, Accra, Ghana; MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya; Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom; Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>SEEDS Writing Group</CollectiveName></Author><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>Ryan</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Twine</LastName><ForeName>Rhian</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Connor</LastName><ForeName>Myles</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Collinson</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Masanja</LastName><ForeName>Honratio</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Mathew</LastName><ForeName>Alexander</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Kakooza</LastName><ForeName>Angelina</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Pariyo</LastName><ForeName>George</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Peterson</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Ndyo-mughenyi</LastName><ForeName>Donald</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Odhiambo</LastName><ForeName>Rachael</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Chengo</LastName><ForeName>Eddie</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Chabi</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bauni</LastName><ForeName>Evasius</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Kamuyu</LastName><ForeName>Gathoni</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Odera</LastName><ForeName>Victor Mung'ala</ForeName><Initials>VM</Initials></Author><Author ValidYN="Y"><LastName>Mageto</LastName><ForeName>James O</ForeName><Initials>JO</Initials></Author><Author ValidYN="Y"><LastName>Ae-Ngibise</LastName><ForeName>Ken</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Akpalu</LastName><ForeName>Bright</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Akpalu</LastName><ForeName>Albert</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Agbokey</LastName><ForeName>Francis</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Adjei</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Owusu-Agyei</LastName><ForeName>Seth</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Kleinschmidt</LastName><ForeName>Immo</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Doku</LastName><ForeName>Victor C K</ForeName><Initials>VC</Initials></Author><Author ValidYN="Y"><LastName>Odermatt</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Neville</LastName><ForeName>Brian</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Sander</LastName><ForeName>Josemir W</ForeName><Initials>JW</Initials></Author><Author 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Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>069683/Z/02/Z</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2009 Nov;31(11):697-705</RefSource><PMID Version="1">19825109</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 1997 May;38(5):541-6</RefSource><PMID 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2013;6:19305</RefSource><PMID Version="1">23364087</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2006 Oct;5(10):823-7</RefSource><PMID Version="1">16987728</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2005;46 Suppl 11:33-5</RefSource><PMID Version="1">16393176</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Popul Health Metr. 2003 Apr 14;1(1):4</RefSource><PMID Version="1">12773212</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2013 Apr;54(4):757-63</RefSource><PMID Version="1">23350750</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 2007 Jan;101(1):48-55</RefSource><PMID Version="1">16905166</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Seizure. 2005 Apr;14(3):175-82</RefSource><PMID 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Public Health Policy. 2011;32 Suppl 1:S30-6</RefSource><PMID Version="1">21730991</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Epidemiol. 2012 Aug;41(4):988-1001</RefSource><PMID Version="1">22933647</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2002 Nov;43(11):1402-9</RefSource><PMID Version="1">12423392</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2007 Mar;6(3):269-78</RefSource><PMID Version="1">17303533</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2009 Oct;50(10):2310-3</RefSource><PMID Version="1">19583783</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2013 Aug;54(8):1352-9</RefSource><PMID Version="1">23750825</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1376-81</RefSource><PMID Version="1">15377680</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002423" MajorTopicYN="N">Cause of Death</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004827" MajorTopicYN="N">Epilepsy</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" 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