Antibody screening tests variably overestimate the prevalence of hepatitis C virus infection among HIV-infected adults in Ghana.
Identifieur interne : 000726 ( Ncbi/Merge ); précédent : 000725; suivant : 000727Antibody screening tests variably overestimate the prevalence of hepatitis C virus infection among HIV-infected adults in Ghana.
Auteurs : S. King [Royaume-Uni] ; K. Adjei-Asante ; L. Appiah ; D. Adinku ; A. Beloukas ; M. Atkins ; S F Sarfo ; D. Chadwick ; R O Phillips ; A M GerettiSource :
- Journal of viral hepatitis [ 1365-2893 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN viral (sang), Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Anticorps de l'hépatite C (sang), Dépistage systématique, Femelle, Ghana (épidémiologie), Génotype, Humains, Hépatite C (diagnostic), Hépatite C (épidémiologie), Infections à VIH (), Mâle, Protéines du core viral (génétique), Protéines virales non structurales (génétique), Techniques de génotypage, Tests sérologiques, Études séroépidémiologiques.
- MESH :
- diagnostic : Hépatite C.
- génétique : Protéines du core viral, Protéines virales non structurales.
- sang : ARN viral, Anticorps de l'hépatite C.
- épidémiologie : Ghana, Hépatite C.
- Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Dépistage systématique, Femelle, Génotype, Humains, Infections à VIH, Mâle, Techniques de génotypage, Tests sérologiques, Études séroépidémiologiques.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Female, Genotype, Genotyping Techniques, Ghana (epidemiology), HIV Infections (complications), Hepatitis C (diagnosis), Hepatitis C (epidemiology), Hepatitis C Antibodies (blood), Humans, Male, Mass Screening, Middle Aged, RNA, Viral (blood), Sequence Analysis, DNA, Seroepidemiologic Studies, Serologic Tests, Viral Core Proteins (genetics), Viral Nonstructural Proteins (genetics).
- MESH :
- chemical , blood : Hepatitis C Antibodies, RNA, Viral.
- geographic , epidemiology : Ghana.
- complications : HIV Infections.
- diagnosis : Hepatitis C.
- epidemiology : Hepatitis C.
- chemical , genetics : Viral Core Proteins, Viral Nonstructural Proteins.
- Adult, Female, Genotype, Genotyping Techniques, Humans, Male, Mass Screening, Middle Aged, Sequence Analysis, DNA, Seroepidemiologic Studies, Serologic Tests.
Abstract
HIV coinfection with HCV has been poorly studied in sub-Saharan Africa, and the reliability of available seroprevalence estimates remains uncertain. The study aim was to determine HCV RNA prevalence in HIV-infected subjects receiving care in Kumasi, Ghana, and relate the findings to HCV antibody detection. From a population of 1520 HIV-infected adults, all HBsAg-positive subjects (n = 236) and a random subset of HBsAg-negative subject (n = 172) were screened for HCV RNA using pooled plasma; positive samples were genotyped by core and NS5B sequencing. HCV antibodies were detected by three commercial screening assays and confirmed by the line immunoassay. HCV RNA was detected in 4/408 subjects (1.0%, 95% confidence interval 0.0-1.9%), comprising 3/236 (1.3%; 0.0-2.8%) HBsAg-positive and 1/172 (0.6%; 0.0-1.8%) HBsAg-negative subjects. HCV RNA-positive subjects showed reactivity in all three antibody screening assays. Among HCV RNA-negative subjects, 5/67 (7.5%), 5/67 (7.5%) and 19/67 (28.4%) showed antibody reactivity by each screening assay, respectively, including two (3.0%) with reactivity by all three assays. Only one sample (1.5%) had confirmed antibody reactivity by line immunoassay indicating past HCV infection. HCV-positive subjects (three males, two females) were aged 30-46 years, by questionnaire-based interview reported surgical procedures and blood transfusion as risk factors for infection. HCV genotypes were 2 (subtypes 2j, 2l, 2k/unassigned) and 1 (subtype unassigned). Without further testing, HCV antibody screening assays variably overestimated HCV prevalence among HIV-infected subjects in Ghana. These findings inform the interpretation of previous seroprevalence estimates based upon screening assays alone.
DOI: 10.1111/jvh.12354
PubMed: 25394987
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King</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Global Health, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Adjei Asante, K" sort="Adjei Asante, K" uniqKey="Adjei Asante K" first="K" last="Adjei-Asante">K. Adjei-Asante</name></author><author><name sortKey="Appiah, L" sort="Appiah, L" uniqKey="Appiah L" first="L" last="Appiah">L. Appiah</name></author><author><name sortKey="Adinku, D" sort="Adinku, D" uniqKey="Adinku D" first="D" last="Adinku">D. Adinku</name></author><author><name sortKey="Beloukas, A" sort="Beloukas, A" uniqKey="Beloukas A" first="A" last="Beloukas">A. Beloukas</name></author><author><name sortKey="Atkins, M" sort="Atkins, M" uniqKey="Atkins M" first="M" last="Atkins">M. 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Chadwick</name></author><author><name sortKey="Phillips, R O" sort="Phillips, R O" uniqKey="Phillips R" first="R O" last="Phillips">R O Phillips</name></author><author><name sortKey="Geretti, A M" sort="Geretti, A M" uniqKey="Geretti A" first="A M" last="Geretti">A M Geretti</name></author></analytic><series><title level="j">Journal of viral hepatitis</title><idno type="eISSN">1365-2893</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Female</term><term>Genotype</term><term>Genotyping Techniques</term><term>Ghana (epidemiology)</term><term>HIV Infections (complications)</term><term>Hepatitis C (diagnosis)</term><term>Hepatitis C (epidemiology)</term><term>Hepatitis C Antibodies (blood)</term><term>Humans</term><term>Male</term><term>Mass Screening</term><term>Middle Aged</term><term>RNA, Viral (blood)</term><term>Sequence Analysis, DNA</term><term>Seroepidemiologic Studies</term><term>Serologic Tests</term><term>Viral Core Proteins (genetics)</term><term>Viral Nonstructural Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (sang)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de séquence d'ADN</term><term>Anticorps de l'hépatite C (sang)</term><term>Dépistage systématique</term><term>Femelle</term><term>Ghana (épidémiologie)</term><term>Génotype</term><term>Humains</term><term>Hépatite C (diagnostic)</term><term>Hépatite C (épidémiologie)</term><term>Infections à VIH ()</term><term>Mâle</term><term>Protéines du core viral (génétique)</term><term>Protéines virales non structurales (génétique)</term><term>Techniques de génotypage</term><term>Tests sérologiques</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hepatitis C Antibodies</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hepatitis C</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hépatite C</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hepatitis C</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Core Proteins</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines du core viral</term><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term><term>Anticorps de l'hépatite C</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Hépatite C</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Genotype</term><term>Genotyping Techniques</term><term>Humans</term><term>Male</term><term>Mass Screening</term><term>Middle Aged</term><term>Sequence Analysis, DNA</term><term>Seroepidemiologic Studies</term><term>Serologic Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de séquence d'ADN</term><term>Dépistage systématique</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Infections à VIH</term><term>Mâle</term><term>Techniques de génotypage</term><term>Tests sérologiques</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HIV coinfection with HCV has been poorly studied in sub-Saharan Africa, and the reliability of available seroprevalence estimates remains uncertain. The study aim was to determine HCV RNA prevalence in HIV-infected subjects receiving care in Kumasi, Ghana, and relate the findings to HCV antibody detection. From a population of 1520 HIV-infected adults, all HBsAg-positive subjects (n = 236) and a random subset of HBsAg-negative subject (n = 172) were screened for HCV RNA using pooled plasma; positive samples were genotyped by core and NS5B sequencing. HCV antibodies were detected by three commercial screening assays and confirmed by the line immunoassay. HCV RNA was detected in 4/408 subjects (1.0%, 95% confidence interval 0.0-1.9%), comprising 3/236 (1.3%; 0.0-2.8%) HBsAg-positive and 1/172 (0.6%; 0.0-1.8%) HBsAg-negative subjects. HCV RNA-positive subjects showed reactivity in all three antibody screening assays. Among HCV RNA-negative subjects, 5/67 (7.5%), 5/67 (7.5%) and 19/67 (28.4%) showed antibody reactivity by each screening assay, respectively, including two (3.0%) with reactivity by all three assays. Only one sample (1.5%) had confirmed antibody reactivity by line immunoassay indicating past HCV infection. HCV-positive subjects (three males, two females) were aged 30-46 years, by questionnaire-based interview reported surgical procedures and blood transfusion as risk factors for infection. HCV genotypes were 2 (subtypes 2j, 2l, 2k/unassigned) and 1 (subtype unassigned). Without further testing, HCV antibody screening assays variably overestimated HCV prevalence among HIV-infected subjects in Ghana. These findings inform the interpretation of previous seroprevalence estimates based upon screening assays alone.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25394987</PMID><DateCreated><Year>2015</Year><Month>04</Month><Day>07</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>23</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2893</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of viral hepatitis</Title><ISOAbbreviation>J. Viral Hepat.</ISOAbbreviation></Journal><ArticleTitle>Antibody screening tests variably overestimate the prevalence of hepatitis C virus infection among HIV-infected adults in Ghana.</ArticleTitle><Pagination><MedlinePgn>461-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jvh.12354</ELocationID><Abstract><AbstractText>HIV coinfection with HCV has been poorly studied in sub-Saharan Africa, and the reliability of available seroprevalence estimates remains uncertain. The study aim was to determine HCV RNA prevalence in HIV-infected subjects receiving care in Kumasi, Ghana, and relate the findings to HCV antibody detection. From a population of 1520 HIV-infected adults, all HBsAg-positive subjects (n = 236) and a random subset of HBsAg-negative subject (n = 172) were screened for HCV RNA using pooled plasma; positive samples were genotyped by core and NS5B sequencing. HCV antibodies were detected by three commercial screening assays and confirmed by the line immunoassay. HCV RNA was detected in 4/408 subjects (1.0%, 95% confidence interval 0.0-1.9%), comprising 3/236 (1.3%; 0.0-2.8%) HBsAg-positive and 1/172 (0.6%; 0.0-1.8%) HBsAg-negative subjects. HCV RNA-positive subjects showed reactivity in all three antibody screening assays. Among HCV RNA-negative subjects, 5/67 (7.5%), 5/67 (7.5%) and 19/67 (28.4%) showed antibody reactivity by each screening assay, respectively, including two (3.0%) with reactivity by all three assays. Only one sample (1.5%) had confirmed antibody reactivity by line immunoassay indicating past HCV infection. HCV-positive subjects (three males, two females) were aged 30-46 years, by questionnaire-based interview reported surgical procedures and blood transfusion as risk factors for infection. HCV genotypes were 2 (subtypes 2j, 2l, 2k/unassigned) and 1 (subtype unassigned). Without further testing, HCV antibody screening assays variably overestimated HCV prevalence among HIV-infected subjects in Ghana. These findings inform the interpretation of previous seroprevalence estimates based upon screening assays alone.</AbstractText><CopyrightInformation>© 2014 John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>King</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adjei-Asante</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Appiah</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Adinku</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Beloukas</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Atkins</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Sarfo</LastName><ForeName>S F</ForeName><Initials>SF</Initials></Author><Author ValidYN="Y"><LastName>Chadwick</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>R O</ForeName><Initials>RO</Initials></Author><Author ValidYN="Y"><LastName>Geretti</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Viral Hepat</MedlineTA><NlmUniqueID>9435672</NlmUniqueID><ISSNLinking>1352-0504</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018937">Hepatitis C Antibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C087036">NS-5 protein, hepatitis C virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014758">Viral Core Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017361">Viral Nonstructural Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C069130">nucleocapsid protein, Hepatitis C virus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060005" MajorTopicYN="N">Genotyping Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006526" MajorTopicYN="N">Hepatitis C</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018937" MajorTopicYN="N">Hepatitis C Antibodies</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008403" MajorTopicYN="N">Mass Screening</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016036" MajorTopicYN="N">Seroepidemiologic Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012698" MajorTopicYN="N">Serologic Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014758" MajorTopicYN="N">Viral Core Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017361" MajorTopicYN="N">Viral Nonstructural Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Africa</Keyword><Keyword MajorTopicYN="N">RNA</Keyword><Keyword MajorTopicYN="N">antibody</Keyword><Keyword MajorTopicYN="N">genotype</Keyword><Keyword MajorTopicYN="N">serology</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>04</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>08</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25394987</ArticleId><ArticleId IdType="doi">10.1111/jvh.12354</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Adinku, D" sort="Adinku, D" uniqKey="Adinku D" first="D" last="Adinku">D. Adinku</name><name sortKey="Adjei Asante, K" sort="Adjei Asante, K" uniqKey="Adjei Asante K" first="K" last="Adjei-Asante">K. Adjei-Asante</name><name sortKey="Appiah, L" sort="Appiah, L" uniqKey="Appiah L" first="L" last="Appiah">L. Appiah</name><name sortKey="Atkins, M" sort="Atkins, M" uniqKey="Atkins M" first="M" last="Atkins">M. Atkins</name><name sortKey="Beloukas, A" sort="Beloukas, A" uniqKey="Beloukas A" first="A" last="Beloukas">A. Beloukas</name><name sortKey="Chadwick, D" sort="Chadwick, D" uniqKey="Chadwick D" first="D" last="Chadwick">D. Chadwick</name><name sortKey="Geretti, A M" sort="Geretti, A M" uniqKey="Geretti A" first="A M" last="Geretti">A M Geretti</name><name sortKey="Phillips, R O" sort="Phillips, R O" uniqKey="Phillips R" first="R O" last="Phillips">R O Phillips</name><name sortKey="Sarfo, S F" sort="Sarfo, S F" uniqKey="Sarfo S" first="S F" last="Sarfo">S F Sarfo</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="King, S" sort="King, S" uniqKey="King S" first="S" last="King">S. King</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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