SidaGhanaV1, Ncbi, Merge, bibRecord, 000660

High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia.

Identifieur interne : 000660 ( Ncbi/Merge ); précédent : 000659; suivant : 000661

High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia.

Auteurs : Nicole Wolter ; Stefano Tempia ; Cheryl Cohen ; Shabir A. Madhi ; Marietjie Venter ; Jocelyn Moyes ; Sibongile Walaza ; Babatyi Malope-Kgokong ; Michelle Groome ; Mignon Du Plessis ; Victoria Magomani ; Marthi Pretorius ; Orienka Hellferscee ; Halima Dawood ; Kathleen Kahn [Ghana] ; Ebrahim Variava [Afrique du Sud] ; Keith P. Klugman [Géorgie (pays)] ; Anne Von Gottberg

Source :

The Journal of infectious diseases [ 1537-6613 ] ; 2014.

RBID : pubmed:24907383

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Bactériémie (microbiologie), Bactériémie (épidémiologie), Charge bactérienne, Co-infection (microbiologie), Co-infection (virologie), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections de l'appareil respiratoire (microbiologie), Infections de l'appareil respiratoire (virologie), Jeune adulte, Maladies virales (), Maladies virales (virologie), Mâle, Nourrisson, Partie nasale du pharynx (microbiologie), Partie nasale du pharynx (virologie), Pneumonie à pneumocoques (), Pneumonie à pneumocoques (anatomopathologie), Pneumonie à pneumocoques (microbiologie), Réaction de polymérisation en chaine en temps réel, République d'Afrique du Sud, Streptococcus pneumoniae (isolement et purification), Sujet âgé, Sujet âgé de 80 ans ou plus, Virus (), Virus (isolement et purification), Études prospectives.
MESH :
- anatomopathologie : Pneumonie à pneumocoques.
- isolement et purification : Streptococcus pneumoniae, Virus.
- microbiologie : Bactériémie, Co-infection, Infections de l'appareil respiratoire, Partie nasale du pharynx, Pneumonie à pneumocoques.
- virologie : Co-infection, Infections de l'appareil respiratoire, Maladies virales, Partie nasale du pharynx.
- épidémiologie : Bactériémie.
- Adolescent, Adulte, Adulte d'âge moyen, Charge bactérienne, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Maladies virales, Mâle, Nourrisson, Pneumonie à pneumocoques, Réaction de polymérisation en chaine en temps réel, République d'Afrique du Sud, Sujet âgé, Sujet âgé de 80 ans ou plus, Virus, Études prospectives.
Wicri :
- geographic : Afrique du Sud.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Bacteremia (epidemiology), Bacteremia (microbiology), Bacterial Load, Child, Child, Preschool, Coinfection (microbiology), Coinfection (virology), Female, Humans, Infant, Male, Middle Aged, Nasopharynx (microbiology), Nasopharynx (virology), Pneumonia, Pneumococcal (complications), Pneumonia, Pneumococcal (microbiology), Pneumonia, Pneumococcal (pathology), Prospective Studies, Real-Time Polymerase Chain Reaction, Respiratory Tract Infections (microbiology), Respiratory Tract Infections (virology), South Africa, Streptococcus pneumoniae (isolation & purification), Virus Diseases (complications), Virus Diseases (virology), Viruses (classification), Viruses (isolation & purification), Young Adult.
MESH :
- geographic : South Africa.
- classification : Viruses.
- complications : Pneumonia, Pneumococcal, Virus Diseases.
- epidemiology : Bacteremia.
- isolation & purification : Streptococcus pneumoniae, Viruses.
- microbiology : Bacteremia, Coinfection, Nasopharynx, Pneumonia, Pneumococcal, Respiratory Tract Infections.
- pathology : Pneumonia, Pneumococcal.
- virology : Coinfection, Nasopharynx, Respiratory Tract Infections, Virus Diseases.
- Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Load, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Prospective Studies, Real-Time Polymerase Chain Reaction, Young Adult.

Abstract

We identified factors associated with pneumococcal colonization, high colonization density, and invasive pneumococcal pneumonia among patients hospitalized with acute lower respiratory tract infections (ALRTIs).

DOI: 10.1093/infdis/jiu326
PubMed: 24907383

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to stream PubMed, to step Corpus: 000907
to stream PubMed, to step Curation: 000906
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pubmed:24907383

Le document en format XML

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<author><name sortKey="Malope Kgokong, Babatyi" sort="Malope Kgokong, Babatyi" uniqKey="Malope Kgokong B" first="Babatyi" last="Malope-Kgokong">Babatyi Malope-Kgokong</name>
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<author><name sortKey="Groome, Michelle" sort="Groome, Michelle" uniqKey="Groome M" first="Michelle" last="Groome">Michelle Groome</name>
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<author><name sortKey="Magomani, Victoria" sort="Magomani, Victoria" uniqKey="Magomani V" first="Victoria" last="Magomani">Victoria Magomani</name>
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</affiliation>
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<author><name sortKey="Hellferscee, Orienka" sort="Hellferscee, Orienka" uniqKey="Hellferscee O" first="Orienka" last="Hellferscee">Orienka Hellferscee</name>
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<wicri:noCountry code="subField">National Health Laboratory Service</wicri:noCountry>
</affiliation>
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<author><name sortKey="Dawood, Halima" sort="Dawood, Halima" uniqKey="Dawood H" first="Halima" last="Dawood">Halima Dawood</name>
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<country xml:lang="fr">Ghana</country>
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</placeName>
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<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Hubert Department of Global Health, Rollins School of Public Health Division of Infectious Diseases, School of Medicine, Emory University, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Von Gottberg, Anne" sort="Von Gottberg, Anne" uniqKey="Von Gottberg A" first="Anne" last="Von Gottberg">Anne Von Gottberg</name>
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<wicri:noCountry code="subField">National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit</wicri:noCountry>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia.</title>
<author><name sortKey="Wolter, Nicole" sort="Wolter, Nicole" uniqKey="Wolter N" first="Nicole" last="Wolter">Nicole Wolter</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Influenza Division, Centers for Disease Control and Prevention.</nlm:affiliation>
<wicri:noCountry code="subField">Centers for Disease Control and Prevention</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Faculty of Health Sciences.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service Faculty of Health Sciences</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A" last="Madhi">Shabir A. Madhi</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine-Preventable Diseases.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine-Preventable Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Venter, Marietjie" sort="Venter, Marietjie" uniqKey="Venter M" first="Marietjie" last="Venter">Marietjie Venter</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Zoonoses Research Unit, Department of Medical Virology, University of Pretoria.</nlm:affiliation>
<wicri:noCountry code="subField">University of Pretoria</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Moyes, Jocelyn" sort="Moyes, Jocelyn" uniqKey="Moyes J" first="Jocelyn" last="Moyes">Jocelyn Moyes</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Walaza, Sibongile" sort="Walaza, Sibongile" uniqKey="Walaza S" first="Sibongile" last="Walaza">Sibongile Walaza</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Malope Kgokong, Babatyi" sort="Malope Kgokong, Babatyi" uniqKey="Malope Kgokong B" first="Babatyi" last="Malope-Kgokong">Babatyi Malope-Kgokong</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Groome, Michelle" sort="Groome, Michelle" uniqKey="Groome M" first="Michelle" last="Groome">Michelle Groome</name>
<affiliation><nlm:affiliation>Department of Science and Technology/National Research Foundation: Vaccine-Preventable Diseases.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Science and Technology/National Research Foundation: Vaccine-Preventable Diseases.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Du Plessis, Mignon" sort="Du Plessis, Mignon" uniqKey="Du Plessis M" first="Mignon" last="Du Plessis">Mignon Du Plessis</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Magomani, Victoria" sort="Magomani, Victoria" uniqKey="Magomani V" first="Victoria" last="Magomani">Victoria Magomani</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service Medical Research Council: Respiratory and Meningeal Pathogens Research Unit</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pretorius, Marthi" sort="Pretorius, Marthi" uniqKey="Pretorius M" first="Marthi" last="Pretorius">Marthi Pretorius</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hellferscee, Orienka" sort="Hellferscee, Orienka" uniqKey="Hellferscee O" first="Orienka" last="Hellferscee">Orienka Hellferscee</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Dawood, Halima" sort="Dawood, Halima" uniqKey="Dawood H" first="Halima" last="Dawood">Halima Dawood</name>
<affiliation><nlm:affiliation>Pietermaritzburg Metropolitan Hospitals University of KwaZulu Natal.</nlm:affiliation>
<wicri:noCountry code="no comma">Pietermaritzburg Metropolitan Hospitals University of KwaZulu Natal.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name>
<affiliation wicri:level="4"><nlm:affiliation>MRC/Wits Rural Public Health and Health Transition Research Unit Research Unit (Agincourt), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg Centre for Global Health Research, Umeå University, Sweden INDEPTH Network, Accra, Ghana.</nlm:affiliation>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>MRC/Wits Rural Public Health and Health Transition Research Unit Research Unit (Agincourt), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg Centre for Global Health Research, Umeå University, Sweden INDEPTH Network, Accra</wicri:regionArea>
<placeName><settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
</placeName>
<orgName type="university">Université du Witwatersrand</orgName>
</affiliation>
</author>
<author><name sortKey="Variava, Ebrahim" sort="Variava, Ebrahim" uniqKey="Variava E" first="Ebrahim" last="Variava">Ebrahim Variava</name>
<affiliation wicri:level="1"><nlm:affiliation>Klerksdorp/Tshepong Hospital, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Klerksdorp/Tshepong Hospital</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klugman, Keith P" sort="Klugman, Keith P" uniqKey="Klugman K" first="Keith P" last="Klugman">Keith P. Klugman</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Hubert Department of Global Health, Rollins School of Public Health Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia.</nlm:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Hubert Department of Global Health, Rollins School of Public Health Division of Infectious Diseases, School of Medicine, Emory University, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Von Gottberg, Anne" sort="Von Gottberg, Anne" uniqKey="Von Gottberg A" first="Anne" last="Von Gottberg">Anne Von Gottberg</name>
<affiliation><nlm:affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.</nlm:affiliation>
<wicri:noCountry code="subField">National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of infectious diseases</title>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Bacteremia (epidemiology)</term>
<term>Bacteremia (microbiology)</term>
<term>Bacterial Load</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Coinfection (microbiology)</term>
<term>Coinfection (virology)</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nasopharynx (microbiology)</term>
<term>Nasopharynx (virology)</term>
<term>Pneumonia, Pneumococcal (complications)</term>
<term>Pneumonia, Pneumococcal (microbiology)</term>
<term>Pneumonia, Pneumococcal (pathology)</term>
<term>Prospective Studies</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Respiratory Tract Infections (microbiology)</term>
<term>Respiratory Tract Infections (virology)</term>
<term>South Africa</term>
<term>Streptococcus pneumoniae (isolation & purification)</term>
<term>Virus Diseases (complications)</term>
<term>Virus Diseases (virology)</term>
<term>Viruses (classification)</term>
<term>Viruses (isolation & purification)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Bactériémie (microbiologie)</term>
<term>Bactériémie (épidémiologie)</term>
<term>Charge bactérienne</term>
<term>Co-infection (microbiologie)</term>
<term>Co-infection (virologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections de l'appareil respiratoire (microbiologie)</term>
<term>Infections de l'appareil respiratoire (virologie)</term>
<term>Jeune adulte</term>
<term>Maladies virales ()</term>
<term>Maladies virales (virologie)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Partie nasale du pharynx (microbiologie)</term>
<term>Partie nasale du pharynx (virologie)</term>
<term>Pneumonie à pneumocoques ()</term>
<term>Pneumonie à pneumocoques (anatomopathologie)</term>
<term>Pneumonie à pneumocoques (microbiologie)</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>République d'Afrique du Sud</term>
<term>Streptococcus pneumoniae (isolement et purification)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Virus ()</term>
<term>Virus (isolement et purification)</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>South Africa</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Pneumonie à pneumocoques</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Pneumonia, Pneumococcal</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Bacteremia</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Streptococcus pneumoniae</term>
<term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Streptococcus pneumoniae</term>
<term>Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Bactériémie</term>
<term>Co-infection</term>
<term>Infections de l'appareil respiratoire</term>
<term>Partie nasale du pharynx</term>
<term>Pneumonie à pneumocoques</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bacteremia</term>
<term>Coinfection</term>
<term>Nasopharynx</term>
<term>Pneumonia, Pneumococcal</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pneumonia, Pneumococcal</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Co-infection</term>
<term>Infections de l'appareil respiratoire</term>
<term>Maladies virales</term>
<term>Partie nasale du pharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coinfection</term>
<term>Nasopharynx</term>
<term>Respiratory Tract Infections</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Bactériémie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Bacterial Load</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Charge bactérienne</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Maladies virales</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Pneumonie à pneumocoques</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>République d'Afrique du Sud</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Virus</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Afrique du Sud</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We identified factors associated with pneumococcal colonization, high colonization density, and invasive pneumococcal pneumonia among patients hospitalized with acute lower respiratory tract infections (ALRTIs).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24907383</PMID>
<DateCreated><Year>2014</Year>
<Month>10</Month>
<Day>25</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>12</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>10</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>210</Volume>
<Issue>10</Issue>
<PubDate><Year>2014</Year>
<Month>Nov</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia.</ArticleTitle>
<Pagination><MedlinePgn>1649-57</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiu326</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We identified factors associated with pneumococcal colonization, high colonization density, and invasive pneumococcal pneumonia among patients hospitalized with acute lower respiratory tract infections (ALRTIs).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In 2010, 4025 cases were enrolled in surveillance in South Africa. A total of 969 of 4025 systematically selected nasopharyngeal-oropharyngeal specimens (24%) were tested for respiratory viruses and Streptococcus pneumoniae by real-time polymerase chain reaction. Of these, 749 (77%) had blood tested for S. pneumoniae.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Pneumococcal colonization was detected in 55% of cases (534 of 969). On multivariable analysis that controlled for age and tuberculosis treatment, infection with influenza virus (adjusted odds ratio [OR], 2.2; 95% confidence interval [CI], 1.1-4.5), adenovirus (adjusted OR, 1.7; 95% CI, 1.1-2.7), rhinovirus (adjusted OR, 1.6; 95% CI, 1.1-2.3), and human immunodeficiency virus (HIV; adjusted OR, 1.6; 95% CI, 1.1-2.4) were associated with pneumococcal colonization. High colonization density was associated with respiratory virus coinfection (adjusted OR, 1.7; 95% CI, 1.1-2.6) and invasive pneumococcal pneumonia (adjusted OR, 2.3; 95% CI, 1.3-4.0), after adjustment for age and sex. Seven percent (52 of 749) had pneumococci detected in blood. On multivariable analysis among colonized cases, invasive pneumococcal pneumonia was associated with HIV (adjusted OR, 3.2; 95% CI, 1.4-7.5), influenza virus (adjusted OR, 8.2; 95% CI, 2.7-25.0), high colonization density (adjusted OR, 18.7; 95% CI, 2.3-155.1), and ≥5 days of hospitalization (adjusted OR, 3.7; 95% CI, 1.7-8.2).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Respiratory virus infection was associated with elevated colonization density and, in turn, invasive pneumococcal pneumonia.</AbstractText>
<CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wolter</LastName>
<ForeName>Nicole</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tempia</LastName>
<ForeName>Stefano</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Influenza Division, Centers for Disease Control and Prevention.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cohen</LastName>
<ForeName>Cheryl</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Faculty of Health Sciences.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Madhi</LastName>
<ForeName>Shabir A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Medical Research Council: Respiratory and Meningeal Pathogens Research Unit Department of Science and Technology/National Research Foundation: Vaccine-Preventable Diseases.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Venter</LastName>
<ForeName>Marietjie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Zoonoses Research Unit, Department of Medical Virology, University of Pretoria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moyes</LastName>
<ForeName>Jocelyn</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Walaza</LastName>
<ForeName>Sibongile</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Malope-Kgokong</LastName>
<ForeName>Babatyi</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Groome</LastName>
<ForeName>Michelle</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Science and Technology/National Research Foundation: Vaccine-Preventable Diseases.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>du Plessis</LastName>
<ForeName>Mignon</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Magomani</LastName>
<ForeName>Victoria</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pretorius</LastName>
<ForeName>Marthi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hellferscee</LastName>
<ForeName>Orienka</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dawood</LastName>
<ForeName>Halima</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Pietermaritzburg Metropolitan Hospitals University of KwaZulu Natal.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kahn</LastName>
<ForeName>Kathleen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>MRC/Wits Rural Public Health and Health Transition Research Unit Research Unit (Agincourt), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg Centre for Global Health Research, Umeå University, Sweden INDEPTH Network, Accra, Ghana.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Variava</LastName>
<ForeName>Ebrahim</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Klerksdorp/Tshepong Hospital, South Africa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klugman</LastName>
<ForeName>Keith P</ForeName>
<Initials>KP</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Hubert Department of Global Health, Rollins School of Public Health Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>von Gottberg</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service Faculty of Health Sciences Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>5U51IP000155</GrantID>
<Acronym>IP</Acronym>
<Agency>NCIRD CDC HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>06</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Infect Dis</MedlineTA>
<NlmUniqueID>0413675</NlmUniqueID>
<ISSNLinking>0022-1899</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016470" MajorTopicYN="N">Bacteremia</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058491" MajorTopicYN="N">Bacterial Load</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060085" MajorTopicYN="N">Coinfection</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011018" MajorTopicYN="N">Pneumonia, Pneumococcal</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013019" MajorTopicYN="N" Type="Geographic">South Africa</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013296" MajorTopicYN="N">Streptococcus pneumoniae</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bacterial loads</Keyword>
<Keyword MajorTopicYN="N">colonization</Keyword>
<Keyword MajorTopicYN="N">invasive pneumococcal disease</Keyword>
<Keyword MajorTopicYN="N">pneumococcus</Keyword>
<Keyword MajorTopicYN="N">respiratory virus</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>6</Month>
<Day>8</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>6</Month>
<Day>8</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>12</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
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<ArticleIdList><ArticleId IdType="pubmed">24907383</ArticleId>
<ArticleId IdType="pii">jiu326</ArticleId>
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<affiliations><list><country><li>Afrique du Sud</li>
<li>Ghana</li>
<li>Géorgie (pays)</li>
</country>
<region><li>Région du Grand Accra</li>
</region>
<settlement><li>Accra</li>
</settlement>
<orgName><li>Université du Witwatersrand</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name>
<name sortKey="Dawood, Halima" sort="Dawood, Halima" uniqKey="Dawood H" first="Halima" last="Dawood">Halima Dawood</name>
<name sortKey="Du Plessis, Mignon" sort="Du Plessis, Mignon" uniqKey="Du Plessis M" first="Mignon" last="Du Plessis">Mignon Du Plessis</name>
<name sortKey="Groome, Michelle" sort="Groome, Michelle" uniqKey="Groome M" first="Michelle" last="Groome">Michelle Groome</name>
<name sortKey="Hellferscee, Orienka" sort="Hellferscee, Orienka" uniqKey="Hellferscee O" first="Orienka" last="Hellferscee">Orienka Hellferscee</name>
<name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A" last="Madhi">Shabir A. Madhi</name>
<name sortKey="Magomani, Victoria" sort="Magomani, Victoria" uniqKey="Magomani V" first="Victoria" last="Magomani">Victoria Magomani</name>
<name sortKey="Malope Kgokong, Babatyi" sort="Malope Kgokong, Babatyi" uniqKey="Malope Kgokong B" first="Babatyi" last="Malope-Kgokong">Babatyi Malope-Kgokong</name>
<name sortKey="Moyes, Jocelyn" sort="Moyes, Jocelyn" uniqKey="Moyes J" first="Jocelyn" last="Moyes">Jocelyn Moyes</name>
<name sortKey="Pretorius, Marthi" sort="Pretorius, Marthi" uniqKey="Pretorius M" first="Marthi" last="Pretorius">Marthi Pretorius</name>
<name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name>
<name sortKey="Venter, Marietjie" sort="Venter, Marietjie" uniqKey="Venter M" first="Marietjie" last="Venter">Marietjie Venter</name>
<name sortKey="Von Gottberg, Anne" sort="Von Gottberg, Anne" uniqKey="Von Gottberg A" first="Anne" last="Von Gottberg">Anne Von Gottberg</name>
<name sortKey="Walaza, Sibongile" sort="Walaza, Sibongile" uniqKey="Walaza S" first="Sibongile" last="Walaza">Sibongile Walaza</name>
<name sortKey="Wolter, Nicole" sort="Wolter, Nicole" uniqKey="Wolter N" first="Nicole" last="Wolter">Nicole Wolter</name>
</noCountry>
<country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name>
</region>
</country>
<country name="Afrique du Sud"><noRegion><name sortKey="Variava, Ebrahim" sort="Variava, Ebrahim" uniqKey="Variava E" first="Ebrahim" last="Variava">Ebrahim Variava</name>
</noRegion>
</country>
<country name="Géorgie (pays)"><noRegion><name sortKey="Klugman, Keith P" sort="Klugman, Keith P" uniqKey="Klugman K" first="Keith P" last="Klugman">Keith P. Klugman</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	Le SIDA au Ghana (serveur d'exploration)
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Le SIDA au Ghana (serveur d'exploration)

High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia.

High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia.

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