Diagnosis of treponemal co-infection in HIV-infected West Africans.
Identifieur interne : 000514 ( Ncbi/Merge ); précédent : 000513; suivant : 000515Diagnosis of treponemal co-infection in HIV-infected West Africans.
Auteurs : Yaasir Mamoojee [Royaume-Uni] ; Grace Tan ; Sandra Gittins ; Stephen Sarfo ; Lisa Stephenson ; David Carrington ; George Bedu-Addo ; Richard Phillips ; Lambert T. Appiah ; David ChadwickSource :
- Tropical medicine & international health : TM & IH [ 1365-3156 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte, Comorbidité, Femelle, Ghana (épidémiologie), Humains, Infections à VIH (épidémiologie), Mâle, Sensibilité et spécificité, Systèmes automatisés lit malade, Sérodiagnostic de la syphilis (), Tests sérologiques (), Tréponématoses (diagnostic), Tréponématoses (épidémiologie), Études séroépidémiologiques, Études transversales.
- MESH :
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Comorbidity, Cross-Sectional Studies, Female, Ghana (epidemiology), HIV Infections (epidemiology), Humans, Male, Point-of-Care Systems, Sensitivity and Specificity, Seroepidemiologic Studies, Serologic Tests (methods), Syphilis Serodiagnosis (methods), Treponemal Infections (diagnosis), Treponemal Infections (epidemiology).
- MESH :
- geographic , epidemiology : Ghana.
- diagnosis : Treponemal Infections.
- epidemiology : HIV Infections, Treponemal Infections.
- methods : Serologic Tests, Syphilis Serodiagnosis.
- Adult, Comorbidity, Cross-Sectional Studies, Female, Humans, Male, Point-of-Care Systems, Sensitivity and Specificity, Seroepidemiologic Studies.
Abstract
To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection.
DOI: 10.1111/j.1365-3156.2012.03090.x
PubMed: 22994205
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Appiah</name></author><author><name sortKey="Chadwick, David" sort="Chadwick, David" uniqKey="Chadwick D" first="David" last="Chadwick">David Chadwick</name></author></analytic><series><title level="j">Tropical medicine & international health : TM & IH</title><idno type="eISSN">1365-3156</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Female</term><term>Ghana (epidemiology)</term><term>HIV Infections (epidemiology)</term><term>Humans</term><term>Male</term><term>Point-of-Care Systems</term><term>Sensitivity and Specificity</term><term>Seroepidemiologic Studies</term><term>Serologic Tests (methods)</term><term>Syphilis Serodiagnosis (methods)</term><term>Treponemal Infections (diagnosis)</term><term>Treponemal Infections (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Comorbidité</term><term>Femelle</term><term>Ghana (épidémiologie)</term><term>Humains</term><term>Infections à VIH (épidémiologie)</term><term>Mâle</term><term>Sensibilité et spécificité</term><term>Systèmes automatisés lit malade</term><term>Sérodiagnostic de la syphilis ()</term><term>Tests sérologiques ()</term><term>Tréponématoses (diagnostic)</term><term>Tréponématoses (épidémiologie)</term><term>Études séroépidémiologiques</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Treponemal Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tréponématoses</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term><term>Treponemal Infections</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Serologic Tests</term><term>Syphilis Serodiagnosis</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Infections à VIH</term><term>Tréponématoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Point-of-Care Systems</term><term>Sensitivity and Specificity</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Comorbidité</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sensibilité et spécificité</term><term>Systèmes automatisés lit malade</term><term>Sérodiagnostic de la syphilis</term><term>Tests sérologiques</term><term>Études séroépidémiologiques</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22994205</PMID><DateCreated><Year>2013</Year><Month>12</Month><Day>16</Day></DateCreated><DateCompleted><Year>2014</Year><Month>02</Month><Day>07</Day></DateCompleted><DateRevised><Year>2013</Year><Month>12</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-3156</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>12</Issue><PubDate><Year>2012</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Tropical medicine & international health : TM & IH</Title><ISOAbbreviation>Trop. Med. Int. Health</ISOAbbreviation></Journal><ArticleTitle>Diagnosis of treponemal co-infection in HIV-infected West Africans.</ArticleTitle><Pagination><MedlinePgn>1521-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1365-3156.2012.03090.x</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.</AbstractText><CopyrightInformation>© 2012 Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mamoojee</LastName><ForeName>Yaasir</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>The James Cook University Hospital, Middlesbrough, UK Komfo Anokye Teaching Hospital, Kumasi, Ghana Health Protection Agency South West Regional Laboratory, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Grace</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Gittins</LastName><ForeName>Sandra</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Sarfo</LastName><ForeName>Stephen</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Stephenson</LastName><ForeName>Lisa</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Carrington</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Bedu-Addo</LastName><ForeName>George</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Appiah</LastName><ForeName>Lambert T</ForeName><Initials>LT</Initials></Author><Author ValidYN="Y"><LastName>Chadwick</LastName><ForeName>David</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>09</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trop Med Int Health</MedlineTA><NlmUniqueID>9610576</NlmUniqueID><ISSNLinking>1360-2276</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019095" MajorTopicYN="N">Point-of-Care Systems</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016036" MajorTopicYN="N">Seroepidemiologic Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012698" MajorTopicYN="N">Serologic Tests</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013588" MajorTopicYN="N">Syphilis Serodiagnosis</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014211" MajorTopicYN="N">Treponemal Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Africa</Keyword><Keyword MajorTopicYN="N">Afrique</Keyword><Keyword MajorTopicYN="N">HIV</Keyword><Keyword MajorTopicYN="N">VIH</Keyword><Keyword MajorTopicYN="N">diagnosis</Keyword><Keyword MajorTopicYN="N">diagnostic</Keyword><Keyword MajorTopicYN="N">diagnóstico</Keyword><Keyword MajorTopicYN="N">pian</Keyword><Keyword MajorTopicYN="N">pián</Keyword><Keyword MajorTopicYN="N">sensibilidad y especificidad</Keyword><Keyword MajorTopicYN="N">sensibilité et spécificité</Keyword><Keyword MajorTopicYN="N">sensitivity and specificity</Keyword><Keyword MajorTopicYN="N">syphilis</Keyword><Keyword MajorTopicYN="N">sífilis</Keyword><Keyword MajorTopicYN="N">yaws</Keyword><Keyword MajorTopicYN="N">África</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>2</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22994205</ArticleId><ArticleId IdType="doi">10.1111/j.1365-3156.2012.03090.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Appiah, Lambert T" sort="Appiah, Lambert T" uniqKey="Appiah L" first="Lambert T" last="Appiah">Lambert T. Appiah</name><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name><name sortKey="Carrington, David" sort="Carrington, David" uniqKey="Carrington D" first="David" last="Carrington">David Carrington</name><name sortKey="Chadwick, David" sort="Chadwick, David" uniqKey="Chadwick D" first="David" last="Chadwick">David Chadwick</name><name sortKey="Gittins, Sandra" sort="Gittins, Sandra" uniqKey="Gittins S" first="Sandra" last="Gittins">Sandra Gittins</name><name sortKey="Phillips, Richard" sort="Phillips, Richard" uniqKey="Phillips R" first="Richard" last="Phillips">Richard Phillips</name><name sortKey="Sarfo, Stephen" sort="Sarfo, Stephen" uniqKey="Sarfo S" first="Stephen" last="Sarfo">Stephen Sarfo</name><name sortKey="Stephenson, Lisa" sort="Stephenson, Lisa" uniqKey="Stephenson L" first="Lisa" last="Stephenson">Lisa Stephenson</name><name sortKey="Tan, Grace" sort="Tan, Grace" uniqKey="Tan G" first="Grace" last="Tan">Grace Tan</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Mamoojee, Yaasir" sort="Mamoojee, Yaasir" uniqKey="Mamoojee Y" first="Yaasir" last="Mamoojee">Yaasir Mamoojee</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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