Prevalence and impact of hepatitis B and C virus co-infections in antiretroviral treatment naïve patients with HIV infection at a major treatment center in Ghana.
Identifieur interne : 000464 ( Ncbi/Curation ); précédent : 000463; suivant : 000465Prevalence and impact of hepatitis B and C virus co-infections in antiretroviral treatment naïve patients with HIV infection at a major treatment center in Ghana.
Auteurs : Kwamena William Coleman Sagoe [Ghana] ; Afrakoma Adjoa Agyei ; Francesca Ziga ; Margaret Lartey [Ghana] ; Theophilus K. Adiku ; Makafui Seshi ; Max Q. Arens ; Julius Abraham Addo MingleSource :
- Journal of medical virology [ 1096-9071 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (administration et posologie), Anticorps de l'hépatite C (sang), Antigènes de surface du virus de l'hépatite B (sang), Charge virale, Co-infection (épidémiologie), Comorbidité, Femelle, Ghana, Humains, Hépatite B (), Hépatite B (épidémiologie), Hépatite C (), Hépatite C (épidémiologie), Immunoglobuline M (sang), Infections à VIH (), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Mâle, Numération des lymphocytes CD4, Thérapie antirétrovirale hautement active (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification).
- MESH :
- administration et posologie : Agents antiVIH.
- isolement et purification : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- sang : Anticorps de l'hépatite C, Antigènes de surface du virus de l'hépatite B, Immunoglobuline M.
- traitement médicamenteux : Infections à VIH.
- virologie : Infections à VIH.
- épidémiologie : Co-infection, Hépatite B, Hépatite C.
- Adulte, Adulte d'âge moyen, Charge virale, Comorbidité, Femelle, Ghana, Humains, Hépatite B, Hépatite C, Infections à VIH, Mâle, Numération des lymphocytes CD4, Thérapie antirétrovirale hautement active.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Anti-HIV Agents (administration & dosage), Antiretroviral Therapy, Highly Active (methods), CD4 Lymphocyte Count, Coinfection (epidemiology), Comorbidity, Female, Ghana, HIV Infections (complications), HIV Infections (drug therapy), HIV Infections (virology), HIV-1 (isolation & purification), Hepatitis B (complications), Hepatitis B (epidemiology), Hepatitis B Surface Antigens (blood), Hepatitis C (complications), Hepatitis C (epidemiology), Hepatitis C Antibodies (blood), Humans, Immunoglobulin M (blood), Male, Middle Aged, Viral Load.
- MESH :
- chemical , administration & dosage : Anti-HIV Agents.
- chemical , blood : Hepatitis B Surface Antigens, Hepatitis C Antibodies, Immunoglobulin M.
- geographic : Ghana.
- complications : HIV Infections, Hepatitis B, Hepatitis C.
- drug therapy : HIV Infections.
- epidemiology : Coinfection, Hepatitis B, Hepatitis C.
- isolation & purification : HIV-1.
- methods : Antiretroviral Therapy, Highly Active.
- virology : HIV Infections.
- Adult, CD4 Lymphocyte Count, Comorbidity, Female, Humans, Male, Middle Aged, Viral Load.
Abstract
Data on the effects of the presence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients co-infected with these viruses and HIV in West Africa are conflicting and little information is available in Ghana. A cohort of 138 treatment naïve individuals infected with HIV was screened for HBV and HCV serologic markers; HBsAg positive patients were tested for HBeAg, anti-HBe, and anti-HBc IgM. The viral load of HIV-1 in the plasma was determined in 81 patients. Eighteen of the 138 patients (13%) and 5 (3.6%) had HBsAg and anti-HCV, respectively. None of the patients had anti-HBc IgM, but 10 (55.6%) and 8 (44.4%) of the 18 patients who were HBsAg positive had HBeAg and anti-HBe, respectively. In patients with measurement of CD4(+) undertaken within 1 month (n = 83), CD4(+) count was significantly lower in patients with HBeAg (median [IQR], 81 [22-144]) as compared to those with anti-HBe (median [IQR], 210 [197-222]) (P = 0.002, CI: -96.46 to 51.21). However, those with HIV mono-infection had similar CD4(+) counts (median [IQR], 57 [14-159]) compared to those with HBeAg (P = 1.0, CI: -71.75 to 73.66). Similar results were obtained if CD4(+) count was measured within 2 months prior to initiation of HAART (n = 119). Generally, HBV and anti-HCV did not affect CD4(+) and viral loads of HIV-1 in plasma but patients with HIV and HBV co-infection who had HBeAg had more severe immune suppression as compared to those with anti-HBe. This may have implication for initiating HAART in HBV endemic areas.
DOI: 10.1002/jmv.22262
PubMed: 22095533
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pubmed:22095533Le document en format XML
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xml:lang="en">Data on the effects of the presence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients co-infected with these viruses and HIV in West Africa are conflicting and little information is available in Ghana. A cohort of 138 treatment naïve individuals infected with HIV was screened for HBV and HCV serologic markers; HBsAg positive patients were tested for HBeAg, anti-HBe, and anti-HBc IgM. The viral load of HIV-1 in the plasma was determined in 81 patients. Eighteen of the 138 patients (13%) and 5 (3.6%) had HBsAg and anti-HCV, respectively. None of the patients had anti-HBc IgM, but 10 (55.6%) and 8 (44.4%) of the 18 patients who were HBsAg positive had HBeAg and anti-HBe, respectively. In patients with measurement of CD4(+) undertaken within 1 month (n = 83), CD4(+) count was significantly lower in patients with HBeAg (median [IQR], 81 [22-144]) as compared to those with anti-HBe (median [IQR], 210 [197-222]) (P = 0.002, CI: -96.46 to 51.21). However, those with HIV mono-infection had similar CD4(+) counts (median [IQR], 57 [14-159]) compared to those with HBeAg (P = 1.0, CI: -71.75 to 73.66). Similar results were obtained if CD4(+) count was measured within 2 months prior to initiation of HAART (n = 119). Generally, HBV and anti-HCV did not affect CD4(+) and viral loads of HIV-1 in plasma but patients with HIV and HBV co-infection who had HBeAg had more severe immune suppression as compared to those with anti-HBe. This may have implication for initiating HAART in HBV endemic areas.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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