Initiating antiretroviral treatment in a resource-constrained setting: does clinical staging effectively identify patients in need?
Identifieur interne : 000328 ( Ncbi/Curation ); précédent : 000327; suivant : 000329Initiating antiretroviral treatment in a resource-constrained setting: does clinical staging effectively identify patients in need?
Auteurs : K. Torpey [Zambie] ; M. Lartey ; R. Amenyah ; N A Addo ; J. Obeng-Baah ; Y. Rahman ; C. Suzuki ; Y D Mukadi ; R. ColebundersSource :
- International journal of STD & AIDS [ 0956-4624 ] ; 2009.
Descripteurs français
- KwdFr :
- Adulte, Agents antiVIH (administration et posologie), Agents antiVIH (usage thérapeutique), Détermination de l'admissibilité (), Femelle, Ghana (épidémiologie), Humains, Infections à VIH (immunologie), Infections à VIH (physiopathologie), Infections à VIH (traitement médicamenteux), Mâle, Numération des lymphocytes CD4, Pays en voie de développement, Population rurale, Population urbaine, Sensibilité et spécificité, Valeur prédictive des tests, Évaluation des besoins.
- MESH :
- administration et posologie : Agents antiVIH.
- immunologie : Infections à VIH.
- physiopathologie : Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- épidémiologie : Ghana.
- Adulte, Détermination de l'admissibilité, Femelle, Humains, Mâle, Numération des lymphocytes CD4, Pays en voie de développement, Population rurale, Population urbaine, Sensibilité et spécificité, Valeur prédictive des tests, Évaluation des besoins.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Anti-HIV Agents (administration & dosage), Anti-HIV Agents (therapeutic use), CD4 Lymphocyte Count, Developing Countries, Eligibility Determination (methods), Female, Ghana (epidemiology), HIV Infections (drug therapy), HIV Infections (immunology), HIV Infections (physiopathology), Humans, Male, Needs Assessment, Predictive Value of Tests, Rural Population, Sensitivity and Specificity, Urban Population.
- MESH :
- chemical , administration & dosage : Anti-HIV Agents.
- chemical , therapeutic use : Anti-HIV Agents.
- geographic , epidemiology : Ghana.
- drug therapy : HIV Infections.
- immunology : HIV Infections.
- methods : Eligibility Determination.
- physiopathology : HIV Infections.
- Adult, CD4 Lymphocyte Count, Developing Countries, Female, Humans, Male, Needs Assessment, Predictive Value of Tests, Rural Population, Sensitivity and Specificity, Urban Population.
Abstract
In industrialized countries, the initiation of antiretroviral therapy (ART) is based on virological, immunological and clinical markers. The objective of this study was to identify treatment gaps when ART initiation is based on clinical staging alone. The method employed was a retrospective study of 5784 patients enrolled in an HIV treatment programme in two urban and two rural sites in Ghana. Of the patients, 29.5% were in clinical Stages I and II and had a CD4+ T-lymphocyte count less than 200 cells/mm(3). Significantly more patients in clinical Stage I from urban sites (37.0%) had a CD4+ T-lymphocyte count less than 200 cells/mm(3) as compared with patients from rural sites (23.8%) (P value <0.05). In addition, more men (39.9%) in clinical Stage I had a CD4+ T-lymphocyte count less than 200 cells/mm(3) when compared with women (27.4%) (P value <0.05). In conclusion, clinical staging cannot identify a relatively large number of patients who need ART. A wider availability of CD4+ T-lymphocyte count testing will optimize the identification of patients eligible for ART.
DOI: 10.1258/ijsa.2008.008333
PubMed: 19451324
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000564
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000564
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000564
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000328
Links to Exploration step
pubmed:19451324Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Initiating antiretroviral treatment in a resource-constrained setting: does clinical staging effectively identify patients in need?</title>
<author><name sortKey="Torpey, K" sort="Torpey, K" uniqKey="Torpey K" first="K" last="Torpey">K. Torpey</name>
<affiliation wicri:level="1"><nlm:affiliation>Family Health International, Lusaka, Zambia. Ktorpey@zpct.org</nlm:affiliation>
<country xml:lang="fr">Zambie</country>
<wicri:regionArea>Family Health International, Lusaka</wicri:regionArea>
<wicri:noRegion>Lusaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lartey, M" sort="Lartey, M" uniqKey="Lartey M" first="M" last="Lartey">M. Lartey</name>
</author>
<author><name sortKey="Amenyah, R" sort="Amenyah, R" uniqKey="Amenyah R" first="R" last="Amenyah">R. Amenyah</name>
</author>
<author><name sortKey="Addo, N A" sort="Addo, N A" uniqKey="Addo N" first="N A" last="Addo">N A Addo</name>
</author>
<author><name sortKey="Obeng Baah, J" sort="Obeng Baah, J" uniqKey="Obeng Baah J" first="J" last="Obeng-Baah">J. Obeng-Baah</name>
</author>
<author><name sortKey="Rahman, Y" sort="Rahman, Y" uniqKey="Rahman Y" first="Y" last="Rahman">Y. Rahman</name>
</author>
<author><name sortKey="Suzuki, C" sort="Suzuki, C" uniqKey="Suzuki C" first="C" last="Suzuki">C. Suzuki</name>
</author>
<author><name sortKey="Mukadi, Y D" sort="Mukadi, Y D" uniqKey="Mukadi Y" first="Y D" last="Mukadi">Y D Mukadi</name>
</author>
<author><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R" last="Colebunders">R. Colebunders</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="RBID">pubmed:19451324</idno>
<idno type="pmid">19451324</idno>
<idno type="doi">10.1258/ijsa.2008.008333</idno>
<idno type="wicri:Area/PubMed/Corpus">000564</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000564</idno>
<idno type="wicri:Area/PubMed/Curation">000564</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000564</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000564</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000564</idno>
<idno type="wicri:Area/Ncbi/Merge">000328</idno>
<idno type="wicri:Area/Ncbi/Curation">000328</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Initiating antiretroviral treatment in a resource-constrained setting: does clinical staging effectively identify patients in need?</title>
<author><name sortKey="Torpey, K" sort="Torpey, K" uniqKey="Torpey K" first="K" last="Torpey">K. Torpey</name>
<affiliation wicri:level="1"><nlm:affiliation>Family Health International, Lusaka, Zambia. Ktorpey@zpct.org</nlm:affiliation>
<country xml:lang="fr">Zambie</country>
<wicri:regionArea>Family Health International, Lusaka</wicri:regionArea>
<wicri:noRegion>Lusaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lartey, M" sort="Lartey, M" uniqKey="Lartey M" first="M" last="Lartey">M. Lartey</name>
</author>
<author><name sortKey="Amenyah, R" sort="Amenyah, R" uniqKey="Amenyah R" first="R" last="Amenyah">R. Amenyah</name>
</author>
<author><name sortKey="Addo, N A" sort="Addo, N A" uniqKey="Addo N" first="N A" last="Addo">N A Addo</name>
</author>
<author><name sortKey="Obeng Baah, J" sort="Obeng Baah, J" uniqKey="Obeng Baah J" first="J" last="Obeng-Baah">J. Obeng-Baah</name>
</author>
<author><name sortKey="Rahman, Y" sort="Rahman, Y" uniqKey="Rahman Y" first="Y" last="Rahman">Y. Rahman</name>
</author>
<author><name sortKey="Suzuki, C" sort="Suzuki, C" uniqKey="Suzuki C" first="C" last="Suzuki">C. Suzuki</name>
</author>
<author><name sortKey="Mukadi, Y D" sort="Mukadi, Y D" uniqKey="Mukadi Y" first="Y D" last="Mukadi">Y D Mukadi</name>
</author>
<author><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R" last="Colebunders">R. Colebunders</name>
</author>
</analytic>
<series><title level="j">International journal of STD & AIDS</title>
<idno type="ISSN">0956-4624</idno>
<imprint><date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Anti-HIV Agents (administration & dosage)</term>
<term>Anti-HIV Agents (therapeutic use)</term>
<term>CD4 Lymphocyte Count</term>
<term>Developing Countries</term>
<term>Eligibility Determination (methods)</term>
<term>Female</term>
<term>Ghana (epidemiology)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (physiopathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Needs Assessment</term>
<term>Predictive Value of Tests</term>
<term>Rural Population</term>
<term>Sensitivity and Specificity</term>
<term>Urban Population</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Agents antiVIH (administration et posologie)</term>
<term>Agents antiVIH (usage thérapeutique)</term>
<term>Détermination de l'admissibilité ()</term>
<term>Femelle</term>
<term>Ghana (épidémiologie)</term>
<term>Humains</term>
<term>Infections à VIH (immunologie)</term>
<term>Infections à VIH (physiopathologie)</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Pays en voie de développement</term>
<term>Population rurale</term>
<term>Population urbaine</term>
<term>Sensibilité et spécificité</term>
<term>Valeur prédictive des tests</term>
<term>Évaluation des besoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Agents antiVIH</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Eligibility Determination</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>CD4 Lymphocyte Count</term>
<term>Developing Countries</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Needs Assessment</term>
<term>Predictive Value of Tests</term>
<term>Rural Population</term>
<term>Sensitivity and Specificity</term>
<term>Urban Population</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Détermination de l'admissibilité</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Pays en voie de développement</term>
<term>Population rurale</term>
<term>Population urbaine</term>
<term>Sensibilité et spécificité</term>
<term>Valeur prédictive des tests</term>
<term>Évaluation des besoins</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In industrialized countries, the initiation of antiretroviral therapy (ART) is based on virological, immunological and clinical markers. The objective of this study was to identify treatment gaps when ART initiation is based on clinical staging alone. The method employed was a retrospective study of 5784 patients enrolled in an HIV treatment programme in two urban and two rural sites in Ghana. Of the patients, 29.5% were in clinical Stages I and II and had a CD4+ T-lymphocyte count less than 200 cells/mm(3). Significantly more patients in clinical Stage I from urban sites (37.0%) had a CD4+ T-lymphocyte count less than 200 cells/mm(3) as compared with patients from rural sites (23.8%) (P value <0.05). In addition, more men (39.9%) in clinical Stage I had a CD4+ T-lymphocyte count less than 200 cells/mm(3) when compared with women (27.4%) (P value <0.05). In conclusion, clinical staging cannot identify a relatively large number of patients who need ART. A wider availability of CD4+ T-lymphocyte count testing will optimize the identification of patients eligible for ART.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000328 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000328 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaGhanaV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:19451324 |texte= Initiating antiretroviral treatment in a resource-constrained setting: does clinical staging effectively identify patients in need? }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:19451324" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a SidaGhanaV1
This area was generated with Dilib version V0.6.31. |