The association of anti-phospholipid antibodies with parity in placental malaria.
Identifieur interne : 000186 ( Ncbi/Curation ); précédent : 000185; suivant : 000187The association of anti-phospholipid antibodies with parity in placental malaria.
Auteurs : S. Owens [Gambie] ; L W Chamley ; J. Ordi ; B J Brabin ; P M JohnsonSource :
- Clinical and experimental immunology [ 0009-9104 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Anticoagulants (immunologie), Anticorps anticardiolipines (immunologie), Anticorps antiphospholipides (immunologie), Apolipoprotéines (immunologie), Cardiolipides (immunologie), Complications de la grossesse et maladies infectieuses (immunologie), Femelle, Glycoprotéines (immunologie), Grossesse, Humains, Immunoglobuline G (analyse), Maladies du placenta (immunologie), Paludisme (immunologie), Parité (immunologie), Phosphatidylsérine (immunologie), Test ELISA (), bêta 2-Glycoprotéine I, Études transversales.
- MESH :
- analyse : Immunoglobuline G.
- immunologie : Anticoagulants, Anticorps anticardiolipines, Anticorps antiphospholipides, Apolipoprotéines, Cardiolipides, Complications de la grossesse et maladies infectieuses, Glycoprotéines, Maladies du placenta, Paludisme, Parité, Phosphatidylsérine.
- Adulte, Femelle, Grossesse, Humains, Test ELISA, bêta 2-Glycoprotéine I, Études transversales.
English descriptors
- KwdEn :
- Adult, Antibodies, Anticardiolipin (immunology), Antibodies, Antiphospholipid (immunology), Anticoagulants (immunology), Apolipoproteins (immunology), Cardiolipins (immunology), Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay (methods), Female, Glycoproteins (immunology), Humans, Immunoglobulin G (analysis), Malaria (immunology), Parity (immunology), Phosphatidylserines (immunology), Placenta Diseases (immunology), Pregnancy, Pregnancy Complications, Infectious (immunology), beta 2-Glycoprotein I.
- MESH :
- chemical , analysis : Immunoglobulin G.
- chemical , immunology : Antibodies, Anticardiolipin, Antibodies, Antiphospholipid, Anticoagulants, Apolipoproteins, Cardiolipins, Glycoproteins, Phosphatidylserines.
- immunology : Malaria, Parity, Placenta Diseases, Pregnancy Complications, Infectious.
- methods : Enzyme-Linked Immunosorbent Assay.
- Adult, Cross-Sectional Studies, Female, Humans, Pregnancy, beta 2-Glycoprotein I.
Abstract
Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, beta(2) glycoprotein I (beta2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and beta2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-beta2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, beta2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of beta2GPI-independent aPL profiles, and does not support a role for beta2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.
DOI: 10.1111/j.1365-2249.2005.02936.x
PubMed: 16297164
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Owens</name><affiliation wicri:level="1"><nlm:affiliation>MRC Laboratories, Atlantic Road, Fajara, The Gambia.</nlm:affiliation><country xml:lang="fr">Gambie</country><wicri:regionArea>MRC Laboratories, Atlantic Road, Fajara</wicri:regionArea><wicri:noRegion>Fajara</wicri:noRegion></affiliation></author><author><name sortKey="Chamley, L W" sort="Chamley, L W" uniqKey="Chamley L" first="L W" last="Chamley">L W Chamley</name></author><author><name sortKey="Ordi, J" sort="Ordi, J" uniqKey="Ordi J" first="J" last="Ordi">J. Ordi</name></author><author><name sortKey="Brabin, B J" sort="Brabin, B J" uniqKey="Brabin B" first="B J" last="Brabin">B J Brabin</name></author><author><name sortKey="Johnson, P M" sort="Johnson, P M" uniqKey="Johnson P" first="P M" last="Johnson">P M Johnson</name></author></analytic><series><title level="j">Clinical and experimental immunology</title><idno type="ISSN">0009-9104</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Anticardiolipin (immunology)</term><term>Antibodies, Antiphospholipid (immunology)</term><term>Anticoagulants (immunology)</term><term>Apolipoproteins (immunology)</term><term>Cardiolipins (immunology)</term><term>Cross-Sectional Studies</term><term>Enzyme-Linked Immunosorbent Assay (methods)</term><term>Female</term><term>Glycoproteins (immunology)</term><term>Humans</term><term>Immunoglobulin G (analysis)</term><term>Malaria (immunology)</term><term>Parity (immunology)</term><term>Phosphatidylserines (immunology)</term><term>Placenta Diseases (immunology)</term><term>Pregnancy</term><term>Pregnancy Complications, Infectious (immunology)</term><term>beta 2-Glycoprotein I</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anticoagulants (immunologie)</term><term>Anticorps anticardiolipines (immunologie)</term><term>Anticorps antiphospholipides (immunologie)</term><term>Apolipoprotéines (immunologie)</term><term>Cardiolipides (immunologie)</term><term>Complications de la grossesse et maladies infectieuses (immunologie)</term><term>Femelle</term><term>Glycoprotéines (immunologie)</term><term>Grossesse</term><term>Humains</term><term>Immunoglobuline G (analyse)</term><term>Maladies du placenta (immunologie)</term><term>Paludisme (immunologie)</term><term>Parité (immunologie)</term><term>Phosphatidylsérine (immunologie)</term><term>Test ELISA ()</term><term>bêta 2-Glycoprotéine I</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Anticardiolipin</term><term>Antibodies, Antiphospholipid</term><term>Anticoagulants</term><term>Apolipoproteins</term><term>Cardiolipins</term><term>Glycoproteins</term><term>Phosphatidylserines</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticoagulants</term><term>Anticorps anticardiolipines</term><term>Anticorps antiphospholipides</term><term>Apolipoprotéines</term><term>Cardiolipides</term><term>Complications de la grossesse et maladies infectieuses</term><term>Glycoprotéines</term><term>Maladies du placenta</term><term>Paludisme</term><term>Parité</term><term>Phosphatidylsérine</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Malaria</term><term>Parity</term><term>Placenta Diseases</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Pregnancy</term><term>beta 2-Glycoprotein I</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Test ELISA</term><term>bêta 2-Glycoprotéine I</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, beta(2) glycoprotein I (beta2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and beta2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-beta2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, beta2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of beta2GPI-independent aPL profiles, and does not support a role for beta2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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