T-lymphocytopaenia, opportunistic infections and pathological findings in Ghanaian AIDS patients and their sexual partners.
Identifieur interne : 000C62 ( Ncbi/Checkpoint ); précédent : 000C61; suivant : 000C63T-lymphocytopaenia, opportunistic infections and pathological findings in Ghanaian AIDS patients and their sexual partners.
Auteurs : N K Ayisi [Ghana] ; E K Wiredu ; T. Sata ; C. Nyadedzor ; V K Tsiagbe ; M. Newman ; C N Cofie ; K. TaneguchiSource :
- East African medical journal [ 0012-835X ] ; 1997.
Descripteurs français
- KwdFr :
- Adulte, Apoptose, Cause de décès, Enfant, Femelle, Ghana, Humains, Infections opportunistes liées au SIDA (anatomopathologie), Lymphocytes T, Lymphopénie (virologie), Mâle, Partenaire sexuel, Rapport CD4-CD8, Syndrome d'immunodéficience acquise (), Syndrome d'immunodéficience acquise (immunologie), Syndrome d'immunodéficience acquise (sang), VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2), Études cas-témoins.
- MESH :
- anatomopathologie : Infections opportunistes liées au SIDA.
- immunologie : Syndrome d'immunodéficience acquise.
- sang : Syndrome d'immunodéficience acquise.
- virologie : Lymphopénie.
- Adulte, Apoptose, Cause de décès, Enfant, Femelle, Ghana, Humains, Lymphocytes T, Mâle, Partenaire sexuel, Rapport CD4-CD8, Syndrome d'immunodéficience acquise, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2), Études cas-témoins.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- AIDS-Related Opportunistic Infections (pathology), Acquired Immunodeficiency Syndrome (blood), Acquired Immunodeficiency Syndrome (complications), Acquired Immunodeficiency Syndrome (immunology), Adult, Apoptosis, CD4-CD8 Ratio, Case-Control Studies, Cause of Death, Child, Female, Ghana, HIV-1, HIV-2, Humans, Lymphopenia (virology), Male, Sexual Partners, T-Lymphocytes.
- MESH :
- geographic : Ghana.
- blood : Acquired Immunodeficiency Syndrome.
- complications : Acquired Immunodeficiency Syndrome.
- immunology : Acquired Immunodeficiency Syndrome.
- pathology : AIDS-Related Opportunistic Infections.
- virology : Lymphopenia.
- Adult, Apoptosis, CD4-CD8 Ratio, Case-Control Studies, Cause of Death, Child, Female, HIV-1, HIV-2, Humans, Male, Sexual Partners, T-Lymphocytes.
Abstract
Ninety-nine patients at Center for Disease Control (CDC) clinical stage IV were studied. Twelve (12.12%) of these patients turned out to be HIV seronegative. Ten out of the 12 HIV negative patients were immunocompetent whereas the other two had proportional decreases in both CD4+ and CD8+ T-lymphocytes. HIV-1, HIV-2, and dual infection, were detected in 51.5%, 2%, and 22.2% respectively of clinical AIDS patients. The other 12.12% of clinical AIDS patients were indeterminate for HIV antibodies. All HIV positive patients with the exception of two, were immunocompromised with respect to CD4+ and CD8+ T-lymphocyte counts. Two healthy spouses and three children of patients who died from the disease were seronegative for HIV antibodies. Herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV) antibody titres were higher in HIV infected than uninfected blood. Patients with chronic diarrhoea, lymphadenopathy, pneumonia, and tuberculosis, either alone or in combination of two or more of such symptoms, were found to be more likely to be confirmed by serology and immunology as definitive AIDS patients in Ghana. In postmortem studies on 20 patients, pneumonia due to tuberculosis constituted the major cause of death. Toxoplasmosis, cytomegaloviral eosophagitis and enteritis, and cryptococcosis were the major opportunistic infections detected. Programmed cell death (apoptosis) was found by the DNA gel electrophoresis method to be an unlikely major mechanism of accelerated culture induced death of PBMCs from CDC stage IV AIDS patients.
PubMed: 9557423
Affiliations:
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS-Related Opportunistic Infections (pathology)</term>
<term>Acquired Immunodeficiency Syndrome (blood)</term>
<term>Acquired Immunodeficiency Syndrome (complications)</term>
<term>Acquired Immunodeficiency Syndrome (immunology)</term>
<term>Adult</term>
<term>Apoptosis</term>
<term>CD4-CD8 Ratio</term>
<term>Case-Control Studies</term>
<term>Cause of Death</term>
<term>Child</term>
<term>Female</term>
<term>Ghana</term>
<term>HIV-1</term>
<term>HIV-2</term>
<term>Humans</term>
<term>Lymphopenia (virology)</term>
<term>Male</term>
<term>Sexual Partners</term>
<term>T-Lymphocytes</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Apoptose</term>
<term>Cause de décès</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Ghana</term>
<term>Humains</term>
<term>Infections opportunistes liées au SIDA (anatomopathologie)</term>
<term>Lymphocytes T</term>
<term>Lymphopénie (virologie)</term>
<term>Mâle</term>
<term>Partenaire sexuel</term>
<term>Rapport CD4-CD8</term>
<term>Syndrome d'immunodéficience acquise ()</term>
<term>Syndrome d'immunodéficience acquise (immunologie)</term>
<term>Syndrome d'immunodéficience acquise (sang)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2)</term>
<term>Études cas-témoins</term>
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</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Acquired Immunodeficiency Syndrome</term>
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<term>Apoptosis</term>
<term>CD4-CD8 Ratio</term>
<term>Case-Control Studies</term>
<term>Cause of Death</term>
<term>Child</term>
<term>Female</term>
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<term>HIV-2</term>
<term>Humans</term>
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<term>T-Lymphocytes</term>
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<term>Apoptose</term>
<term>Cause de décès</term>
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<term>Ghana</term>
<term>Humains</term>
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<term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2)</term>
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<front><div type="abstract" xml:lang="en">Ninety-nine patients at Center for Disease Control (CDC) clinical stage IV were studied. Twelve (12.12%) of these patients turned out to be HIV seronegative. Ten out of the 12 HIV negative patients were immunocompetent whereas the other two had proportional decreases in both CD4+ and CD8+ T-lymphocytes. HIV-1, HIV-2, and dual infection, were detected in 51.5%, 2%, and 22.2% respectively of clinical AIDS patients. The other 12.12% of clinical AIDS patients were indeterminate for HIV antibodies. All HIV positive patients with the exception of two, were immunocompromised with respect to CD4+ and CD8+ T-lymphocyte counts. Two healthy spouses and three children of patients who died from the disease were seronegative for HIV antibodies. Herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV) antibody titres were higher in HIV infected than uninfected blood. Patients with chronic diarrhoea, lymphadenopathy, pneumonia, and tuberculosis, either alone or in combination of two or more of such symptoms, were found to be more likely to be confirmed by serology and immunology as definitive AIDS patients in Ghana. In postmortem studies on 20 patients, pneumonia due to tuberculosis constituted the major cause of death. Toxoplasmosis, cytomegaloviral eosophagitis and enteritis, and cryptococcosis were the major opportunistic infections detected. Programmed cell death (apoptosis) was found by the DNA gel electrophoresis method to be an unlikely major mechanism of accelerated culture induced death of PBMCs from CDC stage IV AIDS patients.</div>
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