Prevalence of persistent and latent viruses in untreated patients infected with HIV-1 from Ghana, West Africa.
Identifieur interne : 000342 ( Ncbi/Checkpoint ); précédent : 000341; suivant : 000343Prevalence of persistent and latent viruses in untreated patients infected with HIV-1 from Ghana, West Africa.
Auteurs : Lara Isobel Compston [Royaume-Uni] ; Chengyao Li ; Francis Sarkodie ; Shirley Owusu-Ofori ; Ohene Opare-Sem ; Jean-Pierre AllainSource :
- Journal of medical virology [ 1096-9071 ] ; 2009.
Descripteurs français
- KwdFr :
- Adolescent, Adulte d'âge moyen, Cellules sanguines (virologie), Comorbidité, Cytomegalovirus (isolement et purification), Ghana (épidémiologie), Herpèsvirus humain de type 3 (isolement et purification), Herpèsvirus humain de type 4 (isolement et purification), Herpèsvirus humain de type 8 (isolement et purification), Humains, Infections à VIH (), Jeune adulte, Latence virale, Maladies virales (virologie), Maladies virales (épidémiologie), Parvovirus humain B19 (isolement et purification), Plasma sanguin (virologie), Prévalence, Réaction de polymérisation en chaîne (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification), Virus GB-C (isolement et purification), Virus de l'hépatite B (isolement et purification), Virémie.
- MESH :
- isolement et purification : Cytomegalovirus, Herpèsvirus humain de type 3, Herpèsvirus humain de type 4, Herpèsvirus humain de type 8, Parvovirus humain B19, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus GB-C, Virus de l'hépatite B.
- virologie : Cellules sanguines, Maladies virales, Plasma sanguin.
- épidémiologie : Ghana, Maladies virales.
- Adolescent, Adulte d'âge moyen, Comorbidité, Humains, Infections à VIH, Jeune adulte, Latence virale, Prévalence, Réaction de polymérisation en chaîne, Virémie.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adolescent, Blood Cells (virology), Comorbidity, Cytomegalovirus (isolation & purification), GB virus C (isolation & purification), Ghana (epidemiology), HIV Infections (complications), HIV-1 (isolation & purification), Hepatitis B virus (isolation & purification), Herpesvirus 3, Human (isolation & purification), Herpesvirus 4, Human (isolation & purification), Herpesvirus 8, Human (isolation & purification), Humans, Middle Aged, Parvovirus B19, Human (isolation & purification), Plasma (virology), Polymerase Chain Reaction (methods), Prevalence, Viremia, Virus Diseases (epidemiology), Virus Diseases (virology), Virus Latency, Young Adult.
- MESH :
- geographic , epidemiology : Ghana.
- complications : HIV Infections.
- epidemiology : Virus Diseases.
- isolation & purification : Cytomegalovirus, GB virus C, HIV-1, Hepatitis B virus, Herpesvirus 3, Human, Herpesvirus 4, Human, Herpesvirus 8, Human, Parvovirus B19, Human.
- methods : Polymerase Chain Reaction.
- virology : Blood Cells, Plasma, Virus Diseases.
- Adolescent, Comorbidity, Humans, Middle Aged, Prevalence, Viremia, Virus Latency, Young Adult.
Abstract
Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV-1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV-negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus-C (GBV-C), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus-8 (HHV-8) and varicella-zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV-C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P < 0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P < 0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P < 0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV-1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P < or = 0.001. The background seroprevalence in blood donors was high for B19V (> or =64%), HBV (> or =70%), CMV and EBV (> or =90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV-8 (asymptomatic and symptomatic HIV).
DOI: 10.1002/jmv.21614
PubMed: 19774687
Affiliations:
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purification)</term><term>Hepatitis B virus (isolation & purification)</term><term>Herpesvirus 3, Human (isolation & purification)</term><term>Herpesvirus 4, Human (isolation & purification)</term><term>Herpesvirus 8, Human (isolation & purification)</term><term>Humans</term><term>Middle Aged</term><term>Parvovirus B19, Human (isolation & purification)</term><term>Plasma (virology)</term><term>Polymerase Chain Reaction (methods)</term><term>Prevalence</term><term>Viremia</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (virology)</term><term>Virus Latency</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Cellules sanguines (virologie)</term><term>Comorbidité</term><term>Cytomegalovirus (isolement et purification)</term><term>Ghana (épidémiologie)</term><term>Herpèsvirus humain de type 3 (isolement et purification)</term><term>Herpèsvirus humain de type 4 (isolement et purification)</term><term>Herpèsvirus humain de type 8 (isolement et purification)</term><term>Humains</term><term>Infections à VIH ()</term><term>Jeune adulte</term><term>Latence virale</term><term>Maladies virales (virologie)</term><term>Maladies virales (épidémiologie)</term><term>Parvovirus humain B19 (isolement et purification)</term><term>Plasma sanguin (virologie)</term><term>Prévalence</term><term>Réaction de polymérisation en chaîne ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term><term>Virus GB-C (isolement et purification)</term><term>Virus de l'hépatite B (isolement et purification)</term><term>Virémie</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Virus 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xml:lang="en">Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV-1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV-negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus-C (GBV-C), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus-8 (HHV-8) and varicella-zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV-C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P < 0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P < 0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P < 0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV-1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P < or = 0.001. The background seroprevalence in blood donors was high for B19V (> or =64%), HBV (> or =70%), CMV and EBV (> or =90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV-8 (asymptomatic and symptomatic HIV).</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><name sortKey="Li, Chengyao" sort="Li, Chengyao" uniqKey="Li C" first="Chengyao" last="Li">Chengyao Li</name><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Compston, Lara Isobel" sort="Compston, Lara Isobel" uniqKey="Compston L" first="Lara Isobel" last="Compston">Lara Isobel Compston</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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