SidaGhanaV1, Main, Merge, bibRecord, 001599

Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana

Identifieur interne : 001599 ( Main/Merge ); précédent : 001598; suivant : 001600

Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana

Auteurs : T. S. Van Der Werf [Ghana, Pays-Bas] ; P. K. Das [Pays-Bas] ; D. Van Soolingen [Pays-Bas] ; S. Yong [Pays-Bas] ; T. W. Van Der Mark [Pays-Bas] ; R. Van Den Akker [Pays-Bas]

Source :

Medical Microbiology and Immunology [ 0300-8584 ] ; 1992-05-01.

RBID : ISTEX:43F0C0D6ADC2DD29F2A69C9C51058D8DBF5E5968

Descripteurs français

Wicri :
- geographic : Ghana.
- topic : Protection de l'environnement, Santé publique.

English descriptors

Abstract

Abstract: In order to assess the diagnostic usefulness of the A60 (ANDA Biologicals, Strassbourg, France) sero-diagnostic enzyme-linked immunosorbent assay (ELISA) kit for tuberculosis in Africa, sera of 53 pulmonary smear-positive tuberculosis (TB) patients, 30 apparently healthy control subjects and 6 AIDS suspects were sampled in Agogo Hospital in the forest area of Ghana. These sera were analyzed for antibodies to HIV-1 and HIV-2, and IgG-antibodies to the A60 BCG-antigen, while the non-HIV individuals were tested for total IgG levels. One healthy control subject, all of 6 AIDS suspects and 7 of the TB patients has HIV infections. In the non-HIV TB group, the sensitivity and specifity of the A60 ELISA was 78% and 86%, respectively, which was much poorer than expected from published reports about the A60 test. The A60 test failed, completely however, to discriminate between TB and non-TB in the HIV-positive group. In the non-HIV groups, total IgG levels were significantly higher in TB patients than in controls. It seems that the usefulness of the A60 ELISA test to diagnose tuberculosis is very limited in this high-incidence area, and that it seems to be of no value in patients infected with HIV.

Url:

https://api.istex.fr/document/43F0C0D6ADC2DD29F2A69C9C51058D8DBF5E5968/fulltext/pdf

DOI: 10.1007/BF00189425

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000000
to stream Istex, to step Curation: 000000
to stream Istex, to step Checkpoint: 000900

Links to Exploration step

ISTEX:43F0C0D6ADC2DD29F2A69C9C51058D8DBF5E5968

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana</title>
<author><name sortKey="Van Der Werf, T S" sort="Van Der Werf, T S" uniqKey="Van Der Werf T" first="T. S." last="Van Der Werf">T. S. Van Der Werf</name>
</author>
<author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P. K." last="Das">P. K. Das</name>
</author>
<author><name sortKey="Van Soolingen, D" sort="Van Soolingen, D" uniqKey="Van Soolingen D" first="D." last="Van Soolingen">D. Van Soolingen</name>
</author>
<author><name sortKey="Yong, S" sort="Yong, S" uniqKey="Yong S" first="S." last="Yong">S. Yong</name>
</author>
<author><name sortKey="Van Der Mark, T W" sort="Van Der Mark, T W" uniqKey="Van Der Mark T" first="T. W." last="Van Der Mark">T. W. Van Der Mark</name>
</author>
<author><name sortKey="Van Den Akker, R" sort="Van Den Akker, R" uniqKey="Van Den Akker R" first="R." last="Van Den Akker">R. Van Den Akker</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:43F0C0D6ADC2DD29F2A69C9C51058D8DBF5E5968</idno>
<date when="1992" year="1992">1992</date>
<idno type="doi">10.1007/BF00189425</idno>
<idno type="url">https://api.istex.fr/document/43F0C0D6ADC2DD29F2A69C9C51058D8DBF5E5968/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000000</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000000</idno>
<idno type="wicri:Area/Istex/Curation">000000</idno>
<idno type="wicri:Area/Istex/Checkpoint">000900</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000900</idno>
<idno type="wicri:doubleKey">0300-8584:1992:Van Der Werf T:sero:diagnosis:of</idno>
<idno type="wicri:Area/Main/Merge">001599</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana</title>
<author><name sortKey="Van Der Werf, T S" sort="Van Der Werf, T S" uniqKey="Van Der Werf T" first="T. S." last="Van Der Werf">T. S. Van Der Werf</name>
<affiliation wicri:level="1"><country xml:lang="fr">Ghana</country>
<wicri:regionArea>Agogo Hospital</wicri:regionArea>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pulmonary Diseases, Groningen University Hospital, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P. K." last="Das">P. K. Das</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Dermatology and Pathology, Academic Medical Center, Meibergdreef 9, NL-1105 AZ, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Microbiology and Virology, National Institute of Public Health and Environmental Protection, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Soolingen, D" sort="Van Soolingen, D" uniqKey="Van Soolingen D" first="D." last="Van Soolingen">D. Van Soolingen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Microbiology and Virology, National Institute of Public Health and Environmental Protection, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yong, S" sort="Yong, S" uniqKey="Yong S" first="S." last="Yong">S. Yong</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Dermatology and Pathology, Academic Medical Center, Meibergdreef 9, NL-1105 AZ, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Mark, T W" sort="Van Der Mark, T W" uniqKey="Van Der Mark T" first="T. W." last="Van Der Mark">T. W. Van Der Mark</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pulmonary Diseases, Groningen University Hospital, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Den Akker, R" sort="Van Den Akker, R" uniqKey="Van Den Akker R" first="R." last="Van Den Akker">R. Van Den Akker</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Microbiology and Virology, National Institute of Public Health and Environmental Protection, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Medical Microbiology and Immunology</title>
<title level="j" type="abbrev">Med Microbiol Immunol</title>
<idno type="ISSN">0300-8584</idno>
<idno type="eISSN">1432-1831</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1992-05-01">1992-05-01</date>
<biblScope unit="volume">181</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="71">71</biblScope>
<biblScope unit="page" to="76">76</biblScope>
</imprint>
<idno type="ISSN">0300-8584</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0300-8584</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agogo</term>
<term>Agogo hospital</term>
<term>Anda biologicals</term>
<term>Assay</term>
<term>Cocito</term>
<term>Control subjects</term>
<term>Diagnostic kits</term>
<term>Diagnostic usefulness</term>
<term>Dutch patients</term>
<term>Elisa</term>
<term>Environmental protection</term>
<term>Enzyme immunoassay</term>
<term>Forest area</term>
<term>Ghana</term>
<term>Ghanaian</term>
<term>Ghanaian controls</term>
<term>Healthy controls</term>
<term>Higher levels</term>
<term>Humoral</term>
<term>Immunol</term>
<term>Immunosorbent</term>
<term>Immunosorbent assay</term>
<term>Median</term>
<term>Microbiol immunol</term>
<term>Mycobacterial</term>
<term>Mycobacterial antigen</term>
<term>Mycobacterium boris</term>
<term>National institute</term>
<term>Other mycobacterial diseases</term>
<term>Public health</term>
<term>Serological test</term>
<term>Serum antibody assay</term>
<term>Test results</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Agogo</term>
<term>Agogo hospital</term>
<term>Anda biologicals</term>
<term>Assay</term>
<term>Cocito</term>
<term>Control subjects</term>
<term>Diagnostic kits</term>
<term>Diagnostic usefulness</term>
<term>Dutch patients</term>
<term>Elisa</term>
<term>Environmental protection</term>
<term>Enzyme immunoassay</term>
<term>Forest area</term>
<term>Ghana</term>
<term>Ghanaian</term>
<term>Ghanaian controls</term>
<term>Healthy controls</term>
<term>Higher levels</term>
<term>Humoral</term>
<term>Immunol</term>
<term>Immunosorbent</term>
<term>Immunosorbent assay</term>
<term>Median</term>
<term>Microbiol immunol</term>
<term>Mycobacterial</term>
<term>Mycobacterial antigen</term>
<term>Mycobacterium boris</term>
<term>National institute</term>
<term>Other mycobacterial diseases</term>
<term>Public health</term>
<term>Serological test</term>
<term>Serum antibody assay</term>
<term>Test results</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Protection de l'environnement</term>
<term>Santé publique</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: In order to assess the diagnostic usefulness of the A60 (ANDA Biologicals, Strassbourg, France) sero-diagnostic enzyme-linked immunosorbent assay (ELISA) kit for tuberculosis in Africa, sera of 53 pulmonary smear-positive tuberculosis (TB) patients, 30 apparently healthy control subjects and 6 AIDS suspects were sampled in Agogo Hospital in the forest area of Ghana. These sera were analyzed for antibodies to HIV-1 and HIV-2, and IgG-antibodies to the A60 BCG-antigen, while the non-HIV individuals were tested for total IgG levels. One healthy control subject, all of 6 AIDS suspects and 7 of the TB patients has HIV infections. In the non-HIV TB group, the sensitivity and specifity of the A60 ELISA was 78% and 86%, respectively, which was much poorer than expected from published reports about the A60 test. The A60 test failed, completely however, to discriminate between TB and non-TB in the HIV-positive group. In the non-HIV groups, total IgG levels were significantly higher in TB patients than in controls. It seems that the usefulness of the A60 ELISA test to diagnose tuberculosis is very limited in this high-incidence area, and that it seems to be of no value in patients infected with HIV.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001599 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001599 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaGhanaV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:43F0C0D6ADC2DD29F2A69C9C51058D8DBF5E5968
   |texte=   Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana
}}

This area was generated with Dilib version V0.6.31.
Data generation: Tue Nov 7 18:07:38 2017. Site generation: Tue Mar 5 15:01:57 2024

	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA au Ghana (serveur d'exploration)

Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana

Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri