SidaGhanaV1, Main, Merge, bibRecord, 001392

T-lymphocytopaenia, opportunistic infections and pathological findings in Ghanaian AIDS patients and their sexual partners

Identifieur interne : 001392 ( Main/Merge ); précédent : 001391; suivant : 001393

T-lymphocytopaenia, opportunistic infections and pathological findings in Ghanaian AIDS patients and their sexual partners

Auteurs : N. K. Ayisi [Ghana] ; E. K. Wiredu [Ghana] ; T. Sata [Japon] ; C. Nyadedzor [Ghana] ; V. K. Tsiagbe [Ghana] ; M. Newman [Ghana] ; C. N. Cofie [Ghana] ; K. Taneguchi [Japon]

Source :

East African medical journal [ 0012-835X ] ; 1997.

RBID : Pascal:98-0226560

Descripteurs français

Pascal (Inist)
- SIDA, Séropositivité, Autopsie, Infection opportuniste, Etiologie, Association, Maladie, Lymphopénie, Lymphocyte T, Ghana, Homme.
Wicri :
- geographic : Ghana.
- topic : Association, Maladie, Homme.

English descriptors

KwdEn :
- AIDS, Association, Autopsy, Disease, Etiology, Ghana, Human, Lymphocytopenia, Opportunistic infection, Seropositivity, T-Lymphocyte.

Abstract

Ninety-nine patients at Center for Disease Control (CDC) clinical stage IV were studied. Twelve (12.12%) of these patients turned out to be HIV seronegative. Ten out of the 12 HIV negative patients were immunocompetent whereas the other two had proportional decreases in both CD4+ and CD8+ T-lymphocytes. HIV-1, HIV-2, and dual infection, were detected in 51.5%, 2%, and 22.2% respectively of clinical AIDS patients. The other 12.12% of clinical AIDS patients were indeterminate for HIV antibodies. All HIV positive patients with the exception of two, were immunocompromised with respect to CD4+ and CD8+ T-lymphocyte counts. Two healthy spouses and three children of patients who died from the disease were seronegative for HIV antibodies. Herpes simplex virus type 2 (HSV- 2) and cytomegalovirus (CMV) antibody titres were higher in HIV infected than uninfected blood. Patients with chronic diarrhoea, lymphadenopathy, pneumonia, and tuberculosis, either alone or in combination of two or more of such symptoms, were found to be more likely to be confirmed by serology and immunology as definitive AIDS patients in Ghana. In postmortem studies on 20 patients, pneumonia due to tuberculosis constituted the major cause of death. Toxoplasmosis, cytomegaloviral eosophagitis and enteritis, and cryptococcosis were the major opportunistic infections detected. Programmed cell death (apoptosis) was found by the DNA gel electrophoresis method to be an unlikely major mechanism of accelerated culture induced death of PBMCs from CDC stage IV AIDS patients.

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Pascal:98-0226560

Le document en format XML

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<author><name sortKey="Ayisi, N K" sort="Ayisi, N K" uniqKey="Ayisi N" first="N. K." last="Ayisi">N. K. Ayisi</name>
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<author><name sortKey="Sata, T" sort="Sata, T" uniqKey="Sata T" first="T." last="Sata">T. Sata</name>
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<author><name sortKey="Taneguchi, K" sort="Taneguchi, K" uniqKey="Taneguchi K" first="K." last="Taneguchi">K. Taneguchi</name>
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<author><name sortKey="Newman, M" sort="Newman, M" uniqKey="Newman M" first="M." last="Newman">M. Newman</name>
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<author><name sortKey="Cofie, C N" sort="Cofie, C N" uniqKey="Cofie C" first="C. N." last="Cofie">C. N. Cofie</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Medicine & Therapeutics, University of Ghana Medical School</s1>
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<s3>GHA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Ghana</country>
<placeName><settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
</placeName>
</affiliation>
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<author><name sortKey="Taneguchi, K" sort="Taneguchi, K" uniqKey="Taneguchi K" first="K." last="Taneguchi">K. Taneguchi</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Mie National Hospital</s1>
<s2>Mie</s2>
<s3>JPN</s3>
<sZ>8 aut.</sZ>
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<term>Etiology</term>
<term>Ghana</term>
<term>Human</term>
<term>Lymphocytopenia</term>
<term>Opportunistic infection</term>
<term>Seropositivity</term>
<term>T-Lymphocyte</term>
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<term>Séropositivité</term>
<term>Autopsie</term>
<term>Infection opportuniste</term>
<term>Etiologie</term>
<term>Association</term>
<term>Maladie</term>
<term>Lymphopénie</term>
<term>Lymphocyte T</term>
<term>Ghana</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Ninety-nine patients at Center for Disease Control (CDC) clinical stage IV were studied. Twelve (12.12%) of these patients turned out to be HIV seronegative. Ten out of the 12 HIV negative patients were immunocompetent whereas the other two had proportional decreases in both CD4+ and CD8+ T-lymphocytes. HIV-1, HIV-2, and dual infection, were detected in 51.5%, 2%, and 22.2% respectively of clinical AIDS patients. The other 12.12% of clinical AIDS patients were indeterminate for HIV antibodies. All HIV positive patients with the exception of two, were immunocompromised with respect to CD4+ and CD8+ T-lymphocyte counts. Two healthy spouses and three children of patients who died from the disease were seronegative for HIV antibodies. Herpes simplex virus type 2 (HSV- 2) and cytomegalovirus (CMV) antibody titres were higher in HIV infected than uninfected blood. Patients with chronic diarrhoea, lymphadenopathy, pneumonia, and tuberculosis, either alone or in combination of two or more of such symptoms, were found to be more likely to be confirmed by serology and immunology as definitive AIDS patients in Ghana. In postmortem studies on 20 patients, pneumonia due to tuberculosis constituted the major cause of death. Toxoplasmosis, cytomegaloviral eosophagitis and enteritis, and cryptococcosis were the major opportunistic infections detected. Programmed cell death (apoptosis) was found by the DNA gel electrophoresis method to be an unlikely major mechanism of accelerated culture induced death of PBMCs from CDC stage IV AIDS patients.</div>
</front>
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<name sortKey="Nyadedzor, C" sort="Nyadedzor, C" uniqKey="Nyadedzor C" first="C." last="Nyadedzor">C. Nyadedzor</name>
<name sortKey="Tsiagbe, V K" sort="Tsiagbe, V K" uniqKey="Tsiagbe V" first="V. K." last="Tsiagbe">V. K. Tsiagbe</name>
<name sortKey="Wiredu, E K" sort="Wiredu, E K" uniqKey="Wiredu E" first="E. K." last="Wiredu">E. K. Wiredu</name>
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<country name="Japon"><region name="Région de Kantō"><name sortKey="Sata, T" sort="Sata, T" uniqKey="Sata T" first="T." last="Sata">T. Sata</name>
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	Le SIDA au Ghana (serveur d'exploration)
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Le SIDA au Ghana (serveur d'exploration)

T-lymphocytopaenia, opportunistic infections and pathological findings in Ghanaian AIDS patients and their sexual partners

T-lymphocytopaenia, opportunistic infections and pathological findings in Ghanaian AIDS patients and their sexual partners

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri