CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population
Identifieur interne : 000A42 ( Main/Exploration ); précédent : 000A41; suivant : 000A43CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population
Auteurs : Thorsten Thye [Allemagne] ; Genevieve Scarisbrick [Ghana] ; Edmund N. L. Browne [Ghana] ; Margaret Amanua Chinbuah [Ghana] ; John Gyapong [Ghana] ; Ivy Osei [Ghana] ; Ellis Owusu-Dabo [Ghana] ; Stefan Niemann [Allemagne] ; Sabine Rüsch-Gerdes [Allemagne] ; Christian G. Meyer [Allemagne] ; Rolf D. Horstmann [Allemagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Descripteurs français
- KwdFr :
- Amorces ADN, Antigène CTLA-4, Antigènes CD (immunologie), Ghana, Génotype, Haplotypes, Humains, Maladies auto-immunes (génétique), Maladies auto-immunes (immunologie), Polymorphisme de nucléotide simple, Séquence nucléotidique, Tuberculose pulmonaire (génétique), Tuberculose pulmonaire (immunologie), Études cas-témoins.
- MESH :
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Antigens, CD (immunology), Autoimmune Diseases (genetics), Autoimmune Diseases (immunology), Base Sequence, CTLA-4 Antigen, Case-Control Studies, DNA Primers, Genotype, Ghana, Haplotypes, Humans, Polymorphism, Single Nucleotide, Tuberculosis, Pulmonary (genetics), Tuberculosis, Pulmonary (immunology).
- MESH :
- chemical , immunology : Antigens, CD.
- geographic : Ghana.
- genetics : Autoimmune Diseases, Tuberculosis, Pulmonary.
- immunology : Autoimmune Diseases, Tuberculosis, Pulmonary.
- Base Sequence, CTLA-4 Antigen, Case-Control Studies, DNA Primers, Genotype, Haplotypes, Humans, Polymorphism, Single Nucleotide.
Abstract
The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (
Url:
DOI: 10.1371/journal.pone.0006307
PubMed: 19609446
PubMed Central: 2707621
Affiliations:
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Le document en format XML
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Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population</title>
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Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population</title>
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<term>Autoimmune Diseases (immunology)</term>
<term>Base Sequence</term>
<term>CTLA-4 Antigen</term>
<term>Case-Control Studies</term>
<term>DNA Primers</term>
<term>Genotype</term>
<term>Ghana</term>
<term>Haplotypes</term>
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<term>Génotype</term>
<term>Haplotypes</term>
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<term>Maladies auto-immunes (génétique)</term>
<term>Maladies auto-immunes (immunologie)</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Séquence nucléotidique</term>
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<term>Tuberculose pulmonaire (immunologie)</term>
<term>Études cas-témoins</term>
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<term>CTLA-4 Antigen</term>
<term>Case-Control Studies</term>
<term>DNA Primers</term>
<term>Genotype</term>
<term>Haplotypes</term>
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<term>Polymorphism, Single Nucleotide</term>
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<term>Antigène CTLA-4</term>
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<term>Génotype</term>
<term>Haplotypes</term>
<term>Humains</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Séquence nucléotidique</term>
<term>Études cas-témoins</term>
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<front><div type="abstract" xml:lang="en"><p>The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (<italic>CTLA4</italic>
), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases and appears to reduce T-cell inhibitory activity. In Ghana, West Africa, we compared the frequencies of <italic>CTLA4</italic>
+6230 A/G and 6 haplotype-tagging SNPs in 2010 smear-positive, HIV-negative patients with pulmonary tuberculosis (TB) and 2346 controls matched for age, gender and ethnicity. We found no difference in allele frequencies between cases and controls. However, +6230A and a distinct <italic>CTLA4</italic>
haplotype and a diplotype comprising the +6230A allele were significantly less frequent among cases with large opacities in chest radiographs compared to those with small ones (P<sub>corrected [cor]</sub>
= 0.002, P<sub>cor</sub>
= 0.00045, P = 0.0005, respectively). This finding suggests that an increased T-cell activity associated with the <italic>CTLA4</italic>
+6230G allele contributes to pathology rather than to protection in pulmonary TB.</p>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Ghana</li>
</country>
<region><li>Hambourg</li>
<li>Région du Grand Accra</li>
</region>
<settlement><li>Accra</li>
<li>Hambourg</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Hambourg"><name sortKey="Thye, Thorsten" sort="Thye, Thorsten" uniqKey="Thye T" first="Thorsten" last="Thye">Thorsten Thye</name>
</region>
<name sortKey="Horstmann, Rolf D" sort="Horstmann, Rolf D" uniqKey="Horstmann R" first="Rolf D." last="Horstmann">Rolf D. Horstmann</name>
<name sortKey="Meyer, Christian G" sort="Meyer, Christian G" uniqKey="Meyer C" first="Christian G." last="Meyer">Christian G. Meyer</name>
<name sortKey="Niemann, Stefan" sort="Niemann, Stefan" uniqKey="Niemann S" first="Stefan" last="Niemann">Stefan Niemann</name>
<name sortKey="Rusch Gerdes, Sabine" sort="Rusch Gerdes, Sabine" uniqKey="Rusch Gerdes S" first="Sabine" last="Rüsch-Gerdes">Sabine Rüsch-Gerdes</name>
<name sortKey="Thye, Thorsten" sort="Thye, Thorsten" uniqKey="Thye T" first="Thorsten" last="Thye">Thorsten Thye</name>
</country>
<country name="Ghana"><noRegion><name sortKey="Scarisbrick, Genevieve" sort="Scarisbrick, Genevieve" uniqKey="Scarisbrick G" first="Genevieve" last="Scarisbrick">Genevieve Scarisbrick</name>
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<name sortKey="Chinbuah, Margaret Amanua" sort="Chinbuah, Margaret Amanua" uniqKey="Chinbuah M" first="Margaret Amanua" last="Chinbuah">Margaret Amanua Chinbuah</name>
<name sortKey="Gyapong, John" sort="Gyapong, John" uniqKey="Gyapong J" first="John" last="Gyapong">John Gyapong</name>
<name sortKey="Osei, Ivy" sort="Osei, Ivy" uniqKey="Osei I" first="Ivy" last="Osei">Ivy Osei</name>
<name sortKey="Owusu Dabo, Ellis" sort="Owusu Dabo, Ellis" uniqKey="Owusu Dabo E" first="Ellis" last="Owusu-Dabo">Ellis Owusu-Dabo</name>
<name sortKey="Owusu Dabo, Ellis" sort="Owusu Dabo, Ellis" uniqKey="Owusu Dabo E" first="Ellis" last="Owusu-Dabo">Ellis Owusu-Dabo</name>
</country>
</tree>
</affiliations>
</record>
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