Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure
Identifieur interne : 000829 ( Main/Exploration ); précédent : 000828; suivant : 000830Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure
Auteurs : Debbie Humphries ; Emily Mosites ; Joseph Otchere ; Welbeck Amoani Twum ; Lauren Woo ; Hinckley Jones-Sanpei ; Lisa M. Harrison ; Richard D. Bungiro ; Blair Benham-Pyle ; Langbong Bimi ; Dominic Edoh ; Kwabena Bosompem ; Michael Wilson ; Michael CappelloSource :
- The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2011.
Abstract
A cross-sectional pilot study of hookworm infection was carried out among 292 subjects from 62 households in Kintampo North, Ghana. The overall prevalence of hookworm infection was 45%, peaking in those 11–20 years old (58.5%). In children, risk factors for hookworm infection included coinfection with malaria and increased serum immunoglobulin G reactivity to hookworm secretory antigens. Risk factors for infection in adults included poor nutritional status, not using a latrine, not wearing shoes, and occupation (farming). Although albendazole therapy was associated with an overall egg reduction rate of 82%, 37 subjects (39%) remained infected. Among those who failed therapy, treatment was not associated with a significant reduction in egg excretion, and nearly one-third had higher counts on repeat examination. These data confirm a high prevalence of low-intensity hookworm infection in central Ghana and its association with poor nutritional status. The high rate of albendazole failure raises concern about emerging resistance.
Url:
DOI: 10.4269/ajtmh.2011.11-0003
PubMed: 21540391
PubMed Central: 3083749
Affiliations:
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