SidaGhanaV1, Main, Exploration, bibRecord, 000792

Evidence of Multiple Introductions and Autochthonous Transmission of the HIV Type 1 CRF02_AG Clade in Brazil

Identifieur interne : 000792 ( Main/Exploration ); précédent : 000791; suivant : 000793

Evidence of Multiple Introductions and Autochthonous Transmission of the HIV Type 1 CRF02_AG Clade in Brazil

Auteurs : Edson Oliveira Delatorre [Brésil] ; Gonzalo Bello [Brésil] ; Walter A. Eyer-Silva [Brésil] ; Saada L. Chequer-Fernandez [Brésil] ; Mariza G. Morgado [Brésil] ; José Carlos Couto-Fernandez [Brésil]

Source :

AIDS research and human retroviruses [ 0889-2229 ] ; 2012.

RBID : Pascal:12-0390142

Descripteurs français

Pascal (Inist)
- Virus HIV1, Transmission, Brésil.
Wicri :
- geographic : Brésil.

English descriptors

KwdEn :
- Brazil, HIV-1 virus, Transmission.

Abstract

HIV-1 CRF02_AG is the most prevalent intersubtype recombinant form worldwide. Six HIV-1 samples from patients living in Rio de Janeiro, Brazil, were subtyped as CRF02_AG at the pol gene between 2004 and 2011. To trace the origin of these viruses, they were compared with 793 CRF02_AG pol sequences of African origin and another four Brazilian CRF02_AG pol sequences previously described. Phylogenetic analysis reveals that there have been at least four introductions of the CRF02_AG clade in Brazil, as signified by the presence of four phylogenetically distinct lineages, probably originated from western African countries (Benin, Ghana, and Guinea-Bissau). At least two CRF02_AG Brazilian lineages were successful in getting established and disseminated throughout the Rio de Janeiro state, with evidence of both horizontal and vertical transmission. Continuous epidemiological surveillance of HIV-1 strains circulating in Brazil is of paramount importance to the early detection of newly emerging viral lineages.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000015
to stream PascalFrancis, to step Curation: 000114
to stream PascalFrancis, to step Checkpoint: 000018
to stream Main, to step Merge: 000793
to stream Main, to step Curation: 000792

Le document en format XML

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<author><name sortKey="Eyer Silva, Walter A" sort="Eyer Silva, Walter A" uniqKey="Eyer Silva W" first="Walter A." last="Eyer-Silva">Walter A. Eyer-Silva</name>
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<author><name sortKey="Couto Fernandez, Jose Carlos" sort="Couto Fernandez, Jose Carlos" uniqKey="Couto Fernandez J" first="José Carlos" last="Couto-Fernandez">José Carlos Couto-Fernandez</name>
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<author><name sortKey="Couto Fernandez, Jose Carlos" sort="Couto Fernandez, Jose Carlos" uniqKey="Couto Fernandez J" first="José Carlos" last="Couto-Fernandez">José Carlos Couto-Fernandez</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratorio de AIDS and Imunologia Molecular, Instituto Oswaldo Cruz-Fiocruz</s1>
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<series><title level="j" type="main">AIDS research and human retroviruses</title>
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<front><div type="abstract" xml:lang="en">HIV-1 CRF02_AG is the most prevalent intersubtype recombinant form worldwide. Six HIV-1 samples from patients living in Rio de Janeiro, Brazil, were subtyped as CRF02_AG at the pol gene between 2004 and 2011. To trace the origin of these viruses, they were compared with 793 CRF02_AG pol sequences of African origin and another four Brazilian CRF02_AG pol sequences previously described. Phylogenetic analysis reveals that there have been at least four introductions of the CRF02_AG clade in Brazil, as signified by the presence of four phylogenetically distinct lineages, probably originated from western African countries (Benin, Ghana, and Guinea-Bissau). At least two CRF02_AG Brazilian lineages were successful in getting established and disseminated throughout the Rio de Janeiro state, with evidence of both horizontal and vertical transmission. Continuous epidemiological surveillance of HIV-1 strains circulating in Brazil is of paramount importance to the early detection of newly emerging viral lineages.</div>
</front>
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<affiliations><list><country><li>Brésil</li>
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<tree><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Oliveira Delatorre, Edson" sort="Oliveira Delatorre, Edson" uniqKey="Oliveira Delatorre E" first="Edson" last="Oliveira Delatorre">Edson Oliveira Delatorre</name>
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<name sortKey="Bello, Gonzalo" sort="Bello, Gonzalo" uniqKey="Bello G" first="Gonzalo" last="Bello">Gonzalo Bello</name>
<name sortKey="Chequer Fernandez, Saada L" sort="Chequer Fernandez, Saada L" uniqKey="Chequer Fernandez S" first="Saada L." last="Chequer-Fernandez">Saada L. Chequer-Fernandez</name>
<name sortKey="Couto Fernandez, Jose Carlos" sort="Couto Fernandez, Jose Carlos" uniqKey="Couto Fernandez J" first="José Carlos" last="Couto-Fernandez">José Carlos Couto-Fernandez</name>
<name sortKey="Eyer Silva, Walter A" sort="Eyer Silva, Walter A" uniqKey="Eyer Silva W" first="Walter A." last="Eyer-Silva">Walter A. Eyer-Silva</name>
<name sortKey="Morgado, Mariza G" sort="Morgado, Mariza G" uniqKey="Morgado M" first="Mariza G." last="Morgado">Mariza G. Morgado</name>
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Evidence of Multiple Introductions and Autochthonous Transmission of the HIV Type 1 CRF02_AG Clade in Brazil

Evidence of Multiple Introductions and Autochthonous Transmission of the HIV Type 1 CRF02_AG Clade in Brazil

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri