SidaGhanaV1, Main, Exploration, bibRecord, 000779

CD4‐ and CD3‐T Lymphocyte Reference Values of Immunocompetent Urban and Rural Subjects in an African Nation

Identifieur interne : 000779 ( Main/Exploration ); précédent : 000778; suivant : 000780

CD4‐ and CD3‐T Lymphocyte Reference Values of Immunocompetent Urban and Rural Subjects in an African Nation

Auteurs : M. P. Adoga [Nigeria, Royaume-Uni] ; G. R. Pennap [Nigeria] ; P. A. John [Nigeria] ; P. T. Shawulu [Nigeria] ; S. V. Kaba [Nigeria] ; J. C. Forbi [Nigeria] ; S. M. Agwale [Nigeria, États-Unis]

Source :

Scandinavian Journal of Immunology [ 0300-9475 ] ; 2012-07.

RBID : ISTEX:0ED5A45A04ABEAAB8E0346956E2FC11EB031B411

Descripteurs français

Wicri :
- geographic : Nigeria.
- topic : Immunologie, Population rurale, Population urbaine.

English descriptors

Abstract

Studies on the reference values of CD4 and CD3 T cells in healthy individuals have continued to gain significance because of the importance of these immunological markers in the initiation of combination antiretroviral therapy (cART). The aim of the present study was to determine and compare the reference values of CD4 and CD3 T cells in urban and rural Nigerians who were human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) negative. After ethical clearance and informed consent, 1123 subjects who met the inclusion criteria [mean age = 24.4 (± 11.2) years] were recruited in this study. Blood samples were analysed using the BD FACScount cytometer according to the manufacturer’s instructions. Of the overall 1123 subjects, reference means of CD4, CD3 and CD4/CD3 ratio were 1030 ± 367, 1757 ± 609 cells/μl and 0.59 ± 0.08, respectively. Five hundred and fifty‐one (49.1%) were an urban population with the mean CD4, CD3 and CD4/CD3 T cell ratio of 1032 ± 369, 1761 ± 612 cells/μl and 0.59 (±0.08), respectively. The remaining 572 (50.9%) were of a rural population with the mean CD4, CD3 and CD4/CD3 T cell ratio of 1028 ± 459, 1753 ± 958 cells/μl and 0.59 ± 0.13, respectively. Subjects with higher CD4 and CD3 T cells were more likely to be female than male (P < 0.05). There was no significant difference between the T cell values of the two populations (P > 0.05). Our findings provide new insight in the CD4 and CD3 T cell reference values of Nigerians.

Url:

https://api.istex.fr/document/0ED5A45A04ABEAAB8E0346956E2FC11EB031B411/fulltext/pdf

DOI: 10.1111/j.1365-3083.2012.02700.x

Affiliations:

Nigeria, Royaume-Uni, États-Unis

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Le document en format XML

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<term>African populations</term>
<term>Aids patients</term>
<term>Biological sciences</term>
<term>Blackwell publishing</term>
<term>Blood donors</term>
<term>Cancer immunotherapy</term>
<term>Cart regimen</term>
<term>Cell count</term>
<term>Cell ratio</term>
<term>Cell reference values</term>
<term>Cell values</term>
<term>Clin</term>
<term>Clin diagn</term>
<term>Clin vaccine immunol</term>
<term>Clinical trials</term>
<term>Conclusive statement</term>
<term>Consent forms</term>
<term>Considerable variations</term>
<term>Diagn</term>
<term>Facscount</term>
<term>Healthy individuals</term>
<term>Healthy nigerians</term>
<term>Illiterate participants</term>
<term>Immune response</term>
<term>Immunohematological reference ranges</term>
<term>Immunol</term>
<term>Immunology</term>
<term>Inclusion criteria</term>
<term>Institutional review board</term>
<term>Limited data</term>
<term>Literate family representatives</term>
<term>Lymphocyte</term>
<term>Lymphocyte count</term>
<term>Lymphocyte reference values</term>
<term>Lymphocyte subsets</term>
<term>Microbiology unit</term>
<term>Nasarawa</term>
<term>Nasarawa state</term>
<term>Nasarawa state university</term>
<term>Nigeria</term>
<term>Nigerian</term>
<term>Normal values</term>
<term>Other african countries</term>
<term>Other therapies</term>
<term>Pregnant women</term>
<term>Present study</term>
<term>Reference values</term>
<term>Rural population</term>
<term>Rural populations</term>
<term>Scandinavian journal</term>
<term>Seronegative individuals</term>
<term>Subset</term>
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<term>African populations</term>
<term>Aids patients</term>
<term>Biological sciences</term>
<term>Blackwell publishing</term>
<term>Blood donors</term>
<term>Cancer immunotherapy</term>
<term>Cart regimen</term>
<term>Cell count</term>
<term>Cell ratio</term>
<term>Cell reference values</term>
<term>Cell values</term>
<term>Clin</term>
<term>Clin diagn</term>
<term>Clin vaccine immunol</term>
<term>Clinical trials</term>
<term>Conclusive statement</term>
<term>Consent forms</term>
<term>Considerable variations</term>
<term>Diagn</term>
<term>Facscount</term>
<term>Healthy individuals</term>
<term>Healthy nigerians</term>
<term>Illiterate participants</term>
<term>Immune response</term>
<term>Immunohematological reference ranges</term>
<term>Immunol</term>
<term>Immunology</term>
<term>Inclusion criteria</term>
<term>Institutional review board</term>
<term>Limited data</term>
<term>Literate family representatives</term>
<term>Lymphocyte</term>
<term>Lymphocyte count</term>
<term>Lymphocyte reference values</term>
<term>Lymphocyte subsets</term>
<term>Microbiology unit</term>
<term>Nasarawa</term>
<term>Nasarawa state</term>
<term>Nasarawa state university</term>
<term>Nigeria</term>
<term>Nigerian</term>
<term>Normal values</term>
<term>Other african countries</term>
<term>Other therapies</term>
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<term>Present study</term>
<term>Reference values</term>
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<term>Scandinavian journal</term>
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<front><div type="abstract" xml:lang="en">Studies on the reference values of CD4 and CD3 T cells in healthy individuals have continued to gain significance because of the importance of these immunological markers in the initiation of combination antiretroviral therapy (cART). The aim of the present study was to determine and compare the reference values of CD4 and CD3 T cells in urban and rural Nigerians who were human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) negative. After ethical clearance and informed consent, 1123 subjects who met the inclusion criteria [mean age = 24.4 (± 11.2) years] were recruited in this study. Blood samples were analysed using the BD FACScount cytometer according to the manufacturer’s instructions. Of the overall 1123 subjects, reference means of CD4, CD3 and CD4/CD3 ratio were 1030 ± 367, 1757 ± 609 cells/μl and 0.59 ± 0.08, respectively. Five hundred and fifty‐one (49.1%) were an urban population with the mean CD4, CD3 and CD4/CD3 T cell ratio of 1032 ± 369, 1761 ± 612 cells/μl and 0.59 (±0.08), respectively. The remaining 572 (50.9%) were of a rural population with the mean CD4, CD3 and CD4/CD3 T cell ratio of 1028 ± 459, 1753 ± 958 cells/μl and 0.59 ± 0.13, respectively. Subjects with higher CD4 and CD3 T cells were more likely to be female than male (P < 0.05). There was no significant difference between the T cell values of the two populations (P > 0.05). Our findings provide new insight in the CD4 and CD3 T cell reference values of Nigerians.</div>
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<name sortKey="Shawulu, P T" sort="Shawulu, P T" uniqKey="Shawulu P" first="P. T." last="Shawulu">P. T. Shawulu</name>
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Le SIDA au Ghana (serveur d'exploration)

CD4‐ and CD3‐T Lymphocyte Reference Values of Immunocompetent Urban and Rural Subjects in an African Nation

CD4‐ and CD3‐T Lymphocyte Reference Values of Immunocompetent Urban and Rural Subjects in an African Nation

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri