Hepatic Enzyme Alterations in HIV Patients on Antiretroviral Therapy: A Case-Control Study in a Hospital Setting in Ghana
Identifieur interne : 000324 ( Main/Exploration ); précédent : 000323; suivant : 000325Hepatic Enzyme Alterations in HIV Patients on Antiretroviral Therapy: A Case-Control Study in a Hospital Setting in Ghana
Auteurs : Derick Nii Mensah Osakunor [Ghana] ; Christian Obirikorang [Ghana] ; Vincent Fianu [Ghana] ; Isaac Asare [Ghana] ; Mavis Dakorah [Ghana]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Agents antiVIH (usage thérapeutique), Alanine transaminase (analyse), Aspartate aminotransferases (analyse), Femelle, Foie (enzymologie), Ghana, Humains, Infections à VIH (traitement médicamenteux), Jeune adulte, Lymphocytes T CD4+ (cytologie), Mâle, Numération des lymphocytes CD4, Phosphatase alcaline (analyse), Sujet âgé, gamma-Glutamyltransferase (analyse), Études cas-témoins, Évolution de la maladie.
- MESH :
- analyse : Alanine transaminase, Aspartate aminotransferases, Phosphatase alcaline, gamma-Glutamyltransferase.
- cytologie : Lymphocytes T CD4+.
- enzymologie : Foie.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Ghana, Humains, Jeune adulte, Mâle, Numération des lymphocytes CD4, Sujet âgé, Études cas-témoins, Évolution de la maladie.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Alanine Transaminase (analysis), Alkaline Phosphatase (analysis), Anti-HIV Agents (therapeutic use), Aspartate Aminotransferases (analysis), CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes (cytology), Case-Control Studies, Disease Progression, Female, Ghana, HIV Infections (drug therapy), Humans, Liver (enzymology), Male, Middle Aged, Young Adult, gamma-Glutamyltransferase (analysis).
- MESH :
- chemical , analysis : Alanine Transaminase, Alkaline Phosphatase, Aspartate Aminotransferases, gamma-Glutamyltransferase.
- chemical , therapeutic use : Anti-HIV Agents.
- geographic : Ghana.
- cytology : CD4-Positive T-Lymphocytes.
- drug therapy : HIV Infections.
- enzymology : Liver.
- Adolescent, Adult, Aged, CD4 Lymphocyte Count, Case-Control Studies, Disease Progression, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Diagnosing hepatic injury in HIV infection can be a herculean task for clinicians as several factors may be involved. In this study, we sought to determine the effects of antiretroviral therapy (ART) and disease progression on hepatic enzymes in HIV patients.
A case-control study conducted from January to May 2014 at the Akwatia Government Hospital, Eastern region, Ghana, The study included 209 HIV patients on ART (designated HIV-ART) and 132 ART-naive HIV patients (designated HIV-Controls). Data gathered included demography, clinical history and results of blood tests for hepatic enzymes. We employed the Fisher’s, Chi-square, unpaired t-test and Pearson’s correlation in analysis, using GraphPad Prism and SPSS. A
Median CD4 lymphocyte count of HIV-ART participants (604.00
Antiretroviral therapy amongst this population has minimal effects on hepatic enzymes and does not suggest modifications in therapy. Hepatic injury may occur in HIV, even in the absence of ART and other traditional factors. Monitoring of hepatic enzymes is still important in HIV patients.
Url:
DOI: 10.1371/journal.pone.0134449
PubMed: 26247879
PubMed Central: 4527699
Affiliations:
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Le document en format XML
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<term>Adult</term>
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<term>Alanine Transaminase (analysis)</term>
<term>Alkaline Phosphatase (analysis)</term>
<term>Anti-HIV Agents (therapeutic use)</term>
<term>Aspartate Aminotransferases (analysis)</term>
<term>CD4 Lymphocyte Count</term>
<term>CD4-Positive T-Lymphocytes (cytology)</term>
<term>Case-Control Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Ghana</term>
<term>HIV Infections (drug therapy)</term>
<term>Humans</term>
<term>Liver (enzymology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Agents antiVIH (usage thérapeutique)</term>
<term>Alanine transaminase (analyse)</term>
<term>Aspartate aminotransferases (analyse)</term>
<term>Femelle</term>
<term>Foie (enzymologie)</term>
<term>Ghana</term>
<term>Humains</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Jeune adulte</term>
<term>Lymphocytes T CD4+ (cytologie)</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
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<term>gamma-Glutamyltransferase (analyse)</term>
<term>Études cas-témoins</term>
<term>Évolution de la maladie</term>
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<term>Alkaline Phosphatase</term>
<term>Aspartate Aminotransferases</term>
<term>gamma-Glutamyltransferase</term>
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<term>Phosphatase alcaline</term>
<term>gamma-Glutamyltransferase</term>
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<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
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<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Foie</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Liver</term>
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<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>CD4 Lymphocyte Count</term>
<term>Case-Control Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
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<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
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<term>Études cas-témoins</term>
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<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title>
<p>Diagnosing hepatic injury in HIV infection can be a herculean task for clinicians as several factors may be involved. In this study, we sought to determine the effects of antiretroviral therapy (ART) and disease progression on hepatic enzymes in HIV patients.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>A case-control study conducted from January to May 2014 at the Akwatia Government Hospital, Eastern region, Ghana, The study included 209 HIV patients on ART (designated HIV-ART) and 132 ART-naive HIV patients (designated HIV-Controls). Data gathered included demography, clinical history and results of blood tests for hepatic enzymes. We employed the Fisher’s, Chi-square, unpaired t-test and Pearson’s correlation in analysis, using GraphPad Prism and SPSS. A <italic>P</italic>
value < 0.05 was considered significant.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>Median CD4 lymphocyte count of HIV-ART participants (604.00 <italic>cells/mm<sup>3</sup>
</italic>
) was higher than that of HIV-Controls (491.50 <italic>cells/mm3; P</italic>
= 0.0005). Mean values of ALP, ALT, AST and GGT did not differ between the two groups compared (P > 0.05). There was a significant positive correlation between hepatic enzymes (ALP, ALT, AST and GGT) for both groups (p < 0.01 each). Duration of ART correlated positively with ALT (p < 0.05). The effect size of disease progression on hepatic enzymes for both groups was small.</p>
</sec>
<sec id="sec004"><title>Conclusion</title>
<p>Antiretroviral therapy amongst this population has minimal effects on hepatic enzymes and does not suggest modifications in therapy. Hepatic injury may occur in HIV, even in the absence of ART and other traditional factors. Monitoring of hepatic enzymes is still important in HIV patients.</p>
</sec>
</div>
</front>
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