Disparate distribution of hepatitis B virus genotypes in four sub-Saharan African countries
Identifieur interne : 000615 ( Main/Curation ); précédent : 000614; suivant : 000616Disparate distribution of hepatitis B virus genotypes in four sub-Saharan African countries
Auteurs : Joseph C. Forbi [États-Unis] ; Yousr Ben-Ayed [États-Unis] ; Guo-Liang Xia [États-Unis] ; Gilberto Vaughan [États-Unis] ; Jan Drobeniuc [États-Unis] ; William M. Switzer [États-Unis] ; Yury E. Khudyakov [États-Unis]Source :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1386-6532 ] ; 2013.
Descripteurs français
- KwdFr :
- ADN viral (), ADN viral (génétique), Afrique subsaharienne (épidémiologie), Analyse de regroupements, Analyse de séquence d'ADN, Antigènes de surface du virus de l'hépatite B (génétique), Données de séquences moléculaires, Femelle, Grossesse, Génotype, Humains, Hépatite B (virologie), Hépatite B (épidémiologie), Mâle, Phylogéographie, Prévalence, Variation génétique, Virus de l'hépatite B (), Virus de l'hépatite B (génétique), Virus de l'hépatite B (isolement et purification), Épidémiologie moléculaire.
- MESH :
- génétique : ADN viral, Antigènes de surface du virus de l'hépatite B, Virus de l'hépatite B.
- isolement et purification : Virus de l'hépatite B.
- virologie : Hépatite B.
- épidémiologie : Afrique subsaharienne, Hépatite B.
- ADN viral, Analyse de regroupements, Analyse de séquence d'ADN, Données de séquences moléculaires, Femelle, Grossesse, Génotype, Humains, Mâle, Phylogéographie, Prévalence, Variation génétique, Virus de l'hépatite B, Épidémiologie moléculaire.
English descriptors
- KwdEn :
- Africa South of the Sahara (epidemiology), Cluster Analysis, DNA, Viral (chemistry), DNA, Viral (genetics), Female, Genetic Variation, Genotype, Hepatitis B (epidemiology), Hepatitis B (virology), Hepatitis B Surface Antigens (genetics), Hepatitis B virus (classification), Hepatitis B virus (genetics), Hepatitis B virus (isolation & purification), Humans, Male, Molecular Epidemiology, Molecular Sequence Data, Phylogeography, Pregnancy, Prevalence, Sequence Analysis, DNA.
- MESH :
- chemical , chemistry : DNA, Viral.
- geographic , epidemiology : Africa South of the Sahara.
- chemical , genetics : DNA, Viral, Hepatitis B Surface Antigens.
- classification : Hepatitis B virus.
- epidemiology : Hepatitis B.
- genetics : Hepatitis B virus.
- isolation & purification : Hepatitis B virus.
- virology : Hepatitis B.
- Cluster Analysis, Female, Genetic Variation, Genotype, Humans, Male, Molecular Epidemiology, Molecular Sequence Data, Phylogeography, Pregnancy, Prevalence, Sequence Analysis, DNA.
Abstract
Hepatitis B virus (HBV) places a substantial health burden on Africa. Here, we investigated genetic diversity of HBV variants circulating in 4 countries of sub-Saharan Africa using archived samples. In total, 1492 plasma samples were tested from HIV-infected individuals and pregnant women, among which 143 (9.6%) were PCR-positive for HBV DNA (Côte d’Ivoire, 70/608 [11.5%]; Ghana, 13/444 [2.9%]; Cameroon, 33/303 [10.9%]; and Uganda, 27/137 [19.7%]).
Phylogenetic analysis of the
The observations of pan-African and global dissemination of HBV/A1 and HBV/A2, and the circulation of HBV/E and HBV/A3 almost exclusively in West and Central Africa suggest a more recent increase in prevalence in Africa of HBV/E and HBV/A3 compared to HBV/A1 and HBV/A2. The broad genetic heterogeneity of HBsAg detected here may impact the efficacy of prevention and control efforts in sub-Saharan Africa.
Url:
DOI: 10.1016/j.jcv.2013.06.028
PubMed: 23871163
PubMed Central: 4591023
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PMC:4591023Le document en format XML
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<term>Cluster Analysis</term>
<term>DNA, Viral (chemistry)</term>
<term>DNA, Viral (genetics)</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Genotype</term>
<term>Hepatitis B (epidemiology)</term>
<term>Hepatitis B (virology)</term>
<term>Hepatitis B Surface Antigens (genetics)</term>
<term>Hepatitis B virus (classification)</term>
<term>Hepatitis B virus (genetics)</term>
<term>Hepatitis B virus (isolation & purification)</term>
<term>Humans</term>
<term>Male</term>
<term>Molecular Epidemiology</term>
<term>Molecular Sequence Data</term>
<term>Phylogeography</term>
<term>Pregnancy</term>
<term>Prevalence</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral ()</term>
<term>ADN viral (génétique)</term>
<term>Afrique subsaharienne (épidémiologie)</term>
<term>Analyse de regroupements</term>
<term>Analyse de séquence d'ADN</term>
<term>Antigènes de surface du virus de l'hépatite B (génétique)</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Génotype</term>
<term>Humains</term>
<term>Hépatite B (virologie)</term>
<term>Hépatite B (épidémiologie)</term>
<term>Mâle</term>
<term>Phylogéographie</term>
<term>Prévalence</term>
<term>Variation génétique</term>
<term>Virus de l'hépatite B ()</term>
<term>Virus de l'hépatite B (génétique)</term>
<term>Virus de l'hépatite B (isolement et purification)</term>
<term>Épidémiologie moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa South of the Sahara</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Viral</term>
<term>Hepatitis B Surface Antigens</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Hepatitis B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hepatitis B</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepatitis B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN viral</term>
<term>Antigènes de surface du virus de l'hépatite B</term>
<term>Virus de l'hépatite B</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Hepatitis B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de l'hépatite B</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite B</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis B</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique subsaharienne</term>
<term>Hépatite B</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cluster Analysis</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Molecular Epidemiology</term>
<term>Molecular Sequence Data</term>
<term>Phylogeography</term>
<term>Pregnancy</term>
<term>Prevalence</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term>
<term>Analyse de regroupements</term>
<term>Analyse de séquence d'ADN</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Phylogéographie</term>
<term>Prévalence</term>
<term>Variation génétique</term>
<term>Virus de l'hépatite B</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Hepatitis B virus (HBV) places a substantial health burden on Africa. Here, we investigated genetic diversity of HBV variants circulating in 4 countries of sub-Saharan Africa using archived samples. In total, 1492 plasma samples were tested from HIV-infected individuals and pregnant women, among which 143 (9.6%) were PCR-positive for HBV DNA (Côte d’Ivoire, 70/608 [11.5%]; Ghana, 13/444 [2.9%]; Cameroon, 33/303 [10.9%]; and Uganda, 27/137 [19.7%]).</p>
</sec>
<sec id="S2"><title>Study design/results</title>
<p id="P2">Phylogenetic analysis of the <italic>S</italic>
-gene sequences identified HBV genotypes E (HBV/E, <italic>n</italic>
= 96) and A (HBV/A, <italic>n</italic>
= 47) distributed as follows: 87% of HBV/E and 13% of HBV/A in Côte d’Ivoire; 100% of HBV/E in Ghana; 67% of HBV/E and 33% of HBV/A in Cameroon; and 100% of HBV/A in Uganda. The average and maximal nucleotide distances among HBV/E sequences were 1.9% and 6.4%, respectively, suggesting a greater genetic diversity for this genotype than previously reported (<italic>p</italic>
< 0.001). HBV/A strains were classified into subgenotypes HBV/A1, HBV/A2 and HBV/A3. In Uganda, 93% of HBV/A strains belonged to HBV/A1 whereas HBV/A3 was the only subgenotype of HBV/A found in Cameroon. In Côte d’Ivoire, HBV/A strains were classified as HBV/A1 (11.1%), HBV/A2 (33.3%) and HBV/A3 (55.6%). Phylogeographic analysis of the sequences available from Africa supported earlier suggestions on the origin of HBV/A1, HBV/A2 and HBV/A3 in East, South and West/Central Africa, respectively. Using predicted amino acid sequences, hepatitis B surface antigen (HBsAg) was classified into serotype <italic>ayw4</italic>
in 93% of HBV/E strains and <italic>adw2</italic>
in 68% of HBV/A strains. Also, 7.7% of the sequences carried substitutions in HBsAg associated with immune escape.</p>
</sec>
<sec id="S3"><title>Conclusions</title>
<p id="P3">The observations of pan-African and global dissemination of HBV/A1 and HBV/A2, and the circulation of HBV/E and HBV/A3 almost exclusively in West and Central Africa suggest a more recent increase in prevalence in Africa of HBV/E and HBV/A3 compared to HBV/A1 and HBV/A2. The broad genetic heterogeneity of HBsAg detected here may impact the efficacy of prevention and control efforts in sub-Saharan Africa.</p>
</sec>
</div>
</front>
</TEI>
</record>
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