SidaGhanaV1, Istex, Curation, bibRecord, 000089

Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa

Identifieur interne : 000089 ( Istex/Curation ); précédent : 000088; suivant : 000090

Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa

Auteurs : Lara Isobel Compston [Royaume-Uni] ; Chengyao Li [République populaire de Chine] ; Francis Sarkodie [Ghana] ; Shirley Owusu-Ofori [Ghana] ; Ohene Opare-Sem [Ghana] ; Jean-Pierre Allain [Royaume-Uni]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2009-11.

RBID : ISTEX:5630810CCAEE5A5C636C1E3A8338507F90D61929

English descriptors

Abstract

Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV‐1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV‐negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus‐C (GBV‐C), cytomegalovirus (CMV), Epstein–Barr virus (EBV), human herpesvirus‐8 (HHV‐8) and varicella‐zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV‐C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P < 0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P < 0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P < 0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV‐1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P ≤ 0.001. The background seroprevalence in blood donors was high for B19V (≥64%), HBV (≥70%), CMV and EBV (≥90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV‐8 (asymptomatic and symptomatic HIV). J. Med. Virol. 81:1860–1868, 2009. © 2009 Wiley‐Liss, Inc.

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https://api.istex.fr/document/5630810CCAEE5A5C636C1E3A8338507F90D61929/fulltext/pdf

DOI: 10.1002/jmv.21614

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody prevalence</term>
<term>Antibody response</term>
<term>Assay</term>
<term>Asymptomatic</term>
<term>Background prevalence</term>
<term>Baseline odds</term>
<term>Black boxes</term>
<term>Blood donor</term>
<term>Blood donor controls</term>
<term>Blood donor group</term>
<term>Blood donors</term>
<term>Bold donor controls</term>
<term>Bone marrow</term>
<term>Cambridge blood centre</term>
<term>Cell count</term>
<term>Cellular</term>
<term>Cellular fraction</term>
<term>Cellular samples</term>
<term>Clin</term>
<term>Clin microbiol</term>
<term>Clinical implications</term>
<term>Clinical stage</term>
<term>Cohort</term>
<term>Compston</term>
<term>Control group</term>
<term>Detectable viraemia</term>
<term>Donor</term>
<term>Exact test</term>
<term>Ghanaian blood donors</term>
<term>Grant sponsor</term>
<term>Gray boxes</term>
<term>Healthy blood donors</term>
<term>Hepatitis</term>
<term>Herpesvirus</term>
<term>Human herpesvirus</term>
<term>Human virus</term>
<term>Immune</term>
<term>Immune restoration disease</term>
<term>Important role</term>
<term>Infection</term>
<term>Komfo anokye teaching hospital</term>
<term>Natural history</term>
<term>Occult</term>
<term>Occult hepatitis</term>
<term>Odds ratio</term>
<term>Odds ratios</term>
<term>Opportunistic infection</term>
<term>Opportunistic infections</term>
<term>Overall prevalence</term>
<term>Parvovirus</term>
<term>Peripheral blood</term>
<term>Persistent viruses</term>
<term>Plasma fraction</term>
<term>Plasma samples</term>
<term>Plasma viraemia</term>
<term>Positive cohorts</term>
<term>Positive groups</term>
<term>Potential marker</term>
<term>Potential reactivation</term>
<term>Predictor</term>
<term>Prevalence</term>
<term>Prospective study</term>
<term>Reactivation</term>
<term>Risk factors</term>
<term>Roche diagnostics</term>
<term>Seroprevalence</term>
<term>Sexual transmission</term>
<term>Single virus</term>
<term>Symptomatic group</term>
<term>Symptomatic patients</term>
<term>Target virus</term>
<term>Total number</term>
<term>Transmission routes</term>
<term>Untreated patients</term>
<term>Useful guide</term>
<term>Viraemia</term>
<term>Viraemia prevalence</term>
<term>Viral</term>
<term>Viral load</term>
<term>Viral markers</term>
<term>Viral reactivation</term>
<term>Viral replication</term>
<term>Virol</term>
<term>Virus</term>
<term>Virus infection</term>
<term>Virus load</term>
<term>Whole blood</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Antibody prevalence</term>
<term>Antibody response</term>
<term>Assay</term>
<term>Asymptomatic</term>
<term>Background prevalence</term>
<term>Baseline odds</term>
<term>Black boxes</term>
<term>Blood donor</term>
<term>Blood donor controls</term>
<term>Blood donor group</term>
<term>Blood donors</term>
<term>Bold donor controls</term>
<term>Bone marrow</term>
<term>Cambridge blood centre</term>
<term>Cell count</term>
<term>Cellular</term>
<term>Cellular fraction</term>
<term>Cellular samples</term>
<term>Clin</term>
<term>Clin microbiol</term>
<term>Clinical implications</term>
<term>Clinical stage</term>
<term>Cohort</term>
<term>Compston</term>
<term>Control group</term>
<term>Detectable viraemia</term>
<term>Donor</term>
<term>Exact test</term>
<term>Ghanaian blood donors</term>
<term>Grant sponsor</term>
<term>Gray boxes</term>
<term>Healthy blood donors</term>
<term>Hepatitis</term>
<term>Herpesvirus</term>
<term>Human herpesvirus</term>
<term>Human virus</term>
<term>Immune</term>
<term>Immune restoration disease</term>
<term>Important role</term>
<term>Infection</term>
<term>Komfo anokye teaching hospital</term>
<term>Natural history</term>
<term>Occult</term>
<term>Occult hepatitis</term>
<term>Odds ratio</term>
<term>Odds ratios</term>
<term>Opportunistic infection</term>
<term>Opportunistic infections</term>
<term>Overall prevalence</term>
<term>Parvovirus</term>
<term>Peripheral blood</term>
<term>Persistent viruses</term>
<term>Plasma fraction</term>
<term>Plasma samples</term>
<term>Plasma viraemia</term>
<term>Positive cohorts</term>
<term>Positive groups</term>
<term>Potential marker</term>
<term>Potential reactivation</term>
<term>Predictor</term>
<term>Prevalence</term>
<term>Prospective study</term>
<term>Reactivation</term>
<term>Risk factors</term>
<term>Roche diagnostics</term>
<term>Seroprevalence</term>
<term>Sexual transmission</term>
<term>Single virus</term>
<term>Symptomatic group</term>
<term>Symptomatic patients</term>
<term>Target virus</term>
<term>Total number</term>
<term>Transmission routes</term>
<term>Untreated patients</term>
<term>Useful guide</term>
<term>Viraemia</term>
<term>Viraemia prevalence</term>
<term>Viral</term>
<term>Viral load</term>
<term>Viral markers</term>
<term>Viral reactivation</term>
<term>Viral replication</term>
<term>Virol</term>
<term>Virus</term>
<term>Virus infection</term>
<term>Virus load</term>
<term>Whole blood</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV‐1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV‐negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus‐C (GBV‐C), cytomegalovirus (CMV), Epstein–Barr virus (EBV), human herpesvirus‐8 (HHV‐8) and varicella‐zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV‐C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P < 0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P < 0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P < 0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV‐1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P ≤ 0.001. The background seroprevalence in blood donors was high for B19V (≥64%), HBV (≥70%), CMV and EBV (≥90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV‐8 (asymptomatic and symptomatic HIV). J. Med. Virol. 81:1860–1868, 2009. © 2009 Wiley‐Liss, Inc.</div>
</front>
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Le SIDA au Ghana (serveur d'exploration)

Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa

Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa

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Abstract

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