SidaGhanaV1, Istex, Corpus, bibRecord, 000977

Anaemia, blood transfusion practices, HIV and mortality among women of reproductive age in western Kenya

Identifieur interne : 000977 ( Istex/Corpus ); précédent : 000976; suivant : 000978

Anaemia, blood transfusion practices, HIV and mortality among women of reproductive age in western Kenya

Auteurs : J. R. Zucker ; E. M. Lackritz ; T. K. Ruebush ; A. W. Hightower ; J. E. Adungosi ; J. B. O. Were ; C. C. Campbell

Source :

Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1994-03.

RBID : ISTEX:A30C7880E426BFED4B135373B9E492E3DB99A6B2

Abstract

Severe anaemia among women in sub-Saharan Africa is frequently treated with blood transfusions. The risk of transmission of human immunodeficiency virus (HIV) through blood products has led to a re-evaluation of the indications for transfusions. Prospective surveillance of women admitted to a district hospital in western Kenya was conducted from 1 December 1990 to 31 July 1991, for haemoglobin (Hb) transfusion status, and outcome. Of the 2986 enrolled women (mean Hb 10.4 g/dL, SD±2.6, median age 24.4 years), 6% were severely anaemic (Hb <6.0 g/dL). Severe anaemia was associated with a higher mortality rate (10.7% vs. 1.4%, odds ratio (OR) = 8.2, 95% confidence interval (CI) 2.6, 34.2) compared with women with Hb ⩾ 6.0 g/dL. Decreased mortality rates in hospital were observed with increasing Hb values (OR = 0.43, 95% CI 0.19, 0.98), but blood transfusions did not improve survival in hospital (OR = 1.56, 95% CI 0.22, 11.03). The attributable mortality due to HIV infection and severe anaemia was 75% and 31%, respectively. Maternal/child health care services must include prevention strategies for HIV transmission and the prevention, recognition, and treatment of severe anaemia.

Url:

https://api.istex.fr/document/A30C7880E426BFED4B135373B9E492E3DB99A6B2/fulltext/pdf

DOI: 10.1016/0035-9203(94)90283-6

Links to Exploration step

ISTEX:A30C7880E426BFED4B135373B9E492E3DB99A6B2

Le document en format XML

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<aff id="AFF1">

<label>1</label>
Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA</aff>

<aff id="AFF2">

<label>2</label>
Clinical Research Centre, Kenya Medical Research Institute, Nairobi, Kenya</aff>

<aff id="AFF3">

<label>3</label>
Siaya District Hospital, Siaya, Kenya</aff>
</contrib-group>

<author-notes>

<corresp id="COR1">Address for correspondence: Dr J. R. Zucker, Malaria Branch, CDC, 1600 Clifton Road, Mailstop F-12, Atlanta, GA 30333, USA.</corresp>
</author-notes>

<pub-date pub-type="ppub">

<month>3</month>

<year>1994</year>
</pub-date>

<volume>88</volume>

<issue>2</issue>

<fpage>173</fpage>

<lpage>176</lpage>

<history><date date-type="received"><day>19</day>

<month>4</month>

<year>1993</year>
</date>
<date date-type="accepted"><day>8</day>

<month>7</month>

<year>1993</year>
</date>
</history>

<permissions><copyright-year>1994</copyright-year>

</permissions>

<abstract>

<title>Abstract</title>

<p>Severe anaemia among women in sub-Saharan Africa is frequently treated with blood transfusions. The risk of transmission of human immunodeficiency virus (HIV) through blood products has led to a re-evaluation of the indications for transfusions. Prospective surveillance of women admitted to a district hospital in western Kenya was conducted from 1 December 1990 to 31 July 1991, for haemoglobin (Hb) transfusion status, and outcome. Of the 2986 enrolled women (mean Hb 10.4 g/dL, SD±2.6, median age 24.4 years), 6% were severely anaemic (Hb <6.0 g/dL). Severe anaemia was associated with a higher mortality rate (10.7% vs. 1.4%, odds ratio (OR) = 8.2, 95% confidence interval (CI) 2.6, 34.2) compared with women with Hb ⩾ 6.0 g/dL. Decreased mortality rates in hospital were observed with increasing Hb values (OR = 0.43, 95% CI 0.19, 0.98), but blood transfusions did not improve survival in hospital (OR = 1.56, 95% CI 0.22, 11.03). The attributable mortality due to HIV infection and severe anaemia was 75% and 31%, respectively. Maternal/child health care services must include prevention strategies for HIV transmission and the prevention, recognition, and treatment of severe anaemia.</p>
</abstract>

<custom-meta-wrap>

<custom-meta>

<meta-name>cover-date</meta-name>

<meta-value>March-April 1994</meta-value>

</custom-meta>

</custom-meta-wrap>

</article-meta>

</front>

<back>

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<affiliation>Clinical Research Centre, Kenya Medical Research Institute, Nairobi, Kenya</affiliation>
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<abstract>Severe anaemia among women in sub-Saharan Africa is frequently treated with blood transfusions. The risk of transmission of human immunodeficiency virus (HIV) through blood products has led to a re-evaluation of the indications for transfusions. Prospective surveillance of women admitted to a district hospital in western Kenya was conducted from 1 December 1990 to 31 July 1991, for haemoglobin (Hb) transfusion status, and outcome. Of the 2986 enrolled women (mean Hb 10.4 g/dL, SD±2.6, median age 24.4 years), 6% were severely anaemic (Hb <6.0 g/dL). Severe anaemia was associated with a higher mortality rate (10.7% vs. 1.4%, odds ratio (OR) = 8.2, 95% confidence interval (CI) 2.6, 34.2) compared with women with Hb ⩾ 6.0 g/dL. Decreased mortality rates in hospital were observed with increasing Hb values (OR = 0.43, 95% CI 0.19, 0.98), but blood transfusions did not improve survival in hospital (OR = 1.56, 95% CI 0.22, 11.03). The attributable mortality due to HIV infection and severe anaemia was 75% and 31%, respectively. Maternal/child health care services must include prevention strategies for HIV transmission and the prevention, recognition, and treatment of severe anaemia.</abstract>
<note type="author-notes">Address for correspondence: Dr J. R. Zucker, Malaria Branch, CDC, 1600 Clifton Road, Mailstop F-12, Atlanta, GA 30333, USA.</note>
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Anaemia, blood transfusion practices, HIV and mortality among women of reproductive age in western Kenya

Anaemia, blood transfusion practices, HIV and mortality among women of reproductive age in western Kenya

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