Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa
Identifieur interne : 000338 ( Istex/Corpus ); précédent : 000337; suivant : 000339Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa
Auteurs : Francesca Gobbini ; Shirley Owusu-Ofori ; Anne-Geneviève Marcelin ; Daniel Candotti ; Jean-Pierre AllainSource :
- Transfusion [ 0041-1132 ] ; 2012-11.
English descriptors
- KwdEn :
- Assay, Blood donors, Blood products, Blood recipients, Blood samples, Blood transfusion, Bootstrap value, Cambridge blood centre, Cellular fraction, Donor, Genotype, Ghana, Ghanaian, Ghanaian samples, Ghanaian sequences, Guinean samples, Herpesvirus, High titer, Human herpesvirus, Human herpesvirus type, Immune response, Immunocompetent recipients, Immunosuppressive drugs, Komfo anokye teaching hospital, Minor capsid protein, Posttransfusion, Posttransfusion sample, Posttransfusion samples, Serologic, Seronegative, Seronegative recipients, Seropositive, Seropositive blood, Seroprevalence, Transfusion, Transfusion transmission, Transfusion volume, Viral load, West africa, Whole blood.
- Teeft :
- Assay, Blood donors, Blood products, Blood recipients, Blood samples, Blood transfusion, Bootstrap value, Cambridge blood centre, Cellular fraction, Donor, Genotype, Ghana, Ghanaian, Ghanaian samples, Ghanaian sequences, Guinean samples, Herpesvirus, High titer, Human herpesvirus, Human herpesvirus type, Immune response, Immunocompetent recipients, Immunosuppressive drugs, Komfo anokye teaching hospital, Minor capsid protein, Posttransfusion, Posttransfusion sample, Posttransfusion samples, Serologic, Seronegative, Seronegative recipients, Seropositive, Seropositive blood, Seroprevalence, Transfusion, Transfusion transmission, Transfusion volume, Viral load, West africa, Whole blood.
Abstract
BACKGROUND: Human herpesvirus 8 (HHV‐8) seroprevalence ranges between less than 5% in Europe and North America and 50% to 70% in sub‐Saharan Africa. Evidence of HHV‐8 transfusion transmission is only indirect. We conducted a serologic (anti‐HHV‐8) and molecular (HHV‐8 DNA) study of samples from paired donor‐immunocompetent recipients transfused with whole blood.
Url:
DOI: 10.1111/j.1537-2995.2012.03607.x
Links to Exploration step
ISTEX:9E211FE5028F62D309BCDE38024144571E3B5B0ELe document en format XML
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the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Marcelin, Anne Enevieve" sort="Marcelin, Anne Enevieve" uniqKey="Marcelin A" first="Anne-Geneviève" last="Marcelin">Anne-Geneviève Marcelin</name><affiliation><mods:affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><affiliation><mods:affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; 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the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><affiliation><mods:affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Allain, Jean Ierre" sort="Allain, Jean Ierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation><mods:affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jpa1000@cam.ac.uk</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Transfusion</title><title level="j" type="alt">TRANSFUSION</title><idno type="ISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><imprint><biblScope unit="vol">52</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2294">2294</biblScope><biblScope unit="page" to="2299">2299</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2012-11">2012-11</date></imprint><idno type="ISSN">0041-1132</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-1132</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Assay</term><term>Blood donors</term><term>Blood products</term><term>Blood recipients</term><term>Blood samples</term><term>Blood transfusion</term><term>Bootstrap value</term><term>Cambridge blood centre</term><term>Cellular fraction</term><term>Donor</term><term>Genotype</term><term>Ghana</term><term>Ghanaian</term><term>Ghanaian samples</term><term>Ghanaian sequences</term><term>Guinean samples</term><term>Herpesvirus</term><term>High titer</term><term>Human herpesvirus</term><term>Human herpesvirus type</term><term>Immune response</term><term>Immunocompetent recipients</term><term>Immunosuppressive drugs</term><term>Komfo anokye teaching hospital</term><term>Minor capsid protein</term><term>Posttransfusion</term><term>Posttransfusion sample</term><term>Posttransfusion samples</term><term>Serologic</term><term>Seronegative</term><term>Seronegative recipients</term><term>Seropositive</term><term>Seropositive blood</term><term>Seroprevalence</term><term>Transfusion</term><term>Transfusion transmission</term><term>Transfusion volume</term><term>Viral load</term><term>West africa</term><term>Whole blood</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Assay</term><term>Blood donors</term><term>Blood products</term><term>Blood recipients</term><term>Blood samples</term><term>Blood transfusion</term><term>Bootstrap value</term><term>Cambridge blood centre</term><term>Cellular fraction</term><term>Donor</term><term>Genotype</term><term>Ghana</term><term>Ghanaian</term><term>Ghanaian samples</term><term>Ghanaian sequences</term><term>Guinean samples</term><term>Herpesvirus</term><term>High titer</term><term>Human herpesvirus</term><term>Human herpesvirus type</term><term>Immune response</term><term>Immunocompetent recipients</term><term>Immunosuppressive drugs</term><term>Komfo anokye teaching hospital</term><term>Minor capsid protein</term><term>Posttransfusion</term><term>Posttransfusion sample</term><term>Posttransfusion samples</term><term>Serologic</term><term>Seronegative</term><term>Seronegative recipients</term><term>Seropositive</term><term>Seropositive blood</term><term>Seroprevalence</term><term>Transfusion</term><term>Transfusion transmission</term><term>Transfusion volume</term><term>Viral load</term><term>West africa</term><term>Whole blood</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">BACKGROUND: Human herpesvirus 8 (HHV‐8) seroprevalence ranges between less than 5% in Europe and North America and 50% to 70% in sub‐Saharan Africa. Evidence of HHV‐8 transfusion transmission is only indirect. We conducted a serologic (anti‐HHV‐8) and molecular (HHV‐8 DNA) study of samples from paired donor‐immunocompetent recipients transfused with whole blood.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>transfusion</json:string><json:string>genotype</json:string><json:string>herpesvirus</json:string><json:string>seropositive</json:string><json:string>ghanaian</json:string><json:string>seroprevalence</json:string><json:string>human herpesvirus</json:string><json:string>seronegative</json:string><json:string>blood transfusion</json:string><json:string>serologic</json:string><json:string>posttransfusion</json:string><json:string>transfusion transmission</json:string><json:string>blood donors</json:string><json:string>whole blood</json:string><json:string>ghanaian sequences</json:string><json:string>seropositive blood</json:string><json:string>west africa</json:string><json:string>assay</json:string><json:string>blood samples</json:string><json:string>transfusion volume</json:string><json:string>donor</json:string><json:string>blood products</json:string><json:string>posttransfusion sample</json:string><json:string>human herpesvirus type</json:string><json:string>immunocompetent recipients</json:string><json:string>viral load</json:string><json:string>minor capsid protein</json:string><json:string>immunosuppressive drugs</json:string><json:string>blood recipients</json:string><json:string>seronegative recipients</json:string><json:string>posttransfusion samples</json:string><json:string>komfo anokye teaching hospital</json:string><json:string>ghanaian samples</json:string><json:string>guinean samples</json:string><json:string>cellular fraction</json:string><json:string>bootstrap value</json:string><json:string>high titer</json:string><json:string>immune response</json:string><json:string>cambridge blood centre</json:string><json:string>ghana</json:string></teeft></keywords><author><json:item><name>Francesca Gobbini</name><affiliations><json:string>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</json:string></affiliations></json:item><json:item><name>Shirley Owusu‐Ofori</name><affiliations><json:string>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</json:string></affiliations></json:item><json:item><name>Anne‐Geneviève Marcelin</name><affiliations><json:string>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</json:string></affiliations></json:item><json:item><name>Daniel Candotti</name><affiliations><json:string>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</json:string></affiliations></json:item><json:item><name>Jean‐Pierre Allain</name><affiliations><json:string>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</json:string><json:string>E-mail: jpa1000@cam.ac.uk</json:string></affiliations></json:item></author><articleId><json:string>TRF3607</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>shortCommunication</json:string></originalGenre><qualityIndicators><score>3.674</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 783 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>364</abstractCharCount><pdfWordCount>3086</pdfWordCount><pdfCharCount>21281</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>49</abstractWordCount></qualityIndicators><title>Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa</title><genre><json:string>brief-communication</json:string></genre><host><title>Transfusion</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1537-2995</json:string></doi><issn><json:string>0041-1132</json:string></issn><eissn><json:string>1537-2995</json:string></eissn><publisherId><json:string>TRF</json:string></publisherId><volume>52</volume><issue>11</issue><pages><first>2294</first><last>2299</last><total>6</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>TRANSFUSION COMPLICATIONS</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>hematology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>cardiovascular system & hematology</json:string></scienceMetrix></categories><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1111/j.1537-2995.2012.03607.x</json:string></doi><id>9E211FE5028F62D309BCDE38024144571E3B5B0E</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/9E211FE5028F62D309BCDE38024144571E3B5B0E/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/9E211FE5028F62D309BCDE38024144571E3B5B0E/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9E211FE5028F62D309BCDE38024144571E3B5B0E/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><availability><licence>© 2012 American Association of Blood Banks</licence></availability><date type="published" when="2012-11"></date></publicationStmt><notesStmt><note type="content-type" subtype="brief-communication" source="shortCommunication" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="brief-communication"><analytic><title level="a" type="main">Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa</title><title level="a" type="short">HHV‐8 TRANSFUSION TRANSMISSION IN WEST AFRICA</title><author xml:id="author-0000"><persName><forename type="first">Francesca</forename><surname>Gobbini</surname></persName><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Shirley</forename><surname>Owusu‐Ofori</surname></persName><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Anne‐Geneviève</forename><surname>Marcelin</surname></persName><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Daniel</forename><surname>Candotti</surname></persName><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation></author><author xml:id="author-0004" role="corresp"><persName><forename type="first">Jean‐Pierre</forename><surname>Allain</surname></persName><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation><affiliation>J.‐P. Allain, Department of Haematology, Cambridge Blood Centre, Long Road, Cambridge CB2 2PT, UK; e‐mail: jpa1000@cam.ac.uk.</affiliation></author><idno type="istex">9E211FE5028F62D309BCDE38024144571E3B5B0E</idno><idno type="DOI">10.1111/j.1537-2995.2012.03607.x</idno><idno type="unit">TRF3607</idno><idno type="toTypesetVersion">file:TRF.TRF3607.pdf</idno></analytic><monogr><title level="j" type="main">Transfusion</title><title level="j" type="alt">TRANSFUSION</title><idno type="pISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><idno type="book-DOI">10.1111/(ISSN)1537-2995</idno><idno type="book-part-DOI">10.1111/trf.2012.52.issue-11</idno><idno type="product">TRF</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">52</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2294">2294</biblScope><biblScope unit="page" to="2299">2299</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2012-11"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">BACKGROUND:</hi> Human herpesvirus 8 (HHV‐8) seroprevalence ranges between less than 5% in Europe and North America and 50% to 70% in sub‐Saharan Africa. Evidence of HHV‐8 transfusion transmission is only indirect. We conducted a serologic (anti‐HHV‐8) and molecular (HHV‐8 DNA) study of samples from paired donor‐immunocompetent recipients transfused with whole blood.</p><p><hi rend="bold">STUDY DESIGN AND METHODS:</hi> Samples from 252 donor‐recipient pairs were tested. Immunoglobulin G to HHV‐8 was detected with enzyme immunoassays and confirmed with an in‐house immunofluorescence assay. The cellular fraction from seroreactive donors and their recipients was tested for HHV‐8 DNA.</p><p><hi rend="bold">RESULTS:</hi> Anti‐HHV‐8 was positive (reactive in two or more assays) in 28 (11%) patients and 16 (6%) donors. Of 12 seronegative recipients (at risk of transmission) receiving seropositive blood, one very likely transmission was identified (8.3% confidence interval, 0%‐23%). The donor blood contained HHV‐8 DNA and his and four other donors' sequences clustered separately from recorded genotypes with a 97% bootstrap constituting a distinct genotype.</p><p><hi rend="bold">CONCLUSIONS:</hi> HHV‐8 is transmitted in Ghana but does not carry clinical consequences since most patients are immunocompetent. The clinical risk will increase with the availability of immunosuppressive drugs in sub‐Saharan Africa. We propose that a new genotype (HHV‐8‐G for Ghana) be added to the current nomenclature.</p></abstract><textClass><classCode scheme="tocHeading1">TRANSFUSION COMPLICATIONS</classCode><classCode scheme="articleCategory">TRANSFUSION COMPLICATIONS</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/9E211FE5028F62D309BCDE38024144571E3B5B0E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1537-2995</doi><issn type="print">0041-1132</issn><issn type="electronic">1537-2995</issn><idGroup><id type="product" value="TRF"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="TRANSFUSION">Transfusion</title></titleGroup></publicationMeta><publicationMeta level="part" position="11111"><doi>10.1111/trf.2012.52.issue-11</doi><copyright ownership="thirdParty">© 2012 AABB</copyright><numberingGroup><numbering number="52" type="journalVolume">52</numbering><numbering type="journalIssue">11</numbering></numberingGroup><coverDate startDate="2012-11">November 2012</coverDate></publicationMeta><publicationMeta level="unit" position="60" status="forIssue" type="shortCommunication"><doi origin="wiley">10.1111/j.1537-2995.2012.03607.x</doi><idGroup><id type="unit" value="TRF3607"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">TRANSFUSION COMPLICATIONS</title><title type="articleCategory">TRANSFUSION COMPLICATIONS</title></titleGroup><copyright>© 2012 American Association of Blood Banks</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.9 mode:FullText" date="2012-11-06"></event><event date="2012-11-07" type="xmlCorrected"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-03-15"></event><event type="firstOnline" date="2012-03-15"></event><event type="publishedOnlineFinalForm" date="2012-11-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst">2294</numbering><numbering type="pageLast">2299</numbering></numberingGroup><correspondenceTo>J.‐P. Allain, Department of Haematology, Cambridge Blood Centre, Long Road, Cambridge CB2 2PT, UK; e‐mail: <email>jpa1000@cam.ac.uk</email>.
</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:TRF.TRF3607.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received for publication October 12, 2011; revision received January 10, 2012, and accepted January 10, 2012.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="17"></count><count type="wordTotal" number="3476"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa</title><title type="shortAuthors">GOBBINI ET AL.</title><title type="short">HHV‐8 TRANSFUSION TRANSMISSION IN WEST AFRICA</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Francesca</givenNames><familyName>Gobbini</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Shirley</givenNames><familyName>Owusu‐Ofori</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Anne‐Geneviève</givenNames><familyName>Marcelin</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Daniel</givenNames><familyName>Candotti</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Jean‐Pierre</givenNames><familyName>Allain</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>BACKGROUND:</b> Human herpesvirus 8 (HHV‐8) seroprevalence ranges between less than 5% in Europe and North America and 50% to 70% in sub‐Saharan Africa. Evidence of HHV‐8 transfusion transmission is only indirect. We conducted a serologic (anti‐HHV‐8) and molecular (HHV‐8 DNA) study of samples from paired donor‐immunocompetent recipients transfused with whole blood.</p><p><b>STUDY DESIGN AND METHODS:</b> Samples from 252 donor‐recipient pairs were tested. Immunoglobulin G to HHV‐8 was detected with enzyme immunoassays and confirmed with an in‐house immunofluorescence assay. The cellular fraction from seroreactive donors and their recipients was tested for HHV‐8 DNA.</p><p><b>RESULTS:</b> Anti‐HHV‐8 was positive (reactive in two or more assays) in 28 (11%) patients and 16 (6%) donors. Of 12 seronegative recipients (at risk of transmission) receiving seropositive blood, one very likely transmission was identified (8.3% confidence interval, 0%‐23%). The donor blood contained HHV‐8 DNA and his and four other donors' sequences clustered separately from recorded genotypes with a 97% bootstrap constituting a distinct genotype.</p><p><b>CONCLUSIONS:</b> HHV‐8 is transmitted in Ghana but does not carry clinical consequences since most patients are immunocompetent. The clinical risk will increase with the availability of immunosuppressive drugs in sub‐Saharan Africa. We propose that a new genotype (HHV‐8‐G for Ghana) be added to the current nomenclature.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>The BOTIA repository was supported by a grant from the FP6 EC (SP23‐CT‐2006‐006487).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>HHV‐8 TRANSFUSION TRANSMISSION IN WEST AFRICA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa</title></titleInfo><name type="personal"><namePart type="given">Francesca</namePart><namePart type="family">Gobbini</namePart><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shirley</namePart><namePart type="family">Owusu‐Ofori</namePart><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anne‐Geneviève</namePart><namePart type="family">Marcelin</namePart><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel</namePart><namePart type="family">Candotti</namePart><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Pierre</namePart><namePart type="family">Allain</namePart><affiliation>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana; the Virology Laboratory Hospital Pitié‐Salpêtrière, Paris, France; and the National Blood Service, Cambridge Blood Centre, Cambridge, UK.</affiliation><affiliation>E-mail: jpa1000@cam.ac.uk</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="shortCommunication"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2012-11</dateIssued><edition>Received for publication October 12, 2011; revision received January 10, 2012, and accepted January 10, 2012.</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">17</extent><extent unit="words">3476</extent></physicalDescription><abstract>BACKGROUND: Human herpesvirus 8 (HHV‐8) seroprevalence ranges between less than 5% in Europe and North America and 50% to 70% in sub‐Saharan Africa. Evidence of HHV‐8 transfusion transmission is only indirect. We conducted a serologic (anti‐HHV‐8) and molecular (HHV‐8 DNA) study of samples from paired donor‐immunocompetent recipients transfused with whole blood.</abstract><abstract>STUDY DESIGN AND METHODS: Samples from 252 donor‐recipient pairs were tested. Immunoglobulin G to HHV‐8 was detected with enzyme immunoassays and confirmed with an in‐house immunofluorescence assay. The cellular fraction from seroreactive donors and their recipients was tested for HHV‐8 DNA.</abstract><abstract>RESULTS: Anti‐HHV‐8 was positive (reactive in two or more assays) in 28 (11%) patients and 16 (6%) donors. Of 12 seronegative recipients (at risk of transmission) receiving seropositive blood, one very likely transmission was identified (8.3% confidence interval, 0%‐23%). The donor blood contained HHV‐8 DNA and his and four other donors' sequences clustered separately from recorded genotypes with a 97% bootstrap constituting a distinct genotype.</abstract><abstract>CONCLUSIONS: HHV‐8 is transmitted in Ghana but does not carry clinical consequences since most patients are immunocompetent. The clinical risk will increase with the availability of immunosuppressive drugs in sub‐Saharan Africa. We propose that a new genotype (HHV‐8‐G for Ghana) be added to the current nomenclature.</abstract><relatedItem type="host"><titleInfo><title>Transfusion</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>TRANSFUSION COMPLICATIONS</topic></subject><identifier type="ISSN">0041-1132</identifier><identifier type="eISSN">1537-2995</identifier><identifier type="DOI">10.1111/(ISSN)1537-2995</identifier><identifier type="PublisherID">TRF</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>2294</start><end>2299</end><total>6</total></extent></part></relatedItem><identifier type="istex">9E211FE5028F62D309BCDE38024144571E3B5B0E</identifier><identifier type="DOI">10.1111/j.1537-2995.2012.03607.x</identifier><identifier type="ArticleID">TRF3607</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2012 AABB© 2012 American Association of Blood Banks</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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