[Anemia as a risk factor for CKD and CVD].
Identifieur interne : 000185 ( Main/Corpus ); précédent : 000184; suivant : 000186[Anemia as a risk factor for CKD and CVD].
Auteurs : Kazuhiko Tsuruya ; Hideki HirakataSource :
- Nihon rinsho. Japanese journal of clinical medicine [ 0047-1852 ] ; 2008.
English descriptors
- KwdEn :
- Anemia (blood), Anemia (complications), Anemia (drug therapy), Cardiovascular Diseases (etiology), Cardiovascular Diseases (prevention & control), Chronic Disease, Disease Progression, Erythropoietin (therapeutic use), Hematinics (therapeutic use), Hemoglobins (metabolism), Humans, Kidney Diseases (etiology), Kidney Diseases (prevention & control), Kidney Failure, Chronic (etiology), Kidney Failure, Chronic (prevention & control), Prognosis, Randomized Controlled Trials as Topic, Recombinant Proteins, Risk Factors, Syndrome.
- MESH :
- chemical , metabolism : Hemoglobins.
- chemical , therapeutic use : Erythropoietin, Hematinics.
- blood : Anemia.
- complications : Anemia.
- drug therapy : Anemia.
- etiology : Cardiovascular Diseases, Kidney Diseases, Kidney Failure, Chronic.
- prevention & control : Cardiovascular Diseases, Kidney Diseases, Kidney Failure, Chronic.
- Chronic Disease, Disease Progression, Humans, Prognosis, Randomized Controlled Trials as Topic, Recombinant Proteins, Risk Factors, Syndrome.
Abstract
Chronic kidney disease (CKD) is now recognized as a risk factor of both end-stage renal disease (ESRD) and independently cardiovascular disease (CVD). Therefore, a specific renoprotective intervention is strongly recommended, including blood pressure control as well as anemia improvement with erythropoietin stimulating agents (ESAs). Treatment of renal anemia with ESAs has been proved to improve quality of life (QOL) and finally reduce patient mortality. Recently, Silverberg, et al. created a novel clinical entity of Cardio-Renal Anemia (CRA) syndrome, in which anemia plays a key role for worsening both CKD and cardiac performance in a vicious circle. An appropriate and vigorous treatment of anemia has now been accepted to terminate or weaken the circle. Recently, two large-scaled randomized controlled trials were reported, being the CREATE (cardiovascular risk reduction by early anemia treatment with epoetin beta) study and the CHOIR (correction of hemoglobin and outcomes in renal insufficiency) study. They demonstrated that early initiation of ESA treatment and targeting at higher hemoglobin level (near normal level) failed to show the lowering effects for cardiovascular events as compared to a group in which Hb targeting was lower (sub-normal level) in pre-dialysis CKD patients. While there has been many argues in these reports especially about baseline patients characteristics, being a quite high incidence of severe cardiovascular co-morbidity. Thus, further evidences should be accumulated to resolve a proper target level of Hb in ESA treatment.
PubMed: 18788410
Links to Exploration step
pubmed:18788410Le document en format XML
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<author><name sortKey="Tsuruya, Kazuhiko" sort="Tsuruya, Kazuhiko" uniqKey="Tsuruya K" first="Kazuhiko" last="Tsuruya">Kazuhiko Tsuruya</name>
<affiliation><nlm:affiliation>Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hirakata, Hideki" sort="Hirakata, Hideki" uniqKey="Hirakata H" first="Hideki" last="Hirakata">Hideki Hirakata</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[Anemia as a risk factor for CKD and CVD].</title>
<author><name sortKey="Tsuruya, Kazuhiko" sort="Tsuruya, Kazuhiko" uniqKey="Tsuruya K" first="Kazuhiko" last="Tsuruya">Kazuhiko Tsuruya</name>
<affiliation><nlm:affiliation>Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University.</nlm:affiliation>
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<author><name sortKey="Hirakata, Hideki" sort="Hirakata, Hideki" uniqKey="Hirakata H" first="Hideki" last="Hirakata">Hideki Hirakata</name>
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<series><title level="j">Nihon rinsho. Japanese journal of clinical medicine</title>
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<imprint><date when="2008" type="published">2008</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anemia (blood)</term>
<term>Anemia (complications)</term>
<term>Anemia (drug therapy)</term>
<term>Cardiovascular Diseases (etiology)</term>
<term>Cardiovascular Diseases (prevention & control)</term>
<term>Chronic Disease</term>
<term>Disease Progression</term>
<term>Erythropoietin (therapeutic use)</term>
<term>Hematinics (therapeutic use)</term>
<term>Hemoglobins (metabolism)</term>
<term>Humans</term>
<term>Kidney Diseases (etiology)</term>
<term>Kidney Diseases (prevention & control)</term>
<term>Kidney Failure, Chronic (etiology)</term>
<term>Kidney Failure, Chronic (prevention & control)</term>
<term>Prognosis</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Recombinant Proteins</term>
<term>Risk Factors</term>
<term>Syndrome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemoglobins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Erythropoietin</term>
<term>Hematinics</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Anemia</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Anemia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anemia</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cardiovascular Diseases</term>
<term>Kidney Diseases</term>
<term>Kidney Failure, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term>
<term>Kidney Diseases</term>
<term>Kidney Failure, Chronic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Chronic Disease</term>
<term>Disease Progression</term>
<term>Humans</term>
<term>Prognosis</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Recombinant Proteins</term>
<term>Risk Factors</term>
<term>Syndrome</term>
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<front><div type="abstract" xml:lang="en">Chronic kidney disease (CKD) is now recognized as a risk factor of both end-stage renal disease (ESRD) and independently cardiovascular disease (CVD). Therefore, a specific renoprotective intervention is strongly recommended, including blood pressure control as well as anemia improvement with erythropoietin stimulating agents (ESAs). Treatment of renal anemia with ESAs has been proved to improve quality of life (QOL) and finally reduce patient mortality. Recently, Silverberg, et al. created a novel clinical entity of Cardio-Renal Anemia (CRA) syndrome, in which anemia plays a key role for worsening both CKD and cardiac performance in a vicious circle. An appropriate and vigorous treatment of anemia has now been accepted to terminate or weaken the circle. Recently, two large-scaled randomized controlled trials were reported, being the CREATE (cardiovascular risk reduction by early anemia treatment with epoetin beta) study and the CHOIR (correction of hemoglobin and outcomes in renal insufficiency) study. They demonstrated that early initiation of ESA treatment and targeting at higher hemoglobin level (near normal level) failed to show the lowering effects for cardiovascular events as compared to a group in which Hb targeting was lower (sub-normal level) in pre-dialysis CKD patients. While there has been many argues in these reports especially about baseline patients characteristics, being a quite high incidence of severe cardiovascular co-morbidity. Thus, further evidences should be accumulated to resolve a proper target level of Hb in ESA treatment.</div>
</front>
</TEI>
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<DateCompleted><Year>2008</Year>
<Month>10</Month>
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<DateRevised><Year>2011</Year>
<Month>11</Month>
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<Issue>9</Issue>
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<Title>Nihon rinsho. Japanese journal of clinical medicine</Title>
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<ArticleTitle>[Anemia as a risk factor for CKD and CVD].</ArticleTitle>
<Pagination><MedlinePgn>1786-93</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Chronic kidney disease (CKD) is now recognized as a risk factor of both end-stage renal disease (ESRD) and independently cardiovascular disease (CVD). Therefore, a specific renoprotective intervention is strongly recommended, including blood pressure control as well as anemia improvement with erythropoietin stimulating agents (ESAs). Treatment of renal anemia with ESAs has been proved to improve quality of life (QOL) and finally reduce patient mortality. Recently, Silverberg, et al. created a novel clinical entity of Cardio-Renal Anemia (CRA) syndrome, in which anemia plays a key role for worsening both CKD and cardiac performance in a vicious circle. An appropriate and vigorous treatment of anemia has now been accepted to terminate or weaken the circle. Recently, two large-scaled randomized controlled trials were reported, being the CREATE (cardiovascular risk reduction by early anemia treatment with epoetin beta) study and the CHOIR (correction of hemoglobin and outcomes in renal insufficiency) study. They demonstrated that early initiation of ESA treatment and targeting at higher hemoglobin level (near normal level) failed to show the lowering effects for cardiovascular events as compared to a group in which Hb targeting was lower (sub-normal level) in pre-dialysis CKD patients. While there has been many argues in these reports especially about baseline patients characteristics, being a quite high incidence of severe cardiovascular co-morbidity. Thus, further evidences should be accumulated to resolve a proper target level of Hb in ESA treatment.</AbstractText>
</Abstract>
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<ForeName>Kazuhiko</ForeName>
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<AffiliationInfo><Affiliation>Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University.</Affiliation>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000740" MajorTopicYN="N">Anemia</DescriptorName>
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<MeshHeading><DescriptorName UI="D007674" MajorTopicYN="N">Kidney Diseases</DescriptorName>
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<MeshHeading><DescriptorName UI="D007676" MajorTopicYN="N">Kidney Failure, Chronic</DescriptorName>
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<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
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<MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
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<MeshHeading><DescriptorName UI="D013577" MajorTopicYN="N">Syndrome</DescriptorName>
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<NumberOfReferences>28</NumberOfReferences>
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