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Vastly Different Exercise Programs Similarly Improve Parkinsonian Symptoms: A Randomized Clinical Trial.

Identifieur interne : 000185 ( Main/Exploration ); précédent : 000184; suivant : 000186

Vastly Different Exercise Programs Similarly Improve Parkinsonian Symptoms: A Randomized Clinical Trial.

Auteurs : J Zsef Tollár [Oman] ; Ferenc Nagy [Hongrie] ; Tibor Hortobágyi [Pays-Bas]

Source :

RBID : pubmed:30368495

Descripteurs français

English descriptors

Abstract

OBJECTIVES

To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson's disease (PD) patients' mobility and clinical symptoms.

DESIGN

Randomized clinical trial.

SETTING

Outpatient physiotherapy clinic in a hospital.

PARTICIPANTS

Seventy-four stage 2-3, nondemented PD patients were included in this study.

INTERVENTION

The groups were as follows: EXE (n = 25), CYC (n = 25), and a wait-listed control group (CON; n = 24). The EXE and CYC groups exercised 5×/week for 5 weeks, matched at 80% of the age-predicted maximal heart rate.

MAIN OUTCOMES

The primary outcome was the Movement Disorders Society Unified Parkinson's Disease Rating Scale (UPDRS-II) score. Secondary outcomes were Parkinson's Disease Quastionnaire-39 (PDQ-39), the Beck Depression Inventory (BDI), the Schwab and England Activities of Daily Living (SE-ADL) scale, Euro-Quality of Life-5 Dimensions (EQ-5D) questionnaire, the Berg Balance Scale (BBS), the Balance Evaluation Systems Test (BESTest), the Tinetti Assessment Tool (TAT), the Dynamic Gait Index, the 6-min walk test (6MWT), and standing posturography.

RESULTS

After treatment, UPDRS-II scores improved (mean change: EXE, -4.5 points; CYC, -3.2 points). The results for the other outcomes (EXE and CYC, respectively) were: PDQ, 13 and 17%; BDI, -2.5 and -2.1 points; 6MWT, 129.6 and 141.6 m; and EQ-5D, 12 and 9% (all p < 0.05, but there was no difference between groups). EXE vs. CYC resulted in improved SE-ADL (8.4 and 4.0 points, effect size [ES]: 0.12), BBS (8.8 and 4.2 points, ES: 0.44), and 2 measures of posturography (ES: 0.11 and 0.21) (p < 0.05). BESTtest, TAT, the Dynamic Gait Index, and 4 out of 6 posturography measures did not change (p > 0.05).

CONCLUSION

Two highly different exercise programs resulted in similar improvement of most motor and clinical symptoms in PD patients.


DOI: 10.1159/000493127
PubMed: 30368495


Affiliations:


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Le document en format XML

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<term>Depression (physiopathology)</term>
<term>Exercise Therapy (classification)</term>
<term>Exercise Therapy (methods)</term>
<term>Female (MeSH)</term>
<term>Gait (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mobility Limitation (MeSH)</term>
<term>Muscle Rigidity (diagnosis)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (therapy)</term>
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<term>Quality of Life (MeSH)</term>
<term>Surveys and Questionnaires (MeSH)</term>
<term>Symptom Assessment (methods)</term>
<term>Treatment Outcome (MeSH)</term>
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<term>Adulte d'âge moyen (MeSH)</term>
<term>Démarche (MeSH)</term>
<term>Dépression (diagnostic)</term>
<term>Dépression (physiopathologie)</term>
<term>Enquêtes et questionnaires (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Maladie de Parkinson (diagnostic)</term>
<term>Maladie de Parkinson (physiopathologie)</term>
<term>Maladie de Parkinson (psychologie)</term>
<term>Maladie de Parkinson (thérapie)</term>
<term>Mobilité réduite (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Qualité de vie (MeSH)</term>
<term>Raideur musculaire (diagnostic)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Traitement par les exercices physiques (classification)</term>
<term>Traitement par les exercices physiques (méthodes)</term>
<term>Équilibre postural (MeSH)</term>
<term>Évaluation des symptômes (méthodes)</term>
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<term>Exercise Therapy</term>
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<term>Muscle Rigidity</term>
<term>Parkinson Disease</term>
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<term>Maladie de Parkinson</term>
<term>Raideur musculaire</term>
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<term>Symptom Assessment</term>
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<term>Évaluation des symptômes</term>
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<term>Parkinson Disease</term>
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<term>Enquêtes et questionnaires</term>
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<term>Humains</term>
<term>Mobilité réduite</term>
<term>Mâle</term>
<term>Qualité de vie</term>
<term>Résultat thérapeutique</term>
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<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVES</b>
</p>
<p>To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson's disease (PD) patients' mobility and clinical symptoms.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>DESIGN</b>
</p>
<p>Randomized clinical trial.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>SETTING</b>
</p>
<p>Outpatient physiotherapy clinic in a hospital.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>PARTICIPANTS</b>
</p>
<p>Seventy-four stage 2-3, nondemented PD patients were included in this study.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>INTERVENTION</b>
</p>
<p>The groups were as follows: EXE (n = 25), CYC (n = 25), and a wait-listed control group (CON; n = 24). The EXE and CYC groups exercised 5×/week for 5 weeks, matched at 80% of the age-predicted maximal heart rate.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>MAIN OUTCOMES</b>
</p>
<p>The primary outcome was the Movement Disorders Society Unified Parkinson's Disease Rating Scale (UPDRS-II) score. Secondary outcomes were Parkinson's Disease Quastionnaire-39 (PDQ-39), the Beck Depression Inventory (BDI), the Schwab and England Activities of Daily Living (SE-ADL) scale, Euro-Quality of Life-5 Dimensions (EQ-5D) questionnaire, the Berg Balance Scale (BBS), the Balance Evaluation Systems Test (BESTest), the Tinetti Assessment Tool (TAT), the Dynamic Gait Index, the 6-min walk test (6MWT), and standing posturography.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>After treatment, UPDRS-II scores improved (mean change: EXE, -4.5 points; CYC, -3.2 points). The results for the other outcomes (EXE and CYC, respectively) were: PDQ, 13 and 17%; BDI, -2.5 and -2.1 points; 6MWT, 129.6 and 141.6 m; and EQ-5D, 12 and 9% (all p < 0.05, but there was no difference between groups). EXE vs. CYC resulted in improved SE-ADL (8.4 and 4.0 points, effect size [ES]: 0.12), BBS (8.8 and 4.2 points, ES: 0.44), and 2 measures of posturography (ES: 0.11 and 0.21) (p < 0.05). BESTtest, TAT, the Dynamic Gait Index, and 4 out of 6 posturography measures did not change (p > 0.05).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>Two highly different exercise programs resulted in similar improvement of most motor and clinical symptoms in PD patients.</p>
</div>
</front>
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<AbstractText Label="OBJECTIVES">To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson's disease (PD) patients' mobility and clinical symptoms.</AbstractText>
<AbstractText Label="DESIGN">Randomized clinical trial.</AbstractText>
<AbstractText Label="SETTING">Outpatient physiotherapy clinic in a hospital.</AbstractText>
<AbstractText Label="PARTICIPANTS">Seventy-four stage 2-3, nondemented PD patients were included in this study.</AbstractText>
<AbstractText Label="INTERVENTION">The groups were as follows: EXE (n = 25), CYC (n = 25), and a wait-listed control group (CON; n = 24). The EXE and CYC groups exercised 5×/week for 5 weeks, matched at 80% of the age-predicted maximal heart rate.</AbstractText>
<AbstractText Label="MAIN OUTCOMES">The primary outcome was the Movement Disorders Society Unified Parkinson's Disease Rating Scale (UPDRS-II) score. Secondary outcomes were Parkinson's Disease Quastionnaire-39 (PDQ-39), the Beck Depression Inventory (BDI), the Schwab and England Activities of Daily Living (SE-ADL) scale, Euro-Quality of Life-5 Dimensions (EQ-5D) questionnaire, the Berg Balance Scale (BBS), the Balance Evaluation Systems Test (BESTest), the Tinetti Assessment Tool (TAT), the Dynamic Gait Index, the 6-min walk test (6MWT), and standing posturography.</AbstractText>
<AbstractText Label="RESULTS">After treatment, UPDRS-II scores improved (mean change: EXE, -4.5 points; CYC, -3.2 points). The results for the other outcomes (EXE and CYC, respectively) were: PDQ, 13 and 17%; BDI, -2.5 and -2.1 points; 6MWT, 129.6 and 141.6 m; and EQ-5D, 12 and 9% (all p < 0.05, but there was no difference between groups). EXE vs. CYC resulted in improved SE-ADL (8.4 and 4.0 points, effect size [ES]: 0.12), BBS (8.8 and 4.2 points, ES: 0.44), and 2 measures of posturography (ES: 0.11 and 0.21) (p < 0.05). BESTtest, TAT, the Dynamic Gait Index, and 4 out of 6 posturography measures did not change (p > 0.05).</AbstractText>
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</noRegion>
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<country name="Hongrie">
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<name sortKey="Nagy, Ferenc" sort="Nagy, Ferenc" uniqKey="Nagy F" first="Ferenc" last="Nagy">Ferenc Nagy</name>
</noRegion>
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<country name="Pays-Bas">
<region name="Groningue (province)">
<name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name>
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