The Joint Occurrence of Osteoporosis and Sarcopenia (Osteosarcopenia): Definitions and Characteristics.
Identifieur interne : 000034 ( Main/Exploration ); précédent : 000033; suivant : 000035The Joint Occurrence of Osteoporosis and Sarcopenia (Osteosarcopenia): Definitions and Characteristics.
Auteurs : Walter Sepúlveda-Loyola [Brésil] ; Steven Phu [Australie] ; Ebrahim Bani Hassan [Australie] ; Sharon L. Brennan-Olsen [Australie] ; Jesse Zanker [Australie] ; Sara Vogrin [Australie] ; Romy Conzade [Allemagne] ; Ben Kirk [Australie] ; Ahmed Al Saedi [Australie] ; Vanessa Probst [Brésil] ; Gustavo Duque [Australie]Source :
- Journal of the American Medical Directors Association [ 1538-9375 ] ; 2020.
Abstract
OBJECTIVES
We sought to examine the associations of osteosarcopenia with physical performance, balance, and falls and fractures in community-dwelling older adults. Additionally, we aimed to determine which clinical outcomes are associated with specific components of osteosarcopenia.
DESIGN
Cross-sectional study.
SETTING AND PARTICIPANTS
253 participants (77% women; aged 77.9 ± 0.42 years) who presented for a falls and fractures risk assessment in Melbourne, Australia.
METHODS
Participants were mobile, community-dwelling older adults (≥65 years) free of cognitive impairment. Body composition (via dual-energy x-ray absorptiometry), physical performance [via Timed Up and Go (TUG) and Short Physical Performance Battery (SPPB)], and balance [via Four-Square Step test (FSS) and posturography] were examined. Falls in the past year and fractures in the past 5 years were self-reported. Osteosarcopenia was defined as (1) low bone mineral density (BMD) [T score <-1 standard deviation (SD)] combined with sarcopenia and (2) osteoporosis (BMD T score ≤-2.5 SD) combined with severe sarcopenia. For sarcopenia, we employed the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP1), the revised criteria (EWGSOP2), and that of the Foundation for the National Institutes for Health (FNIH). Kruskal-Wallis and logistic regression tests were used for statistical analysis.
RESULTS
Osteosarcopenia was associated with worse SPPB, TUG, FSS, limit of stability, and falls and fractures history. Additionally, osteosarcopenia (using the severe sarcopenia classification) conferred an increased rate of falls [odds ratios (ORs) from 2.83 to 3.63; P < .05 for all] and fractures (ORs from 3.86 to 4.38; P < .05 for all) when employing the EWGSOP2 and FNIH definitions, respectively.
CONCLUSIONS AND IMPLICATIONS
Compared with the nonosteosarcopenic group, those with osteosarcopenia had greater impairment of physical performance and balance. The EWGSOP2 and FNIH criteria resulted in the strongest associations with physical performance and self-reported falls and fractures.
DOI: 10.1016/j.jamda.2019.09.005
PubMed: 31669290
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Joint Occurrence of Osteoporosis and Sarcopenia (Osteosarcopenia): Definitions and Characteristics.</title><author><name sortKey="Sepulveda Loyola, Walter" sort="Sepulveda Loyola, Walter" uniqKey="Sepulveda Loyola W" first="Walter" last="Sepúlveda-Loyola">Walter Sepúlveda-Loyola</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina</wicri:regionArea><wicri:noRegion>Londrina</wicri:noRegion></affiliation></author><author><name sortKey="Phu, Steven" sort="Phu, Steven" uniqKey="Phu S" first="Steven" last="Phu">Steven Phu</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Bani Hassan, Ebrahim" sort="Bani Hassan, Ebrahim" uniqKey="Bani Hassan E" first="Ebrahim" last="Bani Hassan">Ebrahim Bani Hassan</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Brennan Olsen, Sharon L" sort="Brennan Olsen, Sharon L" uniqKey="Brennan Olsen S" first="Sharon L" last="Brennan-Olsen">Sharon L. Brennan-Olsen</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Zanker, Jesse" sort="Zanker, Jesse" uniqKey="Zanker J" first="Jesse" last="Zanker">Jesse Zanker</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Vogrin, Sara" sort="Vogrin, Sara" uniqKey="Vogrin S" first="Sara" last="Vogrin">Sara Vogrin</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Conzade, Romy" sort="Conzade, Romy" uniqKey="Conzade R" first="Romy" last="Conzade">Romy Conzade</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Kirk, Ben" sort="Kirk, Ben" uniqKey="Kirk B" first="Ben" last="Kirk">Ben Kirk</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Al Saedi, Ahmed" sort="Al Saedi, Ahmed" uniqKey="Al Saedi A" first="Ahmed" last="Al Saedi">Ahmed Al Saedi</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Probst, Vanessa" sort="Probst, Vanessa" uniqKey="Probst V" first="Vanessa" last="Probst">Vanessa Probst</name><affiliation wicri:level="1"><nlm:affiliation>Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina</wicri:regionArea><wicri:noRegion>Londrina</wicri:noRegion></affiliation></author><author><name sortKey="Duque, Gustavo" sort="Duque, Gustavo" uniqKey="Duque G" first="Gustavo" last="Duque">Gustavo Duque</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia. Electronic address: gustavo.duque@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31669290</idno><idno type="pmid">31669290</idno><idno type="doi">10.1016/j.jamda.2019.09.005</idno><idno type="wicri:Area/Main/Corpus">000170</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000170</idno><idno type="wicri:Area/Main/Curation">000170</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000170</idno><idno type="wicri:Area/Main/Exploration">000170</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Joint Occurrence of Osteoporosis and Sarcopenia (Osteosarcopenia): Definitions and Characteristics.</title><author><name sortKey="Sepulveda Loyola, Walter" sort="Sepulveda Loyola, Walter" uniqKey="Sepulveda Loyola W" first="Walter" last="Sepúlveda-Loyola">Walter Sepúlveda-Loyola</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina</wicri:regionArea><wicri:noRegion>Londrina</wicri:noRegion></affiliation></author><author><name sortKey="Phu, Steven" sort="Phu, Steven" uniqKey="Phu S" first="Steven" last="Phu">Steven Phu</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Bani Hassan, Ebrahim" sort="Bani Hassan, Ebrahim" uniqKey="Bani Hassan E" first="Ebrahim" last="Bani Hassan">Ebrahim Bani Hassan</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Brennan Olsen, Sharon L" sort="Brennan Olsen, Sharon L" uniqKey="Brennan Olsen S" first="Sharon L" last="Brennan-Olsen">Sharon L. Brennan-Olsen</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Zanker, Jesse" sort="Zanker, Jesse" uniqKey="Zanker J" first="Jesse" last="Zanker">Jesse Zanker</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Vogrin, Sara" sort="Vogrin, Sara" uniqKey="Vogrin S" first="Sara" last="Vogrin">Sara Vogrin</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Conzade, Romy" sort="Conzade, Romy" uniqKey="Conzade R" first="Romy" last="Conzade">Romy Conzade</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Kirk, Ben" sort="Kirk, Ben" uniqKey="Kirk B" first="Ben" last="Kirk">Ben Kirk</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Al Saedi, Ahmed" sort="Al Saedi, Ahmed" uniqKey="Al Saedi A" first="Ahmed" last="Al Saedi">Ahmed Al Saedi</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Probst, Vanessa" sort="Probst, Vanessa" uniqKey="Probst V" first="Vanessa" last="Probst">Vanessa Probst</name><affiliation wicri:level="1"><nlm:affiliation>Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina</wicri:regionArea><wicri:noRegion>Londrina</wicri:noRegion></affiliation></author><author><name sortKey="Duque, Gustavo" sort="Duque, Gustavo" uniqKey="Duque G" first="Gustavo" last="Duque">Gustavo Duque</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia. Electronic address: gustavo.duque@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of the American Medical Directors Association</title><idno type="eISSN">1538-9375</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>We sought to examine the associations of osteosarcopenia with physical performance, balance, and falls and fractures in community-dwelling older adults. Additionally, we aimed to determine which clinical outcomes are associated with specific components of osteosarcopenia.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Cross-sectional study.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING AND PARTICIPANTS</b></p><p>253 participants (77% women; aged 77.9 ± 0.42 years) who presented for a falls and fractures risk assessment in Melbourne, Australia.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Participants were mobile, community-dwelling older adults (≥65 years) free of cognitive impairment. Body composition (via dual-energy x-ray absorptiometry), physical performance [via Timed Up and Go (TUG) and Short Physical Performance Battery (SPPB)], and balance [via Four-Square Step test (FSS) and posturography] were examined. Falls in the past year and fractures in the past 5 years were self-reported. Osteosarcopenia was defined as (1) low bone mineral density (BMD) [T score <-1 standard deviation (SD)] combined with sarcopenia and (2) osteoporosis (BMD T score ≤-2.5 SD) combined with severe sarcopenia. For sarcopenia, we employed the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP1), the revised criteria (EWGSOP2), and that of the Foundation for the National Institutes for Health (FNIH). Kruskal-Wallis and logistic regression tests were used for statistical analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Osteosarcopenia was associated with worse SPPB, TUG, FSS, limit of stability, and falls and fractures history. Additionally, osteosarcopenia (using the severe sarcopenia classification) conferred an increased rate of falls [odds ratios (ORs) from 2.83 to 3.63; P < .05 for all] and fractures (ORs from 3.86 to 4.38; P < .05 for all) when employing the EWGSOP2 and FNIH definitions, respectively.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS AND IMPLICATIONS</b></p><p>Compared with the nonosteosarcopenic group, those with osteosarcopenia had greater impairment of physical performance and balance. The EWGSOP2 and FNIH criteria resulted in the strongest associations with physical performance and self-reported falls and fractures.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31669290</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-9375</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>02</Month></PubDate></JournalIssue><Title>Journal of the American Medical Directors Association</Title><ISOAbbreviation>J Am Med Dir Assoc</ISOAbbreviation></Journal><ArticleTitle>The Joint Occurrence of Osteoporosis and Sarcopenia (Osteosarcopenia): Definitions and Characteristics.</ArticleTitle><Pagination><MedlinePgn>220-225</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1525-8610(19)30656-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jamda.2019.09.005</ELocationID><Abstract><AbstractText Label="OBJECTIVES">We sought to examine the associations of osteosarcopenia with physical performance, balance, and falls and fractures in community-dwelling older adults. Additionally, we aimed to determine which clinical outcomes are associated with specific components of osteosarcopenia.</AbstractText><AbstractText Label="DESIGN">Cross-sectional study.</AbstractText><AbstractText Label="SETTING AND PARTICIPANTS">253 participants (77% women; aged 77.9 ± 0.42 years) who presented for a falls and fractures risk assessment in Melbourne, Australia.</AbstractText><AbstractText Label="METHODS">Participants were mobile, community-dwelling older adults (≥65 years) free of cognitive impairment. Body composition (via dual-energy x-ray absorptiometry), physical performance [via Timed Up and Go (TUG) and Short Physical Performance Battery (SPPB)], and balance [via Four-Square Step test (FSS) and posturography] were examined. Falls in the past year and fractures in the past 5 years were self-reported. Osteosarcopenia was defined as (1) low bone mineral density (BMD) [T score <-1 standard deviation (SD)] combined with sarcopenia and (2) osteoporosis (BMD T score ≤-2.5 SD) combined with severe sarcopenia. For sarcopenia, we employed the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP1), the revised criteria (EWGSOP2), and that of the Foundation for the National Institutes for Health (FNIH). Kruskal-Wallis and logistic regression tests were used for statistical analysis.</AbstractText><AbstractText Label="RESULTS">Osteosarcopenia was associated with worse SPPB, TUG, FSS, limit of stability, and falls and fractures history. Additionally, osteosarcopenia (using the severe sarcopenia classification) conferred an increased rate of falls [odds ratios (ORs) from 2.83 to 3.63; P < .05 for all] and fractures (ORs from 3.86 to 4.38; P < .05 for all) when employing the EWGSOP2 and FNIH definitions, respectively.</AbstractText><AbstractText Label="CONCLUSIONS AND IMPLICATIONS">Compared with the nonosteosarcopenic group, those with osteosarcopenia had greater impairment of physical performance and balance. The EWGSOP2 and FNIH criteria resulted in the strongest associations with physical performance and self-reported falls and fractures.</AbstractText><CopyrightInformation>Copyright © 2019 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sepúlveda-Loyola</LastName><ForeName>Walter</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phu</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bani Hassan</LastName><ForeName>Ebrahim</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brennan-Olsen</LastName><ForeName>Sharon L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zanker</LastName><ForeName>Jesse</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vogrin</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conzade</LastName><ForeName>Romy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia; Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirk</LastName><ForeName>Ben</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al Saedi</LastName><ForeName>Ahmed</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Probst</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Masters and PhD Programme in Rehabilitation Sciences, Londrina State University (UEL) and University North of Paraná (UNOPAR), Londrina, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duque</LastName><ForeName>Gustavo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Victoria, Australia. Electronic address: gustavo.duque@unimelb.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Am Med Dir Assoc</MedlineTA><NlmUniqueID>100893243</NlmUniqueID><ISSNLinking>1525-8610</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Aging</Keyword><Keyword MajorTopicYN="Y">falls</Keyword><Keyword MajorTopicYN="Y">fracture</Keyword><Keyword MajorTopicYN="Y">osteoporosis</Keyword><Keyword MajorTopicYN="Y">osteosarcopenia</Keyword><Keyword MajorTopicYN="Y">physical performance</Keyword><Keyword MajorTopicYN="Y">sarcopenia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>06</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>09</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>09</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31669290</ArticleId><ArticleId IdType="pii">S1525-8610(19)30656-5</ArticleId><ArticleId IdType="doi">10.1016/j.jamda.2019.09.005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li></country></list><tree><country name="Brésil"><noRegion><name sortKey="Sepulveda Loyola, Walter" sort="Sepulveda Loyola, Walter" uniqKey="Sepulveda Loyola W" first="Walter" last="Sepúlveda-Loyola">Walter Sepúlveda-Loyola</name></noRegion><name sortKey="Probst, Vanessa" sort="Probst, Vanessa" uniqKey="Probst V" first="Vanessa" last="Probst">Vanessa Probst</name></country><country name="Australie"><noRegion><name sortKey="Phu, Steven" sort="Phu, Steven" uniqKey="Phu S" first="Steven" last="Phu">Steven Phu</name></noRegion><name sortKey="Al Saedi, Ahmed" sort="Al Saedi, Ahmed" uniqKey="Al Saedi A" first="Ahmed" last="Al Saedi">Ahmed Al Saedi</name><name sortKey="Bani Hassan, Ebrahim" sort="Bani Hassan, Ebrahim" uniqKey="Bani Hassan E" first="Ebrahim" last="Bani Hassan">Ebrahim Bani Hassan</name><name sortKey="Brennan Olsen, Sharon L" sort="Brennan Olsen, Sharon L" uniqKey="Brennan Olsen S" first="Sharon L" last="Brennan-Olsen">Sharon L. Brennan-Olsen</name><name sortKey="Duque, Gustavo" sort="Duque, Gustavo" uniqKey="Duque G" first="Gustavo" last="Duque">Gustavo Duque</name><name sortKey="Kirk, Ben" sort="Kirk, Ben" uniqKey="Kirk B" first="Ben" last="Kirk">Ben Kirk</name><name sortKey="Vogrin, Sara" sort="Vogrin, Sara" uniqKey="Vogrin S" first="Sara" last="Vogrin">Sara Vogrin</name><name sortKey="Zanker, Jesse" sort="Zanker, Jesse" uniqKey="Zanker J" first="Jesse" last="Zanker">Jesse Zanker</name></country><country name="Allemagne"><noRegion><name sortKey="Conzade, Romy" sort="Conzade, Romy" uniqKey="Conzade R" first="Romy" last="Conzade">Romy Conzade</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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