Postural imbalance and falls in PSP correlate with functional pathology of the thalamus.
Identifieur interne : 000C39 ( Main/Curation ); précédent : 000C38; suivant : 000C40Postural imbalance and falls in PSP correlate with functional pathology of the thalamus.
Auteurs : A. Zwergal [Allemagne] ; C. La Fougère ; S. Lorenzl ; A. Rominger ; G. Xiong ; L. Deutschenbaur ; J. Linn ; S. Krafczyk ; M. Dieterich ; T. Brandt ; M. Strupp ; P. Bartenstein ; K. JahnSource :
- Neurology [ 1526-632X ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Cartographie cérébrale (MeSH), Chutes accidentelles (MeSH), Femelle (MeSH), Fluorodésoxyglucose F18 (MeSH), Humains (MeSH), Imagerie par résonance magnétique (méthodes), Mâle (MeSH), Oeil (MeSH), Oxygène (sang), Paralysie supranucléaire progressive (anatomopathologie), Paralysie supranucléaire progressive (imagerie diagnostique), Paralysie supranucléaire progressive (physiopathologie), Repos (MeSH), Statistiques comme sujet (MeSH), Sujet âgé (MeSH), Thalamus (imagerie diagnostique), Thalamus (physiopathologie), Thalamus (vascularisation), Tomographie par émission de positons (méthodes), Traitement d'image par ordinateur (MeSH), Équilibre postural (physiologie), Évaluation de l'invalidité (MeSH).
- MESH :
- anatomopathologie : Paralysie supranucléaire progressive.
- imagerie diagnostique : Paralysie supranucléaire progressive, Thalamus.
- méthodes : Imagerie par résonance magnétique, Tomographie par émission de positons.
- physiologie : Équilibre postural.
- physiopathologie : Paralysie supranucléaire progressive, Thalamus.
- sang : Oxygène.
- vascularisation : Thalamus.
- Adulte d'âge moyen, Cartographie cérébrale, Chutes accidentelles, Femelle, Fluorodésoxyglucose F18, Humains, Mâle, Oeil, Repos, Statistiques comme sujet, Sujet âgé, Traitement d'image par ordinateur, Évaluation de l'invalidité.
English descriptors
- KwdEn :
- Accidental Falls (MeSH), Aged (MeSH), Brain Mapping (MeSH), Disability Evaluation (MeSH), Eye (MeSH), Female (MeSH), Fluorodeoxyglucose F18 (MeSH), Humans (MeSH), Image Processing, Computer-Assisted (MeSH), Magnetic Resonance Imaging (methods), Male (MeSH), Middle Aged (MeSH), Oxygen (blood), Positron-Emission Tomography (methods), Postural Balance (physiology), Rest (MeSH), Statistics as Topic (MeSH), Supranuclear Palsy, Progressive (diagnostic imaging), Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (physiopathology), Thalamus (blood supply), Thalamus (diagnostic imaging), Thalamus (physiopathology).
- MESH :
- chemical , blood : Oxygen.
- chemical : Fluorodeoxyglucose F18.
- blood supply : Thalamus.
- diagnostic imaging : Supranuclear Palsy, Progressive, Thalamus.
- methods : Magnetic Resonance Imaging, Positron-Emission Tomography.
- pathology : Supranuclear Palsy, Progressive.
- physiology : Postural Balance.
- physiopathology : Supranuclear Palsy, Progressive, Thalamus.
- Accidental Falls, Aged, Brain Mapping, Disability Evaluation, Eye, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Rest, Statistics as Topic.
Abstract
OBJECTIVE
To determine how postural imbalance and falls are related to regional cerebral glucose metabolism (PET) and functional activation of the cerebral postural network (fMRI) in patients with progressive supranuclear palsy (PSP).
METHODS
Sixteen patients with PSP, who had self-monitored their frequency of falls, underwent a standardized clinical assessment, posturographic measurement of balance during modified sensory input, and a resting [¹⁸F]FDG-PET. In addition, patients performed an fMRI paradigm using mental imagery of standing. Results were compared to healthy controls (n = 16).
RESULTS
The frequency of falls/month in patients (range 1-40) correlated with total PSP rating score (r = 0.90). Total sway path in PSP significantly correlated with frequency of falls, especially during modulated sensory input (eyes open: r = 0.62, eyes closed: r = 0.67, eyes open/head extended: r = 0.84, eyes open/foam-padded platform: r = 0.87). Higher sway path values and frequency of falls were associated with decreased regional glucose metabolism (rCGM) in the thalamus (sway path: r = -0.80, falls: r = -0.64) and increased rCGM in the precentral gyrus (sway path: r = 0.79, falls: r = 0.64). Mental imagery of standing during fMRI revealed a reduced activation of the mesencephalic brainstem tegmentum and the thalamus in patients with postural imbalance and falls.
CONCLUSIONS
The new and clinically relevant finding of this study is that imbalance and falls in PSP are closely associated with thalamic dysfunction. Deficits in thalamic postural control get most evident when balance is assessed during modified sensory input. The results are consistent with the hypothesis that reduced thalamic activation via the ascending brainstem projections may cause postural imbalance in PSP.
DOI: 10.1212/WNL.0b013e318223c79d
PubMed: 21613601
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Zwergal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and IFB, Ludwig-Maximilians-University of Munich, Munich, Germany. andreas.zwergal@med.uni-muenchen.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and IFB, Ludwig-Maximilians-University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="La Fougere, C" sort="La Fougere, C" uniqKey="La Fougere C" first="C" last="La Fougère">C. La Fougère</name></author><author><name sortKey="Lorenzl, S" sort="Lorenzl, S" uniqKey="Lorenzl S" first="S" last="Lorenzl">S. Lorenzl</name></author><author><name sortKey="Rominger, A" sort="Rominger, A" uniqKey="Rominger A" first="A" last="Rominger">A. Rominger</name></author><author><name sortKey="Xiong, G" sort="Xiong, G" uniqKey="Xiong G" first="G" last="Xiong">G. 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Jahn</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accidental Falls (MeSH)</term><term>Aged (MeSH)</term><term>Brain Mapping (MeSH)</term><term>Disability Evaluation (MeSH)</term><term>Eye (MeSH)</term><term>Female (MeSH)</term><term>Fluorodeoxyglucose F18 (MeSH)</term><term>Humans (MeSH)</term><term>Image Processing, Computer-Assisted (MeSH)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Oxygen (blood)</term><term>Positron-Emission Tomography (methods)</term><term>Postural Balance (physiology)</term><term>Rest (MeSH)</term><term>Statistics as Topic (MeSH)</term><term>Supranuclear Palsy, Progressive (diagnostic imaging)</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Thalamus (blood supply)</term><term>Thalamus (diagnostic imaging)</term><term>Thalamus (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Cartographie cérébrale (MeSH)</term><term>Chutes accidentelles (MeSH)</term><term>Femelle (MeSH)</term><term>Fluorodésoxyglucose F18 (MeSH)</term><term>Humains (MeSH)</term><term>Imagerie par résonance magnétique (méthodes)</term><term>Mâle (MeSH)</term><term>Oeil (MeSH)</term><term>Oxygène (sang)</term><term>Paralysie supranucléaire progressive (anatomopathologie)</term><term>Paralysie supranucléaire progressive (imagerie diagnostique)</term><term>Paralysie supranucléaire progressive (physiopathologie)</term><term>Repos (MeSH)</term><term>Statistiques comme sujet (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Thalamus (imagerie diagnostique)</term><term>Thalamus (physiopathologie)</term><term>Thalamus (vascularisation)</term><term>Tomographie par émission de positons (méthodes)</term><term>Traitement d'image par ordinateur (MeSH)</term><term>Équilibre postural (physiologie)</term><term>Évaluation de l'invalidité (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Paralysie supranucléaire progressive</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Supranuclear Palsy, Progressive</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Paralysie supranucléaire progressive</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Imagerie par résonance magnétique</term><term>Tomographie par émission de positons</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Équilibre postural</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Paralysie supranucléaire progressive</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Supranuclear Palsy, Progressive</term><term>Thalamus</term></keywords><keywords scheme="MESH" 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xml:lang="en"><p><b>OBJECTIVE</b></p><p>To determine how postural imbalance and falls are related to regional cerebral glucose metabolism (PET) and functional activation of the cerebral postural network (fMRI) in patients with progressive supranuclear palsy (PSP).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Sixteen patients with PSP, who had self-monitored their frequency of falls, underwent a standardized clinical assessment, posturographic measurement of balance during modified sensory input, and a resting [¹⁸F]FDG-PET. In addition, patients performed an fMRI paradigm using mental imagery of standing. Results were compared to healthy controls (n = 16).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The frequency of falls/month in patients (range 1-40) correlated with total PSP rating score (r = 0.90). Total sway path in PSP significantly correlated with frequency of falls, especially during modulated sensory input (eyes open: r = 0.62, eyes closed: r = 0.67, eyes open/head extended: r = 0.84, eyes open/foam-padded platform: r = 0.87). Higher sway path values and frequency of falls were associated with decreased regional glucose metabolism (rCGM) in the thalamus (sway path: r = -0.80, falls: r = -0.64) and increased rCGM in the precentral gyrus (sway path: r = 0.79, falls: r = 0.64). Mental imagery of standing during fMRI revealed a reduced activation of the mesencephalic brainstem tegmentum and the thalamus in patients with postural imbalance and falls.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The new and clinically relevant finding of this study is that imbalance and falls in PSP are closely associated with thalamic dysfunction. Deficits in thalamic postural control get most evident when balance is assessed during modified sensory input. The results are consistent with the hypothesis that reduced thalamic activation via the ascending brainstem projections may cause postural imbalance in PSP.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21613601</PMID><DateCompleted><Year>2011</Year><Month>09</Month><Day>09</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>77</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Jul</Month><Day>12</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Postural imbalance and falls in PSP correlate with functional pathology of the thalamus.</ArticleTitle><Pagination><MedlinePgn>101-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0b013e318223c79d</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine how postural imbalance and falls are related to regional cerebral glucose metabolism (PET) and functional activation of the cerebral postural network (fMRI) in patients with progressive supranuclear palsy (PSP).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Sixteen patients with PSP, who had self-monitored their frequency of falls, underwent a standardized clinical assessment, posturographic measurement of balance during modified sensory input, and a resting [¹⁸F]FDG-PET. In addition, patients performed an fMRI paradigm using mental imagery of standing. Results were compared to healthy controls (n = 16).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The frequency of falls/month in patients (range 1-40) correlated with total PSP rating score (r = 0.90). Total sway path in PSP significantly correlated with frequency of falls, especially during modulated sensory input (eyes open: r = 0.62, eyes closed: r = 0.67, eyes open/head extended: r = 0.84, eyes open/foam-padded platform: r = 0.87). Higher sway path values and frequency of falls were associated with decreased regional glucose metabolism (rCGM) in the thalamus (sway path: r = -0.80, falls: r = -0.64) and increased rCGM in the precentral gyrus (sway path: r = 0.79, falls: r = 0.64). Mental imagery of standing during fMRI revealed a reduced activation of the mesencephalic brainstem tegmentum and the thalamus in patients with postural imbalance and falls.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The new and clinically relevant finding of this study is that imbalance and falls in PSP are closely associated with thalamic dysfunction. Deficits in thalamic postural control get most evident when balance is assessed during modified sensory input. The results are consistent with the hypothesis that reduced thalamic activation via the ascending brainstem projections may cause postural imbalance in PSP.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zwergal</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology and IFB, Ludwig-Maximilians-University of Munich, Munich, Germany. andreas.zwergal@med.uni-muenchen.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>la Fougère</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Lorenzl</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rominger</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Deutschenbaur</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Linn</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Krafczyk</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Dieterich</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Brandt</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Strupp</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bartenstein</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Jahn</LastName><ForeName>K</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>05</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance></Chemical><Chemical><RegistryNumber>S88TT14065</RegistryNumber><NameOfSubstance UI="D010100">Oxygen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000058" MajorTopicYN="Y">Accidental Falls</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001931" MajorTopicYN="N">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004185" MajorTopicYN="N">Disability Evaluation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005123" MajorTopicYN="N">Eye</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019788" MajorTopicYN="N">Fluorodeoxyglucose F18</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010100" MajorTopicYN="N">Oxygen</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004856" MajorTopicYN="N">Postural Balance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012146" MajorTopicYN="N">Rest</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013223" MajorTopicYN="N">Statistics as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013494" MajorTopicYN="N">Supranuclear Palsy, Progressive</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013788" MajorTopicYN="N">Thalamus</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="N">blood supply</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21613601</ArticleId><ArticleId IdType="pii">WNL.0b013e318223c79d</ArticleId><ArticleId IdType="doi">10.1212/WNL.0b013e318223c79d</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Postural imbalance and falls in PSP correlate with functional pathology of the thalamus.
}}
Pour générer des pages wiki
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a PosturoV1
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