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Cluster analysis of auditory and vestibular test results in definite Menière's disease.

Identifieur interne : 000C13 ( Main/Corpus ); précédent : 000C12; suivant : 000C14

Cluster analysis of auditory and vestibular test results in definite Menière's disease.

Auteurs : Lourdes Montes-Jovellar ; Francisco Guillen-Grima ; Nicolas Perez-Fernandez

Source :

RBID : pubmed:21792974

English descriptors

Abstract

OBJECTIVES/HYPOTHESIS

To determine whether patients with Menière's disease can be grouped into distinct subtypes based on a cluster analysis of distinct disease parameters.

STUDY DESIGN

Prospective study at a tertiary center associated with a university hospital.

METHODS

The study included 153 patients diagnosed with unilateral definite Menière's disease. The main variables employed were taken from auditory, vestibular, posturographic, and disability assessments.

RESULTS

A four-cluster solution best fitted the data. Each cluster represented a distinct patient profile. Cluster 1 patients (13.1%) were the eldest, with the worst hearing bilaterally and good vestibular function but with a significant postural impact and a low level of disability. Cluster 2 patients (41.2%) were the least affected in all the parameters that were close to normal. Cluster 3 patients (34.6%) were the most affected, experiencing frequent and intense vertigo attacks, and they were visually dependent. Cluster 4 patients (11.1%) had strong asymmetric hearing between both ears and the most uncompensated vestibular deficit; they were moderately disabled.

CONCLUSIONS

We have identified four distinct profiles of patients with definite Menière's disease that we consider as "mildly active elderly," "mildly active young," "active compensated," and "active uncompensated." We have demonstrated that only in a restricted population of patients can the American Academy of Otolaryngology-Head and Neck Surgery staging system provide analysis of subtypes of the disease.


DOI: 10.1002/lary.21844
PubMed: 21792974

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pubmed:21792974

Le document en format XML

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<title xml:lang="en">Cluster analysis of auditory and vestibular test results in definite Menière's disease.</title>
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<name sortKey="Montes Jovellar, Lourdes" sort="Montes Jovellar, Lourdes" uniqKey="Montes Jovellar L" first="Lourdes" last="Montes-Jovellar">Lourdes Montes-Jovellar</name>
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<nlm:affiliation>Department of Otorhinolaryngology, Clínica Universidad de Navarra, University Hospital and Medical School, University of Navarra, Navarra, Spain.</nlm:affiliation>
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<name sortKey="Guillen Grima, Francisco" sort="Guillen Grima, Francisco" uniqKey="Guillen Grima F" first="Francisco" last="Guillen-Grima">Francisco Guillen-Grima</name>
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<name sortKey="Perez Fernandez, Nicolas" sort="Perez Fernandez, Nicolas" uniqKey="Perez Fernandez N" first="Nicolas" last="Perez-Fernandez">Nicolas Perez-Fernandez</name>
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<term>Audiometry (MeSH)</term>
<term>Cluster Analysis (MeSH)</term>
<term>Disability Evaluation (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hearing Loss (complications)</term>
<term>Hearing Loss (diagnosis)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Meniere Disease (classification)</term>
<term>Meniere Disease (diagnosis)</term>
<term>Meniere Disease (physiopathology)</term>
<term>Middle Aged (MeSH)</term>
<term>Postural Balance (MeSH)</term>
<term>Predictive Value of Tests (MeSH)</term>
<term>Sensitivity and Specificity (MeSH)</term>
<term>Vestibular Function Tests (MeSH)</term>
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<b>OBJECTIVES/HYPOTHESIS</b>
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<p>To determine whether patients with Menière's disease can be grouped into distinct subtypes based on a cluster analysis of distinct disease parameters.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>STUDY DESIGN</b>
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<p>Prospective study at a tertiary center associated with a university hospital.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
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<p>The study included 153 patients diagnosed with unilateral definite Menière's disease. The main variables employed were taken from auditory, vestibular, posturographic, and disability assessments.</p>
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<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>A four-cluster solution best fitted the data. Each cluster represented a distinct patient profile. Cluster 1 patients (13.1%) were the eldest, with the worst hearing bilaterally and good vestibular function but with a significant postural impact and a low level of disability. Cluster 2 patients (41.2%) were the least affected in all the parameters that were close to normal. Cluster 3 patients (34.6%) were the most affected, experiencing frequent and intense vertigo attacks, and they were visually dependent. Cluster 4 patients (11.1%) had strong asymmetric hearing between both ears and the most uncompensated vestibular deficit; they were moderately disabled.</p>
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