Predictors of vertigo in patients with untreated vestibular schwannoma.
Identifieur interne : 000867 ( Main/Corpus ); précédent : 000866; suivant : 000868Predictors of vertigo in patients with untreated vestibular schwannoma.
Auteurs : Jan Fredrik Andersen ; Kathrin Skorpa Nilsen ; Flemming Slinning Vassbotn ; Per M Ller ; Erling Myrseth ; Morten Lund-Johansen ; Frederik Kragerud GoplenSource :
- Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [ 1537-4505 ] ; 2015.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Caloric Tests (MeSH), Cohort Studies (MeSH), Dizziness (epidemiology), Dizziness (etiology), Ear, Inner (physiopathology), Female (MeSH), Hearing Tests (MeSH), Humans (MeSH), Magnetic Resonance Imaging (MeSH), Male (MeSH), Middle Aged (MeSH), Neuroma, Acoustic (complications), Neuroma, Acoustic (pathology), Neuroma, Acoustic (physiopathology), Prospective Studies (MeSH), Quality of Life (MeSH), Sensation Disorders (MeSH), Vertigo (epidemiology), Vertigo (etiology), Vertigo (physiopathology), Young Adult (MeSH).
- MESH :
- complications : Neuroma, Acoustic.
- epidemiology : Dizziness, Vertigo.
- etiology : Dizziness, Vertigo.
- pathology : Neuroma, Acoustic.
- physiopathology : Ear, Inner, Neuroma, Acoustic, Vertigo.
- Adolescent, Adult, Aged, Aged, 80 and over, Caloric Tests, Cohort Studies, Female, Hearing Tests, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Quality of Life, Sensation Disorders, Young Adult.
Abstract
OBJECTIVES
Previous studies have shown that vertigo is the most powerful negative predictor of quality of life in patients with vestibular schwannomas, but the variability in vertigo symptom severity is still poorly understood. We wanted to find out whether vertigo could be related to objective parameters such as tumor size, location, vestibular nerve function, hearing, and postural stability in patients with untreated vestibular schwannomas.
STUDY DESIGN
Baseline data from prospective cohort study.
SETTING
Tertiary referral center.
PATIENTS
Four hundred thirty-four consecutive patients with unilateral VS diagnosed on MRI. Mean age 56 years (range 16-84 yr). Fifty-three percent women.
INTERVENTION
Diagnostic, with a medical history, otolaryngological examination, pure-tone and speech audiometry, MRI, posturography, and videonystagmography with bithermal caloric tests.
MAIN OUTCOME MEASURE
Dizziness measured on a 100-mm visual analog scale (VAS). Secondary outcome measures were canal paresis and postural imbalance (static and dynamic posturography).
RESULTS
Three hundred three patients (70%) completed the VAS. Severe dizziness, defined as VAS 75 or greater, was reported by 9% of the patients. Larger tumors were associated with higher risk of postural instability and canal paresis. Moderate to severe dizziness was associated with postural imbalance and canal paresis, and possibly with small to medium-sized tumors. Postural instability was related to tumor size and canal paresis when measured by dynamic, but not with static, posturography.
CONCLUSION
A minority of VS patients experience severe vestibular symptoms related to canal paresis and postural instability. A curvilinear relationship is hypothesized between tumor size and dizziness.
DOI: 10.1097/MAO.0000000000000668
PubMed: 25415462
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pubmed:25415462Le document en format XML
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and ‡Department of Clinical Medicine, University of Bergen, N-5021 Bergen, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Nilsen, Kathrin Skorpa" sort="Nilsen, Kathrin Skorpa" uniqKey="Nilsen K" first="Kathrin Skorpa" last="Nilsen">Kathrin Skorpa Nilsen</name></author><author><name sortKey="Vassbotn, Flemming Slinning" sort="Vassbotn, Flemming Slinning" uniqKey="Vassbotn F" first="Flemming Slinning" last="Vassbotn">Flemming Slinning Vassbotn</name></author><author><name sortKey="M Ller, Per" sort="M Ller, Per" uniqKey="M Ller P" first="Per" last="M Ller">Per M Ller</name></author><author><name sortKey="Myrseth, Erling" sort="Myrseth, Erling" uniqKey="Myrseth E" first="Erling" last="Myrseth">Erling Myrseth</name></author><author><name sortKey="Lund Johansen, Morten" sort="Lund Johansen, Morten" uniqKey="Lund Johansen M" first="Morten" last="Lund-Johansen">Morten Lund-Johansen</name></author><author><name sortKey="Goplen, Frederik Kragerud" sort="Goplen, Frederik Kragerud" uniqKey="Goplen F" first="Frederik Kragerud" last="Goplen">Frederik Kragerud Goplen</name></author></analytic><series><title level="j">Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology</title><idno type="eISSN">1537-4505</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Caloric Tests (MeSH)</term><term>Cohort Studies (MeSH)</term><term>Dizziness (epidemiology)</term><term>Dizziness (etiology)</term><term>Ear, Inner (physiopathology)</term><term>Female (MeSH)</term><term>Hearing Tests (MeSH)</term><term>Humans (MeSH)</term><term>Magnetic Resonance Imaging (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neuroma, Acoustic (complications)</term><term>Neuroma, Acoustic (pathology)</term><term>Neuroma, Acoustic (physiopathology)</term><term>Prospective Studies (MeSH)</term><term>Quality of Life (MeSH)</term><term>Sensation Disorders (MeSH)</term><term>Vertigo (epidemiology)</term><term>Vertigo (etiology)</term><term>Vertigo (physiopathology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Neuroma, Acoustic</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dizziness</term><term>Vertigo</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dizziness</term><term>Vertigo</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neuroma, Acoustic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Ear, Inner</term><term>Neuroma, Acoustic</term><term>Vertigo</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Caloric Tests</term><term>Cohort Studies</term><term>Female</term><term>Hearing Tests</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Quality of Life</term><term>Sensation Disorders</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>Previous studies have shown that vertigo is the most powerful negative predictor of quality of life in patients with vestibular schwannomas, but the variability in vertigo symptom severity is still poorly understood. We wanted to find out whether vertigo could be related to objective parameters such as tumor size, location, vestibular nerve function, hearing, and postural stability in patients with untreated vestibular schwannomas.</p></div><div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b></p><p>Baseline data from prospective cohort study.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING</b></p><p>Tertiary referral center.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS</b></p><p>Four hundred thirty-four consecutive patients with unilateral VS diagnosed on MRI. Mean age 56 years (range 16-84 yr). Fifty-three percent women.</p></div><div type="abstract" xml:lang="en"><p><b>INTERVENTION</b></p><p>Diagnostic, with a medical history, otolaryngological examination, pure-tone and speech audiometry, MRI, posturography, and videonystagmography with bithermal caloric tests.</p></div><div type="abstract" xml:lang="en"><p><b>MAIN OUTCOME MEASURE</b></p><p>Dizziness measured on a 100-mm visual analog scale (VAS). Secondary outcome measures were canal paresis and postural imbalance (static and dynamic posturography).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Three hundred three patients (70%) completed the VAS. Severe dizziness, defined as VAS 75 or greater, was reported by 9% of the patients. Larger tumors were associated with higher risk of postural instability and canal paresis. Moderate to severe dizziness was associated with postural imbalance and canal paresis, and possibly with small to medium-sized tumors. Postural instability was related to tumor size and canal paresis when measured by dynamic, but not with static, posturography.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>A minority of VS patients experience severe vestibular symptoms related to canal paresis and postural instability. A curvilinear relationship is hypothesized between tumor size and dizziness.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">25415462</PMID><DateCompleted><Year>2015</Year><Month>09</Month><Day>16</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-4505</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology</Title><ISOAbbreviation>Otol Neurotol</ISOAbbreviation></Journal><ArticleTitle>Predictors of vertigo in patients with untreated vestibular schwannoma.</ArticleTitle><Pagination><MedlinePgn>647-52</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MAO.0000000000000668</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Previous studies have shown that vertigo is the most powerful negative predictor of quality of life in patients with vestibular schwannomas, but the variability in vertigo symptom severity is still poorly understood. We wanted to find out whether vertigo could be related to objective parameters such as tumor size, location, vestibular nerve function, hearing, and postural stability in patients with untreated vestibular schwannomas.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Baseline data from prospective cohort study.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Tertiary referral center.</AbstractText><AbstractText Label="PATIENTS" NlmCategory="METHODS">Four hundred thirty-four consecutive patients with unilateral VS diagnosed on MRI. Mean age 56 years (range 16-84 yr). Fifty-three percent women.</AbstractText><AbstractText Label="INTERVENTION" NlmCategory="METHODS">Diagnostic, with a medical history, otolaryngological examination, pure-tone and speech audiometry, MRI, posturography, and videonystagmography with bithermal caloric tests.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURE" NlmCategory="METHODS">Dizziness measured on a 100-mm visual analog scale (VAS). Secondary outcome measures were canal paresis and postural imbalance (static and dynamic posturography).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Three hundred three patients (70%) completed the VAS. Severe dizziness, defined as VAS 75 or greater, was reported by 9% of the patients. Larger tumors were associated with higher risk of postural instability and canal paresis. Moderate to severe dizziness was associated with postural imbalance and canal paresis, and possibly with small to medium-sized tumors. Postural instability was related to tumor size and canal paresis when measured by dynamic, but not with static, posturography.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">A minority of VS patients experience severe vestibular symptoms related to canal paresis and postural instability. A curvilinear relationship is hypothesized between tumor size and dizziness.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Andersen</LastName><ForeName>Jan Fredrik</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>*Departments of Otolaryngology Head and Neck Surgery and †Neurosurgery, Haukeland University Hospital, N-5021 Bergen, Norway; and ‡Department of Clinical Medicine, University of Bergen, N-5021 Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nilsen</LastName><ForeName>Kathrin Skorpa</ForeName><Initials>KS</Initials></Author><Author ValidYN="Y"><LastName>Vassbotn</LastName><ForeName>Flemming Slinning</ForeName><Initials>FS</Initials></Author><Author ValidYN="Y"><LastName>Møller</LastName><ForeName>Per</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Myrseth</LastName><ForeName>Erling</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lund-Johansen</LastName><ForeName>Morten</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Goplen</LastName><ForeName>Frederik Kragerud</ForeName><Initials>FK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Otol Neurotol</MedlineTA><NlmUniqueID>100961504</NlmUniqueID><ISSNLinking>1531-7129</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002150" MajorTopicYN="N">Caloric Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004244" MajorTopicYN="N">Dizziness</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007758" MajorTopicYN="N">Ear, Inner</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006320" MajorTopicYN="N">Hearing Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009464" MajorTopicYN="N">Neuroma, Acoustic</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012678" MajorTopicYN="N">Sensation Disorders</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014717" MajorTopicYN="N">Vertigo</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>11</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>11</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25415462</ArticleId><ArticleId IdType="doi">10.1097/MAO.0000000000000668</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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