Stance instability in preclinical SCA1 mutation carriers: A 4-year prospective posturography study.
Identifieur interne : 000528 ( Main/Corpus ); précédent : 000527; suivant : 000529Stance instability in preclinical SCA1 mutation carriers: A 4-year prospective posturography study.
Auteurs : Lorenzo Nanetti ; Dario Alpini ; Valentina Mattei ; Anna Castaldo ; Alessia Mongelli ; Greta Brenna ; Cinzia Gellera ; Caterina MariottiSource :
- Gait & posture [ 1879-2219 ] ; 2017.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Asymptomatic Diseases (MeSH), Ataxin-1 (genetics), Case-Control Studies (MeSH), Disease Progression (MeSH), Female (MeSH), Follow-Up Studies (MeSH), Genetic Markers (MeSH), Heterozygote (MeSH), Humans (MeSH), Male (MeSH), Mutation (MeSH), Postural Balance (physiology), Prospective Studies (MeSH), Spinocerebellar Ataxias (diagnosis), Spinocerebellar Ataxias (genetics), Spinocerebellar Ataxias (physiopathology), Young Adult (MeSH).
- MESH :
- chemical , genetics : Ataxin-1.
- diagnosis : Spinocerebellar Ataxias.
- genetics : Spinocerebellar Ataxias.
- physiology : Postural Balance.
- physiopathology : Spinocerebellar Ataxias.
- Adolescent, Adult, Asymptomatic Diseases, Case-Control Studies, Disease Progression, Female, Follow-Up Studies, Genetic Markers, Heterozygote, Humans, Male, Mutation, Prospective Studies, Young Adult.
Abstract
OBJECTIVE
We aimed to study postural balance in preclinical Spinocerebellar ataxia type 1 (SCA1) mutation carriers to identify and observe specific motor functional deficit before evident clinical manifestation.
METHODS
Participants were 9 asymptomatic SCA1 mutation carriers (6M/3F), aged 31.8±7years (range 22-44), and 17 age-matched non-carrier controls (5M/12F) (age 18-42). Subjects underwent postural tests on a force platform (Tetrax
RESULTS
In controls, ST was unchanged from baseline to 4-year evaluations in all standing conditions. SCA1 mutation carriers performed similarly to controls in the postural tasks with open eyes, whereas in conditions without visual feedback SCA1 carriers had significantly higher ST than controls at all longitudinal evaluations. Close-to-disease onset carriers (≤7years) showed more prominent time-dependent stance abnormalities (p<0.0001 for all comparisons).
CONCLUSIONS
Traceable and progressive postural abnormalities can be observed in preclinical close-to-onset SCA1 carriers. Quantitative analysis of stance could represent a promising outcome measure in clinical trials including preclinical subjects.
DOI: 10.1016/j.gaitpost.2017.05.007
PubMed: 28551466
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stance instability in preclinical SCA1 mutation carriers: A 4-year prospective posturography study.</title><author><name sortKey="Nanetti, Lorenzo" sort="Nanetti, Lorenzo" uniqKey="Nanetti L" first="Lorenzo" last="Nanetti">Lorenzo Nanetti</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: lorenzo.nanetti@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Alpini, Dario" sort="Alpini, Dario" uniqKey="Alpini D" first="Dario" last="Alpini">Dario Alpini</name><affiliation><nlm:affiliation>ENT-Otoneurology Service Fondazione don Carlo Gnocchi, Milan, Italy. Electronic address: dario.alpini@fastwebnet.it.</nlm:affiliation></affiliation></author><author><name sortKey="Mattei, Valentina" sort="Mattei, Valentina" uniqKey="Mattei V" first="Valentina" last="Mattei">Valentina Mattei</name><affiliation><nlm:affiliation>ENT-Otoneurology Service Fondazione don Carlo Gnocchi, Milan, Italy. Electronic address: mattei.v@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Castaldo, Anna" sort="Castaldo, Anna" uniqKey="Castaldo A" first="Anna" last="Castaldo">Anna Castaldo</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: anna.castaldo@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Mongelli, Alessia" sort="Mongelli, Alessia" uniqKey="Mongelli A" first="Alessia" last="Mongelli">Alessia Mongelli</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: alessia.mongelli@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Brenna, Greta" sort="Brenna, Greta" uniqKey="Brenna G" first="Greta" last="Brenna">Greta Brenna</name><affiliation><nlm:affiliation>Clinical Research Unit, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy. Electronic address: greta.brenna@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Gellera, Cinzia" sort="Gellera, Cinzia" uniqKey="Gellera C" first="Cinzia" last="Gellera">Cinzia Gellera</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: cinzia.gellera@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: caterina.mariotti@istituto-besta.it.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28551466</idno><idno type="pmid">28551466</idno><idno type="doi">10.1016/j.gaitpost.2017.05.007</idno><idno type="wicri:Area/Main/Corpus">000528</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000528</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Stance instability in preclinical SCA1 mutation carriers: A 4-year prospective posturography study.</title><author><name sortKey="Nanetti, Lorenzo" sort="Nanetti, Lorenzo" uniqKey="Nanetti L" first="Lorenzo" last="Nanetti">Lorenzo Nanetti</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: lorenzo.nanetti@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Alpini, Dario" sort="Alpini, Dario" uniqKey="Alpini D" first="Dario" last="Alpini">Dario Alpini</name><affiliation><nlm:affiliation>ENT-Otoneurology Service Fondazione don Carlo Gnocchi, Milan, Italy. Electronic address: dario.alpini@fastwebnet.it.</nlm:affiliation></affiliation></author><author><name sortKey="Mattei, Valentina" sort="Mattei, Valentina" uniqKey="Mattei V" first="Valentina" last="Mattei">Valentina Mattei</name><affiliation><nlm:affiliation>ENT-Otoneurology Service Fondazione don Carlo Gnocchi, Milan, Italy. Electronic address: mattei.v@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Castaldo, Anna" sort="Castaldo, Anna" uniqKey="Castaldo A" first="Anna" last="Castaldo">Anna Castaldo</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: anna.castaldo@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Mongelli, Alessia" sort="Mongelli, Alessia" uniqKey="Mongelli A" first="Alessia" last="Mongelli">Alessia Mongelli</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: alessia.mongelli@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Brenna, Greta" sort="Brenna, Greta" uniqKey="Brenna G" first="Greta" last="Brenna">Greta Brenna</name><affiliation><nlm:affiliation>Clinical Research Unit, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy. Electronic address: greta.brenna@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Gellera, Cinzia" sort="Gellera, Cinzia" uniqKey="Gellera C" first="Cinzia" last="Gellera">Cinzia Gellera</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: cinzia.gellera@istituto-besta.it.</nlm:affiliation></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation><nlm:affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: caterina.mariotti@istituto-besta.it.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Gait & posture</title><idno type="eISSN">1879-2219</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Asymptomatic Diseases (MeSH)</term><term>Ataxin-1 (genetics)</term><term>Case-Control Studies (MeSH)</term><term>Disease Progression (MeSH)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Genetic Markers (MeSH)</term><term>Heterozygote (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Mutation (MeSH)</term><term>Postural Balance (physiology)</term><term>Prospective Studies (MeSH)</term><term>Spinocerebellar Ataxias (diagnosis)</term><term>Spinocerebellar Ataxias (genetics)</term><term>Spinocerebellar Ataxias (physiopathology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ataxin-1</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Asymptomatic Diseases</term><term>Case-Control Studies</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Genetic Markers</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Mutation</term><term>Prospective Studies</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>We aimed to study postural balance in preclinical Spinocerebellar ataxia type 1 (SCA1) mutation carriers to identify and observe specific motor functional deficit before evident clinical manifestation.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Participants were 9 asymptomatic SCA1 mutation carriers (6M/3F), aged 31.8±7years (range 22-44), and 17 age-matched non-carrier controls (5M/12F) (age 18-42). Subjects underwent postural tests on a force platform (Tetrax</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In controls, ST was unchanged from baseline to 4-year evaluations in all standing conditions. SCA1 mutation carriers performed similarly to controls in the postural tasks with open eyes, whereas in conditions without visual feedback SCA1 carriers had significantly higher ST than controls at all longitudinal evaluations. Close-to-disease onset carriers (≤7years) showed more prominent time-dependent stance abnormalities (p<0.0001 for all comparisons).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Traceable and progressive postural abnormalities can be observed in preclinical close-to-onset SCA1 carriers. Quantitative analysis of stance could represent a promising outcome measure in clinical trials including preclinical subjects.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">28551466</PMID><DateCompleted><Year>2018</Year><Month>03</Month><Day>21</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-2219</ISSN><JournalIssue CitedMedium="Internet"><Volume>57</Volume><PubDate><Year>2017</Year><Month>09</Month></PubDate></JournalIssue><Title>Gait & posture</Title><ISOAbbreviation>Gait Posture</ISOAbbreviation></Journal><ArticleTitle>Stance instability in preclinical SCA1 mutation carriers: A 4-year prospective posturography study.</ArticleTitle><Pagination><MedlinePgn>11-14</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0966-6362(17)30190-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.gaitpost.2017.05.007</ELocationID><Abstract><AbstractText Label="OBJECTIVE">We aimed to study postural balance in preclinical Spinocerebellar ataxia type 1 (SCA1) mutation carriers to identify and observe specific motor functional deficit before evident clinical manifestation.</AbstractText><AbstractText Label="METHODS">Participants were 9 asymptomatic SCA1 mutation carriers (6M/3F), aged 31.8±7years (range 22-44), and 17 age-matched non-carrier controls (5M/12F) (age 18-42). Subjects underwent postural tests on a force platform (Tetrax<sup>®</sup>-IBS, Sunlight Medical Ltd.) with and without visual feedback. Amount of body sway was represented by stability index (ST). Tests were repeated after 2- and 4-years. Estimated years to onset were calculated.</AbstractText><AbstractText Label="RESULTS">In controls, ST was unchanged from baseline to 4-year evaluations in all standing conditions. SCA1 mutation carriers performed similarly to controls in the postural tasks with open eyes, whereas in conditions without visual feedback SCA1 carriers had significantly higher ST than controls at all longitudinal evaluations. Close-to-disease onset carriers (≤7years) showed more prominent time-dependent stance abnormalities (p<0.0001 for all comparisons).</AbstractText><AbstractText Label="CONCLUSIONS">Traceable and progressive postural abnormalities can be observed in preclinical close-to-onset SCA1 carriers. Quantitative analysis of stance could represent a promising outcome measure in clinical trials including preclinical subjects.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nanetti</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: lorenzo.nanetti@istituto-besta.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alpini</LastName><ForeName>Dario</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>ENT-Otoneurology Service Fondazione don Carlo Gnocchi, Milan, Italy. Electronic address: dario.alpini@fastwebnet.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mattei</LastName><ForeName>Valentina</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>ENT-Otoneurology Service Fondazione don Carlo Gnocchi, Milan, Italy. Electronic address: mattei.v@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castaldo</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: anna.castaldo@istituto-besta.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mongelli</LastName><ForeName>Alessia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: alessia.mongelli@istituto-besta.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brenna</LastName><ForeName>Greta</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy. Electronic address: greta.brenna@istituto-besta.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gellera</LastName><ForeName>Cinzia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: cinzia.gellera@istituto-besta.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mariotti</LastName><ForeName>Caterina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan Italy. Electronic address: caterina.mariotti@istituto-besta.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Gait Posture</MedlineTA><NlmUniqueID>9416830</NlmUniqueID><ISSNLinking>0966-6362</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000593749">ATXN1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000067696">Ataxin-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005819">Genetic Markers</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058070" MajorTopicYN="N">Asymptomatic Diseases</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000067696" MajorTopicYN="N">Ataxin-1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005819" MajorTopicYN="N">Genetic Markers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006579" MajorTopicYN="N">Heterozygote</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004856" MajorTopicYN="N">Postural Balance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020754" MajorTopicYN="N">Spinocerebellar Ataxias</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Gait disorders</Keyword><Keyword MajorTopicYN="Y">Hereditary ataxia</Keyword><Keyword MajorTopicYN="Y">Preclinical gene mutation carriers</Keyword><Keyword MajorTopicYN="Y">Spinocerebellar ataxia</Keyword><Keyword MajorTopicYN="Y">Trinucleotide repeat diseases</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>05</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>3</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28551466</ArticleId><ArticleId IdType="pii">S0966-6362(17)30190-X</ArticleId><ArticleId IdType="doi">10.1016/j.gaitpost.2017.05.007</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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