Cerebellar rTMS for motor control in progressive supranuclear palsy.
Identifieur interne : 000200 ( Main/Corpus ); précédent : 000199; suivant : 000201Cerebellar rTMS for motor control in progressive supranuclear palsy.
Auteurs : M L Dale ; W H Devries ; M. Mancini ; M S GeorgeSource :
- Brain stimulation [ 1876-4754 ]
English descriptors
- KwdEn :
- Cerebellum (physiology), Evoked Potentials, Motor (physiology), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pilot Projects (MeSH), Postural Balance (physiology), Speech (physiology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (physiopathology), Supranuclear Palsy, Progressive (therapy), Transcranial Magnetic Stimulation (methods).
- MESH :
- diagnosis : Supranuclear Palsy, Progressive.
- methods : Transcranial Magnetic Stimulation.
- physiology : Cerebellum, Evoked Potentials, Motor, Postural Balance, Speech.
- physiopathology : Supranuclear Palsy, Progressive.
- therapy : Supranuclear Palsy, Progressive.
- Female, Humans, Male, Middle Aged, Pilot Projects.
Abstract
BACKGROUND
Stimulatory cerebellar TMS is a promising tool to improve motor control in neurodegenerative disorders.
OBJECTIVE/HYPOTHESIS
Our goal was to use 10Hz cerebellar rTMS to augment cerebellar-brain inhibition (CBI) for improved postural stability and speech in patients with progressive supranuclear palsy (PSP).
METHODS
We performed CBI assessments with neuronavigation before and after high frequency cerebellar rTMS or sham TMS in two patients with PSP, using a double cone coil for the conditioning pulse and a figure-of-eight coil for the test pulse and treatments. We collected posturography data and speech samples before and after treatment.
RESULTS
After treatment, CBI increased by 50% in subject 1 and by 32% in subject 2, and postural stability and speech improved. The protocol was well tolerated, but the sham was not consistently believable.
CONCLUSION
Cerebellar rTMS may improve postural stability and speech in PSP, but cooled coils with vibrotactile sham capability are needed for larger future studies.
DOI: 10.1016/j.brs.2019.07.017
PubMed: 31378601
Links to Exploration step
pubmed:31378601Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebellar rTMS for motor control in progressive supranuclear palsy.</title>
<author><name sortKey="Dale, M L" sort="Dale, M L" uniqKey="Dale M" first="M L" last="Dale">M L Dale</name>
<affiliation><nlm:affiliation>Murray Center for Research on Parkinson's & Related Disorders, Department of Neurology, Medical University of South Carolina, Charleston, SC, USA. Electronic address: dalem@ohsu.edu.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Devries, W H" sort="Devries, W H" uniqKey="Devries W" first="W H" last="Devries">W H Devries</name>
<affiliation><nlm:affiliation>Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mancini, M" sort="Mancini, M" uniqKey="Mancini M" first="M" last="Mancini">M. Mancini</name>
<affiliation><nlm:affiliation>Balance Disorders Laboratory, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.</nlm:affiliation>
</affiliation>
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<author><name sortKey="George, M S" sort="George, M S" uniqKey="George M" first="M S" last="George">M S George</name>
<affiliation><nlm:affiliation>Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Cerebellar rTMS for motor control in progressive supranuclear palsy.</title>
<author><name sortKey="Dale, M L" sort="Dale, M L" uniqKey="Dale M" first="M L" last="Dale">M L Dale</name>
<affiliation><nlm:affiliation>Murray Center for Research on Parkinson's & Related Disorders, Department of Neurology, Medical University of South Carolina, Charleston, SC, USA. Electronic address: dalem@ohsu.edu.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Devries, W H" sort="Devries, W H" uniqKey="Devries W" first="W H" last="Devries">W H Devries</name>
<affiliation><nlm:affiliation>Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mancini, M" sort="Mancini, M" uniqKey="Mancini M" first="M" last="Mancini">M. Mancini</name>
<affiliation><nlm:affiliation>Balance Disorders Laboratory, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="George, M S" sort="George, M S" uniqKey="George M" first="M S" last="George">M S George</name>
<affiliation><nlm:affiliation>Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.</nlm:affiliation>
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<series><title level="j">Brain stimulation</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellum (physiology)</term>
<term>Evoked Potentials, Motor (physiology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pilot Projects (MeSH)</term>
<term>Postural Balance (physiology)</term>
<term>Speech (physiology)</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
<term>Supranuclear Palsy, Progressive (physiopathology)</term>
<term>Supranuclear Palsy, Progressive (therapy)</term>
<term>Transcranial Magnetic Stimulation (methods)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Transcranial Magnetic Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebellum</term>
<term>Evoked Potentials, Motor</term>
<term>Postural Balance</term>
<term>Speech</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pilot Projects</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Stimulatory cerebellar TMS is a promising tool to improve motor control in neurodegenerative disorders.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVE/HYPOTHESIS</b>
</p>
<p>Our goal was to use 10Hz cerebellar rTMS to augment cerebellar-brain inhibition (CBI) for improved postural stability and speech in patients with progressive supranuclear palsy (PSP).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We performed CBI assessments with neuronavigation before and after high frequency cerebellar rTMS or sham TMS in two patients with PSP, using a double cone coil for the conditioning pulse and a figure-of-eight coil for the test pulse and treatments. We collected posturography data and speech samples before and after treatment.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>After treatment, CBI increased by 50% in subject 1 and by 32% in subject 2, and postural stability and speech improved. The protocol was well tolerated, but the sham was not consistently believable.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Cerebellar rTMS may improve postural stability and speech in PSP, but cooled coils with vibrotactile sham capability are needed for larger future studies.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>02</Month>
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<Title>Brain stimulation</Title>
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<ArticleTitle>Cerebellar rTMS for motor control in progressive supranuclear palsy.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND">Stimulatory cerebellar TMS is a promising tool to improve motor control in neurodegenerative disorders.</AbstractText>
<AbstractText Label="OBJECTIVE/HYPOTHESIS">Our goal was to use 10Hz cerebellar rTMS to augment cerebellar-brain inhibition (CBI) for improved postural stability and speech in patients with progressive supranuclear palsy (PSP).</AbstractText>
<AbstractText Label="METHODS">We performed CBI assessments with neuronavigation before and after high frequency cerebellar rTMS or sham TMS in two patients with PSP, using a double cone coil for the conditioning pulse and a figure-of-eight coil for the test pulse and treatments. We collected posturography data and speech samples before and after treatment.</AbstractText>
<AbstractText Label="RESULTS">After treatment, CBI increased by 50% in subject 1 and by 32% in subject 2, and postural stability and speech improved. The protocol was well tolerated, but the sham was not consistently believable.</AbstractText>
<AbstractText Label="CONCLUSION">Cerebellar rTMS may improve postural stability and speech in PSP, but cooled coils with vibrotactile sham capability are needed for larger future studies.</AbstractText>
<CopyrightInformation>Published by Elsevier Inc.</CopyrightInformation>
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<MeshHeading><DescriptorName UI="D013494" MajorTopicYN="N">Supranuclear Palsy, Progressive</DescriptorName>
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