Balance Impairments in Patients with Human T-Cell Lymphotropic Virus Type 1 Infection.
Identifieur interne : 000198 ( Main/Corpus ); précédent : 000197; suivant : 000199Balance Impairments in Patients with Human T-Cell Lymphotropic Virus Type 1 Infection.
Auteurs : Beatriz Helena B. Vasconcelos ; Bianca Callegari ; Kelly Helorany A. Costa ; Tatiana G C P. Barroso ; Rita Catarina M. Sousa ; Ghislain Saunier ; Marília B. Xavier ; Givago S. SouzaSource :
- Scientific reports [ 2045-2322 ] ; 2019.
English descriptors
- KwdEn :
- Adult (MeSH), Asymptomatic Infections (MeSH), Case-Control Studies (MeSH), Female (MeSH), HTLV-I Infections (complications), HTLV-I Infections (diagnosis), HTLV-I Infections (physiopathology), HTLV-I Infections (virology), Healthy Volunteers (MeSH), Human T-lymphotropic virus 1 (isolation & purification), Human T-lymphotropic virus 1 (pathogenicity), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Paraparesis, Tropical Spastic (diagnosis), Paraparesis, Tropical Spastic (physiopathology), Paraparesis, Tropical Spastic (virology), Postural Balance (physiology).
- MESH :
- complications : HTLV-I Infections.
- diagnosis : HTLV-I Infections, Paraparesis, Tropical Spastic.
- isolation & purification : Human T-lymphotropic virus 1.
- pathogenicity : Human T-lymphotropic virus 1.
- physiology : Postural Balance.
- physiopathology : HTLV-I Infections, Paraparesis, Tropical Spastic.
- virology : HTLV-I Infections, Paraparesis, Tropical Spastic.
- Adult, Asymptomatic Infections, Case-Control Studies, Female, Healthy Volunteers, Humans, Male, Middle Aged.
Abstract
The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus from the Retroviridae family that infects cluster of differentiation 4 (CD4) T-lymphocytes and stimulates their proliferation. A severe consequence of this infection can be the HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is associated with a progressive demyelinating disease of the upper motor neurons. The HAM/TSP conditions frequently present with neurological complaints such as gait impairment, sphincter disturbances, and several sensory losses. We compared findings from the posturographic evaluation from the asymptomatic HTLV-1 infected subjects, HTLV-1 infected subjects having HAM/TSP, and control group database. A force plate was used to record the postural oscillations. Analysis of variance and multivariate linear discriminant analysis were used to compare the data obtained from the three groups of participants. In general, HAM/TSP patients had worse postural balance control than did the HTLV-1 patients and the controls (p < 0.05). We found that in six out of ten parameters of the postural balance control, there was a gradual increase in impairment from control to HTLV-1 to HAM/TSP groups. All parameters had higher values with the subject's eyes closed. The multivariate linear discriminant analysis showed there was a reasonable difference in results between the control and HAM/TSP groups, and the HTLV-1 group was at the intersecting area between them. We found that HAM/TSP patients had worse balance control than did HTLV-1 infected patients and the control group, but asymptomatic HTLV-1 infected patients represent an intermediate balance control status between controls and HAM/TSP patients. Posturographic parameters can be relied on to identify subtle changes in the balance of HTLV-1 patients and to monitor their functional loss. HTLV-1 is a tropical disease that can be transmitted by sexual intercourse, blood transfusion, and breast-feeding. Some infected subjects develop an HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a condition characterized by spasticity, weakness in lower limbs, and difficulty in walking long distances and going up and down the stairs, besides the history of falls. We compared the body oscillations using a force plate to investigate the postural balance control. HTLV-1 infected patients had imbalance that could be identified by posturographic parameters. Patients with HAM/TSP clearly had balance impairments, while HTLV-1 without HAM/TSP had a subtle impairment that was not seen on clinical scales, suggesting that these patients were in the middle between healthy and HAM/TSP patients, and carried a risk of developing severe imbalance postural control. We suggest that more research should be done with the aim to identify the subtle signs in asymptomatic HTLV-1 patients to investigate if this group of patients need attention similar to the HAM/TSP patients.
DOI: 10.1038/s41598-019-47920-z
PubMed: 31391511
PubMed Central: PMC6685957
Links to Exploration step
pubmed:31391511Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Asymptomatic Infections (MeSH)</term>
<term>Case-Control Studies (MeSH)</term>
<term>Female (MeSH)</term>
<term>HTLV-I Infections (complications)</term>
<term>HTLV-I Infections (diagnosis)</term>
<term>HTLV-I Infections (physiopathology)</term>
<term>HTLV-I Infections (virology)</term>
<term>Healthy Volunteers (MeSH)</term>
<term>Human T-lymphotropic virus 1 (isolation & purification)</term>
<term>Human T-lymphotropic virus 1 (pathogenicity)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Paraparesis, Tropical Spastic (diagnosis)</term>
<term>Paraparesis, Tropical Spastic (physiopathology)</term>
<term>Paraparesis, Tropical Spastic (virology)</term>
<term>Postural Balance (physiology)</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>HTLV-I Infections</term>
<term>Paraparesis, Tropical Spastic</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Human T-lymphotropic virus 1</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Human T-lymphotropic virus 1</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>HTLV-I Infections</term>
<term>Paraparesis, Tropical Spastic</term>
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<term>Paraparesis, Tropical Spastic</term>
</keywords>
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<term>Asymptomatic Infections</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Healthy Volunteers</term>
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<front><div type="abstract" xml:lang="en">The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus from the Retroviridae family that infects cluster of differentiation 4 (CD4) T-lymphocytes and stimulates their proliferation. A severe consequence of this infection can be the HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is associated with a progressive demyelinating disease of the upper motor neurons. The HAM/TSP conditions frequently present with neurological complaints such as gait impairment, sphincter disturbances, and several sensory losses. We compared findings from the posturographic evaluation from the asymptomatic HTLV-1 infected subjects, HTLV-1 infected subjects having HAM/TSP, and control group database. A force plate was used to record the postural oscillations. Analysis of variance and multivariate linear discriminant analysis were used to compare the data obtained from the three groups of participants. In general, HAM/TSP patients had worse postural balance control than did the HTLV-1 patients and the controls (p < 0.05). We found that in six out of ten parameters of the postural balance control, there was a gradual increase in impairment from control to HTLV-1 to HAM/TSP groups. All parameters had higher values with the subject's eyes closed. The multivariate linear discriminant analysis showed there was a reasonable difference in results between the control and HAM/TSP groups, and the HTLV-1 group was at the intersecting area between them. We found that HAM/TSP patients had worse balance control than did HTLV-1 infected patients and the control group, but asymptomatic HTLV-1 infected patients represent an intermediate balance control status between controls and HAM/TSP patients. Posturographic parameters can be relied on to identify subtle changes in the balance of HTLV-1 patients and to monitor their functional loss. HTLV-1 is a tropical disease that can be transmitted by sexual intercourse, blood transfusion, and breast-feeding. Some infected subjects develop an HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a condition characterized by spasticity, weakness in lower limbs, and difficulty in walking long distances and going up and down the stairs, besides the history of falls. We compared the body oscillations using a force plate to investigate the postural balance control. HTLV-1 infected patients had imbalance that could be identified by posturographic parameters. Patients with HAM/TSP clearly had balance impairments, while HTLV-1 without HAM/TSP had a subtle impairment that was not seen on clinical scales, suggesting that these patients were in the middle between healthy and HAM/TSP patients, and carried a risk of developing severe imbalance postural control. We suggest that more research should be done with the aim to identify the subtle signs in asymptomatic HTLV-1 patients to investigate if this group of patients need attention similar to the HAM/TSP patients.</div>
</front>
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<Abstract><AbstractText>The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus from the Retroviridae family that infects cluster of differentiation 4 (CD4) T-lymphocytes and stimulates their proliferation. A severe consequence of this infection can be the HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is associated with a progressive demyelinating disease of the upper motor neurons. The HAM/TSP conditions frequently present with neurological complaints such as gait impairment, sphincter disturbances, and several sensory losses. We compared findings from the posturographic evaluation from the asymptomatic HTLV-1 infected subjects, HTLV-1 infected subjects having HAM/TSP, and control group database. A force plate was used to record the postural oscillations. Analysis of variance and multivariate linear discriminant analysis were used to compare the data obtained from the three groups of participants. In general, HAM/TSP patients had worse postural balance control than did the HTLV-1 patients and the controls (p < 0.05). We found that in six out of ten parameters of the postural balance control, there was a gradual increase in impairment from control to HTLV-1 to HAM/TSP groups. All parameters had higher values with the subject's eyes closed. The multivariate linear discriminant analysis showed there was a reasonable difference in results between the control and HAM/TSP groups, and the HTLV-1 group was at the intersecting area between them. We found that HAM/TSP patients had worse balance control than did HTLV-1 infected patients and the control group, but asymptomatic HTLV-1 infected patients represent an intermediate balance control status between controls and HAM/TSP patients. Posturographic parameters can be relied on to identify subtle changes in the balance of HTLV-1 patients and to monitor their functional loss. HTLV-1 is a tropical disease that can be transmitted by sexual intercourse, blood transfusion, and breast-feeding. Some infected subjects develop an HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a condition characterized by spasticity, weakness in lower limbs, and difficulty in walking long distances and going up and down the stairs, besides the history of falls. We compared the body oscillations using a force plate to investigate the postural balance control. HTLV-1 infected patients had imbalance that could be identified by posturographic parameters. Patients with HAM/TSP clearly had balance impairments, while HTLV-1 without HAM/TSP had a subtle impairment that was not seen on clinical scales, suggesting that these patients were in the middle between healthy and HAM/TSP patients, and carried a risk of developing severe imbalance postural control. We suggest that more research should be done with the aim to identify the subtle signs in asymptomatic HTLV-1 patients to investigate if this group of patients need attention similar to the HAM/TSP patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vasconcelos</LastName>
<ForeName>Beatriz Helena B</ForeName>
<Initials>BHB</Initials>
<AffiliationInfo><Affiliation>Laboratory of Human Motricity, Federal University of Pará, Belém, Pará, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Tropical Medicine Nucleus, Federal University of Pará, Belém, Pará, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Callegari</LastName>
<ForeName>Bianca</ForeName>
<Initials>B</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-9151-3896</Identifier>
<AffiliationInfo><Affiliation>Laboratory of Human Motricity, Federal University of Pará, Belém, Pará, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Costa</LastName>
<ForeName>Kelly Helorany A</ForeName>
<Initials>KHA</Initials>
<AffiliationInfo><Affiliation>Laboratory of Human Motricity, Federal University of Pará, Belém, Pará, Brazil.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Barroso</LastName>
<ForeName>Tatiana G C P</ForeName>
<Initials>TGCP</Initials>
<AffiliationInfo><Affiliation>Tropical Medicine Nucleus, Federal University of Pará, Belém, Pará, Brazil.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Sousa</LastName>
<ForeName>Rita Catarina M</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Saunier</LastName>
<ForeName>Ghislain</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Laboratory of Motor Cognition, Federal University of Pará, Belém, Pará, Brazil.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Xavier</LastName>
<ForeName>Marília B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>Tropical Medicine Nucleus, Federal University of Pará, Belém, Pará, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Souza</LastName>
<ForeName>Givago S</ForeName>
<Initials>GS</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4525-3971</Identifier>
<AffiliationInfo><Affiliation>Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil. givagosouza@ufpa.br.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Tropical Medicine Nucleus, Federal University of Pará, Belém, Pará, Brazil. givagosouza@ufpa.br.</Affiliation>
</AffiliationInfo>
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