Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease.
Identifieur interne : 000153 ( Main/Corpus ); précédent : 000152; suivant : 000154Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease.
Auteurs : Luca Valerio Messa ; Federica Ginanneschi ; Davide Momi ; Lucia Monti ; Carla Battisti ; David Cioncoloni ; Barbara Pucci ; Emiliano Santarnecchi ; Alessandro RossiSource :
- Frontiers in human neuroscience [ 1662-5161 ] ; 2019.
Abstract
For the management of Parkinson's disease (PD), the concept of forced exercise (FE) has drawn interest. In PD subjects, the FE executed with lower limbs has been shown to lessen symptoms and to promote brain adaptive changes. Our study is aimed to investigate the effect of an upper-limb exercise, conceptually comparable with the FE, in PD. Upper-limb exercise was achieved in a sitting position by using a specially designed device (Angel's Wings®). Clinical data, computerized dynamic posturography, magnetic resonance imaging (MRI) (resting-state MRI and arterial spin labeling), and neuropsychological tests were used before and after 2 months' exercise training. We found a significant long-lasting improvement in Unified Parkinson Disease Rating Scale (UPDRS)-III and cognitive scales, along with improvement in balance and postural control (better alignment of the gravity center and improvement in weight symmetry and in anticipatory motor strategies). Computerized dynamic posturography pointed out an enhanced central ability to integrate the vestibular signals with afferents from other sensory systems. Neuroimaging analyses after 2 months' exercise training showed, with respect to pretraining condition, many changes. An increase of the cerebral blood flow was evident in the left primary motor cortex (M1), left supplementary motor cortical area, and left cerebellar cortex. The bilateral globus pallidus showed an increased functional connectivity to the right central operculum, right posterior cingulate gyrus, and left sensorimotor cortex. Seed-to-voxel analysis demonstrated a functional connectivity between M1 and the left superior frontal gyrus. Left crus II showed strengthened connections with the left pre-rolandic area, left post-rolandic area, and left supramarginal area. These findings likely reflect compensatory mechanisms to the neuropathological hallmark of PD. Overall, our results show that this upper-limb exercise model, conceptually comparable with the FE already tested in the lower limbs, leads to a global improvement (involving non-exercised limbs) likely consistent with the functional changes observed in the central nervous system.
DOI: 10.3389/fnhum.2019.00350
PubMed: 31749690
PubMed Central: PMC6843060
Links to Exploration step
pubmed:31749690Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease.</title>
<author><name sortKey="Messa, Luca Valerio" sort="Messa, Luca Valerio" uniqKey="Messa L" first="Luca Valerio" last="Messa">Luca Valerio Messa</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ginanneschi, Federica" sort="Ginanneschi, Federica" uniqKey="Ginanneschi F" first="Federica" last="Ginanneschi">Federica Ginanneschi</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Momi, Davide" sort="Momi, Davide" uniqKey="Momi D" first="Davide" last="Momi">Davide Momi</name>
<affiliation><nlm:affiliation>Siena Brain Investigation and Neuromodulation Lab, Department of Medicine, Surgery and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, Chieti, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Monti, Lucia" sort="Monti, Lucia" uniqKey="Monti L" first="Lucia" last="Monti">Lucia Monti</name>
<affiliation><nlm:affiliation>Unit of Neuroimaging and Neurointervention, Department of Neurological and Neurosensorial Sciences, Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Battisti, Carla" sort="Battisti, Carla" uniqKey="Battisti C" first="Carla" last="Battisti">Carla Battisti</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cioncoloni, David" sort="Cioncoloni, David" uniqKey="Cioncoloni D" first="David" last="Cioncoloni">David Cioncoloni</name>
<affiliation><nlm:affiliation>U.O.P. Professioni della Riabilitazione, Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pucci, Barbara" sort="Pucci, Barbara" uniqKey="Pucci B" first="Barbara" last="Pucci">Barbara Pucci</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Santarnecchi, Emiliano" sort="Santarnecchi, Emiliano" uniqKey="Santarnecchi E" first="Emiliano" last="Santarnecchi">Emiliano Santarnecchi</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Berenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>The Center for Complex Network Research, Department of Physics, Northeastern University, Boston, MA, United States.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rossi, Alessandro" sort="Rossi, Alessandro" uniqKey="Rossi A" first="Alessandro" last="Rossi">Alessandro Rossi</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:31749690</idno>
<idno type="pmid">31749690</idno>
<idno type="doi">10.3389/fnhum.2019.00350</idno>
<idno type="pmc">PMC6843060</idno>
<idno type="wicri:Area/Main/Corpus">000153</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000153</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease.</title>
<author><name sortKey="Messa, Luca Valerio" sort="Messa, Luca Valerio" uniqKey="Messa L" first="Luca Valerio" last="Messa">Luca Valerio Messa</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ginanneschi, Federica" sort="Ginanneschi, Federica" uniqKey="Ginanneschi F" first="Federica" last="Ginanneschi">Federica Ginanneschi</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Momi, Davide" sort="Momi, Davide" uniqKey="Momi D" first="Davide" last="Momi">Davide Momi</name>
<affiliation><nlm:affiliation>Siena Brain Investigation and Neuromodulation Lab, Department of Medicine, Surgery and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, Chieti, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Monti, Lucia" sort="Monti, Lucia" uniqKey="Monti L" first="Lucia" last="Monti">Lucia Monti</name>
<affiliation><nlm:affiliation>Unit of Neuroimaging and Neurointervention, Department of Neurological and Neurosensorial Sciences, Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Battisti, Carla" sort="Battisti, Carla" uniqKey="Battisti C" first="Carla" last="Battisti">Carla Battisti</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cioncoloni, David" sort="Cioncoloni, David" uniqKey="Cioncoloni D" first="David" last="Cioncoloni">David Cioncoloni</name>
<affiliation><nlm:affiliation>U.O.P. Professioni della Riabilitazione, Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pucci, Barbara" sort="Pucci, Barbara" uniqKey="Pucci B" first="Barbara" last="Pucci">Barbara Pucci</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Santarnecchi, Emiliano" sort="Santarnecchi, Emiliano" uniqKey="Santarnecchi E" first="Emiliano" last="Santarnecchi">Emiliano Santarnecchi</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Berenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>The Center for Complex Network Research, Department of Physics, Northeastern University, Boston, MA, United States.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rossi, Alessandro" sort="Rossi, Alessandro" uniqKey="Rossi A" first="Alessandro" last="Rossi">Alessandro Rossi</name>
<affiliation><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in human neuroscience</title>
<idno type="ISSN">1662-5161</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">For the management of Parkinson's disease (PD), the concept of forced exercise (FE) has drawn interest. In PD subjects, the FE executed with lower limbs has been shown to lessen symptoms and to promote brain adaptive changes. Our study is aimed to investigate the effect of an upper-limb exercise, conceptually comparable with the FE, in PD. Upper-limb exercise was achieved in a sitting position by using a specially designed device (Angel's Wings<sup>®</sup>
). Clinical data, computerized dynamic posturography, magnetic resonance imaging (MRI) (resting-state MRI and arterial spin labeling), and neuropsychological tests were used before and after 2 months' exercise training. We found a significant long-lasting improvement in Unified Parkinson Disease Rating Scale (UPDRS)-III and cognitive scales, along with improvement in balance and postural control (better alignment of the gravity center and improvement in weight symmetry and in anticipatory motor strategies). Computerized dynamic posturography pointed out an enhanced central ability to integrate the vestibular signals with afferents from other sensory systems. Neuroimaging analyses after 2 months' exercise training showed, with respect to pretraining condition, many changes. An increase of the cerebral blood flow was evident in the left primary motor cortex (M1), left supplementary motor cortical area, and left cerebellar cortex. The bilateral globus pallidus showed an increased functional connectivity to the right central operculum, right posterior cingulate gyrus, and left sensorimotor cortex. Seed-to-voxel analysis demonstrated a functional connectivity between M1 and the left superior frontal gyrus. Left crus II showed strengthened connections with the left pre-rolandic area, left post-rolandic area, and left supramarginal area. These findings likely reflect compensatory mechanisms to the neuropathological hallmark of PD. Overall, our results show that this upper-limb exercise model, conceptually comparable with the FE already tested in the lower limbs, leads to a global improvement (involving non-exercised limbs) likely consistent with the functional changes observed in the central nervous system.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31749690</PMID>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1662-5161</ISSN>
<JournalIssue CitedMedium="Print"><Volume>13</Volume>
<PubDate><Year>2019</Year>
</PubDate>
</JournalIssue>
<Title>Frontiers in human neuroscience</Title>
<ISOAbbreviation>Front Hum Neurosci</ISOAbbreviation>
</Journal>
<ArticleTitle>Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease.</ArticleTitle>
<Pagination><MedlinePgn>350</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3389/fnhum.2019.00350</ELocationID>
<Abstract><AbstractText>For the management of Parkinson's disease (PD), the concept of forced exercise (FE) has drawn interest. In PD subjects, the FE executed with lower limbs has been shown to lessen symptoms and to promote brain adaptive changes. Our study is aimed to investigate the effect of an upper-limb exercise, conceptually comparable with the FE, in PD. Upper-limb exercise was achieved in a sitting position by using a specially designed device (Angel's Wings<sup>®</sup>
). Clinical data, computerized dynamic posturography, magnetic resonance imaging (MRI) (resting-state MRI and arterial spin labeling), and neuropsychological tests were used before and after 2 months' exercise training. We found a significant long-lasting improvement in Unified Parkinson Disease Rating Scale (UPDRS)-III and cognitive scales, along with improvement in balance and postural control (better alignment of the gravity center and improvement in weight symmetry and in anticipatory motor strategies). Computerized dynamic posturography pointed out an enhanced central ability to integrate the vestibular signals with afferents from other sensory systems. Neuroimaging analyses after 2 months' exercise training showed, with respect to pretraining condition, many changes. An increase of the cerebral blood flow was evident in the left primary motor cortex (M1), left supplementary motor cortical area, and left cerebellar cortex. The bilateral globus pallidus showed an increased functional connectivity to the right central operculum, right posterior cingulate gyrus, and left sensorimotor cortex. Seed-to-voxel analysis demonstrated a functional connectivity between M1 and the left superior frontal gyrus. Left crus II showed strengthened connections with the left pre-rolandic area, left post-rolandic area, and left supramarginal area. These findings likely reflect compensatory mechanisms to the neuropathological hallmark of PD. Overall, our results show that this upper-limb exercise model, conceptually comparable with the FE already tested in the lower limbs, leads to a global improvement (involving non-exercised limbs) likely consistent with the functional changes observed in the central nervous system.</AbstractText>
<CopyrightInformation>Copyright © 2019 Messa, Ginanneschi, Momi, Monti, Battisti, Cioncoloni, Pucci, Santarnecchi and Rossi.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Messa</LastName>
<ForeName>Luca Valerio</ForeName>
<Initials>LV</Initials>
<AffiliationInfo><Affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ginanneschi</LastName>
<ForeName>Federica</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Momi</LastName>
<ForeName>Davide</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Siena Brain Investigation and Neuromodulation Lab, Department of Medicine, Surgery and Neurological Sciences, University of Siena, Siena, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, Chieti, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Monti</LastName>
<ForeName>Lucia</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Unit of Neuroimaging and Neurointervention, Department of Neurological and Neurosensorial Sciences, Azienda Ospedaliera Universitaria Senese, Siena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Battisti</LastName>
<ForeName>Carla</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cioncoloni</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>U.O.P. Professioni della Riabilitazione, Azienda Ospedaliera Universitaria Senese, Siena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pucci</LastName>
<ForeName>Barbara</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Santarnecchi</LastName>
<ForeName>Emiliano</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Berenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>The Center for Complex Network Research, Department of Physics, Northeastern University, Boston, MA, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rossi</LastName>
<ForeName>Alessandro</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>10</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Front Hum Neurosci</MedlineTA>
<NlmUniqueID>101477954</NlmUniqueID>
<ISSNLinking>1662-5161</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ASL</Keyword>
<Keyword MajorTopicYN="N">EquiTest</Keyword>
<Keyword MajorTopicYN="N">Parkinson’s disease</Keyword>
<Keyword MajorTopicYN="N">fMRI</Keyword>
<Keyword MajorTopicYN="N">forced exercise</Keyword>
<Keyword MajorTopicYN="N">resting-state fMRI</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>05</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>09</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>11</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>11</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>11</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>1</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31749690</ArticleId>
<ArticleId IdType="doi">10.3389/fnhum.2019.00350</ArticleId>
<ArticleId IdType="pmc">PMC6843060</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Mov Disord. 2018 Feb;33(2):208-218</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29168899</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain Connect. 2013;3(2):190-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23316956</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurol Sci. 2015 Apr;36(4):585-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25380622</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mov Disord. 2009 Feb 15;24(3):377-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18972546</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Sci Sports Exerc. 2009 Sep;41(9):1778-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19657291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurophysiol. 2017 Sep 1;118(3):1828-1848</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28615340</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Aging Neurosci. 2018 Nov 23;10:388</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30532703</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurorehabil Neural Repair. 2009 Jul-Aug;23(6):600-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19131578</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 1967 May;17(5):427-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6067254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Epidemiol. 1998 Nov;51(11):1025-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9817120</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2010 Feb 15;49(4):3057-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19944173</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mov Disord. 2008 Aug 15;23(11):1546-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18546326</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2011 Feb 1;54(3):1786-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20965257</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):367-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15377747</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2007 Jul 1;36(3):943-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17468013</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2007 Aug 1;37(1):90-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17560126</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurophysiol. 2006 May;95(5):2733-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16467429</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aging (Albany NY). 2018 Jul 20;10(7):1536-1537</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30036186</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exerc Sport Sci Rev. 2011 Oct;39(4):177-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21799425</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2003 May;19(1):163-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12781736</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Radiology. 2003 Aug;228(2):523-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12819338</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurosci Biobehav Rev. 2018 Dec;95:136-169</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30291852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mov Sci. 2011 Apr;30(2):279-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21435732</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain Res. 2010 Jan 15;1310:200-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19900418</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2011 Apr 15;55(4):1728-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21255661</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain Connect. 2016 Feb;6(1):25-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26414696</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Neurol. 2017 Oct 26;8:538</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29123498</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain. 2012 Dec;135(Pt 12):3699-711</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23195207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Syst Neurosci. 2016 Feb 24;10:16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26941621</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Parkinsons Dis. 2012;2012:124527</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22191068</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain. 2013 Aug;136(Pt 8):2405-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23824487</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain Connect. 2012;2(3):125-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22642651</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gait Posture. 2012 Jul;36(3):372-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22633015</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Neurosci. 1993 Jan;16(1):27-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7679234</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2006 Jul 1;31(3):968-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16530430</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2010 Feb 1;49(3):2045-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19857577</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Parkinsonism Relat Disord. 2016 Mar;24:56-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26857399</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S42-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20083005</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Magn Reson Med. 2015 Jan;73(1):102-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24715426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2017 Jan 12;7:40469</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28079169</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroscience. 2003;119(3):899-911</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12809709</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cereb Blood Flow Metab. 2014 Mar;34(3):389-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24301294</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Magn Reson Imaging. 2012 Dec;30(10):1409-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22789842</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Parkinsons Dis. 2012;2012:719167</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23133789</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Psychiatr Res. 1982-1983;17(1):37-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7183759</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurobiol Aging. 2015 Jan;36(1):462-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25095723</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Physiol. 1993 Sep;469:213-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8271199</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2013 Jan 16;33(3):1198-210a</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23325256</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rehabil Res Pract. 2013;2013:375267</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23853722</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurophysiol. 2007 Feb;97(2):1809-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17065245</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2007 Oct 15;38(1):95-113</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17761438</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurol Neurosurg Psychiatry. 2012 Oct;83(10):979-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22752693</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mov Disord. 2017 Jan;10(1):1-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28122432</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain. 2005 Oct;128(Pt 10):2250-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15958505</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gait Posture. 2015 Oct;42(4):485-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26319218</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Prog Brain Res. 2008;171:353-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18718326</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Neurosci. 2002 Sep;25(9):462-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12183207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomed Res Int. 2015;2015:692684</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26180807</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mov Disord. 2008 Apr 15;23(5):631-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18181210</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2009 Jul 1;29(26):8586-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19571149</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011;6(9):e25031</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21949842</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S60-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26360239</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mov Sci. 2011 Apr;30(2):314-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21277644</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Magn Reson Imaging. 2008 Feb;26(2):261-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17826940</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gait Posture. 2006 Nov;24(3):349-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16311036</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Restor Neurol Neurosci. 2018;36(4):535-545</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29889088</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimage. 2008 Nov 1;43(2):388-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18692577</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PosturoV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000153 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000153 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PosturoV1 |flux= Main |étape= Corpus |type= RBID |clé= pubmed:31749690 |texte= Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:31749690" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a PosturoV1
![]() | This area was generated with Dilib version V0.6.37. | ![]() |