Time course of nigrostriatal degeneration in parkinson's disease
Identifieur interne : 002C41 ( Main/Exploration ); précédent : 002C40; suivant : 002C42Time course of nigrostriatal degeneration in parkinson's disease
Auteurs : P. Riederer [Autriche] ; St. Wuketich [Autriche]Source :
- Journal of Neural Transmission [ 0300-9564 ] ; 1976-09-01.
Abstract
Summary: It could be shown that the post mortem analysis of biogenic amines, precursors, and metabolites in the human brain are influenced by various parameters. 1. The patient's medical history; long term observation of the course of the disease; age; sex. 2. Terminal illness; duration of terminal illness. 3. Previous treatment with drugs; last drugs. 4. Time interval between last drug treatment and death; time of day and date of last drug consumption. 5. Rapidity of death; time of death; duration of coma. 6. Changes occurring in tissues before death; patient's constitution during terminal illness. 7. Changes in concentration of the biogenic amines, precursors, and metabolites depending on the patient's age. 8. Time between death and necropsy. 9. Dissection of specimen. 10. Period of storage; temperature of storage. 11. Chronobiological rhythm of substances. 12. Methods of assay. 13. Homogeneity of all mentioned parameters in the control group and patient group. For the first time it could be demonstrated that the time course of nigrostriatal degeneration, independent of the age of the parkinsonian at the beginning of the illness, is linear for the last stage and the denervation progressively increases as the duration of illness progresses.
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DOI: 10.1007/BF01249445
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Riederer</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Ludwig Boltzmann Neurochemistry Institute, Geriatric Hospital of the City of Vienna-Lainz</wicri:regionArea><wicri:noRegion>Geriatric Hospital of the City of Vienna-Lainz</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>The Pathological Institute of the Hospital of the City of Vienna-Lainz</wicri:regionArea></affiliation></author><author><name sortKey="Wuketich, St" sort="Wuketich, St" uniqKey="Wuketich S" first="St." last="Wuketich">St. Wuketich</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Ludwig Boltzmann Neurochemistry Institute, Geriatric Hospital of the City of Vienna-Lainz</wicri:regionArea><wicri:noRegion>Geriatric Hospital of the City of Vienna-Lainz</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>The Pathological Institute of the Hospital of the City of Vienna-Lainz</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neural Transmission</title><title level="j" type="sub">Basic neurosciences and genetics, Parkinson's disease and allied conditions, Alzheimer's disease and related disorders, biological psychiatry</title><title level="j" type="abbrev">J. Neural Transmission</title><idno type="ISSN">0300-9564</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1976-09-01">1976-09-01</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">3-4</biblScope><biblScope unit="page" from="277">277</biblScope><biblScope unit="page" to="301">301</biblScope></imprint><idno type="ISSN">0300-9564</idno></series><idno type="istex">A35592D7C0994DA57D1549413F928CE4889D684F</idno><idno type="DOI">10.1007/BF01249445</idno><idno type="ArticleID">Art10</idno><idno type="ArticleID">BF01249445</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-9564</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: It could be shown that the post mortem analysis of biogenic amines, precursors, and metabolites in the human brain are influenced by various parameters. 1. The patient's medical history; long term observation of the course of the disease; age; sex. 2. Terminal illness; duration of terminal illness. 3. Previous treatment with drugs; last drugs. 4. Time interval between last drug treatment and death; time of day and date of last drug consumption. 5. Rapidity of death; time of death; duration of coma. 6. Changes occurring in tissues before death; patient's constitution during terminal illness. 7. Changes in concentration of the biogenic amines, precursors, and metabolites depending on the patient's age. 8. Time between death and necropsy. 9. Dissection of specimen. 10. Period of storage; temperature of storage. 11. Chronobiological rhythm of substances. 12. Methods of assay. 13. Homogeneity of all mentioned parameters in the control group and patient group. For the first time it could be demonstrated that the time course of nigrostriatal degeneration, independent of the age of the parkinsonian at the beginning of the illness, is linear for the last stage and the denervation progressively increases as the duration of illness progresses.</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Riederer, P" sort="Riederer, P" uniqKey="Riederer P" first="P." last="Riederer">P. Riederer</name></noRegion><name sortKey="Riederer, P" sort="Riederer, P" uniqKey="Riederer P" first="P." last="Riederer">P. Riederer</name><name sortKey="Wuketich, St" sort="Wuketich, St" uniqKey="Wuketich S" first="St." last="Wuketich">St. Wuketich</name><name sortKey="Wuketich, St" sort="Wuketich, St" uniqKey="Wuketich S" first="St." last="Wuketich">St. Wuketich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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