LRRK2 Parkinson’s disease: from animal models to cellular mechanisms
Identifieur interne : 000275 ( Main/Exploration ); précédent : 000274; suivant : 000276LRRK2 Parkinson’s disease: from animal models to cellular mechanisms
Auteurs : Chin-Hsien Lin ; Pei-I Tsai [Taïwan] ; Ruey-Meei Wu [Taïwan] ; Cheng-Ting Chien [Taïwan]Source :
- Reviews in the Neurosciences [ 0334-1763 ] ; 2011-08-01.
Abstract
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) play a major role in the development of Parkinson’s disease. The most frequently defined mutations of LRRK2 are located in the central catalytic region of the LRRK2 protein, suggesting that dysregulations of its enzymatic activities contribute to PD pathogenesis. Herein, we review recent progress in research concerning how LRRK2 mutations affect cellular pathways and lead to neuronal degeneration. We also summarize recent evidence revealing the endogenous function of LRRK2 protein within cells. These concepts can be used to further understand disease pathophysiology and serve as a platform to develop therapeutic strategies for the treatment of Parkinson’s disease.
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DOI: 10.1515/rns.2011.036
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The most frequently defined mutations of LRRK2 are located in the central catalytic region of the LRRK2 protein, suggesting that dysregulations of its enzymatic activities contribute to PD pathogenesis. Herein, we review recent progress in research concerning how LRRK2 mutations affect cellular pathways and lead to neuronal degeneration. We also summarize recent evidence revealing the endogenous function of LRRK2 protein within cells. These concepts can be used to further understand disease pathophysiology and serve as a platform to develop therapeutic strategies for the treatment of Parkinson’s disease.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Lin, Chin Hsien" sort="Lin, Chin Hsien" uniqKey="Lin C" first="Chin-Hsien" last="Lin">Chin-Hsien Lin</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Tsai, Pei I" sort="Tsai, Pei I" uniqKey="Tsai P" first="Pei-I" last="Tsai">Pei-I Tsai</name></noRegion><name sortKey="Chien, Cheng Ting" sort="Chien, Cheng Ting" uniqKey="Chien C" first="Cheng-Ting" last="Chien">Cheng-Ting Chien</name><name sortKey="Wu, Ruey Meei" sort="Wu, Ruey Meei" uniqKey="Wu R" first="Ruey-Meei" last="Wu">Ruey-Meei Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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