Effects of bromocriptine on Parkinsonism A nation‐wide collaborative double‐blind study
Identifieur interne : 002A15 ( Main/Exploration ); précédent : 002A14; suivant : 002A16Effects of bromocriptine on Parkinsonism A nation‐wide collaborative double‐blind study
Auteurs : Yasuo Toyokura ; Yoshikuni Mizuno ; Masao Kase ; Itsuro Sobue ; Yoshigoro Kuroiwa ; Hirotaro Narabayashi ; Masanori Uono ; Takao Nakanishi ; Masakuni Kameyama ; Hitoshi Ito ; Yasuo Shimada ; Makoto IwataSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 1985-08.
Descripteurs français
- Wicri :
- geographic : Japon.
English descriptors
Abstract
ABSTRACT – The effects of bromocriptine in patients with Parkinson's disease manifesting various problems in levodopa therapy were tested in a double‐blind manner with the collaboration of 59 institutions. The slow and low principle was in part adopted. Either bromocriptine or placebo was added to levodopa. Twenty‐nine % of the bromocriptine‐treated patients (n = 108), in contrast to 14.8% of the placebo‐treated (n = 108), showed either marked or moderate improvement (P < 0.05). Twenty to 37% improvement was noted in most of the symptoms studied in those treated with bromocriptine. The significant superiority of bromocriptine was also noted in the effects on wearing‐off phenomena and frozen gait. No irreversible side effects were noted. It is concluded that bromocriptine is useful in patients who are manifesting various difficulties in levodopa therapy. Our results are comparable to those using higher maintenance doses. Dopamine antagonistic actions were not observed. This is unlike the case with experimental animals.
Url:
DOI: 10.1111/j.1600-0404.1985.tb00858.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of bromocriptine on Parkinsonism A nation‐wide collaborative double‐blind study</title><author><name sortKey="Toyokura, Yasuo" sort="Toyokura, Yasuo" uniqKey="Toyokura Y" first="Yasuo" last="Toyokura">Yasuo Toyokura</name></author><author><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name></author><author><name sortKey="Kase, Masao" sort="Kase, Masao" uniqKey="Kase M" first="Masao" last="Kase">Masao Kase</name></author><author><name sortKey="Sobue, Itsuro" sort="Sobue, Itsuro" uniqKey="Sobue I" first="Itsuro" last="Sobue">Itsuro Sobue</name></author><author><name sortKey="Kuroiwa, Yoshigoro" sort="Kuroiwa, Yoshigoro" uniqKey="Kuroiwa Y" first="Yoshigoro" last="Kuroiwa">Yoshigoro Kuroiwa</name></author><author><name sortKey="Narabayashi, Hirotaro" sort="Narabayashi, Hirotaro" uniqKey="Narabayashi H" first="Hirotaro" last="Narabayashi">Hirotaro Narabayashi</name></author><author><name sortKey="Uono, Masanori" sort="Uono, Masanori" uniqKey="Uono M" first="Masanori" last="Uono">Masanori Uono</name></author><author><name sortKey="Nakanishi, Takao" sort="Nakanishi, Takao" uniqKey="Nakanishi T" first="Takao" last="Nakanishi">Takao Nakanishi</name></author><author><name sortKey="Kameyama, Masakuni" sort="Kameyama, Masakuni" uniqKey="Kameyama M" first="Masakuni" last="Kameyama">Masakuni Kameyama</name></author><author><name sortKey="Ito, Hitoshi" sort="Ito, Hitoshi" uniqKey="Ito H" first="Hitoshi" last="Ito">Hitoshi Ito</name></author><author><name sortKey="Shimada, Yasuo" sort="Shimada, Yasuo" uniqKey="Shimada Y" first="Yasuo" last="Shimada">Yasuo Shimada</name></author><author><name sortKey="Iwata, Makoto" sort="Iwata, Makoto" uniqKey="Iwata M" first="Makoto" last="Iwata">Makoto Iwata</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D9CCAF44E90C2E5D3BE1C482AC1684214A0F950F</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1111/j.1600-0404.1985.tb00858.x</idno><idno type="url">https://api.istex.fr/document/D9CCAF44E90C2E5D3BE1C482AC1684214A0F950F/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001E65</idno><idno type="wicri:Area/Main/Curation">001B77</idno><idno type="wicri:Area/Main/Exploration">002A15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of bromocriptine on Parkinsonism A nation‐wide collaborative double‐blind study</title><author><name sortKey="Toyokura, Yasuo" sort="Toyokura, Yasuo" uniqKey="Toyokura Y" first="Yasuo" last="Toyokura">Yasuo Toyokura</name><affiliation><wicri:noCountry code="subField">University of Tokyo</wicri:noCountry></affiliation></author><author><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name><affiliation><wicri:noCountry code="subField">Jichi Medical School</wicri:noCountry></affiliation></author><author><name sortKey="Kase, Masao" sort="Kase, Masao" uniqKey="Kase M" first="Masao" last="Kase">Masao Kase</name><affiliation><wicri:noCountry code="no comma">Segawa Neurology Clinic of Children</wicri:noCountry></affiliation></author><author><name sortKey="Sobue, Itsuro" sort="Sobue, Itsuro" uniqKey="Sobue I" first="Itsuro" last="Sobue">Itsuro Sobue</name><affiliation><wicri:noCountry code="subField">University of Nagoya</wicri:noCountry></affiliation></author><author><name sortKey="Kuroiwa, Yoshigoro" sort="Kuroiwa, Yoshigoro" uniqKey="Kuroiwa Y" first="Yoshigoro" last="Kuroiwa">Yoshigoro Kuroiwa</name><affiliation><wicri:noCountry code="subField">Kyushu University</wicri:noCountry></affiliation></author><author><name sortKey="Narabayashi, Hirotaro" sort="Narabayashi, Hirotaro" uniqKey="Narabayashi H" first="Hirotaro" last="Narabayashi">Hirotaro Narabayashi</name><affiliation><wicri:noCountry code="subField">Juntendo University</wicri:noCountry></affiliation></author><author><name sortKey="Uono, Masanori" sort="Uono, Masanori" uniqKey="Uono M" first="Masanori" last="Uono">Masanori Uono</name><affiliation><wicri:noCountry code="no comma">National Shizuoka Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Nakanishi, Takao" sort="Nakanishi, Takao" uniqKey="Nakanishi T" first="Takao" last="Nakanishi">Takao Nakanishi</name><affiliation><wicri:noCountry code="subField">University of Tsukuba</wicri:noCountry></affiliation></author><author><name sortKey="Kameyama, Masakuni" sort="Kameyama, Masakuni" uniqKey="Kameyama M" first="Masakuni" last="Kameyama">Masakuni Kameyama</name><affiliation><wicri:noCountry code="subField">University of Kyoto</wicri:noCountry></affiliation></author><author><name sortKey="Ito, Hitoshi" sort="Ito, Hitoshi" uniqKey="Ito H" first="Hitoshi" last="Ito">Hitoshi Ito</name><affiliation><wicri:noCountry code="subField">Keio University</wicri:noCountry></affiliation></author><author><name sortKey="Shimada, Yasuo" sort="Shimada, Yasuo" uniqKey="Shimada Y" first="Yasuo" last="Shimada">Yasuo Shimada</name><affiliation><wicri:noCountry code="no comma">Shimada Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Iwata, Makoto" sort="Iwata, Makoto" uniqKey="Iwata M" first="Makoto" last="Iwata">Makoto Iwata</name><affiliation><wicri:noCountry code="subField">University of Tokyo</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurologica Scandinavica</title><idno type="ISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1985-08">1985-08</date><biblScope unit="volume">72</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="157">157</biblScope><biblScope unit="page" to="170">170</biblScope></imprint><idno type="ISSN">0001-6314</idno></series><idno type="istex">D9CCAF44E90C2E5D3BE1C482AC1684214A0F950F</idno><idno type="DOI">10.1111/j.1600-0404.1985.tb00858.x</idno><idno type="ArticleID">ANE157</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bromocriptine</term><term>Japan</term><term>Parkinson's disease</term><term>Parkinsonism</term><term>double‐blind study</term><term>levodopa</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Japon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">ABSTRACT – The effects of bromocriptine in patients with Parkinson's disease manifesting various problems in levodopa therapy were tested in a double‐blind manner with the collaboration of 59 institutions. The slow and low principle was in part adopted. Either bromocriptine or placebo was added to levodopa. Twenty‐nine % of the bromocriptine‐treated patients (n = 108), in contrast to 14.8% of the placebo‐treated (n = 108), showed either marked or moderate improvement (P < 0.05). Twenty to 37% improvement was noted in most of the symptoms studied in those treated with bromocriptine. The significant superiority of bromocriptine was also noted in the effects on wearing‐off phenomena and frozen gait. No irreversible side effects were noted. It is concluded that bromocriptine is useful in patients who are manifesting various difficulties in levodopa therapy. Our results are comparable to those using higher maintenance doses. Dopamine antagonistic actions were not observed. This is unlike the case with experimental animals.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ito, Hitoshi" sort="Ito, Hitoshi" uniqKey="Ito H" first="Hitoshi" last="Ito">Hitoshi Ito</name><name sortKey="Iwata, Makoto" sort="Iwata, Makoto" uniqKey="Iwata M" first="Makoto" last="Iwata">Makoto Iwata</name><name sortKey="Kameyama, Masakuni" sort="Kameyama, Masakuni" uniqKey="Kameyama M" first="Masakuni" last="Kameyama">Masakuni Kameyama</name><name sortKey="Kase, Masao" sort="Kase, Masao" uniqKey="Kase M" first="Masao" last="Kase">Masao Kase</name><name sortKey="Kuroiwa, Yoshigoro" sort="Kuroiwa, Yoshigoro" uniqKey="Kuroiwa Y" first="Yoshigoro" last="Kuroiwa">Yoshigoro Kuroiwa</name><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name><name sortKey="Nakanishi, Takao" sort="Nakanishi, Takao" uniqKey="Nakanishi T" first="Takao" last="Nakanishi">Takao Nakanishi</name><name sortKey="Narabayashi, Hirotaro" sort="Narabayashi, Hirotaro" uniqKey="Narabayashi H" first="Hirotaro" last="Narabayashi">Hirotaro Narabayashi</name><name sortKey="Shimada, Yasuo" sort="Shimada, Yasuo" uniqKey="Shimada Y" first="Yasuo" last="Shimada">Yasuo Shimada</name><name sortKey="Sobue, Itsuro" sort="Sobue, Itsuro" uniqKey="Sobue I" first="Itsuro" last="Sobue">Itsuro Sobue</name><name sortKey="Toyokura, Yasuo" sort="Toyokura, Yasuo" uniqKey="Toyokura Y" first="Yasuo" last="Toyokura">Yasuo Toyokura</name><name sortKey="Uono, Masanori" sort="Uono, Masanori" uniqKey="Uono M" first="Masanori" last="Uono">Masanori Uono</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A15 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A15 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D9CCAF44E90C2E5D3BE1C482AC1684214A0F950F
|texte= Effects of bromocriptine on Parkinsonism A nation‐wide collaborative double‐blind study
}}
| This area was generated with Dilib version V0.6.23. |  |