Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory study
Identifieur interne : 001907 ( Main/Exploration ); précédent : 001906; suivant : 001908Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory study
Auteurs : Gilberto Levy [États-Unis] ; Ming-Xin Tang [États-Unis] ; Lucien J. Cote [États-Unis] ; Elan D. Louis [États-Unis] ; Brenda Alfaro [États-Unis] ; Helen Mejia [États-Unis] ; Yaakov Stern [États-Unis] ; Karen Marder [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-03.
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Abstract
The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 ± 10.3 years), 52 (29%) became demented during a mean follow‐up period of 3.6 ± 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4–2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4–1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3–2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with nonsmokers (RR, 2.0; 95% CI, 1.0–3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2–16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9–3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study. © 2002 Movement Disorder Society.
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DOI: 10.1002/mds.10086
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An exploratory study</title><author><name sortKey="Levy, Gilberto" sort="Levy, Gilberto" uniqKey="Levy G" first="Gilberto" last="Levy">Gilberto Levy</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Tang, Ming In" sort="Tang, Ming In" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. 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Cote</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Alfaro, Brenda" sort="Alfaro, Brenda" uniqKey="Alfaro B" first="Brenda" last="Alfaro">Brenda Alfaro</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-03">2002-03</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="250">250</biblScope><biblScope unit="page" to="257">257</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3A9AC214D9F59646B5C6D7A2E94EAEC6D9313F1A</idno><idno type="DOI">10.1002/mds.10086</idno><idno type="ArticleID">MDS10086</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dementia</term><term>epidemiology</term><term>smoking</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 ± 10.3 years), 52 (29%) became demented during a mean follow‐up period of 3.6 ± 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4–2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4–1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3–2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with nonsmokers (RR, 2.0; 95% CI, 1.0–3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2–16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9–3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study. © 2002 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Levy, Gilberto" sort="Levy, Gilberto" uniqKey="Levy G" first="Gilberto" last="Levy">Gilberto Levy</name></region><name sortKey="Alfaro, Brenda" sort="Alfaro, Brenda" uniqKey="Alfaro B" first="Brenda" last="Alfaro">Brenda Alfaro</name><name sortKey="Alfaro, Brenda" sort="Alfaro, Brenda" uniqKey="Alfaro B" first="Brenda" last="Alfaro">Brenda Alfaro</name><name sortKey="Cote, Lucien J" sort="Cote, Lucien J" uniqKey="Cote L" first="Lucien J." last="Cote">Lucien J. Cote</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Tang, Ming In" sort="Tang, Ming In" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name><name sortKey="Tang, Ming In" sort="Tang, Ming In" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name><name sortKey="Tang, Ming In" sort="Tang, Ming In" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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