A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities
Identifieur interne : 002D13 ( Main/Exploration ); précédent : 002D12; suivant : 002D14A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities
Auteurs : Takashi Ban [Japon] ; Masakazu Hojo [Japon]Source :
- Psychopharmacologia [ 0033-3158 ] ; 1971-03-01.
Abstract
Abstract: The effects of oxotremorine on the EEG and muscular activities of chronically electrode implanted rabbits and the influence of several antiparkinson drugs on these effects were studied simultaneously to clarify the relationships between both of the activities and the possible pathways concerned. Oxotremorine, in doses of 300 μg/kg by intravenous administration, caused an increase in muscular activity for two and a half hours on average, and in the EEG arousal patterns which lasted several hours. 0.03–2.0 mg/kg of scopolamine antagonized muscular activity (65–85%) more than EEG activity (10–45%) induced by oxotremorine, whereas 0.3 to 8.0 mg/kg of trihexyphenidyl antagonized both activities to the same extent (7–73% in the former and 18–75% in the latter). On the other hand, 5–15 mg/kg of diphenhydramine markedly antagonised the muscular activity (10–75%) but had little effect on the EEG activity (3–6%). 2–5 mg/kg of orphenadrine was slightly less effective than diphenhydramine on the muscular activity, and 2–5 mg/kg of propanolol was least effective on these oxotremorine-induced activities.
Url:
DOI: 10.1007/BF00403697
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities</title>
<author><name sortKey="Ban, Takashi" sort="Ban, Takashi" uniqKey="Ban T" first="Takashi" last="Ban">Takashi Ban</name>
</author>
<author><name sortKey="Hojo, Masakazu" sort="Hojo, Masakazu" uniqKey="Hojo M" first="Masakazu" last="Hojo">Masakazu Hojo</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4D9C143517EE3709191E09E45097F42456619F17</idno>
<date when="1971" year="1971">1971</date>
<idno type="doi">10.1007/BF00403697</idno>
<idno type="url">https://api.istex.fr/document/4D9C143517EE3709191E09E45097F42456619F17/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002090</idno>
<idno type="wicri:Area/Main/Curation">001D89</idno>
<idno type="wicri:Area/Main/Exploration">002D13</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities</title>
<author><name sortKey="Ban, Takashi" sort="Ban, Takashi" uniqKey="Ban T" first="Takashi" last="Ban">Takashi Ban</name>
<affiliation wicri:level="4"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hojo, Masakazu" sort="Hojo, Masakazu" uniqKey="Hojo M" first="Masakazu" last="Hojo">Masakazu Hojo</name>
<affiliation wicri:level="4"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Psychopharmacologia</title>
<title level="j" type="abbrev">Psychopharmacologia</title>
<idno type="ISSN">0033-3158</idno>
<idno type="eISSN">1432-2072</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1971-03-01">1971-03-01</date>
<biblScope unit="volume">19</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="1">1</biblScope>
<biblScope unit="page" to="15">15</biblScope>
</imprint>
<idno type="ISSN">0033-3158</idno>
</series>
<idno type="istex">4D9C143517EE3709191E09E45097F42456619F17</idno>
<idno type="DOI">10.1007/BF00403697</idno>
<idno type="ArticleID">Art1</idno>
<idno type="ArticleID">BF00403697</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0033-3158</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The effects of oxotremorine on the EEG and muscular activities of chronically electrode implanted rabbits and the influence of several antiparkinson drugs on these effects were studied simultaneously to clarify the relationships between both of the activities and the possible pathways concerned. Oxotremorine, in doses of 300 μg/kg by intravenous administration, caused an increase in muscular activity for two and a half hours on average, and in the EEG arousal patterns which lasted several hours. 0.03–2.0 mg/kg of scopolamine antagonized muscular activity (65–85%) more than EEG activity (10–45%) induced by oxotremorine, whereas 0.3 to 8.0 mg/kg of trihexyphenidyl antagonized both activities to the same extent (7–73% in the former and 18–75% in the latter). On the other hand, 5–15 mg/kg of diphenhydramine markedly antagonised the muscular activity (10–75%) but had little effect on the EEG activity (3–6%). 2–5 mg/kg of orphenadrine was slightly less effective than diphenhydramine on the muscular activity, and 2–5 mg/kg of propanolol was least effective on these oxotremorine-induced activities.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
<region><li>Région du Kansai</li>
</region>
<settlement><li>Kyoto</li>
</settlement>
<orgName><li>Université de Kyoto</li>
</orgName>
</list>
<tree><country name="Japon"><region name="Région du Kansai"><name sortKey="Ban, Takashi" sort="Ban, Takashi" uniqKey="Ban T" first="Takashi" last="Ban">Takashi Ban</name>
</region>
<name sortKey="Hojo, Masakazu" sort="Hojo, Masakazu" uniqKey="Hojo M" first="Masakazu" last="Hojo">Masakazu Hojo</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D13 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D13 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:4D9C143517EE3709191E09E45097F42456619F17 |texte= A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |