A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities
Identifieur interne : 002D13 ( Main/Exploration ); précédent : 002D12; suivant : 002D14A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities
Auteurs : Takashi Ban [Japon] ; Masakazu Hojo [Japon]Source :
- Psychopharmacologia [ 0033-3158 ] ; 1971-03-01.
Abstract
Abstract: The effects of oxotremorine on the EEG and muscular activities of chronically electrode implanted rabbits and the influence of several antiparkinson drugs on these effects were studied simultaneously to clarify the relationships between both of the activities and the possible pathways concerned. Oxotremorine, in doses of 300 μg/kg by intravenous administration, caused an increase in muscular activity for two and a half hours on average, and in the EEG arousal patterns which lasted several hours. 0.03–2.0 mg/kg of scopolamine antagonized muscular activity (65–85%) more than EEG activity (10–45%) induced by oxotremorine, whereas 0.3 to 8.0 mg/kg of trihexyphenidyl antagonized both activities to the same extent (7–73% in the former and 18–75% in the latter). On the other hand, 5–15 mg/kg of diphenhydramine markedly antagonised the muscular activity (10–75%) but had little effect on the EEG activity (3–6%). 2–5 mg/kg of orphenadrine was slightly less effective than diphenhydramine on the muscular activity, and 2–5 mg/kg of propanolol was least effective on these oxotremorine-induced activities.
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DOI: 10.1007/BF00403697
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