Fluphenazine-induced parkinsonism in the baboon: Pharmacological and metabolic studies
Identifieur interne : 002C91 ( Main/Exploration ); précédent : 002C90; suivant : 002C92Fluphenazine-induced parkinsonism in the baboon: Pharmacological and metabolic studies
Auteurs : J. Dreyfuss [États-Unis] ; B. Beer [États-Unis] ; D. D. Devine [États-Unis] ; B. F. Roberts [États-Unis] ; E. C. Schreiber [États-Unis]Source :
- Neuropharmacology [ 0028-3908 ] ; 1971.
Abstract
Extrapyramidal signs were produced in baboons following the oral administration of 1.5–5 mg/kg per day of fluphenazine dihydrochloride. The drug-induced extrapyramidal signs included tremors at rest or in motion, motor retardation, masque facies, rigidity, and salivation. Administration of the anti-parkinson agents benztropine mesylate or trihexyphenidyl hydrochloride was ineffective in reversing the extrapyramidal signs when these agents were given together with fluphenazine. 7-Hydroxyfluphenazine, a metabolite of fluphenazine in the baboon, was at least 500 times less active than fluphenazine in producing depression and did not produce extrapyramidal signs. Metabolic studies with nuphenazine-14C in the baboon indicated that the biological disposition of the drug resembles that seen previously in the rhesus monkey. The plasma half-life for the elimination of fluphenazine-14C, its metabolites, or both, agrees roughly with the length of time required for extrapyramidal signs to disappear after withdrawal of the drug.
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DOI: 10.1016/0028-3908(72)90094-9
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The drug-induced extrapyramidal signs included tremors at rest or in motion, motor retardation, masque facies, rigidity, and salivation. Administration of the anti-parkinson agents benztropine mesylate or trihexyphenidyl hydrochloride was ineffective in reversing the extrapyramidal signs when these agents were given together with fluphenazine. 7-Hydroxyfluphenazine, a metabolite of fluphenazine in the baboon, was at least 500 times less active than fluphenazine in producing depression and did not produce extrapyramidal signs. Metabolic studies with nuphenazine-14C in the baboon indicated that the biological disposition of the drug resembles that seen previously in the rhesus monkey. 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