Alzheimer's disease: Genetic aspects and associated clinical disorders
Identifieur interne : 002A96 ( Main/Exploration ); précédent : 002A95; suivant : 002A97Alzheimer's disease: Genetic aspects and associated clinical disorders
Auteurs : Heyman [États-Unis] ; William E. E [États-Unis] ; Barrie J. Hurwitz [États-Unis] ; Donald Schmechel [États-Unis] ; Alverta H. Sigmon [États-Unis] ; Tina Weinberg [États-Unis] ; Michael J. Helms [États-Unis] ; Michael Swift [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 1983-11.
Abstract
Genetic aspects and associated clinical disorders were studied in a consecutive series of 68 men and women in whom Alzheimer's disease appeared at or before age 70. Secondary cases of dementia were found in 17 (25%) of the families, affecting 22 of the probands' siblings and parents. The cumulative incidence of Alzheimer's disease in these relatives was approximately 14% at age 75. An increased frequency of Down's syndrome was observed among relatives of the probands: a rate of 3.6 per 1, 000, as compared with an expected rate of 1.3 per 1, 000. A history of thyroid disease was established in 9 (19.6%) of the 46 female probands, a frequency greater than that reported in the general population. There was no excess of hematological malignancies among the blood relatives, and parental age at the time of birth of the probands did not differ from the norm. The results of this study indicate that early‐onset Alzheimer's disease is associated with a genetic factor manifested in a substantial familial aggregation of dementia, a probable excess of Down's syndrome in the probands' relatives, and a possible association with thyroid dysfunction in women with this form of dementia.
Url:
DOI: 10.1002/ana.410140503
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alzheimer's disease: Genetic aspects and associated clinical disorders</title><author><name sortKey="Heyman" sort="Heyman" uniqKey="Heyman" last="Heyman">Heyman</name></author><author><name sortKey="E, William E" sort="E, William E" uniqKey="E W" first="William E." last="E">William E. E</name></author><author><name sortKey="Hurwitz, Barrie J" sort="Hurwitz, Barrie J" uniqKey="Hurwitz B" first="Barrie J." last="Hurwitz">Barrie J. Hurwitz</name></author><author><name sortKey="Schmechel, Donald" sort="Schmechel, Donald" uniqKey="Schmechel D" first="Donald" last="Schmechel">Donald Schmechel</name></author><author><name sortKey="Sigmon, Alverta H" sort="Sigmon, Alverta H" uniqKey="Sigmon A" first="Alverta H." last="Sigmon">Alverta H. Sigmon</name></author><author><name sortKey="Weinberg, Tina" sort="Weinberg, Tina" uniqKey="Weinberg T" first="Tina" last="Weinberg">Tina Weinberg</name></author><author><name sortKey="Helms, Michael J" sort="Helms, Michael J" uniqKey="Helms M" first="Michael J." last="Helms">Michael J. Helms</name></author><author><name sortKey="Swift, Michael" sort="Swift, Michael" uniqKey="Swift M" first="Michael" last="Swift">Michael Swift</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E39DD5CC46FEB056D1DD876EA66D6C5D39CD154D</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1002/ana.410140503</idno><idno type="url">https://api.istex.fr/document/E39DD5CC46FEB056D1DD876EA66D6C5D39CD154D/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001990</idno><idno type="wicri:Area/Main/Curation">001739</idno><idno type="wicri:Area/Main/Exploration">002A96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Alzheimer's disease: Genetic aspects and associated clinical disorders</title><author><name sortKey="Heyman" sort="Heyman" uniqKey="Heyman" last="Heyman">Heyman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Medicine (Neurology) Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="E, William E" sort="E, William E" uniqKey="E W" first="William E." last="E">William E. E</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Departments of Community and Family Medicine (Biometry), Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Hurwitz, Barrie J" sort="Hurwitz, Barrie J" uniqKey="Hurwitz B" first="Barrie J." last="Hurwitz">Barrie J. Hurwitz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Medicine (Neurology) Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Schmechel, Donald" sort="Schmechel, Donald" uniqKey="Schmechel D" first="Donald" last="Schmechel">Donald Schmechel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Medicine (Neurology) Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Sigmon, Alverta H" sort="Sigmon, Alverta H" uniqKey="Sigmon A" first="Alverta H." last="Sigmon">Alverta H. Sigmon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Departments of Community and Family Medicine (Biometry), Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Weinberg, Tina" sort="Weinberg, Tina" uniqKey="Weinberg T" first="Tina" last="Weinberg">Tina Weinberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Medicine (Neurology) Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Helms, Michael J" sort="Helms, Michael J" uniqKey="Helms M" first="Michael J." last="Helms">Michael J. Helms</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Departments of Community and Family Medicine (Biometry), Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Swift, Michael" sort="Swift, Michael" uniqKey="Swift M" first="Michael" last="Swift">Michael Swift</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Medicine (Genetics Curriculum), University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Little, Brown and Company</publisher><pubPlace>Boston</pubPlace><date type="published" when="1983-11">1983-11</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="507">507</biblScope><biblScope unit="page" to="515">515</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">E39DD5CC46FEB056D1DD876EA66D6C5D39CD154D</idno><idno type="DOI">10.1002/ana.410140503</idno><idno type="ArticleID">ANA410140503</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic aspects and associated clinical disorders were studied in a consecutive series of 68 men and women in whom Alzheimer's disease appeared at or before age 70. Secondary cases of dementia were found in 17 (25%) of the families, affecting 22 of the probands' siblings and parents. The cumulative incidence of Alzheimer's disease in these relatives was approximately 14% at age 75. An increased frequency of Down's syndrome was observed among relatives of the probands: a rate of 3.6 per 1, 000, as compared with an expected rate of 1.3 per 1, 000. A history of thyroid disease was established in 9 (19.6%) of the 46 female probands, a frequency greater than that reported in the general population. There was no excess of hematological malignancies among the blood relatives, and parental age at the time of birth of the probands did not differ from the norm. The results of this study indicate that early‐onset Alzheimer's disease is associated with a genetic factor manifested in a substantial familial aggregation of dementia, a probable excess of Down's syndrome in the probands' relatives, and a possible association with thyroid dysfunction in women with this form of dementia.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Heyman" sort="Heyman" uniqKey="Heyman" last="Heyman">Heyman</name></region><name sortKey="E, William E" sort="E, William E" uniqKey="E W" first="William E." last="E">William E. E</name><name sortKey="Helms, Michael J" sort="Helms, Michael J" uniqKey="Helms M" first="Michael J." last="Helms">Michael J. Helms</name><name sortKey="Hurwitz, Barrie J" sort="Hurwitz, Barrie J" uniqKey="Hurwitz B" first="Barrie J." last="Hurwitz">Barrie J. Hurwitz</name><name sortKey="Schmechel, Donald" sort="Schmechel, Donald" uniqKey="Schmechel D" first="Donald" last="Schmechel">Donald Schmechel</name><name sortKey="Sigmon, Alverta H" sort="Sigmon, Alverta H" uniqKey="Sigmon A" first="Alverta H." last="Sigmon">Alverta H. Sigmon</name><name sortKey="Swift, Michael" sort="Swift, Michael" uniqKey="Swift M" first="Michael" last="Swift">Michael Swift</name><name sortKey="Weinberg, Tina" sort="Weinberg, Tina" uniqKey="Weinberg T" first="Tina" last="Weinberg">Tina Weinberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A96 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A96 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E39DD5CC46FEB056D1DD876EA66D6C5D39CD154D
|texte= Alzheimer's disease: Genetic aspects and associated clinical disorders
}}
| This area was generated with Dilib version V0.6.23. |  |