Xenon Contrast CT‐CBF Measurements in Parkinsonism and Normal Aging
Identifieur interne : 002A00 ( Main/Exploration ); précédent : 002999; suivant : 002A01Xenon Contrast CT‐CBF Measurements in Parkinsonism and Normal Aging
Auteurs : Hisao Tachibana [États-Unis] ; John S. Meyer [États-Unis] ; Yasuhisa Kitagawa [États-Unis] ; Norio Tanahashi [États-Unis] ; Prasab Kandula [États-Unis] ; Robert L. Rogers [États-Unis]Source :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 1985-06.
Abstract
Local cerebral blood flow (LCBF) and local tissue:blood partition, coefficient (LΛ) values were measured during CT scanning while patients with different types of Parkinson's syndrome (N = 14) inhaled a contrast mixture of 35–37 per cent stable xenon gas in oxygen. Single‐compartment analysis fitted to infinity was used to calculate LΛ and LCBF values. Results were compared with results from normal age‐matched volunteers (N = 24). Mean hemispheric (p < 0.05) and subcortical (p < 0.05) gray matter LCBF values were reduced in idiopathic Parkinson's disease (N = 11), compared to values from age‐matched normals. Regionally, LCBF reductions included frontal (p < 0.001), parietal cortex (p < 0.05), caudate (p < 0.05), lentiform nuclei (p < 0.001) and thalamus (p < 0.05) reductions. LΛ values were normal. Unilateral tremor and/or rigidity correlated directly with reduced LCBF in contralateral lentiform (p < 0.01) and caudate (p < 0.01) nuclei. In postencephalitic Parkinsonism (N = 1) LCBF reductions were diffuse, with normal LΛ values. In the akinetic form of Parkinsonism (N = 1) associated with lacunar infarcts, LCBF and LΛ reductions were patchy. In Parkinsonism following carbon monoxide poisoning (N = 1), LCBF values of gray and white matter were diffusely reduced and LΛ values were reduced in both pallidal regions. When dementia was present together with Parkinsonism (N = 3), LCBF reductions were more diffuse and severe. Dopaminergic deficiency correlated directly with reduced LCBF values, reflecting the severity of Parkinsonism. J Am Geriatr Soc 33:413, 1985
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DOI: 10.1111/j.1532-5415.1985.tb07152.x
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Meyer</name></author><author><name sortKey="Kitagawa, Yasuhisa" sort="Kitagawa, Yasuhisa" uniqKey="Kitagawa Y" first="Yasuhisa" last="Kitagawa">Yasuhisa Kitagawa</name></author><author><name sortKey="Tanahashi, Norio" sort="Tanahashi, Norio" uniqKey="Tanahashi N" first="Norio" last="Tanahashi">Norio Tanahashi</name></author><author><name sortKey="Kandula, Prasab" sort="Kandula, Prasab" uniqKey="Kandula P" first="Prasab" last="Kandula">Prasab Kandula</name></author><author><name sortKey="Rogers, Robert L" sort="Rogers, Robert L" uniqKey="Rogers R" first="Robert L" last="Rogers">Robert L. 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Rogers</name><affiliation wicri:level="4"><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American Geriatrics Society</title><idno type="ISSN">0002-8614</idno><idno type="eISSN">1532-5415</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1985-06">1985-06</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="413">413</biblScope><biblScope unit="page" to="421">421</biblScope></imprint><idno type="ISSN">0002-8614</idno></series><idno type="istex">68D49C6AFE70B45261F1B2E871F5BB059D909314</idno><idno type="DOI">10.1111/j.1532-5415.1985.tb07152.x</idno><idno type="ArticleID">JGS7152</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-8614</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Local cerebral blood flow (LCBF) and local tissue:blood partition, coefficient (LΛ) values were measured during CT scanning while patients with different types of Parkinson's syndrome (N = 14) inhaled a contrast mixture of 35–37 per cent stable xenon gas in oxygen. Single‐compartment analysis fitted to infinity was used to calculate LΛ and LCBF values. Results were compared with results from normal age‐matched volunteers (N = 24). Mean hemispheric (p < 0.05) and subcortical (p < 0.05) gray matter LCBF values were reduced in idiopathic Parkinson's disease (N = 11), compared to values from age‐matched normals. Regionally, LCBF reductions included frontal (p < 0.001), parietal cortex (p < 0.05), caudate (p < 0.05), lentiform nuclei (p < 0.001) and thalamus (p < 0.05) reductions. LΛ values were normal. Unilateral tremor and/or rigidity correlated directly with reduced LCBF in contralateral lentiform (p < 0.01) and caudate (p < 0.01) nuclei. In postencephalitic Parkinsonism (N = 1) LCBF reductions were diffuse, with normal LΛ values. In the akinetic form of Parkinsonism (N = 1) associated with lacunar infarcts, LCBF and LΛ reductions were patchy. In Parkinsonism following carbon monoxide poisoning (N = 1), LCBF values of gray and white matter were diffusely reduced and LΛ values were reduced in both pallidal regions. When dementia was present together with Parkinsonism (N = 3), LCBF reductions were more diffuse and severe. Dopaminergic deficiency correlated directly with reduced LCBF values, reflecting the severity of Parkinsonism. J Am Geriatr Soc 33:413, 1985</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Tachibana, Hisao" sort="Tachibana, Hisao" uniqKey="Tachibana H" first="Hisao" last="Tachibana">Hisao Tachibana</name></region><name sortKey="Kandula, Prasab" sort="Kandula, Prasab" uniqKey="Kandula P" first="Prasab" last="Kandula">Prasab Kandula</name><name sortKey="Kitagawa, Yasuhisa" sort="Kitagawa, Yasuhisa" uniqKey="Kitagawa Y" first="Yasuhisa" last="Kitagawa">Yasuhisa Kitagawa</name><name sortKey="Meyer, John S" sort="Meyer, John S" uniqKey="Meyer J" first="John S." last="Meyer">John S. Meyer</name><name sortKey="Rogers, Robert L" sort="Rogers, Robert L" uniqKey="Rogers R" first="Robert L" last="Rogers">Robert L. Rogers</name><name sortKey="Tanahashi, Norio" sort="Tanahashi, Norio" uniqKey="Tanahashi N" first="Norio" last="Tanahashi">Norio Tanahashi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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