Neuroprotective effects of α-dihydroergocryptine against damages in the substantia nigra caused by severe treatment with 1-methyl-4-phenyl-1,3,3,6-tetrahydropyridine
Identifieur interne : 002529 ( Main/Exploration ); précédent : 002528; suivant : 002530Neuroprotective effects of α-dihydroergocryptine against damages in the substantia nigra caused by severe treatment with 1-methyl-4-phenyl-1,3,3,6-tetrahydropyridine
Auteurs : G. Bernocchi [Italie] ; G. Gerzeli [Italie] ; E. Scherini [Italie] ; C. Vignola [Italie]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1993-07-01.
Abstract
Summary: The effects on the substantia nigra of α-dihydroergocryptine (DEK), a drug with strong dopaminomimetic activity, were tested with a severe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in monkeys. Compared with monkeys treated with MPTP alone, the animals which received DEK plus MPTP showed reduced neuronal death in the substantia nigra. The reactive astrocytes were increased in number. Moreover, several axons which were immunopositive to phosphorylated neurofilament proteins and with features similar to those of control animals were seen in the pars compacta. The findings suggest that DEK preserves neuronal morphology and brain architecture.
Url:
DOI: 10.1007/BF00334452
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroprotective effects of α-dihydroergocryptine against damages in the substantia nigra caused by severe treatment with 1-methyl-4-phenyl-1,3,3,6-tetrahydropyridine</title><author><name sortKey="Bernocchi, G" sort="Bernocchi, G" uniqKey="Bernocchi G" first="G." last="Bernocchi">G. Bernocchi</name></author><author><name sortKey="Gerzeli, G" sort="Gerzeli, G" uniqKey="Gerzeli G" first="G." last="Gerzeli">G. Gerzeli</name></author><author><name sortKey="Scherini, E" sort="Scherini, E" uniqKey="Scherini E" first="E." last="Scherini">E. Scherini</name></author><author><name sortKey="Vignola, C" sort="Vignola, C" uniqKey="Vignola C" first="C." last="Vignola">C. Vignola</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CF2DF866BB1FF5B6C07ABCC30D4B7F0B6A804841</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1007/BF00334452</idno><idno type="url">https://api.istex.fr/document/CF2DF866BB1FF5B6C07ABCC30D4B7F0B6A804841/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001892</idno><idno type="wicri:Area/Main/Curation">001645</idno><idno type="wicri:Area/Main/Exploration">002529</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neuroprotective effects of α-dihydroergocryptine against damages in the substantia nigra caused by severe treatment with 1-methyl-4-phenyl-1,3,3,6-tetrahydropyridine</title><author><name sortKey="Bernocchi, G" sort="Bernocchi, G" uniqKey="Bernocchi G" first="G." last="Bernocchi">G. Bernocchi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Biologia Animale, Universita' di Pavia, Centro di Studio per l'Istochimica del C.N.R., Piazza Botta 10, I-27100, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Gerzeli, G" sort="Gerzeli, G" uniqKey="Gerzeli G" first="G." last="Gerzeli">G. Gerzeli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Biologia Animale, Universita' di Pavia, Centro di Studio per l'Istochimica del C.N.R., Piazza Botta 10, I-27100, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Scherini, E" sort="Scherini, E" uniqKey="Scherini E" first="E." last="Scherini">E. Scherini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Biologia Animale, Universita' di Pavia, Centro di Studio per l'Istochimica del C.N.R., Piazza Botta 10, I-27100, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Vignola, C" sort="Vignola, C" uniqKey="Vignola C" first="C." last="Vignola">C. Vignola</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Biologia Animale, Universita' di Pavia, Centro di Studio per l'Istochimica del C.N.R., Piazza Botta 10, I-27100, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1993-07-01">1993-07-01</date><biblScope unit="volume">85</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="404">404</biblScope><biblScope unit="page" to="413">413</biblScope></imprint><idno type="ISSN">0001-6322</idno></series><idno type="istex">CF2DF866BB1FF5B6C07ABCC30D4B7F0B6A804841</idno><idno type="DOI">10.1007/BF00334452</idno><idno type="ArticleID">Art9</idno><idno type="ArticleID">BF00334452</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The effects on the substantia nigra of α-dihydroergocryptine (DEK), a drug with strong dopaminomimetic activity, were tested with a severe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in monkeys. Compared with monkeys treated with MPTP alone, the animals which received DEK plus MPTP showed reduced neuronal death in the substantia nigra. The reactive astrocytes were increased in number. Moreover, several axons which were immunopositive to phosphorylated neurofilament proteins and with features similar to those of control animals were seen in the pars compacta. The findings suggest that DEK preserves neuronal morphology and brain architecture.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Bernocchi, G" sort="Bernocchi, G" uniqKey="Bernocchi G" first="G." last="Bernocchi">G. Bernocchi</name></noRegion><name sortKey="Gerzeli, G" sort="Gerzeli, G" uniqKey="Gerzeli G" first="G." last="Gerzeli">G. Gerzeli</name><name sortKey="Scherini, E" sort="Scherini, E" uniqKey="Scherini E" first="E." last="Scherini">E. Scherini</name><name sortKey="Vignola, C" sort="Vignola, C" uniqKey="Vignola C" first="C." last="Vignola">C. Vignola</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002529 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002529 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:CF2DF866BB1FF5B6C07ABCC30D4B7F0B6A804841
|texte= Neuroprotective effects of α-dihydroergocryptine against damages in the substantia nigra caused by severe treatment with 1-methyl-4-phenyl-1,3,3,6-tetrahydropyridine
}}
| This area was generated with Dilib version V0.6.23. |  |