An Integrated Strategy for Evaluation of Metabolic and Oxidative Defects in Neurodegenerative Illness Using Magnetic Resonance Techniques
Identifieur interne : 001E10 ( Main/Exploration ); précédent : 001E09; suivant : 001E11An Integrated Strategy for Evaluation of Metabolic and Oxidative Defects in Neurodegenerative Illness Using Magnetic Resonance Techniques
Auteurs : B. G. Jenkins [États-Unis] ; Y. I. Chen [États-Unis] ; E. Kuestermann [États-Unis] ; N. M. Makris [États-Unis] ; T. V. Nguyen [États-Unis] ; E. Kraft [États-Unis] ; A. L. Brownell [États-Unis] ; H. D. Rosas [États-Unis] ; D. N. Kennedy [États-Unis] ; B. R. Rosen [États-Unis] ; W. J. Koroshetz [États-Unis] ; M. F. Beal [États-Unis]Source :
- Annals of the New York Academy of SciencesOXIDATIVE/ENERGY METABOLISM IN NEURODEGENERATIVE DISORDERS [ 0077-8923 ] ; 1999-11.
Abstract
ABSTRACT: The number of physiologic and metabolic phenomena amenable to analysis using magnetic resonance (MR) techniques is increasing every year. MR techniques can now evalutate tissue parameters relevant to TCA cyclemetabolism, anerobic glycolysis, ATP levels, blood‐brain barrier permeability, macrophage infiltration, cytotoxic edema, spreading depression, cerebral blood flow and volume, and neurotransmitter function. The paramagnetic nature of certain oxidation states of iron leads to the ability to map out brain function using deoxyhemoglobin as an endogenous contrast agent, and also allows for mapping of local tissue iron concentrations. In addition to these metabolic parameters, the number of ways to generate anatomic contrast using MR is also expanding; and in addition to conventional anatomic scans, mapping of axonal fiber tracts can also be performed using the anisotropy of water diffusion. A strategy for integration of these multifarious parameters in a comprehensive neurofunctional exam in neurodegenerative illness is outlined in this paper. The goals of the integrated exam, as applied to a given neurodegenerative illness, can be subdivided into three categories: etiology, natural history, and therapeutic end points. The consequences of oxidative stress and/or mitochondrial dysfunction are explored in the context of the various parameters that can be measured using the integrated MR exam.
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DOI: 10.1111/j.1749-6632.1999.tb07828.x
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Kennedy</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Massachusetts General Hospital NMR Center and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129</wicri:regionArea><wicri:noRegion>Massachusetts 02129</wicri:noRegion></affiliation></author><author><name sortKey="Rosen, B R" sort="Rosen, B R" uniqKey="Rosen B" first="B. R." last="Rosen">B. R. Rosen</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Massachusetts General Hospital NMR Center and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129</wicri:regionArea><wicri:noRegion>Massachusetts 02129</wicri:noRegion></affiliation></author><author><name sortKey="Koroshetz, W J" sort="Koroshetz, W J" uniqKey="Koroshetz W" first="W. J." last="Koroshetz">W. J. 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MR techniques can now evalutate tissue parameters relevant to TCA cyclemetabolism, anerobic glycolysis, ATP levels, blood‐brain barrier permeability, macrophage infiltration, cytotoxic edema, spreading depression, cerebral blood flow and volume, and neurotransmitter function. The paramagnetic nature of certain oxidation states of iron leads to the ability to map out brain function using deoxyhemoglobin as an endogenous contrast agent, and also allows for mapping of local tissue iron concentrations. In addition to these metabolic parameters, the number of ways to generate anatomic contrast using MR is also expanding; and in addition to conventional anatomic scans, mapping of axonal fiber tracts can also be performed using the anisotropy of water diffusion. A strategy for integration of these multifarious parameters in a comprehensive neurofunctional exam in neurodegenerative illness is outlined in this paper. The goals of the integrated exam, as applied to a given neurodegenerative illness, can be subdivided into three categories: etiology, natural history, and therapeutic end points. The consequences of oxidative stress and/or mitochondrial dysfunction are explored in the context of the various parameters that can be measured using the integrated MR exam.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Jenkins, B G" sort="Jenkins, B G" uniqKey="Jenkins B" first="B. G." last="Jenkins">B. G. Jenkins</name></noRegion><name sortKey="Beal, M F" sort="Beal, M F" uniqKey="Beal M" first="M. F." last="Beal">M. F. Beal</name><name sortKey="Brownell, A L" sort="Brownell, A L" uniqKey="Brownell A" first="A. L." last="Brownell">A. L. Brownell</name><name sortKey="Chen, Y I" sort="Chen, Y I" uniqKey="Chen Y" first="Y. I." last="Chen">Y. I. Chen</name><name sortKey="Kennedy, D N" sort="Kennedy, D N" uniqKey="Kennedy D" first="D. N." last="Kennedy">D. N. Kennedy</name><name sortKey="Koroshetz, W J" sort="Koroshetz, W J" uniqKey="Koroshetz W" first="W. J." last="Koroshetz">W. J. Koroshetz</name><name sortKey="Kraft, E" sort="Kraft, E" uniqKey="Kraft E" first="E." last="Kraft">E. Kraft</name><name sortKey="Kuestermann, E" sort="Kuestermann, E" uniqKey="Kuestermann E" first="E." last="Kuestermann">E. Kuestermann</name><name sortKey="Makris, N M" sort="Makris, N M" uniqKey="Makris N" first="N. M." last="Makris">N. M. Makris</name><name sortKey="Nguyen, T V" sort="Nguyen, T V" uniqKey="Nguyen T" first="T. V." last="Nguyen">T. V. Nguyen</name><name sortKey="Rosas, H D" sort="Rosas, H D" uniqKey="Rosas H" first="H. D." last="Rosas">H. D. Rosas</name><name sortKey="Rosen, B R" sort="Rosen, B R" uniqKey="Rosen B" first="B. R." last="Rosen">B. R. Rosen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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