The roles of intracellular protein-degradation pathways in neurodegeneration
Identifieur interne : 001181 ( Main/Exploration ); précédent : 001180; suivant : 001182The roles of intracellular protein-degradation pathways in neurodegeneration
Auteurs : David C. Rubinsztein [Royaume-Uni]Source :
- Nature [ 0028-0836 ] ; 2006-10-19.
Abstract
Many late-onset neurodegenerative diseases, including Parkinson's disease and Huntington's disease, are associated with the formation of intracellular aggregates by toxic proteins. It is therefore crucial to understand the factors that regulate the steady-state levels of these 'toxins', at both the synthetic and degradation stages. The degradation pathways acting on such aggregate-prone cytosolic proteins include the ubiquitinproteasome system and macroautophagy. Dysfunction of the ubiquitinproteasome or macroautophagy pathways might contribute to the pathology of various neurodegenerative conditions. However, enhancing macroautophagy with drugs such as rapamycin could offer a tractable therapeutic strategy for a number of these diseases.
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DOI: 10.1038/nature05291
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