Identification of proteins in human substantia nigra
Identifieur interne : 000D76 ( Main/Exploration ); précédent : 000D75; suivant : 000D77Identification of proteins in human substantia nigra
Auteurs : Efstathia Kitsou [États-Unis] ; Sheng Pan [États-Unis] ; Jianpeng Zhang [États-Unis] ; Min Shi [États-Unis] ; Aram Zabeti [États-Unis] ; Dennis W. Dickson [États-Unis] ; Roger Albin [États-Unis] ; Marla Gearing [États-Unis] ; Daniel T. Kashima [États-Unis] ; Yan Wang [États-Unis] ; Richard P. Beyer [États-Unis] ; Yong Zhou [États-Unis] ; Catherine Pan [États-Unis] ; W. Michael Caudle [États-Unis] ; Jing Zhang [États-Unis]Source :
- PROTEOMICS – Clinical Applications [ 1862-8346 ] ; 2008-05.
English descriptors
Abstract
Characterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD). Therefore, characterization of this region is essential to a better understanding of the pathogenesis of PD. This dataset paper reports two separate studies, where human SNpc was collected from PD and control subjects and 1263 proteins were identified using MALDI‐TOF/TOF as well as linear ion trap MS platforms. With gene ontology analysis, the proteins were categorized according to their biological processes, as well as cellular components. These data were also compared with previous proteomic characterization of the human frontal and temporal cortex, and cerebrospinal fluid to establish shared proteins of relevance. The present dataset is the most extensive survey of the human SNpc proteome, to date. Further characterization of the SNpc proteome will significantly facilitate our understanding of the function and expression of proteins involved in PD, as well as provide potential proteins that may be utilized as biomarkers.
Url:
DOI: 10.1002/prca.200800028
Affiliations:
- États-Unis
- Floride, Géorgie (États-Unis), Michigan, Washington (État)
- Seattle
- Université de Washington
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Appl.</title><idno type="ISSN">1862-8346</idno><idno type="eISSN">1862-8354</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2008-05">2008-05</date><biblScope unit="volume">2</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="776">776</biblScope><biblScope unit="page" to="782">782</biblScope></imprint><idno type="ISSN">1862-8346</idno></series><idno type="istex">1F6195A9F3FFACA2EF0BA6250DE74BC91487020F</idno><idno type="DOI">10.1002/prca.200800028</idno><idno type="ArticleID">PRCA200800028</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1862-8346</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers</term><term>Cerebrospinal fluid</term><term>MS</term><term>Parkinson's disease</term><term>Substantia nigra pars compacta</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Characterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD). Therefore, characterization of this region is essential to a better understanding of the pathogenesis of PD. This dataset paper reports two separate studies, where human SNpc was collected from PD and control subjects and 1263 proteins were identified using MALDI‐TOF/TOF as well as linear ion trap MS platforms. With gene ontology analysis, the proteins were categorized according to their biological processes, as well as cellular components. These data were also compared with previous proteomic characterization of the human frontal and temporal cortex, and cerebrospinal fluid to establish shared proteins of relevance. The present dataset is the most extensive survey of the human SNpc proteome, to date. Further characterization of the SNpc proteome will significantly facilitate our understanding of the function and expression of proteins involved in PD, as well as provide potential proteins that may be utilized as biomarkers.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Géorgie (États-Unis)</li><li>Michigan</li><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Kitsou, Efstathia" sort="Kitsou, Efstathia" uniqKey="Kitsou E" first="Efstathia" last="Kitsou">Efstathia Kitsou</name></noRegion><name sortKey="Albin, Roger" sort="Albin, Roger" uniqKey="Albin R" first="Roger" last="Albin">Roger Albin</name><name sortKey="Beyer, Richard P" sort="Beyer, Richard P" uniqKey="Beyer R" first="Richard P." last="Beyer">Richard P. Beyer</name><name sortKey="Caudle, W Michael" sort="Caudle, W Michael" uniqKey="Caudle W" first="W. Michael" last="Caudle">W. Michael Caudle</name><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><name sortKey="Gearing, Marla" sort="Gearing, Marla" uniqKey="Gearing M" first="Marla" last="Gearing">Marla Gearing</name><name sortKey="Kashima, Daniel T" sort="Kashima, Daniel T" uniqKey="Kashima D" first="Daniel T." last="Kashima">Daniel T. Kashima</name><name sortKey="Pan, Catherine" sort="Pan, Catherine" uniqKey="Pan C" first="Catherine" last="Pan">Catherine Pan</name><name sortKey="Pan, Sheng" sort="Pan, Sheng" uniqKey="Pan S" first="Sheng" last="Pan">Sheng Pan</name><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name><name sortKey="Zabeti, Aram" sort="Zabeti, Aram" uniqKey="Zabeti A" first="Aram" last="Zabeti">Aram Zabeti</name><name sortKey="Zhang, Jianpeng" sort="Zhang, Jianpeng" uniqKey="Zhang J" first="Jianpeng" last="Zhang">Jianpeng Zhang</name><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><name sortKey="Zhou, Yong" sort="Zhou, Yong" uniqKey="Zhou Y" first="Yong" last="Zhou">Yong Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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