The molecular machinery of myelin gene transcription in Schwann cells
Identifieur interne : 000C44 ( Main/Exploration ); précédent : 000C43; suivant : 000C45The molecular machinery of myelin gene transcription in Schwann cells
Auteurs : John Svaren [États-Unis] ; Dies Meijer [Pays-Bas]Source :
- Glia [ 0894-1491 ] ; 2008-11-01.
English descriptors
- KwdEn :
Abstract
During late fetal life, Schwann cells in the peripheral nerves singled out by the larger axons will transit through a promyelinating stage before exiting the cell cycle and initiating myelin formation. A network of extra‐ and intracellular signaling pathways, regulating a transcriptional program of cell differentiation, governs this progression of cellular changes, culminating in a highly differentiated cell. In this review, we focus on the roles of a number of transcription factors not only in myelination, during normal development, but also in demyelination, following nerve trauma. These factors include specification factors involved in early development of Schwann cells from neural crest (Sox10) as well as factors specifically required for transitions into the promyelinating and myelinating stages (Oct6/Scip and Krox20/Egr2). From this description, we can glean the first, still very incomplete, contours of a gene regulatory network that governs myelination and demyelination during development and regeneration. © 2008 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/glia.20767
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The molecular machinery of myelin gene transcription in Schwann cells</title><author><name sortKey="Svaren, John" sort="Svaren, John" uniqKey="Svaren J" first="John" last="Svaren">John Svaren</name></author><author><name sortKey="Meijer, Dies" sort="Meijer, Dies" uniqKey="Meijer D" first="Dies" last="Meijer">Dies Meijer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C37AE51A4AC4E0386749E35449EA9D234692C7E6</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/glia.20767</idno><idno type="url">https://api.istex.fr/document/C37AE51A4AC4E0386749E35449EA9D234692C7E6/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002E72</idno><idno type="wicri:Area/Main/Curation">002A87</idno><idno type="wicri:Area/Main/Exploration">000C44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The molecular machinery of myelin gene transcription in Schwann cells</title><author><name sortKey="Svaren, John" sort="Svaren, John" uniqKey="Svaren J" first="John" last="Svaren">John Svaren</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Comparative Biosciences, School of Veterinary Medicine and Waisman Center, University of Wisconsin‐Madison, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Meijer, Dies" sort="Meijer, Dies" uniqKey="Meijer D" first="Dies" last="Meijer">Dies Meijer</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cell Biology and Genetics, ErasmusMC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Glia</title><title level="j" type="abbrev">Glia</title><idno type="ISSN">0894-1491</idno><idno type="eISSN">1098-1136</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-11-01">2008-11-01</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="1541">1541</biblScope><biblScope unit="page" to="1551">1551</biblScope></imprint><idno type="ISSN">0894-1491</idno></series><idno type="istex">C37AE51A4AC4E0386749E35449EA9D234692C7E6</idno><idno type="DOI">10.1002/glia.20767</idno><idno type="ArticleID">GLIA20767</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0894-1491</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CMT</term><term>Egr2</term><term>Pou3f1</term><term>Sox10</term><term>Srebp</term><term>gene regulation</term><term>peripheral neuropathy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During late fetal life, Schwann cells in the peripheral nerves singled out by the larger axons will transit through a promyelinating stage before exiting the cell cycle and initiating myelin formation. A network of extra‐ and intracellular signaling pathways, regulating a transcriptional program of cell differentiation, governs this progression of cellular changes, culminating in a highly differentiated cell. In this review, we focus on the roles of a number of transcription factors not only in myelination, during normal development, but also in demyelination, following nerve trauma. These factors include specification factors involved in early development of Schwann cells from neural crest (Sox10) as well as factors specifically required for transitions into the promyelinating and myelinating stages (Oct6/Scip and Krox20/Egr2). From this description, we can glean the first, still very incomplete, contours of a gene regulatory network that governs myelination and demyelination during development and regeneration. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Hollande-Méridionale</li><li>Wisconsin</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Svaren, John" sort="Svaren, John" uniqKey="Svaren J" first="John" last="Svaren">John Svaren</name></region></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Meijer, Dies" sort="Meijer, Dies" uniqKey="Meijer D" first="Dies" last="Meijer">Dies Meijer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C44 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C44 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:C37AE51A4AC4E0386749E35449EA9D234692C7E6
|texte= The molecular machinery of myelin gene transcription in Schwann cells
}}
| This area was generated with Dilib version V0.6.23. |  |