Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis
Identifieur interne : 000B47 ( Main/Exploration ); précédent : 000B46; suivant : 000B48Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis
Auteurs : Irena Dujmovic [Serbie] ; Tatjana Pekmezovic [Serbie] ; Radmila Obrenovic [Serbie] ; Aleksandra Nikoli [Serbie] ; Mihailo Spasic [Serbie] ; Marija Mostarica Stojkovic [Serbie] ; Jelena Drulovic [Serbie]Source :
- Clinical Chemistry and Laboratory Medicine [ 1434-6621 ] ; 2009-07-01.
Abstract
Background: Peroxynitrite was hypothesized to be involved in the pathogenesis of multiple sclerosis (MS) through its various neurotoxic effects. Uric acid (UA) was shown to be a strong peroxynitrite scavenger. Methods: We analyzed cerebrospinal fluid (CSF) and serum UA concentrations in 30 MS patients and 20 controls with non-inflammatory neurological diseases (NIND) and correlated these findings with demographic and clinical characteristics of MS patients. Disease activity was assessed by brain magnetic resonance imaging (MRI) and the CSF/serum albumin quotient as an indicator of the state of blood-brain-barrier (BBB). Results: Serum UA concentrations were found to be significantly lower in MS patients compared with controls (p=0.019). CSF UA concentrations were lower in MS patients as compared to controls, as well as in patients with active MS (clinical and/or MRI activity) in comparison to patients with inactive MS or controls, but these differences were not statistically significant. Significant correlation was found between CSF and serum UA concentrations (p=0.016) in MS patients, but not in controls; and between CSF UA concentrations and the CSF/serum albumin quotient in MS patients (p=0.043), but not in controls. Conclusions: Our results support the significance of UA in the pathogenesis of MS. Decreased serum UA concentrations in MS patients might be due to both intrinsically reduced antioxidant capacity and increased UA consumption in MS. CSF UA concentrations may not be a reliable marker of disease activity in MS since its concentration is dependent on leakage of UA molecules from serum through the damaged BBB and the balance between consumption/production within the central nervous system (CNS). Clin Chem Lab Med 2009;47:848–53.
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DOI: 10.1515/CCLM.2009.192
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Clinical Center of Serbia, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Nikoli, Aleksandra" sort="Nikoli, Aleksandra" uniqKey="Nikoli A" first="Aleksandra" last="Nikoli">Aleksandra Nikoli</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Institute for Biological Research “Sinisa Stankovic”, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Spasic, Mihailo" sort="Spasic, Mihailo" uniqKey="Spasic M" first="Mihailo" last="Spasic">Mihailo Spasic</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Institute for Biological Research “Sinisa Stankovic”, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Stojkovic, Marija Mostarica" sort="Stojkovic, Marija Mostarica" uniqKey="Stojkovic M" first="Marija Mostarica" last="Stojkovic">Marija Mostarica Stojkovic</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Institute of Microbiology and Immunology, Belgrade School of Medicine, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Drulovic, Jelena" sort="Drulovic, Jelena" uniqKey="Drulovic J" first="Jelena" last="Drulovic">Jelena Drulovic</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Institute of Neurology, Clinical Center of Serbia, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Chemistry and Laboratory Medicine</title><idno type="ISSN">1434-6621</idno><idno type="eISSN">1437-4331</idno><imprint><publisher>Walter de Gruyter</publisher><date type="published" when="2009-07-01">2009-07-01</date><biblScope unit="volume">47</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="848">848</biblScope><biblScope unit="page" to="853">853</biblScope></imprint><idno type="ISSN">1434-6621</idno></series><idno type="istex">C30EE0776EB9327DCE6866743348EB327160CB29</idno><idno type="DOI">10.1515/CCLM.2009.192</idno><idno type="ArticleID">cclm.2009.192</idno><idno type="Related-article-Href">cclm.2009.192.pdf</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1434-6621</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Peroxynitrite was hypothesized to be involved in the pathogenesis of multiple sclerosis (MS) through its various neurotoxic effects. Uric acid (UA) was shown to be a strong peroxynitrite scavenger. Methods: We analyzed cerebrospinal fluid (CSF) and serum UA concentrations in 30 MS patients and 20 controls with non-inflammatory neurological diseases (NIND) and correlated these findings with demographic and clinical characteristics of MS patients. Disease activity was assessed by brain magnetic resonance imaging (MRI) and the CSF/serum albumin quotient as an indicator of the state of blood-brain-barrier (BBB). Results: Serum UA concentrations were found to be significantly lower in MS patients compared with controls (p=0.019). CSF UA concentrations were lower in MS patients as compared to controls, as well as in patients with active MS (clinical and/or MRI activity) in comparison to patients with inactive MS or controls, but these differences were not statistically significant. Significant correlation was found between CSF and serum UA concentrations (p=0.016) in MS patients, but not in controls; and between CSF UA concentrations and the CSF/serum albumin quotient in MS patients (p=0.043), but not in controls. Conclusions: Our results support the significance of UA in the pathogenesis of MS. Decreased serum UA concentrations in MS patients might be due to both intrinsically reduced antioxidant capacity and increased UA consumption in MS. CSF UA concentrations may not be a reliable marker of disease activity in MS since its concentration is dependent on leakage of UA molecules from serum through the damaged BBB and the balance between consumption/production within the central nervous system (CNS). Clin Chem Lab Med 2009;47:848–53.</div></front></TEI><affiliations><list><country><li>Serbie</li></country></list><tree><country name="Serbie"><noRegion><name sortKey="Dujmovic, Irena" sort="Dujmovic, Irena" uniqKey="Dujmovic I" first="Irena" last="Dujmovic">Irena Dujmovic</name></noRegion><name sortKey="Drulovic, Jelena" sort="Drulovic, Jelena" uniqKey="Drulovic J" first="Jelena" last="Drulovic">Jelena Drulovic</name><name sortKey="Nikoli, Aleksandra" sort="Nikoli, Aleksandra" uniqKey="Nikoli A" first="Aleksandra" last="Nikoli">Aleksandra Nikoli</name><name sortKey="Obrenovic, Radmila" sort="Obrenovic, Radmila" uniqKey="Obrenovic R" first="Radmila" last="Obrenovic">Radmila Obrenovic</name><name sortKey="Pekmezovic, Tatjana" sort="Pekmezovic, Tatjana" uniqKey="Pekmezovic T" first="Tatjana" last="Pekmezovic">Tatjana Pekmezovic</name><name sortKey="Spasic, Mihailo" sort="Spasic, Mihailo" uniqKey="Spasic M" first="Mihailo" last="Spasic">Mihailo Spasic</name><name sortKey="Stojkovic, Marija Mostarica" sort="Stojkovic, Marija Mostarica" uniqKey="Stojkovic M" first="Marija Mostarica" last="Stojkovic">Marija Mostarica Stojkovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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