Parkinson's Disease and Residential Exposure to Maneb and Paraquat From Agricultural Applications in the Central Valley of California
Identifieur interne : 000863 ( Main/Exploration ); précédent : 000862; suivant : 000864Parkinson's Disease and Residential Exposure to Maneb and Paraquat From Agricultural Applications in the Central Valley of California
Auteurs : Sadie Costello [États-Unis] ; Myles Cockburn ; Jeff Bronstein ; Xinbo Zhang ; Beate RitzSource :
- American Journal of Epidemiology [ 0002-9262 ] ; 2009-03-06.
Abstract
Evidence from animal and cell models suggests that pesticides cause a neurodegenerative process leading to Parkinson's disease (PD). Human data are insufficient to support this claim for any specific pesticide, largely because of challenges in exposure assessment. The authors developed and validated an exposure assessment tool based on geographic information systems that integrated information from California Pesticide Use Reports and land-use maps to estimate historical exposure to agricultural pesticides in the residential environment. In 19982007, the authors enrolled 368 incident PD cases and 341 population controls from the Central Valley of California in a case-control study. They generated estimates for maneb and paraquat exposures incurred between 1974 and 1999. Exposure to both pesticides within 500 m of the home increased PD risk by 75% (95% confidence interval (CI): 1.13, 2.73). Persons aged 60 years at the time of diagnosis were at much higher risk when exposed to either maneb or paraquat alone (odds ratio2.27, 95% CI: 0.91, 5.70) or to both pesticides in combination (odds ratio4.17, 95% CI: 1.15, 15.16) in 19741989. This study provides evidence that exposure to a combination of maneb and paraquat increases PD risk, particularly in younger subjects and/or when exposure occurs at younger ages.
Url:
DOI: 10.1093/aje/kwp006
Affiliations:
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Human data are insufficient to support this claim for any specific pesticide, largely because of challenges in exposure assessment. The authors developed and validated an exposure assessment tool based on geographic information systems that integrated information from California Pesticide Use Reports and land-use maps to estimate historical exposure to agricultural pesticides in the residential environment. In 19982007, the authors enrolled 368 incident PD cases and 341 population controls from the Central Valley of California in a case-control study. They generated estimates for maneb and paraquat exposures incurred between 1974 and 1999. Exposure to both pesticides within 500 m of the home increased PD risk by 75% (95% confidence interval (CI): 1.13, 2.73). Persons aged 60 years at the time of diagnosis were at much higher risk when exposed to either maneb or paraquat alone (odds ratio2.27, 95% CI: 0.91, 5.70) or to both pesticides in combination (odds ratio4.17, 95% CI: 1.15, 15.16) in 19741989. This study provides evidence that exposure to a combination of maneb and paraquat increases PD risk, particularly in younger subjects and/or when exposure occurs at younger ages.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><name sortKey="Zhang, Xinbo" sort="Zhang, Xinbo" uniqKey="Zhang X" first="Xinbo" last="Zhang">Xinbo Zhang</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Costello, Sadie" sort="Costello, Sadie" uniqKey="Costello S" first="Sadie" last="Costello">Sadie Costello</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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