A motor cortex excitability and gait analysis on Parkinsonian patients
Identifieur interne : 000839 ( Main/Exploration ); précédent : 000838; suivant : 000840A motor cortex excitability and gait analysis on Parkinsonian patients
Auteurs : François Vacherot [France] ; Shahram Attarian [France] ; Marianne Vaugoyeau [France] ; Jean-Philippe Azulay [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
English descriptors
Abstract
Transcranial magnetic stimulation (TMS) parameters were recorded in a lower limb muscle and correlated with the gait parameters of 25 patients with Parkinson's disease (PD) with and without dopamine substitution treatment (DST) and 10 control subjects. Single and paired‐pulse TMS were recorded in the tibialis anterior muscle (TA). Gait analysis was performed using a 3D motion analysis system. Parkinsonian patients (PP) did not differ from the control subjects (CS) in terms of relaxed motor threshold, active motor threshold (AMT), cortical silent period (CSP), motor‐evoked potential (MEP) amplitude and area, or paired‐pulse TMS with short interstimulus intervals (ISI). At longer ISIs, paired‐pulse TMS showed that the amplitudes of the conditioned MEPs were lower in untreated PP than in CS. DST partially compensated for this difference. Gait analysis showed that the gait of PP undergoing no treatment was slower and the stride length shorter than normal. Both of these parameters improved under DST, however. Analysis of data obtained on all the subjects combined showed that both of the latter parameters were correlated with the paired‐pulse MEP amplitude and area at longer ISIs. In PP, the cortical areas responsible for the lower limb movements seem to undergo intracortical facilitation (ICF) impairments, whereas the intracortical inhibition process is normal. The ICF level was found to be associated to the stride length and the velocity. The fact that only these two gait parameters were found to be dopa responsive indicates that dopaminergic treatment may improve gait disorders by restoring the ICF. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23378
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A motor cortex excitability and gait analysis on Parkinsonian patients</title>
<author><name sortKey="Vacherot, Francois" sort="Vacherot, Francois" uniqKey="Vacherot F" first="François" last="Vacherot">François Vacherot</name>
</author>
<author><name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name>
</author>
<author><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name>
</author>
<author><name sortKey="Azulay, Jean Hilippe" sort="Azulay, Jean Hilippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:59A049396C41983AA1CFD7EEC754810480B9CE6C</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23378</idno>
<idno type="url">https://api.istex.fr/document/59A049396C41983AA1CFD7EEC754810480B9CE6C/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001D29</idno>
<idno type="wicri:Area/Main/Curation">001A49</idno>
<idno type="wicri:Area/Main/Exploration">000839</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A motor cortex excitability and gait analysis on Parkinsonian patients</title>
<author><name sortKey="Vacherot, Francois" sort="Vacherot, Francois" uniqKey="Vacherot F" first="François" last="Vacherot">François Vacherot</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, UMR 6149, Pôle 3C, Equipe “Développement et Pathologie de l'Action” Université de Provence & CNRS, Centre Saint Charles, Marseille</wicri:regionArea>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neuroscience, La Timone Hospital, Marseille</wicri:regionArea>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neuroscience, La Timone Hospital, Marseille</wicri:regionArea>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, UMR 6149, Pôle 3C, Equipe “Développement et Pathologie de l'Action” Université de Provence & CNRS, Centre Saint Charles, Marseille</wicri:regionArea>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, Jean Hilippe" sort="Azulay, Jean Hilippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, UMR 6149, Pôle 3C, Equipe “Développement et Pathologie de l'Action” Université de Provence & CNRS, Centre Saint Charles, Marseille</wicri:regionArea>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neuroscience, La Timone Hospital, Marseille</wicri:regionArea>
<placeName><settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-12-15">2010-12-15</date>
<biblScope unit="volume">25</biblScope>
<biblScope unit="issue">16</biblScope>
<biblScope unit="page" from="2747">2747</biblScope>
<biblScope unit="page" to="2755">2755</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">59A049396C41983AA1CFD7EEC754810480B9CE6C</idno>
<idno type="DOI">10.1002/mds.23378</idno>
<idno type="ArticleID">MDS23378</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>gait analysis</term>
<term>stride length</term>
<term>transcranial magnetic stimulation</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Transcranial magnetic stimulation (TMS) parameters were recorded in a lower limb muscle and correlated with the gait parameters of 25 patients with Parkinson's disease (PD) with and without dopamine substitution treatment (DST) and 10 control subjects. Single and paired‐pulse TMS were recorded in the tibialis anterior muscle (TA). Gait analysis was performed using a 3D motion analysis system. Parkinsonian patients (PP) did not differ from the control subjects (CS) in terms of relaxed motor threshold, active motor threshold (AMT), cortical silent period (CSP), motor‐evoked potential (MEP) amplitude and area, or paired‐pulse TMS with short interstimulus intervals (ISI). At longer ISIs, paired‐pulse TMS showed that the amplitudes of the conditioned MEPs were lower in untreated PP than in CS. DST partially compensated for this difference. Gait analysis showed that the gait of PP undergoing no treatment was slower and the stride length shorter than normal. Both of these parameters improved under DST, however. Analysis of data obtained on all the subjects combined showed that both of the latter parameters were correlated with the paired‐pulse MEP amplitude and area at longer ISIs. In PP, the cortical areas responsible for the lower limb movements seem to undergo intracortical facilitation (ICF) impairments, whereas the intracortical inhibition process is normal. The ICF level was found to be associated to the stride length and the velocity. The fact that only these two gait parameters were found to be dopa responsive indicates that dopaminergic treatment may improve gait disorders by restoring the ICF. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<settlement><li>Marseille</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Vacherot, Francois" sort="Vacherot, Francois" uniqKey="Vacherot F" first="François" last="Vacherot">François Vacherot</name>
</noRegion>
<name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name>
<name sortKey="Azulay, Jean Hilippe" sort="Azulay, Jean Hilippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
<name sortKey="Azulay, Jean Hilippe" sort="Azulay, Jean Hilippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
<name sortKey="Vacherot, Francois" sort="Vacherot, Francois" uniqKey="Vacherot F" first="François" last="Vacherot">François Vacherot</name>
<name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000839 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000839 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:59A049396C41983AA1CFD7EEC754810480B9CE6C |texte= A motor cortex excitability and gait analysis on Parkinsonian patients }}
This area was generated with Dilib version V0.6.23. |